LOCUS       NM_008558               1972 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus Max protein (Max), transcript variant 1, mRNA.
ACCESSION   NM_008558 XM_917137
VERSION     NM_008558.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1972)
  AUTHORS   Suzuki,A., Uranishi,K., Nishimoto,M., Mizuno,Y., Mizuno,S.,
            Takahashi,S., Eisenman,R.N. and Okuda,A.
  TITLE     MAX controls meiotic entry in sexually undifferentiated germ cells
  JOURNAL   Sci Rep 14 (1), 5236 (2024)
   PUBMED   38433229
  REMARK    GeneRIF: MAX controls meiotic entry in sexually undifferentiated
            germ cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1972)
  AUTHORS   Huang,L., Shi,Y., Hu,J., Ding,J., Guo,Z. and Yu,B.
  TITLE     Integrated analysis of mRNA-seq and miRNA-seq reveals the potential
            roles of Egr1, Rxra and Max in kidney stone disease
  JOURNAL   Urolithiasis 51 (1), 13 (2022)
   PUBMED   36484839
  REMARK    GeneRIF: Integrated analysis of mRNA-seq and miRNA-seq reveals the
            potential roles of Egr1, Rxra and Max in kidney stone disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1972)
  AUTHORS   Zhu,J.Y., Wang,G., Huang,X., Lee,H., Lee,J.G., Yang,P., van de
            Leemput,J., Huang,W., Kane,M.A., Yang,P. and Han,Z.
  TITLE     SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes
            through MGA/MAX complex-mediated increased glycolysis
  JOURNAL   Commun Biol 5 (1), 1039 (2022)
   PUBMED   36180527
  REMARK    GeneRIF: SARS-CoV-2 Nsp6 damages Drosophila heart and mouse
            cardiomyocytes through MGA/MAX complex-mediated increased
            glycolysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1972)
  AUTHORS   Mochizuki,K., Sharif,J., Shirane,K., Uranishi,K., Bogutz,A.B.,
            Janssen,S.M., Suzuki,A., Okuda,A., Koseki,H. and Lorincz,M.C.
  TITLE     Repression of germline genes by PRC1.6 and SETDB1 in the early
            embryo precedes DNA methylation-mediated silencing
  JOURNAL   Nat Commun 12 (1), 7020 (2021)
   PUBMED   34857746
  REMARK    GeneRIF: Repression of germline genes by PRC1.6 and SETDB1 in the
            early embryo precedes DNA methylation-mediated silencing.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1972)
  AUTHORS   Lowenstein,E.D., Rusanova,A., Stelzer,J., Hernaiz-Llorens,M.,
            Schroer,A.E., Epifanova,E., Bladt,F., Isik,E.G., Buchert,S.,
            Jia,S., Tarabykin,V. and Hernandez-Miranda,L.R.
  TITLE     Olig3 regulates early cerebellar development
  JOURNAL   Elife 10, e64684 (2021)
   PUBMED   33591268
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1972)
  AUTHORS   Gilladoga,A.D., Edelhoff,S., Blackwood,E.M., Eisenman,R.N. and
            Disteche,C.M.
  TITLE     Mapping of MAX to human chromosome 14 and mouse chromosome 12 by in
            situ hybridization
  JOURNAL   Oncogene 7 (6), 1249-1251 (1992)
   PUBMED   1594250
REFERENCE   7  (bases 1 to 1972)
  AUTHORS   Berberich,S., Hyde-DeRuyscher,N., Espenshade,P. and Cole,M.
  TITLE     max encodes a sequence-specific DNA-binding protein and is not
            regulated by serum growth factors
  JOURNAL   Oncogene 7 (4), 775-779 (1992)
   PUBMED   1565473
REFERENCE   8  (bases 1 to 1972)
  AUTHORS   Blackwood,E.M., Luscher,B. and Eisenman,R.N.
  TITLE     Myc and Max associate in vivo
  JOURNAL   Genes Dev 6 (1), 71-80 (1992)
   PUBMED   1730411
REFERENCE   9  (bases 1 to 1972)
  AUTHORS   Prendergast,G.C., Lawe,D. and Ziff,E.B.
  TITLE     Association of Myn, the murine homolog of max, with c-Myc
            stimulates methylation-sensitive DNA binding and ras
            cotransformation
  JOURNAL   Cell 65 (3), 395-407 (1991)
   PUBMED   1840505
REFERENCE   10 (bases 1 to 1972)
  AUTHORS   Blackwood,E.M. and Eisenman,R.N.
  TITLE     Max: a helix-loop-helix zipper protein that forms a
            sequence-specific DNA-binding complex with Myc
  JOURNAL   Science 251 (4998), 1211-1217 (1991)
   PUBMED   2006410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124556.4.
            
            On Sep 13, 2022 this sequence version replaced NM_008558.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.832223.1,
                                           SRR17784647.498315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               AC124556.4         52068-52296
            230-256             AC124556.4         52997-53023
            257-364             AC124556.4         61010-61117
            365-488             AC124556.4         74196-74319
            489-1972            AC124556.4         75531-77014
FEATURES             Location/Qualifiers
     source          1..1972
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 33.78 cM"
     gene            1..1972
                     /gene="Max"
                     /gene_synonym="bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8"
                     /note="Max protein"
                     /db_xref="GeneID:17187"
                     /db_xref="MGI:MGI:96921"
     exon            1..229
                     /gene="Max"
                     /gene_synonym="bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..676
                     /gene="Max"
                     /gene_synonym="bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein max; protein myn; myc-associated factor X;
                     myc-binding novel HLH/LZ protein"
                     /codon_start=1
                     /product="protein max isoform 1"
                     /protein_id="NP_032584.2"
                     /db_xref="CCDS:CCDS36479.1"
                     /db_xref="GeneID:17187"
                     /db_xref="MGI:MGI:96921"
                     /translation="MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFH
                     SLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRAL
                     EKARSSAQLQTNYPSSDNSLYTNAKGGTISAFDGGSDSSSESEPEEPQSRKKLRMEAS
                     "
     exon            230..256
                     /gene="Max"
                     /gene_synonym="bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8"
                     /inference="alignment:Splign:2.1.0"
     exon            257..364
                     /gene="Max"
                     /gene_synonym="bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8"
                     /inference="alignment:Splign:2.1.0"
     exon            365..488
                     /gene="Max"
                     /gene_synonym="bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8"
                     /inference="alignment:Splign:2.1.0"
     exon            489..1972
                     /gene="Max"
                     /gene_synonym="bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1951..1956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Max"
                     /gene_synonym="bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8"
                     /note="hexamer: AATAAA"
     polyA_site      1972
                     /gene="Max"
                     /gene_synonym="bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8"
                     /note="major polyA site"
ORIGIN      
        1 gccgttgatc cggtgctgca gtgaggtggt tgtcgcccgt gttgtgtgtg cgtgagtgtg
       61 tgtgagtgag tgagcgagtg agtgagtgtg tgcgtggggg cactcggctt gttgttgtcg
      121 gtgacttccc ccttccctcc acccctcccc tccccggccg ccgctgcagt ggccgctccc
      181 tgggccgtag gaaatgagcg ataacgatga catcgaggtg gagagcgacg aagagcaacc
      241 gaggtttcaa tctgcggctg acaagcgggc tcaccataat gcactggaac gaaaacgtag
      301 ggaccacatc aaagacagct ttcacagttt gcgggactca gtcccatcac tccaaggaga
      361 gaaggcatcc cgggcccaaa tcctagacaa agcaacagag tatatccagt atatgcgaag
      421 gaaaaaccat acgcaccagc aagacattga tgacctcaag cggcagaatg ctcttctgga
      481 gcaacaagtc cgtgcactgg agaaggcaag atcaagtgcc caactgcaga ccaactaccc
      541 ctcctcagac aacagcctct acaccaacgc caagggcggc accatctctg ccttcgatgg
      601 gggttcagac tccagctcag aatccgagcc tgaagagccc cagagcagga agaaactccg
      661 gatggaggcc agctaagcca tgcggggcag gccagcaata aaactgtcga ctctctcgtc
      721 gcatcctcct tctgttcatc attagaaccc tcagaaccat tgagaagact ctttattttc
      781 cttttctctt tattaattgt tatttttgca tagaagctct tggacaacag ctctcatccc
      841 cttccctgtg tccactattt ttaaatgtat tcccttcagg ggttcctgtc cccaccagaa
      901 attttaaacc aaaacacccc aacttggcag ctctttctgt ggaggacaga cggccggcca
      961 gacctctgag tacacggtgt cctgcccacc ctaccagctc ctccagccct cagagcacgt
     1021 gcctggagga cgcctgctct accaggctct cctcccagtc ctccctcacc tctgtttggt
     1081 ggactttgtg actctgaact tttctgcttt ggcaagaaga cctgattgga gtaatcagaa
     1141 ctcactccct cctttgtaag gattattttt ttggaaaagc tgtctctcct gttgaaagac
     1201 gggattcttg aagaagtttg tgtggtagaa aaggaaagtg gggacagatt tgcagcaccc
     1261 atggcacagt ctgtaacttc ggctgtttaa gcctgaagac ccagccttcc agaaggccac
     1321 gggacgctgg tatgtatgta taggagacgg cggcagtgaa acgaacggct ctcaggagtg
     1381 ggggtggcta tgtgggtggg gctgggaggg agtcttaggt ggggtagagg ttttgtatta
     1441 agggccagtg atgatgtttt gatatttatt tcctgctact gaaatttgaa tctgaatgaa
     1501 atgcccccta tttctgatga tgtcgatatt gtaaagcgac agattcataa agtaatgatc
     1561 aaatcttcat ttctttctgt gtgtatttct aagaaataga gccaactatt ttgtatgtaa
     1621 ataccaagag cgacttacct ggtactaaac ccacagccca gtccagcctc ccgccctgct
     1681 tctttcctcc tgtcctggaa cttgtcgcca ctgtgtgatc cagtcctggc tctggctgtg
     1741 gtcagcagat cccagtgaag ggtttcttgt cttgatgctt catttctttg tctttttcct
     1801 actctgttgc cggcatttgc tgatttctag tgtatacttt gtagtctcag tcggtgttga
     1861 ttccattcca tggaaataaa gagtatgttg tacatactgc ccaagaattg tcctgcaagt
     1921 taaggcttcc ccctttacta taagaatata aataaaaact tattttatcc tt
//
