LOCUS       NM_001206385            2871 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus mitochondrial antiviral signaling protein (Mavs),
            transcript variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001206385
VERSION     NM_001206385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2871)
  AUTHORS   Zerad,L., Gacem,N., Gayda,F., Day,L., Sinigaglia,K., Richard,L.,
            Parisot,M., Cagnard,N., Mathis,S., Bole-Feysot,C., O'Connell,M.A.,
            Pingault,V., Dambroise,E., Keegan,L.P., Vallat,J.M. and
            Bondurand,N.
  TITLE     Overexpression of Egr1 Transcription Regulator Contributes to
            Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1
            Knockout Mice
  JOURNAL   Cells 13 (23), 1952 (2024)
   PUBMED   39682701
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2871)
  AUTHORS   Gern,O.L., Pavlou,A., Mulenge,F., Busker,L.M., Ghita,L., Aringo,A.,
            Costa,B., Spanier,J., Waltl,I., Stangel,M. and Kalinke,U.
  TITLE     MAVS signaling shapes microglia responses to neurotropic virus
            infection
  JOURNAL   J Neuroinflammation 21 (1), 264 (2024)
   PUBMED   39425188
  REMARK    GeneRIF: MAVS signaling shapes microglia responses to neurotropic
            virus infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2871)
  AUTHORS   Alippe,Y., Wang,L., Coskun,R., Muraro,S.P., Zhao,F.R.,
            Elam-Noll,M., White,J.M., Vota,D.M., Hauk,V.C., Gordon,J.I.,
            Handley,S.A. and Diamond,M.S.
  TITLE     Fetal MAVS and type I IFN signaling pathways control ZIKV infection
            in the placenta and maternal decidua
  JOURNAL   J Exp Med 221 (9) (2024)
   PUBMED   39042188
  REMARK    GeneRIF: Fetal MAVS and type I IFN signaling pathways control ZIKV
            infection in the placenta and maternal decidua.
REFERENCE   4  (bases 1 to 2871)
  AUTHORS   Ashby,K.M., Voboril,M., Salgado,O.C., Lee,S.T., Martinez,R.J.,
            O'Connor,C.H., Breed,E.R., Xuan,S., Roll,C.R., Bachigari,S.,
            Heiland,H., Stetson,D.B., Kotenko,S.V. and Hogquist,K.A.
  TITLE     Sterile production of interferons in the thymus affects T cell
            repertoire selection
  JOURNAL   Sci Immunol 9 (97), eadp1139 (2024)
   PUBMED   39058762
REFERENCE   5  (bases 1 to 2871)
  AUTHORS   Liu,X., Zhu,C., Jia,S., Deng,H., Tang,J., Sun,X., Zeng,X., Chen,X.,
            Wang,Z., Liu,W., Liao,Q., Zha,H., Cai,X. and Xiao,W.
  TITLE     Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation
            and SIRT5-catalyzed desuccinylation orchestrates antiviral innate
            immunity
  JOURNAL   Proc Natl Acad Sci U S A 121 (17), e2314201121 (2024)
   PUBMED   38635631
  REMARK    GeneRIF: Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed
            deacetylation and SIRT5-catalyzed desuccinylation orchestrates
            antiviral innate immunity.
REFERENCE   6  (bases 1 to 2871)
  AUTHORS   Kumar,H., Kawai,T., Kato,H., Sato,S., Takahashi,K., Coban,C.,
            Yamamoto,M., Uematsu,S., Ishii,K.J., Takeuchi,O. and Akira,S.
  TITLE     Essential role of IPS-1 in innate immune responses against RNA
            viruses
  JOURNAL   J Exp Med 203 (7), 1795-1803 (2006)
   PUBMED   16785313
  REMARK    GeneRIF: IPS-1 is the sole adapter in both retinoic acid-inducible
            gene (RIG-I) and melanoma differentiation-associated gene 5 (Mda5)
            signaling that mediates effective responses against a variety of
            RNA viruses.
REFERENCE   7  (bases 1 to 2871)
  AUTHORS   Sun,Q., Sun,L., Liu,H.H., Chen,X., Seth,R.B., Forman,J. and
            Chen,Z.J.
  TITLE     The specific and essential role of MAVS in antiviral innate immune
            responses
  JOURNAL   Immunity 24 (5), 633-642 (2006)
   PUBMED   16713980
REFERENCE   8  (bases 1 to 2871)
  AUTHORS   Meylan,E., Curran,J., Hofmann,K., Moradpour,D., Binder,M.,
            Bartenschlager,R. and Tschopp,J.
  TITLE     Cardif is an adaptor protein in the RIG-I antiviral pathway and is
            targeted by hepatitis C virus
  JOURNAL   Nature 437 (7062), 1167-1172 (2005)
   PUBMED   16177806
REFERENCE   9  (bases 1 to 2871)
  AUTHORS   Xu,L.G., Wang,Y.Y., Han,K.J., Li,L.Y., Zhai,Z. and Shu,H.B.
  TITLE     VISA is an adapter protein required for virus-triggered IFN-beta
            signaling
  JOURNAL   Mol Cell 19 (6), 727-740 (2005)
   PUBMED   16153868
  REMARK    GeneRIF: Data suggest that VISA is critically involved in both
            virus-triggered TLR3-independent and TLR3-mediated antiviral
            interferon signaling.
REFERENCE   10 (bases 1 to 2871)
  AUTHORS   Seth,R.B., Sun,L., Ea,C.K. and Chen,Z.J.
  TITLE     Identification and characterization of MAVS, a mitochondrial
            antiviral signaling protein that activates NF-kappaB and IRF 3
  JOURNAL   Cell 122 (5), 669-682 (2005)
   PUBMED   16125763
  REMARK    GeneRIF: The overexpression of mitochondrial antiviral
            signaling(MAVS)induces the expression of IFN-beta through
            activation of NF-kappaB and IRF 3, thus boosting antiviral
            immunity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153748.1, AK028421.1 and AL808128.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020006.1, AK028421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 16125763; reported by
                                                  MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK153748.1         3-6
            5-1280              AK028421.1         4-1279
            1281-2871           AL808128.4         51705-53295
FEATURES             Location/Qualifiers
     source          1..2871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.3 cM"
     gene            1..2871
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /note="mitochondrial antiviral signaling protein"
                     /db_xref="GeneID:228607"
                     /db_xref="MGI:MGI:2444773"
     exon            1..65
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /inference="alignment:Splign:2.1.0"
     exon            66..240
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1635
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /note="isoform 1 is encoded by transcript variant 2;
                     IFN-beta promoter stimulator-1; mitochondrial anti-viral
                     signaling protein; virus-induced signaling adapter; CARD
                     adapter inducing interferon beta; interferon beta promoter
                     stimulator protein 1"
                     /codon_start=1
                     /product="mitochondrial antiviral-signaling protein
                     isoform 1"
                     /protein_id="NP_001193314.1"
                     /db_xref="CCDS:CCDS16760.1"
                     /db_xref="GeneID:228607"
                     /db_xref="MGI:MGI:2444773"
                     /translation="MTFAEDKTYKYIRDNHSKFCCVDVLEILPYLSCLTASDQDRLRA
                     SYRQIGNRDTLWGLFNNLQRRPGWVEVFIRALQICELPGLADQVTRVYQSYLPPGTSL
                     RSLEPLQLPDFPAAVSGPSAFAPGHNIPDHGLRETPSCPKPVQDTQPPESPVENSEQL
                     LQTNSGAVARMSGGSLIPSPNQQALSPQPSREHQEQEPELGGAHAANVASVPIATYGP
                     VSPTVSFQPLPRTALRTNLLSGVTVSALSADTSLSSSSTGSAFAKGAGDQAKAATCFS
                     TTLTNSVTTSSVPSPRLVPVKTMSSKLPLSSKSTAAMTSTVLTNTAPSKLPSNSVYAG
                     TVPSRVPASVAKAPANTIPPERNSKQAKETPEGPATKVTTGGNQTGPNSSIRSLHSGP
                     EMSKPGVLVSQLDEPFSACSVDLAISPSSSLVSEPNHGPEENEYSSFRIQVDESPSAD
                     LLGSPEPLATQQPQEEEEHCASSMPWAKWLGATSALLAVFLAVMLYRSRRLAQ"
     exon            241..418
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /inference="alignment:Splign:2.1.0"
     exon            419..588
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /inference="alignment:Splign:2.1.0"
     exon            589..742
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1209
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..2871
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2848..2853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /note="hexamer: ATTAAA"
     polyA_site      2871
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /note="major polyA site"
ORIGIN      
        1 cttcatctgc gagggctctg cacagtcgaa cgcggtcaac ctgttgccta gtctggtttc
       61 tcttgtccat ctcagtccat cccaccctgc cagggtccga gtcactccag aagctgagca
      121 gccatgacat ttgctgagga caagacctat aagtatatcc gagacaacca cagcaagttt
      181 tgctgtgttg acgttctgga gatcctgcct tacctgtcct gcctcacagc tagtgaccag
      241 gatcgactgc gggcttccta caggcagatc gggaaccggg acacactctg gggactcttc
      301 aataatctcc agcgccggcc tggctgggtg gaggtcttca tccgggcact gcagatctgt
      361 gagctgcctg ggctggctga tcaagtgact cgagtttatc agagctacct gcctccgggg
      421 acctcactcc gctccctaga gccactgcag ttaccagact ttcctgctgc ggtttctgga
      481 ccctctgcat ttgcgccagg tcacaacatc cctgaccatg gcttacgaga gacaccaagt
      541 tgccccaagc ctgtccagga cacccagcca ccagagtccc cagtagagaa ttcagagcaa
      601 ctcctccaga ccaactccgg ggccgtcgcg aggatgtctg gtggctcttt gataccctct
      661 cctaaccagc aggctctcag ccctcagccc tccagagagc atcaagagca agaaccagaa
      721 ctgggtggcg cccacgcagc aaatgttgcc tctgttccca tagcaaccta tggacctgtg
      781 tctccaaccg tttccttcca gccccttcca cgtactgccc tgaggacaaa cctcttgtct
      841 ggggtcacag tatcagccct atctgctgat acctctttgt cctcctcgtc cactggatca
      901 gcttttgcaa agggagctgg tgaccaggcc aaagctgcca cctgtttcag tactacactc
      961 accaattctg tgactaccag ctcagtgcct tctcccagat tggtcccagt aaaaaccatg
     1021 tcttccaagt tgcccctcag ttcaaagtcc actgctgcga tgacgtctac tgtgctcacc
     1081 aatacagcgc catcaaaatt acccagcaac tcagtgtatg cgggcacagt gccatccaga
     1141 gtgcctgcta gtgtggccaa agcacctgcc aacacaatac cacctgagag gaacagcaag
     1201 caagccaagg agaccccgga gggtccagca accaaagtca ccactggagg caaccagact
     1261 ggaccaaata gcagtatcag gagcttgcac tctggaccag agatgagcaa gccaggtgtg
     1321 ctggtatccc agttggacga gccattctca gcctgctctg tggaccttgc cattagccct
     1381 agcagctcct tggtctcaga acccaaccat ggtccagagg agaatgagta ttcgtccttt
     1441 agaatccagg tagacgaaag ccccagtgct gatctattag gaagccctga gccactagcc
     1501 acccagcagc cccaagaaga ggaagaacat tgtgccagtt caatgccctg ggctaagtgg
     1561 cttggggcca ccagtgcact cttggctgta ttcctggcag tgatgctgta ccgtagtagg
     1621 cgcctggccc agtgaagcct cagctgtatg ctgttctctt gctcagttct gccaagcatg
     1681 ttctctaggc ttgggctagt agaggctgag tcagagaaac ttaaatatgg cgaggtccac
     1741 tgagctatcc aggtagatag ctacaccaag acgtcatcac tgttgggtgg gggagagaca
     1801 ttgttttatc ctggttcata tgtcatcttc tggtcttcag cttttggagg cactgtgtta
     1861 cctccattgc tcctgacctg cccacgtggc agtgtaagag ttcatgctct gtgctcctaa
     1921 ggaggtatct ccaccagctt tatccctgtt ggcccaagcc tgaagatgag gaggtatcgc
     1981 actgttgaca atgcccctca tctcgcccag atcttctgaa acacaagcgt aggtacactg
     2041 atgagtgctc ccatagcatc ttatgccttc caccggcagc ctggtctaag gccttggcag
     2101 gagagcctgg gagtaacaga gtggctggtc tctagggagc tttgagtgct ctgccccttt
     2161 gggccctctc cacagccagt caaccctgag ggtgagtctg gaggttctct gtggactctt
     2221 aagaaagcca gaagcaactg ccaggcctga ggaagcccct gggagggagc ttttctccaa
     2281 cctccttacc ccctcctcgc ttctccactc ctggtctcca ttctctccct atactggatg
     2341 atgagatacc tagtgggcag aactcaggct gggcttgcat cagttccacc ctttccctgg
     2401 cctttagcag atgtctagct tctctagtct tgttcccaat gtagatagcg ggcagctctt
     2461 ccttttactg ggctcctctg agtttgaagg atacagatac ttgcctagta cttatctcag
     2521 agggtgtgag tacaagttct tgccctcctg ccctggctgg ctgagctaag gtgagagtgt
     2581 gagaggcaga gtgcatattg gtaatggcag tctttgagag agcagccttc atctccatca
     2641 tgcttctttc tcctccctgg tcaggtgtag gcctcacctc tgtgcctcac ttttcttacc
     2701 tgtgagatgg ggtgagtatg tgtgtgtata cacacacata cccacagacc cacgcccaca
     2761 cccacacata catgctaata tattctcacc tgtgagatgg aaagtatgca tacattgatg
     2821 ctaatatatt ctagttttat caggataatt aaaagagttt atctgtgcaa a
//
