LOCUS       NM_001399986            4078 bp    mRNA    linear   ROD 20-AUG-2024
DEFINITION  Mus musculus matrin 3 (Matr3), transcript variant 5, mRNA.
ACCESSION   NM_001399986
VERSION     NM_001399986.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4078)
  AUTHORS   Cheng,X., Baki,V.B., Moran,M., Liu,B., Yu,J., Zhao,M., Li,Q.,
            Riethoven,J.J., Gurumurth,C.B., Harris,E.N. and Sun,X.
  TITLE     Liver matrin-3 protects mice against hepatic steatosis and stress
            response via constitutive androstane receptor
  JOURNAL   Mol Metab 86, 101977 (2024)
   PUBMED   38936659
  REMARK    GeneRIF: Liver matrin-3 protects mice against hepatic steatosis and
            stress response via constitutive androstane receptor.
REFERENCE   2  (bases 1 to 4078)
  AUTHORS   Taliani,V., Buonaiuto,G., Desideri,F., Setti,A., Santini,T.,
            Galfre,S., Schirone,L., Mariani,D., Frati,G., Valenti,V.,
            Sciarretta,S., Perlas,E., Nicoletti,C., Musaro,A. and Ballarino,M.
  TITLE     The long noncoding RNA Charme supervises cardiomyocyte maturation
            by controlling cell differentiation programs in the developing
            heart
  JOURNAL   Elife 12, e81360 (2023)
   PUBMED   36877136
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4078)
  AUTHORS   Dominick,M., Houchins,N., Venugopal,V., Zuberi,A.R., Lutz,C.M.,
            Meechooveet,B., Van Keuren-Jensen,K., Bowser,R. and Medina,D.X.
  TITLE     MATR3 P154S knock-in mice do not exhibit motor, muscle or
            neuropathologic features of ALS
  JOURNAL   Biochem Biophys Res Commun 645, 164-172 (2023)
   PUBMED   36689813
  REMARK    GeneRIF: MATR3 P154S knock-in mice do not exhibit motor, muscle or
            neuropathologic features of ALS.
REFERENCE   4  (bases 1 to 4078)
  AUTHORS   Cha,H.J., Uyan,O., Kai,Y., Liu,T., Zhu,Q., Tothova,Z., Botten,G.A.,
            Xu,J., Yuan,G.C., Dekker,J. and Orkin,S.H.
  TITLE     Inner nuclear protein Matrin-3 coordinates cell differentiation by
            stabilizing chromatin architecture
  JOURNAL   Nat Commun 12 (1), 6241 (2021)
   PUBMED   34716321
  REMARK    GeneRIF: Inner nuclear protein Matrin-3 coordinates cell
            differentiation by stabilizing chromatin architecture.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4078)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4078)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 4078)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4078)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 4078)
  AUTHORS   Polydorides,A.D., Okano,H.J., Yang,Y.Y., Stefani,G. and
            Darnell,R.B.
  TITLE     A brain-enriched polypyrimidine tract-binding protein antagonizes
            the ability of Nova to regulate neuron-specific alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6350-6355 (2000)
   PUBMED   10829067
REFERENCE   10 (bases 1 to 4078)
  AUTHORS   Matsushima,Y., Nagabukuro,A., Matsuda,Y. and Kitagawa,Y.
  TITLE     Cloning and genomic mapping of the mouse matrin 3 gene and its
            pseudogenes
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 194-198 (1998)
   PUBMED   9730601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121821.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.31109.1,
                                           SRR9219379.48196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               AC121821.3         53320-53678
            360-1452            AC121821.3         62421-63513
            1453-1514           AC121821.3         68136-68197
            1515-1556           AC121821.3         68994-69035
            1557-1669           AC121821.3         69483-69595
            1670-1722           AC121821.3         69844-69896
            1723-1848           AC121821.3         71748-71873
            1849-1974           AC121821.3         72175-72300
            1975-2142           AC121821.3         72497-72664
            2143-2274           AC121821.3         73294-73425
            2275-2318           AC121821.3         74456-74499
            2319-2685           AC121821.3         75093-75459
            2686-2908           AC121821.3         78209-78431
            2909-3030           AC121821.3         78910-79031
            3031-4078           AC121821.3         80958-82005
FEATURES             Location/Qualifiers
     source          1..4078
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.14 cM"
     gene            1..4078
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /note="matrin 3"
                     /db_xref="GeneID:17184"
                     /db_xref="MGI:MGI:1298379"
     exon            1..359
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     exon            360..1452
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     CDS             541..3081
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /note="isoform a is encoded by transcript variant 5"
                     /codon_start=1
                     /product="matrin-3 isoform a"
                     /protein_id="NP_001386915.1"
                     /db_xref="GeneID:17184"
                     /db_xref="MGI:MGI:1298379"
                     /translation="MSKSFQQSSLGRDSQGHGRDLSAAGIGLLAAATQSLSMPASLGR
                     MNQGTARLASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSRGPLPLSSQHR
                     GDTDQASNILASFGLSARDLDELSRYPEDKITPENLPQILLQLKRRRTEEGPTLSYGR
                     DGRSATREPPYRVPRDDWEEKRHFRRDSFDDRGPSLNPVLDYDHGSRSQESGYYDRMD
                     YEDDRLRDGERCRDDSFFGETSHNYHKFDSEYERMGRGPGPLQERSLFEKKRGAPPSS
                     NIEDFHGLLPKGYPHLCSICDLPVHSNKEWSQHINGASHSRRCQLLLEIYPEWNPDND
                     TGHTMGDPFMLQQSTNPAPGILGPPPPSFHLGGPAVGPRGNLGAGNGNLQGPRHMQKG
                     RVETSRVVHIMDFQRGKNLRYQLLQLVEPFGVISNHLILNKINEAFIEMATTEDAQAA
                     VDYYTTTPALVFGKPVRVHLSQKYKRIKKPEGKPDQKFDQKQELGRVIHLSNLPHSGY
                     SDSAVLKLAEPYGKIKNYILMRMKSQAFIEMETREDAMAMVDHCLKKALWFQGRCVKV
                     DLSEKYKKLVLRIPNRGIDLLKKDKSRKRSYSPDGKESPSDKKSKTDAQKTESPAEGK
                     EQEEKSGEDGEKDTKDDQTEQEPSMLLESEDELLVDEEEAAALLESGSSVGDETDLAN
                     LGDVSSDGKKEPSDKAVKKDPSASATSKKKLKKVDKIEELDQENEAALENGIKNEENT
                     EPGAESAENADDPNKDTSENADGQNDENKEDYTIPDEYRIGPYQPNVPVGIDYVIPKT
                     GFYCKLCSLFYTNEEVAKNTHCSSLPHYQKLKKFLNKLAEERRQKKET"
     exon            1453..1514
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1556
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1669
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1722
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1848
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1974
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2142
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2274
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2318
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2685
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2908
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3030
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..4078
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3436..3441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /note="hexamer: AATAAA"
     polyA_site      3458
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /note="major polyA site"
     regulatory      4058..4063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /note="hexamer: AATAAA"
     polyA_site      4078
                     /gene="Matr3"
                     /gene_synonym="1110061A14Rik; 2810017I02Rik;
                     D030046F20Rik; mKIAA0723"
                     /note="major polyA site"
ORIGIN      
        1 attcgaggag ggtggttaaa gcgaagggac ggtccgtagg agcgcggctc cggtctagcg
       61 cctttgcggg ttttcctccg aaaacggacc taaaatggag gatttcgtag gatgtgagaa
      121 gcttgcgtgt tctgaccaat gtttctttct caggcgtcag tcgcctcgcc agtccctcac
      181 ccatcgccca gtgttgcccc cttcccaaga ctcccgcgtc cctcgcccgc gcgcgatttt
      241 cgccagacat ctggaacaat ccctccccac ccccactccc cccgcagttg cgtaaaaatg
      301 gcggaaaagg aaacgttaac gcttggattt tttgaattgc gtctttggga aagctcttga
      361 gttgtctgct ggttctcagc ttgaagaaga ttctacagtc cttattgatc ctttttcttg
      421 gcgttaccat ttttgaagca aagttaacct agctttctag cttgagcttt ctttttggcc
      481 atcttttaaa actttttttt ttttttttga tctataaaat agacaagaga tagttctaca
      541 atgtccaagt cattccagca gtcatctctc ggtagggatt cacagggtca tgggcgtgac
      601 ctgtctgcag caggaatagg ccttcttgct gctgctaccc agtctttaag tatgccagca
      661 tctcttggaa ggatgaacca gggtactgca cgccttgcta gtttaatgaa tcttggaatg
      721 agttcttcat tgaatcaaca aggagctcat agtgcactgt cttctgctag tacttcttcc
      781 cataatttgc agtctatatt taacattgga agtagaggtc cactcccttt gtcttctcaa
      841 caccgtggag atacagacca ggccagtaat attttggcca gctttggtct gtctgctaga
      901 gacttagatg aactgagtcg ctatccagag gacaagatta ctcctgagaa cttgccccaa
      961 attcttctac agcttaaaag gaggagaact gaagaaggcc ctacattgag ttatggtaga
     1021 gatggcagat ctgctacacg ggagccacca tacagagtac ctagggatga ttgggaagaa
     1081 aaaaggcact ttagaagaga tagttttgat gatcgtggtc ctagtctcaa cccagtgctt
     1141 gattatgacc atggaagtcg ttctcaagaa tctggttatt atgacagaat ggattatgaa
     1201 gatgacagat taagagatgg agaaaggtgt agggatgatt ctttttttgg tgagacctcg
     1261 cataactatc ataaatttga cagtgagtat gagagaatgg gacgtggtcc tggcccctta
     1321 caagagagat ctctctttga gaaaaagagg ggcgctcctc caagtagcaa tattgaagac
     1381 ttccatggac tcttaccgaa gggttatccc catctgtgct ctatatgtga tttgccagtt
     1441 cattctaata aggagtggag tcaacatatc aatggagcaa gtcacagtcg tcgatgccag
     1501 cttcttcttg aaatctaccc agaatggaat cctgacaatg atactggaca cacaatgggt
     1561 gatccattca tgctgcagca gtctacaaac ccagcaccag ggattctggg accgccgcct
     1621 ccttcatttc atcttggagg accagcagtt ggaccaagag gaaatctggg tgctggtaat
     1681 ggaaacctac aaggaccaag acacatgcaa aaaggcagag tggaaaccag ccgagttgtt
     1741 cacattatgg attttcagcg aggaaaaaac ttgagatacc agctgttaca actggtagaa
     1801 ccatttggag tcatttcaaa tcatctgatt ttaaataaaa ttaatgaggc atttattgaa
     1861 atggccacca cagaagatgc tcaggctgct gtggattatt atacaactac accagcatta
     1921 gtgtttggca agccagtgag agttcattta tcccagaagt ataagagaat aaagaaacct
     1981 gaaggaaaac cagatcagaa gtttgatcaa aagcaagaac ttggtcgtgt gatacatctc
     2041 agcaatttac ctcattctgg ctattctgac agtgccgtcc tcaagcttgc tgagccttat
     2101 gggaaaataa agaattatat cttaatgagg atgaaaagtc aggcttttat tgagatggaa
     2161 accagagaag atgcaatggc aatggttgac cactgtttaa agaaggcact ttggtttcag
     2221 gggagatgtg ttaaagttga tctgtctgag aaatacaaaa aactggtgct gcggattcct
     2281 aacagaggca ttgacttact gaaaaaagat aaatcccgga aaagatccta ttctccagat
     2341 ggaaaagaat ctccaagtga taagaagtcc aaaactgatg ctcagaagac tgagagtcca
     2401 gctgagggta aagaacaaga agagaagtcg ggtgaggatg gtgagaagga caccaaggat
     2461 gaccagacag aacaggagcc cagcatgctt cttgaatctg aagatgaact gcttgttgat
     2521 gaggaagaag ctgcagcact actagaaagt ggtagttcag tgggcgatga gaccgatctt
     2581 gctaatttag gggatgtatc ttctgatggg aaaaaggagc cttcagataa agctgtgaaa
     2641 aaagatccaa gtgcttcagc aacatccaag aaaaaactta aaaaagtgga caagattgag
     2701 gaacttgatc aagaaaatga agctgcattg gaaaatggga ttaaaaatga ggaaaataca
     2761 gaaccgggtg ccgaatctgc tgagaatgct gatgatccaa acaaagacac aagtgaaaat
     2821 gcagatggcc aaaatgatga gaataaggag gattatacaa ttcccgatga gtatagaatc
     2881 ggaccatatc agcctaatgt tcctgttggt atagactatg tgatacctaa aacagggttt
     2941 tactgtaagc tgtgttcact cttttataca aatgaagaag ttgcaaagaa tactcattgc
     3001 agcagccttc ctcattatca gaaattaaag aaatttctga ataaattggc agaagaacgg
     3061 aggcagaaga aggaaactta agatgtacaa gaagcttaat tcaaagaaaa cgatggttct
     3121 ttgattttaa tgttaacctt ttttaaaata caatactgat agttagaaaa ctactgtaca
     3181 cttttgtttt agtggaaaat aatagatgtc tgttgtgttt aagtgttata gcaaaaagta
     3241 cacatacggt taagttaatg aaaatgtttt tgtttcatcc gagtgacaac agacaaaagt
     3301 acttcctaaa gattgactgt tgtaagctat ggaaaacaac ttgcaccact aagagaaaga
     3361 taacatagaa ccattcagaa aaatgaaact tagtagtttg aggcttcaaa gaaatgtcaa
     3421 cttctgattc cattcaataa agaacaaaac caattgtatt tttttttact tttcatctga
     3481 aacattccac attttaatct gagccttgca gacttttcat ttgactttgg aagctgtttt
     3541 ggttgcattg catttttaga gaacttcatt catgtgagat tggccattca attgcaggtg
     3601 cagttttctt ttaatgtcat gctgtttaga tgataagaaa tattaagaat tggctttaga
     3661 tttgtaattt ttttctcttg agttcctgct aggttttata ttctagtagt caatgttatt
     3721 tcagtgaaat gtaaaaatat tcccgttctc tttgaccagt attaatttct tgagaaccta
     3781 ttgcctgtca cttgaatcct gtagctgtca tacatctctg gtataagcaa catttgattt
     3841 ttgaagtgtg taaaccatct atattttcaa gatgtaattt tacatttctg catttcaaaa
     3901 ccagtttggc cataattctt gacgcacgct tctaattcat gtacctgcac atgtgacctt
     3961 tgtgagcaga aatttgcatg tataatctgt gtttacttgt aactctctgg ttatatactg
     4021 cttatatctg tggattcaag ttactgaagt gaataccaat aaaaaaaaaa aaaactta
//
