LOCUS       NM_013592               2508 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus matrilin 4 (Matn4), transcript variant 1, mRNA.
ACCESSION   NM_013592
VERSION     NM_013592.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2508)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2508)
  AUTHORS   Brutsch,S.M., Madzharova,E., Pantasis,S., Wustemann,T., Gurri,S.,
            Steenbock,H., Gazdhar,A., Kuhn,G., Angel,P., Bellusci,S.,
            Brinckmann,J., Auf dem Keller,U., Werner,S. and Bordoli,M.R.
  TITLE     Mesenchyme-derived vertebrate lonesome kinase controls lung
            organogenesis by altering the matrisome
  JOURNAL   Cell Mol Life Sci 80 (4), 89 (2023)
   PUBMED   36920550
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2508)
  AUTHORS   Farmer,D.T., Mlcochova,H., Zhou,Y., Koelling,N., Wang,G.,
            Ashley,N., Bugacov,H., Chen,H.J., Parvez,R., Tseng,K.C.,
            Merrill,A.E., Maxson,R.E. Jr., Wilkie,A.O.M., Crump,J.G. and
            Twigg,S.R.F.
  TITLE     The developing mouse coronal suture at single-cell resolution
  JOURNAL   Nat Commun 12 (1), 4797 (2021)
   PUBMED   34376651
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2508)
  AUTHORS   Martinez,M.E. and Hernandez,A.
  TITLE     The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone
            Sensitivity in the Fetal Brain
  JOURNAL   Front Neurosci 15, 703730 (2021)
   PUBMED   34248495
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2508)
  AUTHORS   Youlten,S.E., Kemp,J.P., Logan,J.G., Ghirardello,E.J., Sergio,C.M.,
            Dack,M.R.G., Guilfoyle,S.E., Leitch,V.D., Butterfield,N.C.,
            Komla-Ebri,D., Chai,R.C., Corr,A.P., Smith,J.T., Mohanty,S.T.,
            Morris,J.A., McDonald,M.M., Quinn,J.M.W., McGlade,A.R.,
            Bartonicek,N., Jansson,M., Hatzikotoulas,K., Irving,M.D.,
            Beleza-Meireles,A., Rivadeneira,F., Duncan,E., Richards,J.B.,
            Adams,D.J., Lelliott,C.J., Brink,R., Phan,T.G., Eisman,J.A.,
            Evans,D.M., Zeggini,E., Baldock,P.A., Bassett,J.H.D., Williams,G.R.
            and Croucher,P.I.
  TITLE     Osteocyte transcriptome mapping identifies a molecular landscape
            controlling skeletal homeostasis and susceptibility to skeletal
            disease
  JOURNAL   Nat Commun 12 (1), 2444 (2021)
   PUBMED   33953184
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2508)
  AUTHORS   Klatt,A.R., Paulsson,M. and Wagener,R.
  TITLE     Expression of matrilins during maturation of mouse skeletal tissues
  JOURNAL   Matrix Biol 21 (3), 289-296 (2002)
   PUBMED   12009334
  REMARK    GeneRIF: Expression of matrilin-4 during maturation of mouse
            skeletal tissues
REFERENCE   7  (bases 1 to 2508)
  AUTHORS   Wagener,R., Kobbe,B., Aszodi,A., Aeschlimann,D. and Paulsson,M.
  TITLE     Characterization of the mouse matrilin-4 gene: a 5' antiparallel
            overlap with the gene encoding the transcription factor RBP-l
  JOURNAL   Genomics 76 (1-3), 89-98 (2001)
   PUBMED   11549321
REFERENCE   8  (bases 1 to 2508)
  AUTHORS   Klatt,A.R., Nitsche,D.P., Kobbe,B., Macht,M., Paulsson,M. and
            Wagener,R.
  TITLE     Molecular structure, processing, and tissue distribution of
            matrilin-4
  JOURNAL   J Biol Chem 276 (20), 17267-17275 (2001)
   PUBMED   11279097
REFERENCE   9  (bases 1 to 2508)
  AUTHORS   Wagener,R., Kobbe,B. and Paulsson,M.
  TITLE     Genomic organisation, alternative splicing and primary structure of
            human matrilin-4
  JOURNAL   FEBS Lett 438 (3), 165-170 (1998)
   PUBMED   9827539
REFERENCE   10 (bases 1 to 2508)
  AUTHORS   Wagener,R., Kobbe,B. and Paulsson,M.
  TITLE     Matrilin-4, a new member of the matrilin family of extracellular
            matrix proteins
  JOURNAL   FEBS Lett 436 (1), 123-127 (1998)
   PUBMED   9771906
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590429.10 and AK041073.1.
            
            On Nov 19, 2011 this sequence version replaced NM_013592.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ006140.1, AK041073.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               AL590429.10        146501-146794       c
            295-385             AK041073.1         2-92
            386-2492            AK041073.1         94-2200
            2493-2508           AL590429.10        131369-131384       c
FEATURES             Location/Qualifiers
     source          1..2508
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.16 cM"
     gene            1..2508
                     /gene="Matn4"
                     /gene_synonym="matrilin-4"
                     /note="matrilin 4"
                     /db_xref="GeneID:17183"
                     /db_xref="MGI:MGI:1328314"
     exon            1..328
                     /gene="Matn4"
                     /gene_synonym="matrilin-4"
                     /inference="alignment:Splign:2.1.0"
     exon            329..449
                     /gene="Matn4"
                     /gene_synonym="matrilin-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..2245
                     /gene="Matn4"
                     /gene_synonym="matrilin-4"
                     /note="MAT-4"
                     /codon_start=1
                     /product="matrilin-4 precursor"
                     /protein_id="NP_038620.2"
                     /db_xref="CCDS:CCDS17034.1"
                     /db_xref="GeneID:17183"
                     /db_xref="MGI:MGI:1328314"
                     /translation="MRGPCCWPLSLLLLFLQSWETQLQSAGPRCYNGPLDLVFMIDSS
                     RSVRPFEFETMRQFLVGLLRSLDVGLNATRVGVIQYSSQVQSVFPLGAFSRREDMERA
                     IRAVVPLAQGTMTGLAIQYAMNVAFSEAEGARPSEERVPRVLVIVTDGRPQDRVAEVA
                     AQARARGIEIYAVGVQRADVGSLRTMASPPLDQHVFLVESFDLIQEFGLQFQGRLCGK
                     DLCAELVHGCQHLCVNAPGTFYCACNSGYKLAPDNKNCLALDLCAEGTHGCEHLCVNS
                     VDSYFCRCRAGFALQQDQRSCRAIDYCSFGNHSCQHECVSTLEGPQCRCREGHDLLPD
                     GRSCRVRDFCNDVDHGCEFQCVSEGLSFHCLCPEGRRLQADGKSCDRCREGHVDLVLL
                     VDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAE
                     VKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRDLNVPRVGLVFTDGRSQDDI
                     SVWAARAKEEGIVMYAVGVGKAVEEELREIASEPSELHVSYSPDFSTMTHLLENLKGS
                     ICPEEGIGAGTELRSPCECESLVEFQGRTLGALESLTQNLARLTERLEELENQLASRK
                     "
     exon            450..1019
                     /gene="Matn4"
                     /gene_synonym="matrilin-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1142
                     /gene="Matn4"
                     /gene_synonym="matrilin-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1265
                     /gene="Matn4"
                     /gene_synonym="matrilin-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1388
                     /gene="Matn4"
                     /gene_synonym="matrilin-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1511
                     /gene="Matn4"
                     /gene_synonym="matrilin-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1925
                     /gene="Matn4"
                     /gene_synonym="matrilin-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2078
                     /gene="Matn4"
                     /gene_synonym="matrilin-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2186
                     /gene="Matn4"
                     /gene_synonym="matrilin-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2508
                     /gene="Matn4"
                     /gene_synonym="matrilin-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactccagct gtagcccaat tccggcccgc agctcgcgcc tgcagctccc agagcagcag
       61 gaaaaagggg cgccgtgctt gctggggccc gagtgttgag aggaaggggg agaacgctcc
      121 tgccagtggg aggggtcgca gcccgcgctc cccctcccca ccctcccgct ccaggttaaa
      181 tgcagctgcc gcttgggctc gccctggctg tctggcattc cccacttagg gcaacctgcc
      241 cacgccgccg ccgttacctg gtccaactcc ccaggaggct gggcccgtcg ctctgtagcc
      301 gcacctctga gctgtccggc aggctcagct gcaggctgtg acactgtggt tcgtcatcct
      361 tccaagcacc atgagaggcc cctgctgctg gccactctct ctgttgctgc tcttcctgca
      421 gtcctgggaa actcagctcc agtctgcagg tcctaggtgc tataatgggc ccctggattt
      481 ggtgttcatg attgatagct cccgcagcgt gcgccccttc gagtttgaga ccatgaggca
      541 gttcctagtg ggcctcctcc gcagcctgga cgtgggtctg aacgccacgc gcgttggggt
      601 gatccagtat tctagtcaag tgcagagcgt ctttcccctg ggcgcctttt cgcgccgcga
      661 ggacatggaa cgagccatcc gcgcggtggt gccgctggcg cagggcacca tgaccgggct
      721 ggcgatccag tacgctatga acgtggcctt cagcgaggcc gaaggcgcgc gcccatcgga
      781 ggagcgagtg ccgcgcgtct tggtcatcgt gacagacggg cgacctcaag accgagtggc
      841 cgaagtggcc gctcaggcgc gcgcccgcgg cattgagatc tatgcggtag gggtacagcg
      901 agctgacgtg ggctctcttc gcaccatggc ttcgccgccg ctggatcagc atgtcttctt
      961 agtggagtcc ttcgatctca tccaggagtt tggcctgcag ttccagggcc gcctgtgcgg
     1021 gaaggacctg tgtgctgagt tggttcatgg ctgccaacac ctgtgtgtca acgccccagg
     1081 aacattctac tgcgcctgca actctggcta caagctagca ccagataaca agaattgttt
     1141 ggccttggat ctctgcgctg aaggaaccca tggctgtgaa cacctctgtg tcaactccgt
     1201 ggactcgtat ttctgtcgtt gccgagctgg ctttgcgctc cagcaggacc agaggagctg
     1261 cagagccatt gactactgca gctttggaaa ccacagctgc cagcatgagt gtgtgagcac
     1321 tttggagggg ccacagtgtc gctgcagaga gggccacgac ctgctacctg atgggagaag
     1381 ctgtcgggtc agggacttct gcaatgatgt ggaccatggc tgtgagttcc agtgtgtgag
     1441 tgagggtctt tccttccact gcctgtgccc tgaggggagg cgacttcagg ctgatggcaa
     1501 gagctgtgac cggtgccggg agggccacgt ggatcttgtt ctcctggtgg atggttccaa
     1561 gagcgtgcgc ccacagaact tcgagctggt gaagcgcttc gtgaaccaga ttgtggattt
     1621 ccttgacgtg tctcccgagg gcacacgtgt tgggctggtg cagttctcca gccgggtgcg
     1681 caccgagttc cccctgggcc gctatggcac cgcagctgag gtgaagcagg cagttttggc
     1741 cgtggagtac atggagcgcg gcaccatgac agggctggcc ctgcgtcaca tggtggagca
     1801 cagcttctct gaggcgcagg gcgcgcggcc tcgcgacctc aacgtgcctc gcgtgggctt
     1861 ggtgttcact gatggccgct ctcaggatga catttcagtg tgggcagctc gtgccaaaga
     1921 ggaaggcatc gtcatgtatg ccgtgggcgt gggtaaggct gtggaggaag agctgcgtga
     1981 gatcgcatcg gaaccatcgg agttgcacgt gtcctattct ccggacttta gcaccatgac
     2041 gcacctgctg gagaatctca aaggcagcat ttgcccagag gagggcattg gcgcggggac
     2101 agagcttcgg agtccctgcg aatgcgaaag cctcgtggag ttccagggcc gcacgctggg
     2161 ggcgctcgag agcctgacgc agaacctggc tcggctgaca gagcgcctgg aggagctgga
     2221 gaaccagctg gctagccgaa agtgagggtc gcacgctgtc tgagcagcca cgcgagaccg
     2281 aggccgagcc ccgcagcctg gaccgtccag gagggggcgc tggcgggccc cacgcgctgc
     2341 cttcgagctg gcctcacctg gaccaggagc cagatttagg ggatggggat gaggggatgg
     2401 ggaggtgctg gtggggaagg actgctacac tcgccgcgag ctttgttgga tttctttttt
     2461 tgttttcctt ttctaaaaaa aaaaaaaaaa aatttggttt tcacgggg
//
