LOCUS       NM_010770               3014 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus matrilin 3 (Matn3), mRNA.
ACCESSION   NM_010770
VERSION     NM_010770.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3014)
  AUTHORS   Zhou,X., Zhu,Y., Gao,D., Li,M., Lin,L., Wang,Z., Du,H., Xu,Y.,
            Liu,J., He,Y., Guo,Y., Wang,S., Qiao,S., Bao,Y., Liu,Y. and
            Zhang,H.
  TITLE     Matrilin-3 supports neuroprotection in ischemic stroke by
            suppressing astrocyte-mediated neuroinflammation
  JOURNAL   Cell Rep 43 (4), 113980 (2024)
   PUBMED   38520693
  REMARK    GeneRIF: Matrilin-3 supports neuroprotection in ischemic stroke by
            suppressing astrocyte-mediated neuroinflammation.
REFERENCE   2  (bases 1 to 3014)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3014)
  AUTHORS   Seifer,P., Hay,E., Fleischhauer,L., Heilig,J., Bloch,W.,
            Sonntag,S., Shmerling,D., Clausen-Schaumann,H., Aszodi,A.,
            Niehoff,A., Cohen-Solal,M., Paulsson,M., Wagener,R. and Zaucke,F.
  TITLE     The Matrilin-3 T298M mutation predisposes for post-traumatic
            osteoarthritis in a knock-in mouse model
  JOURNAL   Osteoarthritis Cartilage 29 (1), 78-88 (2021)
   PUBMED   33227438
  REMARK    GeneRIF: The Matrilin-3 T298M mutation predisposes for
            post-traumatic osteoarthritis in a knock-in mouse model.
REFERENCE   4  (bases 1 to 3014)
  AUTHORS   Li,P., Fleischhauer,L., Nicolae,C., Prein,C., Farkas,Z.,
            Saller,M.M., Prall,W.C., Wagener,R., Heilig,J., Niehoff,A.,
            Clausen-Schaumann,H., Alberton,P. and Aszodi,A.
  TITLE     Mice Lacking the Matrilin Family of Extracellular Matrix Proteins
            Develop Mild Skeletal Abnormalities and Are Susceptible to
            Age-Associated Osteoarthritis
  JOURNAL   Int J Mol Sci 21 (2), 666 (2020)
   PUBMED   31963938
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3014)
  AUTHORS   Pirog,K.A., Dennis,E.P., Hartley,C.L., Jackson,R.M., Soul,J.,
            Schwartz,J.M., Bateman,J.F., Boot-Handford,R.P. and Briggs,M.D.
  TITLE     XBP1 signalling is essential for alleviating mutant protein
            aggregation in ER-stress related skeletal disease
  JOURNAL   PLoS Genet 15 (7), e1008215 (2019)
   PUBMED   31260448
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3014)
  AUTHORS   Klatt,A.R., Nitsche,D.P., Kobbe,B., Morgelin,M., Paulsson,M. and
            Wagener,R.
  TITLE     Molecular structure and tissue distribution of matrilin-3, a
            filament-forming extracellular matrix protein expressed during
            skeletal development
  JOURNAL   J Biol Chem 275 (6), 3999-4006 (2000)
   PUBMED   10660556
REFERENCE   7  (bases 1 to 3014)
  AUTHORS   Wagener,R., Kobbe,B., Aszodi,A., Liu,Z., Beier,D.R. and Paulsson,M.
  TITLE     Structure and mapping of the mouse matrilin-3 gene (Matn3), a
            member of a gene family containing a U12-type AT-AC intron
  JOURNAL   Mamm Genome 11 (2), 85-90 (2000)
   PUBMED   10656920
REFERENCE   8  (bases 1 to 3014)
  AUTHORS   Paulsson,M., Piecha,D., Segat,D., Smyth,N. and Wagener,R.
  TITLE     The matrilins: a growing family of A-domain-containing proteins
  JOURNAL   Biochem Soc Trans 27 (6), 824-826 (1999)
   PUBMED   10830110
  REMARK    Review article
REFERENCE   9  (bases 1 to 3014)
  AUTHORS   Costell,M., Gustafsson,E., Aszodi,A., Morgelin,M., Bloch,W.,
            Hunziker,E., Addicks,K., Timpl,R. and Fassler,R.
  TITLE     Perlecan maintains the integrity of cartilage and some basement
            membranes
  JOURNAL   J Cell Biol 147 (5), 1109-1122 (1999)
   PUBMED   10579729
REFERENCE   10 (bases 1 to 3014)
  AUTHORS   Wagener,R., Kobbe,B. and Paulsson,M.
  TITLE     Primary structure of matrilin-3, a new member of a family of
            extracellular matrix proteins related to cartilage matrix protein
            (matrilin-1) and von Willebrand factor
  JOURNAL   FEBS Lett 413 (1), 129-134 (1997)
   PUBMED   9287130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB643484.1, AK048456.1 and AK160954.1.
            
            On Sep 10, 2010 this sequence version replaced NM_010770.3.
            
            Sequence Note: An in-frame AUG is located 25 codons upstream of the
            annotated translation start site but is not being annotated as a
            start site since it would disrupt the signal peptide on
            NP_034900.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048456.1, AK160954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BB643484.1         1-42
            43-2039             AK048456.1         1-1997
            2040-2477           AK160954.1         2018-2455
            2478-3014           AK048456.1         2438-2974
FEATURES             Location/Qualifiers
     source          1..3014
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 3.96 cM"
     gene            1..3014
                     /gene="Matn3"
                     /note="matrilin 3"
                     /db_xref="GeneID:17182"
                     /db_xref="MGI:MGI:1328350"
     exon            1..323
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     exon            324..890
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1016
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1142
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1268
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1394
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1505
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..3014
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2452..2457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Matn3"
                     /note="hexamer: ATTAAA"
     polyA_site      2479
                     /gene="Matn3"
                     /note="major polyA site"
     regulatory      2684..2689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Matn3"
                     /note="hexamer: AATAAA"
     polyA_site      2709
                     /gene="Matn3"
ORIGIN      
        1 agaagcggga cctttaaatt ggttgccaat gtgaggccct atggctgaga cctctgaccc
       61 tgtgtacccc agttacctcg cggctcacag accccggcag gtcgtcaagc ccatcatgtt
      121 gctctcagcc cccttacgcc acctcccggg gcttctgctg ctgctctggc cgctgttgct
      181 cctgccttcc ctggctgctc ctggacgttt ggcccgcgcg agcgtccgcc ggctggggac
      241 acgagtcccc ggaggcagcc ctgggcatct ctctgctctg gctacttcca cccgcgcgcc
      301 atattccggg ggccgcggcg caggtgtttg caagagcagg cctttggact tggtgttcat
      361 cattgatagt tctcgtagcg tccggcctct ggaattcacc aaggtgaaga cctttgtctc
      421 ccgcatcatc gacactctgg acatcggggc cacagacacg agggtggctg tggtgaacta
      481 tgccagcact gtgaagatag agttccagct caacacctat tccgacaagc aggccctgaa
      541 acaggctgtg gcacggatca cacccttgtc aacaggcacc atgtcagggc tagctatcca
      601 gacagcgatg gaggaagcct tcactgtgga ggccggggct cgggggccca tgtctaacat
      661 ccccaaggta gctattatcg tgacagatgg gaggccgcag gaccaggtga atgaggtggc
      721 tgctcgagcc cgtgcatctg gcattgagct gtatgctgtg ggtgtggacc gggcagatat
      781 ggagtccctc aagatgatgg ctagcaagcc cctggaagag cacgtcttct acgtggagac
      841 ctacggggtc attgagaagc tttctgctag attccaggaa accttttgtg ctctggatca
      901 gtgcatgctt ggcacacacc agtgtcagca cgtgtgtgtc agcgatggtg acggcaagca
      961 tcactgcgag tgcagccaag gctacacctt gaacgctgat gggaaaacgt gttcagccat
     1021 tgataagtgt gcccttagca ctcatggatg tgaacagatc tgtgtcaacg acagaaatgg
     1081 ctcttaccac tgcgagtgct atggaggtta cgccttgaat gcagacagga gaacgtgtgc
     1141 agctctggac aaatgcgcct ctggtacaca tggttgccag cacatctgtg tgaatgatgg
     1201 agccgggtcc catcactgtg aatgttttga aggctacact ctgaatgcag ataagaaaac
     1261 atgttcagtc cggaacaagt gtgctctagg cactcatggc tgccagcaca tctgtgtgag
     1321 tgatggagca gtggcctacc actgtgactg cttccctggc tacaccttga atgatgacaa
     1381 gaagacatgt tcagacattg aagaagcccg aagcctcatt tccatagaag acgcctgcgg
     1441 ctgtggggcc acgctggcat tccaggagaa ggtcagctcc catctccaga agctgaacac
     1501 caaacttgac aacattttga agaagttgaa agtaacagaa tatggacaag tacatcgtta
     1561 aactgtgtaa aactctcgcc tggaaatgtg gagggcttga tatatgcgat tctcattctc
     1621 ttgtcacgct atctgatgtg cctgctaata atctgccatt ataaatgctt aacattattt
     1681 ggtaaacagt gtgaggggtt tctggagaac catattgttt tccaaggaga taaatgtgta
     1741 gacccttatt aaaagcaagt ttaatgtctc atagctatga ctgtgaaatc attaataaga
     1801 tagagagtga aaagtttaag gttttgttat ctactgtttg agccatttaa gtttaaattg
     1861 tttatattag taagatgatc ttactcataa aactttaggt ctattttctc ttggtcatat
     1921 ttataatacg aaccagcctt actaccaaga gtgcaaattt tatgaaatat ttacacatac
     1981 aaagataaac taattaaact gagatttaga attgcttact atttttgttt tttttttttg
     2041 ctggaatatt attaaagcta caaacaaggg attataatac atgtacctaa aaataattta
     2101 cacagactaa gtggatgtta tatgacactt ttaattcatt aatgtcatgg aaatgaacaa
     2161 ctaaagagta ctggctatga acttatggtg ctaagatttt tgctaagaga aaaaattttg
     2221 aattctatca ttttgtttta gcatgcaatt ggcaaaatta catatttata gaattaatat
     2281 aataagtaac aagttataat attatcttaa aaactgtcaa taagcctgat ttttcactca
     2341 aaatatactg aatgcataca ctttttaagc gcagctcata acttttagaa cgaaacaatt
     2401 ctgtaaattt tgtgctactt gatctgtttt ggtttgtatt gtttctaata tattaaaagt
     2461 tcccgtcttt ctacattaac ggcatggttg atgtttttat gattcttgtt atttttttct
     2521 atcaagcata ttatgttgaa tggaatgaat aatttttgaa tatgtaacag ctgagaaact
     2581 gaaagaatga aatggtgatg atactctttc aataatttaa tctcatgcct ctgttgaggc
     2641 ataaaatgtt agtaagttca gggtaaacag aaagaagttc ctaaataaaa ccagtggggg
     2701 aaaatgtgat tacagaagtg tgcatgtgct tgagctagtg tttgtgcgca tgcgtgtgct
     2761 tatgtctgca tgggtgcaca cgcaccacag cacatgtgga cgtgtgtggg tggacggttt
     2821 gtggaatggc ttctctcctt ccgccactgt gttctagtga tccggttggt catcaggctt
     2881 ggaggtgggt gcctctgcct gccgagccat cttgccagcc cctcactgtg acattttcag
     2941 aatcccaatc atgtctggat attatcttct gtttcttctt gatagttgaa taataatcct
     3001 ctgtgtatac atgc
//
