LOCUS       NP_034900                481 aa            linear   ROD 07-MAY-2024
DEFINITION  matrilin-3 precursor [Mus musculus].
ACCESSION   NP_034900
VERSION     NP_034900.4
DBSOURCE    REFSEQ: accession NM_010770.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 481)
  AUTHORS   Zhou,X., Zhu,Y., Gao,D., Li,M., Lin,L., Wang,Z., Du,H., Xu,Y.,
            Liu,J., He,Y., Guo,Y., Wang,S., Qiao,S., Bao,Y., Liu,Y. and
            Zhang,H.
  TITLE     Matrilin-3 supports neuroprotection in ischemic stroke by
            suppressing astrocyte-mediated neuroinflammation
  JOURNAL   Cell Rep 43 (4), 113980 (2024)
   PUBMED   38520693
  REMARK    GeneRIF: Matrilin-3 supports neuroprotection in ischemic stroke by
            suppressing astrocyte-mediated neuroinflammation.
REFERENCE   2  (residues 1 to 481)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 481)
  AUTHORS   Seifer,P., Hay,E., Fleischhauer,L., Heilig,J., Bloch,W.,
            Sonntag,S., Shmerling,D., Clausen-Schaumann,H., Aszodi,A.,
            Niehoff,A., Cohen-Solal,M., Paulsson,M., Wagener,R. and Zaucke,F.
  TITLE     The Matrilin-3 T298M mutation predisposes for post-traumatic
            osteoarthritis in a knock-in mouse model
  JOURNAL   Osteoarthritis Cartilage 29 (1), 78-88 (2021)
   PUBMED   33227438
  REMARK    GeneRIF: The Matrilin-3 T298M mutation predisposes for
            post-traumatic osteoarthritis in a knock-in mouse model.
REFERENCE   4  (residues 1 to 481)
  AUTHORS   Li,P., Fleischhauer,L., Nicolae,C., Prein,C., Farkas,Z.,
            Saller,M.M., Prall,W.C., Wagener,R., Heilig,J., Niehoff,A.,
            Clausen-Schaumann,H., Alberton,P. and Aszodi,A.
  TITLE     Mice Lacking the Matrilin Family of Extracellular Matrix Proteins
            Develop Mild Skeletal Abnormalities and Are Susceptible to
            Age-Associated Osteoarthritis
  JOURNAL   Int J Mol Sci 21 (2), 666 (2020)
   PUBMED   31963938
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 481)
  AUTHORS   Pirog,K.A., Dennis,E.P., Hartley,C.L., Jackson,R.M., Soul,J.,
            Schwartz,J.M., Bateman,J.F., Boot-Handford,R.P. and Briggs,M.D.
  TITLE     XBP1 signalling is essential for alleviating mutant protein
            aggregation in ER-stress related skeletal disease
  JOURNAL   PLoS Genet 15 (7), e1008215 (2019)
   PUBMED   31260448
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 481)
  AUTHORS   Klatt,A.R., Nitsche,D.P., Kobbe,B., Morgelin,M., Paulsson,M. and
            Wagener,R.
  TITLE     Molecular structure and tissue distribution of matrilin-3, a
            filament-forming extracellular matrix protein expressed during
            skeletal development
  JOURNAL   J Biol Chem 275 (6), 3999-4006 (2000)
   PUBMED   10660556
REFERENCE   7  (residues 1 to 481)
  AUTHORS   Wagener,R., Kobbe,B., Aszodi,A., Liu,Z., Beier,D.R. and Paulsson,M.
  TITLE     Structure and mapping of the mouse matrilin-3 gene (Matn3), a
            member of a gene family containing a U12-type AT-AC intron
  JOURNAL   Mamm Genome 11 (2), 85-90 (2000)
   PUBMED   10656920
REFERENCE   8  (residues 1 to 481)
  AUTHORS   Paulsson,M., Piecha,D., Segat,D., Smyth,N. and Wagener,R.
  TITLE     The matrilins: a growing family of A-domain-containing proteins
  JOURNAL   Biochem Soc Trans 27 (6), 824-826 (1999)
   PUBMED   10830110
  REMARK    Review article
REFERENCE   9  (residues 1 to 481)
  AUTHORS   Costell,M., Gustafsson,E., Aszodi,A., Morgelin,M., Bloch,W.,
            Hunziker,E., Addicks,K., Timpl,R. and Fassler,R.
  TITLE     Perlecan maintains the integrity of cartilage and some basement
            membranes
  JOURNAL   J Cell Biol 147 (5), 1109-1122 (1999)
   PUBMED   10579729
REFERENCE   10 (residues 1 to 481)
  AUTHORS   Wagener,R., Kobbe,B. and Paulsson,M.
  TITLE     Primary structure of matrilin-3, a new member of a family of
            extracellular matrix proteins related to cartilage matrix protein
            (matrilin-1) and von Willebrand factor
  JOURNAL   FEBS Lett 413 (1), 129-134 (1997)
   PUBMED   9287130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB643484.1, AK048456.1 and AK160954.1.
            
            On Sep 10, 2010 this sequence version replaced NP_034900.3.
            
            Sequence Note: An in-frame AUG is located 25 codons upstream of the
            annotated translation start site but is not being annotated as a
            start site since it would disrupt the signal peptide on
            NP_034900.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048456.1, AK160954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 3.96 cM"
     Protein         1..481
                     /product="matrilin-3 precursor"
                     /calculated_mol_wt=48889
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2975
     mat_peptide     28..481
                     /product="Matrilin-3. /id=PRO_0000007658"
                     /note="propagated from UniProtKB/Swiss-Prot (O35701.2)"
                     /calculated_mol_wt=48889
     Region          75..298
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Site            order(84,155,191)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238752"
     Site            193
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (O35701.2)"
     Region          305..341
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Site            321
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35701.2)"
     Region          347..383
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          389..425
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Site            436
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by FAM20C.
                     /evidence=ECO:0000250|UniProtKB:O15232; propagated from
                     UniProtKB/Swiss-Prot (O35701.2)"
     Region          438..478
                     /region_name="Matrilin_ccoil"
                     /note="Trimeric coiled-coil oligomerization domain of
                     matrilin; pfam10393"
                     /db_xref="CDD:463070"
     CDS             1..481
                     /gene="Matn3"
                     /coded_by="NM_010770.4:116..1561"
                     /db_xref="CCDS:CCDS25806.1"
                     /db_xref="GeneID:17182"
                     /db_xref="MGI:MGI:1328350"
ORIGIN      
        1 mllsaplrhl pglllllwpl lllpslaapg rlarasvrrl gtrvpggspg hlsalatstr
       61 apysggrgag vcksrpldlv fiidssrsvr pleftkvktf vsriidtldi gatdtrvavv
      121 nyastvkief qlntysdkqa lkqavaritp lstgtmsgla iqtameeaft veagargpms
      181 nipkvaiivt dgrpqdqvne vaararasgi elyavgvdra dmeslkmmas kpleehvfyv
      241 etygviekls arfqetfcal dqcmlgthqc qhvcvsdgdg khhcecsqgy tlnadgktcs
      301 aidkcalsth gceqicvndr ngsyhcecyg gyalnadrrt caaldkcasg thgcqhicvn
      361 dgagshhcec fegytlnadk ktcsvrnkca lgthgcqhic vsdgavayhc dcfpgytlnd
      421 dkktcsdiee arslisieda cgcgatlafq ekvsshlqkl ntkldnilkk lkvteygqvh
      481 r
//
