LOCUS       NM_001358780            3577 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus matrilin 2 (Matn2), transcript variant 1, mRNA.
ACCESSION   NM_001358780 XM_006520023
VERSION     NM_001358780.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3577)
  AUTHORS   Wang,Y., Su,L., Wang,W., Zhao,J., Wang,Y., Li,S., Liu,Y., Chai,R.,
            Li,X., Teng,Z., Liu,C., Hu,B., Ji,F. and Jiao,J.
  TITLE     Endothelial Arid1a deletion disrupts the balance among
            angiogenesis, neurogenesis and gliogenesis in the developing brain
  JOURNAL   Cell Prolif 56 (5), e13447 (2023)
   PUBMED   36916004
REFERENCE   2  (bases 1 to 3577)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3577)
  AUTHORS   Li,P., Fleischhauer,L., Nicolae,C., Prein,C., Farkas,Z.,
            Saller,M.M., Prall,W.C., Wagener,R., Heilig,J., Niehoff,A.,
            Clausen-Schaumann,H., Alberton,P. and Aszodi,A.
  TITLE     Mice Lacking the Matrilin Family of Extracellular Matrix Proteins
            Develop Mild Skeletal Abnormalities and Are Susceptible to
            Age-Associated Osteoarthritis
  JOURNAL   Int J Mol Sci 21 (2), 666 (2020)
   PUBMED   31963938
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3577)
  AUTHORS   Luo,J., Zhang,M., Huang,H., Wang,Y., Yuan,X., Ma,S., Liu,J.,
            Zhou,S. and Zhang,S.
  TITLE     Matrilin-2 regulates proliferation, apoptosis and cell cycle during
            radiation-induced injury in HPAEpiC cell
  JOURNAL   Biochem Biophys Res Commun 485 (3), 577-583 (2017)
   PUBMED   27923659
  REMARK    GeneRIF: Data show that the mRNA and protein levels of matrilin-2
            were increased after irradiation treatment in both mouse lung
            tissue and human pulmonary alveolar epithelial cells (HPAEpiC).
REFERENCE   5  (bases 1 to 3577)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3577)
  AUTHORS   Klatt,A.R., Nitsche,D.P., Kobbe,B., Macht,M., Paulsson,M. and
            Wagener,R.
  TITLE     Molecular structure, processing, and tissue distribution of
            matrilin-4
  JOURNAL   J Biol Chem 276 (20), 17267-17275 (2001)
   PUBMED   11279097
REFERENCE   7  (bases 1 to 3577)
  AUTHORS   Segat,D., Frie,C., Nitsche,P.D., Klatt,A.R., Piecha,D., Korpos,E.,
            Deak,F., Wagener,R., Paulsson,M. and Smyth,N.
  TITLE     Expression of matrilin-1, -2 and -3 in developing mouse limbs and
            heart
  JOURNAL   Matrix Biol 19 (7), 649-655 (2000)
   PUBMED   11102754
REFERENCE   8  (bases 1 to 3577)
  AUTHORS   Paulsson,M., Piecha,D., Segat,D., Smyth,N. and Wagener,R.
  TITLE     The matrilins: a growing family of A-domain-containing proteins
  JOURNAL   Biochem Soc Trans 27 (6), 824-826 (1999)
   PUBMED   10830110
  REMARK    Review article
REFERENCE   9  (bases 1 to 3577)
  AUTHORS   Piecha,D., Muratoglu,S., Morgelin,M., Hauser,N., Studer,D.,
            Kiss,I., Paulsson,M. and Deak,F.
  TITLE     Matrilin-2, a large, oligomeric matrix protein, is expressed by a
            great variety of cells and forms fibrillar networks
  JOURNAL   J Biol Chem 274 (19), 13353-13361 (1999)
   PUBMED   10224097
REFERENCE   10 (bases 1 to 3577)
  AUTHORS   Deak,F., Piecha,D., Bachrati,C., Paulsson,M. and Kiss,I.
  TITLE     Primary structure and expression of matrilin-2, the closest
            relative of cartilage matrix protein within the von Willebrand
            factor type A-like module superfamily
  JOURNAL   J Biol Chem 272 (14), 9268-9274 (1997)
   PUBMED   9083061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133101.4, AC144632.4 and AC126028.4.
            
            On Dec 9, 2017 this sequence version replaced XM_006520023.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U69262.1, BC005429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               AC133101.4         4769-4996           c
            229-393             AC144632.4         92090-92254
            394-963             AC144632.4         120590-121159
            964-1086            AC144632.4         131162-131284
            1087-1209           AC144632.4         154254-154376
            1210-1332           AC144632.4         164323-164445
            1333-1455           AC144632.4         174649-174771
            1456-1578           AC144632.4         178434-178556
            1579-1701           AC144632.4         185352-185474
            1702-1824           AC144632.4         185713-185835
            1825-1947           AC144632.4         197941-198063
            1948-2070           AC144632.4         199293-199415
            2071-2193           AC144632.4         201762-201884
            2194-2607           AC144632.4         204033-204446
            2608-2760           AC126028.4         96088-96240         c
            2761-2832           AC126028.4         94961-95032         c
            2833-2967           AC126028.4         94545-94679         c
            2968-3066           AC126028.4         94127-94225         c
            3067-3577           AC126028.4         91470-91980         c
FEATURES             Location/Qualifiers
     source          1..3577
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 13.98 cM"
     gene            1..3577
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /note="matrilin 2"
                     /db_xref="GeneID:17181"
                     /db_xref="MGI:MGI:109613"
     exon            1..228
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            229..393
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..3122
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="matrilin-2 isoform 1 precursor"
                     /protein_id="NP_001345709.1"
                     /db_xref="CCDS:CCDS88747.1"
                     /db_xref="GeneID:17181"
                     /db_xref="MGI:MGI:109613"
                     /translation="MEKMLVGCLLMLGQLFLVLPVDGRERPQARFPSRGRHVRMYPQT
                     ALLESSCENKRADLVFIIDSSRSVNTYDYAKVKEFILDILQFLDIGPDVTRVGLLQYG
                     STVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLREN
                     VPRIIMIVTDGRPQDSVAEVAAKARNTGILIFAIGVGQVDLNTLKAIGSEPHKDHVFL
                     VANFSQIESLTSVFQNKLCTVHMCSVLEHNCAHFCLNTPGSYICKCKQGYILSTDQKT
                     CRIQDLCATEDHGCEQLCVNMLGSFVCQCYSGYTLAEDGKRCTAVDYCASENHGCEHE
                     CVNAESSYLCRCHEGFALNSDKKTCSKIDYCASSNHGCQHECVNAQTSALCRCLKGFM
                     LNPDRKTCRRINYCALNKPGCEHECVNTEEGHYCRCRQGYNLDPNGKTCSRVDHCAQQ
                     DHGCEQLCLNTEESFVCQCSEGFLINDDLKTCSRADYCLLSNHGCEYSCVNTDKSFAC
                     QCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRDDGKTCRR
                     KDVCQDVNHGCEHLCVNSGESYVCKCLEGFRLAEDGKRCRRKNVCKSTQHGCEHMCVN
                     NGNSYLCRCSEGFVLAEDGKHCKRCTEGPIDLVFVIDGSKSLGEENFETVKHFVTGII
                     DSLAVSPKAARVGLLQYSTQVRTEFTLRGFSSAKEMKKAVTHMKYMGKGSMTGLALKH
                     MFERSFTQVEGARPPSTQVPRVAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAI
                     EEELQEIASEPIDKHLFYAEDFSTMGEISEKLKEGICEALEDSGGRQDSAAWDLPQQA
                     HQPTEPEPVTIKIKDLLSCSNFAVQHRFLFEEDNLSRSTQKLFHSTKSSGNPLEESQD
                     QCKCENLILFQNVANEEVRKLTQRLEEMTQRMEALENRLKYR"
     exon            394..963
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1086
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1209
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1332
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1455
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1578
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1701
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1824
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1947
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2070
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2193
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2607
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2760
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2832
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..2967
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3066
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3577
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3554..3559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /note="hexamer: ATTAAA"
     polyA_site      3577
                     /gene="Matn2"
                     /gene_synonym="Crtm2; matrilin-2"
                     /note="major polyA site"
ORIGIN      
        1 tttcagggag cctcccaggc agccagcaag cgcggagagc gcactgggat gggacttgaa
       61 ggcggcttct caggacacgg cgctggcgcg ggattcttgt tcgcgtccgg ggatcggtgc
      121 ccaaggagct ctgcggtcct ctgcggggcg aggcggcgga ccacggagac tgacactcac
      181 agctgctccc ctgtctctct tcccgggtgt cggcggcggt ggctgcagct gcagccctgc
      241 tcctcttgaa gatggagaag atgttggtgg ggtgcttgct gatgcttggg cagctcttcc
      301 ttgtcctccc agttgacggc agagagcgtc cccaagccag gttcccttcc agaggccgtc
      361 atgtccggat gtatccgcag actgcactgc tggagagttc ctgtgagaat aagcgggcag
      421 atctggtgtt catcattgac agctcccgaa gtgtcaacac ctatgactat gcaaaggtca
      481 aggagttcat tctggatatc ctgcagttct tggacatcgg tcctgatgtt acccgagtag
      541 gtctgctcca atatggcagc acggtcaaga acgagttctc cctgaagacc tttaagagga
      601 agtctgaggt ggagagggct gtcaagagaa tgaggcatct atccactggc accatgacag
      661 ggcttgccat ccaatatgcc ctcaacattg ccttctcaga agcagagggg gccaggccct
      721 tgcgggaaaa tgtgccacgc atcataatga ttgtgactga tgggaggcct caggactcgg
      781 tggctgaggt agctgccaag gcccggaaca caggcatcct gatctttgcc atcggtgtcg
      841 gtcaggtgga cctgaataca ctaaaggcca ttgggagtga gccccacaag gaccatgtct
      901 tcctggtggc caatttcagc cagattgagt ccttgacctc agtgttccag aacaaactgt
      961 gcacagtcca catgtgcagc gtcttggaac acaactgtgc ccacttctgc ctcaacacac
     1021 ctggctcgta catctgcaag tgcaagcaag ggtacattct cagcacggat cagaagactt
     1081 gcagaatcca ggatttgtgt gccacagagg accatggttg tgagcagctg tgcgtgaaca
     1141 tgctgggttc ctttgtctgc cagtgctaca gtggctacac cttggccgag gacgggaagc
     1201 gatgtacagc tgtggactac tgtgcctcag aaaatcatgg atgtgaacac gagtgtgtaa
     1261 atgctgaaag ttcctacctg tgccggtgcc acgagggatt tgctcttaac agcgataaga
     1321 aaacatgctc aaagattgac tattgtgcct cttcaaatca cggatgtcag catgagtgtg
     1381 tcaatgccca gacgtctgct ctctgccgct gcctgaaagg cttcatgcta aatccagaca
     1441 ggaaaacttg ccgaaggatc aactactgtg cactgaacaa accaggctgt gagcatgagt
     1501 gtgtgaacac agaggagggt cactactgcc gctgccgtca gggctacaat ctggacccca
     1561 atggcaagac ctgcagccgg gtggaccact gtgcacagca ggaccatggc tgtgagcagc
     1621 tgtgcctgaa cacagaggag tcctttgtct gccagtgctc agaaggcttc cttattaatg
     1681 atgacctcaa gacctgctcc agggcagatt actgcttgct gagcaaccat ggttgtgaat
     1741 actcctgcgt caacacagac aaatcctttg cctgccaatg tcctgagggt catgtgctcc
     1801 gaagcgatgg gaagacctgt gcaaaactgg actcttgtgc tttgggggac catggttgtg
     1861 aacattcatg tgtaagcagt gaagactctt tcgtgtgtca gtgctttgag gggtacattc
     1921 ttcgtgacga tgggaagacc tgcagaagga aagatgtctg ccaggatgtt aaccatggat
     1981 gtgagcacct ttgtgtgaac agtggcgaat catacgtctg caagtgtctg gaggggttca
     2041 ggctggctga ggatgggaag cgctgcagga ggaagaatgt ctgcaagtca acccagcatg
     2101 gctgtgagca catgtgtgtg aacaatggga actcctatct gtgcaggtgc tcagagggct
     2161 ttgtcctagc tgaggatgga aagcactgca agagatgcac tgaaggccca attgacctgg
     2221 tctttgtgat tgatggatcc aagagccttg gagaagagaa ctttgagact gtgaagcact
     2281 ttgtcactgg aatcatagat tccttggcag tttcccccaa agctgctcgt gtggggctgc
     2341 tgcagtattc cacacaggtc cgaacagagt ttaccctgag gggcttcagc tcagccaagg
     2401 aaatgaagaa agccgtgacc cacatgaaat acatgggcaa aggctctatg actgggctgg
     2461 ccctgaaaca catgtttgag agaagtttta cccaagtaga aggggccagg cccccctcca
     2521 cgcaggtacc cagagtagcc atcgtgttca ccgacggacg ggctcaggat gatgtctctg
     2581 agtgggccag taaagccaag gccaatggta tcactatgta tgccgttggg gtaggaaaag
     2641 ccattgagga agaactacag gagattgcct ctgagcccat tgacaagcat ctcttctacg
     2701 ctgaagattt cagcacaatg ggcgaaataa gtgaaaagct gaaagaaggc atctgtgaag
     2761 ctctagaaga ctctggtgga agacaggact cagcagcatg ggacctgcca cagcaggccc
     2821 accagccaac agaacctgag ccagtcacca taaagatcaa agacctactt tcctgttcta
     2881 attttgcagt gcaacataga ttcctgtttg aagaagacaa tctttcacgg tctacacaaa
     2941 aacttttcca ttcaaccaaa tcttcaggaa accctttgga agaaagccag gaccaatgca
     3001 aatgtgaaaa ccttatactg ttccagaacg ttgcaaatga agaagtaaga aaattaaccc
     3061 agcgcttaga agaaatgact caaagaatgg aagctttgga aaatcgccta aaatacagat
     3121 gaagaccaga attgctttta tgtatatttg tacaccatct taaaaaggat tttgacaaag
     3181 gtggtagagc ctcccaccat aagcagacct acaagctgta aagcaaaata caaccagtac
     3241 aggagacact ggattgcttg actgctggac agagaaaatg gagacactga ggtgtctaaa
     3301 ttcaatgagg gtggggggaa ggaatcctga attctgagtt taccatgaga ataaataagc
     3361 tgcgcagtgt agtgttccac ggtgtactgt ggacataatt tccttctact gcaacactga
     3421 aatttcattt tcggcagaaa actgactcca caaattgcta ttttttgtac tggaatttac
     3481 cttgatgtgt atatggacat gtgcataagt cacagagaca tatgttctgt aataagttgg
     3541 atttctacac aatattaaaa ttcaccattc cagaaaa
//
