LOCUS       NM_010769               2002 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus matrilin 1, cartilage matrix protein (Matn1), mRNA.
ACCESSION   NM_010769 XM_972811
VERSION     NM_010769.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2002)
  AUTHORS   Zhang,C.H., Gao,Y., Hung,H.H., Zhuo,Z., Grodzinsky,A.J. and
            Lassar,A.B.
  TITLE     Creb5 coordinates synovial joint formation with the genesis of
            articular cartilage
  JOURNAL   Nat Commun 13 (1), 7295 (2022)
   PUBMED   36435829
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2002)
  AUTHORS   Chen,Y., Wu,J., Zhang,S., Gao,W., Liao,Z., Zhou,T., Li,Y., Su,D.,
            Liu,H., Yang,X., Su,P. and Xu,C.
  TITLE     Hnrnpk maintains chondrocytes survival and function during growth
            plate development via regulating Hif1alpha-glycolysis axis
  JOURNAL   Cell Death Dis 13 (9), 803 (2022)
   PUBMED   36127325
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2002)
  AUTHORS   Li,P., Fleischhauer,L., Nicolae,C., Prein,C., Farkas,Z.,
            Saller,M.M., Prall,W.C., Wagener,R., Heilig,J., Niehoff,A.,
            Clausen-Schaumann,H., Alberton,P. and Aszodi,A.
  TITLE     Mice Lacking the Matrilin Family of Extracellular Matrix Proteins
            Develop Mild Skeletal Abnormalities and Are Susceptible to
            Age-Associated Osteoarthritis
  JOURNAL   Int J Mol Sci 21 (2), 666 (2020)
   PUBMED   31963938
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2002)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2002)
  AUTHORS   Aszodi,A., Beier,D.R., Hiripi,L., Bosze,Z. and Fassler,R.
  TITLE     Sequence, structure and chromosomal localization of Crtm gene
            encoding mouse cartilage matrix protein and its exclusion as a
            candidate for murine achondroplasia
  JOURNAL   Matrix Biol 16 (9), 563-573 (1998)
   PUBMED   9569124
REFERENCE   7  (bases 1 to 2002)
  AUTHORS   Wai,A.W., Ng,L.J., Watanabe,H., Yamada,Y., Tam,P.P. and Cheah,K.S.
  TITLE     Disrupted expression of matrix genes in the growth plate of the
            mouse cartilage matrix deficiency (cmd) mutant
  JOURNAL   Dev Genet 22 (4), 349-358 (1998)
   PUBMED   9664687
REFERENCE   8  (bases 1 to 2002)
  AUTHORS   Deak,F., Piecha,D., Bachrati,C., Paulsson,M. and Kiss,I.
  TITLE     Primary structure and expression of matrilin-2, the closest
            relative of cartilage matrix protein within the von Willebrand
            factor type A-like module superfamily
  JOURNAL   J Biol Chem 272 (14), 9268-9274 (1997)
   PUBMED   9083061
REFERENCE   9  (bases 1 to 2002)
  AUTHORS   Aszodi,A., Hauser,N., Studer,D., Paulsson,M., Hiripi,L. and
            Bosze,Z.
  TITLE     Cloning, sequencing and expression analysis of mouse cartilage
            matrix protein cDNA
  JOURNAL   Eur J Biochem 236 (3), 970-977 (1996)
   PUBMED   8665920
REFERENCE   10 (bases 1 to 2002)
  AUTHORS   Winterbottom,N., Tondravi,M.M., Harrington,T.L., Klier,F.G.,
            Vertel,B.M. and Goetinck,P.F.
  TITLE     Cartilage matrix protein is a component of the collagen fibril of
            cartilage
  JOURNAL   Dev Dyn 193 (3), 266-276 (1992)
   PUBMED   1600245
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014342.1, BC047140.1 and AV020141.1.
            
            On Apr 2, 2008 this sequence version replaced NM_010769.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014342.1, BC047140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AK014342.1         2-34
            34-1996             BC047140.1         1-1963
            1997-2002           AV020141.1         254-259
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 64.09 cM"
     gene            1..2002
                     /gene="Matn1"
                     /gene_synonym="CMP; Crtm; Mat1; matrilin-1"
                     /note="matrilin 1, cartilage matrix protein"
                     /db_xref="GeneID:17180"
                     /db_xref="MGI:MGI:106591"
     exon            1..145
                     /gene="Matn1"
                     /gene_synonym="CMP; Crtm; Mat1; matrilin-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1542
                     /gene="Matn1"
                     /gene_synonym="CMP; Crtm; Mat1; matrilin-1"
                     /note="cartilage matrix protein; matrilin 1, cartilage
                     matrix protein 1"
                     /codon_start=1
                     /product="cartilage matrix protein precursor"
                     /protein_id="NP_034899.2"
                     /db_xref="CCDS:CCDS18713.1"
                     /db_xref="GeneID:17180"
                     /db_xref="MGI:MGI:106591"
                     /translation="MKVTSGPAFALCSLLLLLLLLLQVPDSLSLVPQPRGHLCRTRPT
                     DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGLVNYASTVKPEFPLRAH
                     GSKASLLQAVRRIQPLSTGTMTGLALQFAITKALSDAEGGRARSPDISKVVIVVTDGR
                     PQDSVRDVSERARASGIELFAIGVGRVDKATLRQIASEPQDEHVDYVESYNVIEKLAK
                     KFQEAFCVVSDLCATGDHDCEQLCVSSPGSYTCACHEGFTLNSDGKTCNVCRGGGSGS
                     ATDLVFLIDGSKSVRPENFELVKKFINQIVDTLDVSDRLAQVGLVQYSSSIRQEFPLG
                     RFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRS
                     QDYINDAARKAKDLGFKMFAVGVGNAVEEELREIASEPVADHYFYTADFKTINQIGKK
                     LQKQICVEEDPCACESILKFEAKVEGLLQALTRKLEAVSGRLAVLENRII"
     exon            146..492
                     /gene="Matn1"
                     /gene_synonym="CMP; Crtm; Mat1; matrilin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..715
                     /gene="Matn1"
                     /gene_synonym="CMP; Crtm; Mat1; matrilin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..841
                     /gene="Matn1"
                     /gene_synonym="CMP; Crtm; Mat1; matrilin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1258
                     /gene="Matn1"
                     /gene_synonym="CMP; Crtm; Mat1; matrilin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1411
                     /gene="Matn1"
                     /gene_synonym="CMP; Crtm; Mat1; matrilin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1492
                     /gene="Matn1"
                     /gene_synonym="CMP; Crtm; Mat1; matrilin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..2002
                     /gene="Matn1"
                     /gene_synonym="CMP; Crtm; Mat1; matrilin-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1965..1970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Matn1"
                     /gene_synonym="CMP; Crtm; Mat1; matrilin-1"
                     /note="hexamer: AATAAA"
     regulatory      1975..1980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Matn1"
                     /gene_synonym="CMP; Crtm; Mat1; matrilin-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1994
                     /gene="Matn1"
                     /gene_synonym="CMP; Crtm; Mat1; matrilin-1"
                     /note="major polyA site"
     polyA_site      2000
                     /gene="Matn1"
                     /gene_synonym="CMP; Crtm; Mat1; matrilin-1"
ORIGIN      
        1 agtgtgccgc tgccgctgtc tgtctgagtt gctgcaacca tgaaggtcac ctctggtcca
       61 gcctttgctc tctgtagcct gctgctcctg ctgctgctgc tgctacaggt ccctgatagc
      121 ctcagtcttg tcccccagcc cagagggcac ctctgccgga cacgacccac ggacctggtg
      181 tttgttgtcg atagctctcg aagtgtgaga cccgtggagt ttgagaaggt gaaggtattc
      241 ctgtctcagg tcattgagtc actggatgtg gggcccaatg ccacgagggt gggcttggtc
      301 aactacgcca gcactgtgaa accagagttc ccgctccggg cccatggctc caaggcctcg
      361 ctgctgcaag ctgtgcgccg catccagccg ctgtccacgg gtaccatgac tggcctggct
      421 ctgcaattcg ccatcaccaa ggccttgagt gatgctgagg gtggacgcgc cagatccccc
      481 gacatcagca aggttgtcat cgtggtgact gatgggaggc cccaggacag cgtgcgggac
      541 gtgtctgagc gcgcgagggc cagtggcatt gagctgttcg ccatcggcgt gggccgcgtg
      601 gacaaggcta cgctgcgaca gatcgctagc gagccgcagg acgagcacgt ggattacgtg
      661 gagagctaca atgtcatcga gaagctggcc aagaagttcc aagaggcctt ctgcgtggtg
      721 tccgacctgt gtgccacagg ggaccatgat tgtgagcagc tgtgcgttag ttctcctggc
      781 tcctacacct gtgcctgcca tgagggcttc accctgaaca gcgatggcaa gacctgcaat
      841 gtctgccgtg ggggtggaag cggctcagcc accgacctgg tcttcctcat cgacggatcc
      901 aagagcgtgc ggcctgagaa ctttgagctg gtgaagaagt tcatcaacca gattgtggac
      961 acgttagatg tgtcggacag gctagcccag gtggggctgg tgcagtactc cagctccatt
     1021 cgccaggagt tcccactcgg ccgcttccac accaagaagg acattaaggc cgcggtgcgg
     1081 aacatgtcct acatggagaa aggcaccatg actggcgccg ccttgaagta tctcatagat
     1141 aattctttca ctgtgtccag cggggcaagg cctggagccc agaaggtggg catcgtcttc
     1201 accgatggcc ggagccagga ctacattaat gacgctgcca ggaaggccaa ggaccttggc
     1261 tttaagatgt ttgcggtggg cgtgggcaat gctgtggagg aagagctgag ggagatcgct
     1321 tccgagcccg tggcagacca ctacttttac acagctgact tcaagaccat caaccagatt
     1381 ggcaagaagc tgcagaaaca aatctgtgtg gaggaagacc cctgtgcttg tgagtccata
     1441 ctgaaatttg aggccaaggt ggagggtctg ctgcaggccc tgaccaggaa gctggaagct
     1501 gtgagcgggc ggctggctgt cctggagaac agaatcatct aagaactctg gtggcctggc
     1561 cacttcccac ccaatgcaca gttcttagtg tcctgggaat gccccctgta gctggagtta
     1621 gtctggtttt gctgctttag caagggaacc tgcggaggac ggctgcaggt ctccccagct
     1681 gtcctggggc tgggagcagg aggggacaca tgcttgtgtc tgctgggagt gtgttatgat
     1741 ggtgcctgtg agcatgtgtg tgcctgatgg tgatcatgtg tgtttcagag caagggtgtg
     1801 tgcacaggtg agaacgcagg gaagaggtgt gtgagcgact gcgttcgtta tttttccaac
     1861 ctaaagctta atatattcct gttttttttt tcctccagtt aattctttac ccagtcagtt
     1921 ctttactctg agagattttt tttttgtttg tttcttgaga aaaaaataaa aacaattaaa
     1981 tgtggttcgc tgtacaccct gg
//
