LOCUS       NM_028888               3571 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus microtubule associated tyrosine carboxypeptidase 1
            (Matcap1), transcript variant 1, mRNA.
ACCESSION   NM_028888 XM_486157
VERSION     NM_028888.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3571)
  AUTHORS   Landskron,L., Bak,J., Adamopoulos,A., Kaplani,K., Moraiti,M., van
            den Hengel,L.G., Song,J.Y., Bleijerveld,O.B., Nieuwenhuis,J.,
            Heidebrecht,T., Henneman,L., Moutin,M.J., Barisic,M., Taraviras,S.,
            Perrakis,A. and Brummelkamp,T.R.
  TITLE     Posttranslational modification of microtubules by the MATCAP
            detyrosinase
  JOURNAL   Science 376 (6595), eabn6020 (2022)
   PUBMED   35482892
REFERENCE   2  (bases 1 to 3571)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ064766.1 and BC043046.1.
            
            On Oct 22, 2009 this sequence version replaced NM_028888.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC043046.1, SRR1660817.194051.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164138, SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               CJ064766.1         2-241
            241-2605            BC043046.1         1-2365
            2606-3571           BC043046.1         2369-3334
FEATURES             Location/Qualifiers
     source          1..3571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..3571
                     /gene="Matcap1"
                     /gene_synonym="4931428F04Rik; Kiaa0895l; MATCAP"
                     /note="microtubule associated tyrosine carboxypeptidase 1"
                     /db_xref="GeneID:74356"
                     /db_xref="MGI:MGI:1921606"
     exon            1..125
                     /gene="Matcap1"
                     /gene_synonym="4931428F04Rik; Kiaa0895l; MATCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            126..522
                     /gene="Matcap1"
                     /gene_synonym="4931428F04Rik; Kiaa0895l; MATCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            523..1136
                     /gene="Matcap1"
                     /gene_synonym="4931428F04Rik; Kiaa0895l; MATCAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             579..1982
                     /gene="Matcap1"
                     /gene_synonym="4931428F04Rik; Kiaa0895l; MATCAP"
                     /EC_number="3.4.17.17"
                     /note="microtubule-associated tyrosine carboxypeptidase"
                     /codon_start=1
                     /product="microtubule-associated tyrosine carboxypeptidase
                     1"
                     /protein_id="NP_083164.1"
                     /db_xref="CCDS:CCDS22596.1"
                     /db_xref="GeneID:74356"
                     /db_xref="MGI:MGI:1921606"
                     /translation="MVLDSGTQVYEQAPPRPPAGSPSQHHKLKPSNGNGPPLYPWPES
                     LGMPLALAVPSALQQQTMWQTFSKLHLEQSSHMRRSESTYSVNSTGRRGRGKAPIGRG
                     CDPGGTLRPAASLPHIAKIRKDVGSSSSKSPCMLVALRPTNMDQEREKFFQSHYTYNP
                     QFEYQEPMPMSVLEKYQEASAQFMNQAVGIIEAVLEKFGTYENFEAATGGQLLTKCQI
                     WSTVRKYMQKEGCVGEIVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRH
                     EIGTHYLRGVNNSRQPWHSTEGRLQYGLQPANPTEEGLASLHSVLFRKQPFLWRAALL
                     YYTIHQAAHMSFRQLFQDLAQYVQDEGVRWEYCVRAKRGQTDTSQPGCFSKDQVYLDG
                     ILRILRHRHTIDFQLLTSLGKVSYEDVEQLRPYGVLDNTRVPHFMKDLERYRQQLEHI
                     MTTNRLDEAELGRLLPD"
     exon            1137..1280
                     /gene="Matcap1"
                     /gene_synonym="4931428F04Rik; Kiaa0895l; MATCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1413
                     /gene="Matcap1"
                     /gene_synonym="4931428F04Rik; Kiaa0895l; MATCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1719
                     /gene="Matcap1"
                     /gene_synonym="4931428F04Rik; Kiaa0895l; MATCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1817
                     /gene="Matcap1"
                     /gene_synonym="4931428F04Rik; Kiaa0895l; MATCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..3553
                     /gene="Matcap1"
                     /gene_synonym="4931428F04Rik; Kiaa0895l; MATCAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3533..3538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Matcap1"
                     /gene_synonym="4931428F04Rik; Kiaa0895l; MATCAP"
                     /note="hexamer: ATTAAA"
     polyA_site      3553
                     /gene="Matcap1"
                     /gene_synonym="4931428F04Rik; Kiaa0895l; MATCAP"
                     /note="major polyA site"
ORIGIN      
        1 gcgtcttcgt gtgagcgtgc gcgcgcccga gtgcgcgtgt ctttggcgcg ggcttccatg
       61 gtctcggcgg ccagcgatcg gctttgagga gcaggaactg cgggcagcaa aagaggcgtg
      121 atcaggggtt cttattggtg tgggccacac cctctcattt gtcaccagac cccgccttca
      181 gcagtcaggg actccagcct caccctgaat tcattcattc tgcaactagt gagtgcgtgg
      241 gacgagaggg tgaatcagac ccttcctgac ctcggggagt tcagggcacg gtggggaaat
      301 atggatctag cctccagcca tgacagccta gggctgtcaa gaagccatca agaccctggg
      361 accctttaca catcgggaag gcttcccaga gaaagtgagg cctaaaccgg gccctgaaaa
      421 aaatggttaa gaggttgctc cagggacaca ttggcaaaag aattcttggc agaagaacct
      481 gagacgtgaa agaaacaggt gaattctggt aattacgtgg agaggtcaac agtctgggaa
      541 gttggcacga cagagctgga tgtgaccctc aggagagaat ggtgctggac tcggggacac
      601 aggtgtatga gcaggcaccc cccaggcccc ctgccggttc cccatctcag caccataagc
      661 tgaagccctc aaacggaaat gggccacccc tgtacccctg gcctgagtcc ctggggatgc
      721 ccttggctct ggcagtccct tcagcactgc agcagcagac tatgtggcag accttctcaa
      781 agctgcactt ggagcagagt agccacatgc gtcgcagcga gagcacctac agtgtaaata
      841 gtactggccg gcgggggcgt ggtaaagccc cgattggacg gggatgcgat ccaggaggga
      901 ccctacggcc tgcagcctcc ttacctcaca ttgctaagat tcgaaaggat gtaggcagta
      961 gtagcagcaa gagcccctgt atgttggtgg ccctgcggcc aactaacatg gaccaggaac
     1021 gggaaaagtt cttccagtct cattatacct acaatccaca gttcgagtat caggaaccga
     1081 tgccaatgag tgtgctggag aagtaccagg aggcctctgc gcaattcatg aatcaggcag
     1141 ttggcatcat tgaggctgtc ctggagaagt ttggcactta tgaaaacttt gaggctgcca
     1201 cagggggcca gctgctgacc aagtgccaaa tttggtccac cgtgcgcaaa tacatgcaga
     1261 aggaaggctg tgttggggag attgtggtac agctgagtga agatctactg tcccaggctg
     1321 tgatgatggt ggagaacagc cgacccacac tggccatcaa cttgactgga gcccgccagt
     1381 actggttgga gggcatgctg cggcacgaga taggcaccca ctacctgcgt ggtgtgaata
     1441 attcgcggca accgtggcac agcactgaag gcagattgca gtacggcctt cagccagcca
     1501 accctactga ggagggcctg gctagcctgc atagtgtgct gtttcgaaag caaccattcc
     1561 tgtggcgcgc cgccctgctc tactacacca tccaccaggc ggcgcacatg tccttccgcc
     1621 agctcttcca ggatctggcg cagtacgtgc aggacgaggg tgtacgctgg gagtactgcg
     1681 tccgtgccaa gcgaggacag acggatacct cccagccagg ctgcttcagc aaggaccagg
     1741 tgtacctgga tggcattttg cgcatcctac ggcaccggca caccattgat ttccagctgc
     1801 tgacctcgct gggcaaggtc tcctatgaag acgtggaaca actgcggccc tacggggtgc
     1861 tagacaatac cagagtgccc cacttcatga aggacttgga acgttaccgg cagcagctgg
     1921 aacacatcat gaccaccaac cggctggatg aagcggagct gggccgcctg ctgcctgact
     1981 gatgttgact aagggttata gacagacgct cttgacagag gtcacagatc ggaatatgaa
     2041 gttctttatg gttccatagc ctaggtgttt cttgggggca tttgggaggc caggagcatc
     2101 gtgggcagat gagaagcaac gttagaaggt ttttgtcctt gctacccttc ctggggcctg
     2161 tgaactgcag cagcatgtca cataaactcc tgagcagggg agatgggagg gcgatgagat
     2221 gggagctgag tgtgaataga aatgtgggtt ggtttgggaa tagaaacttg ttcctgcatg
     2281 agatggcttt gggtgtctgg taccactcct tcccttcccc ctacctggcc gattggtgct
     2341 ccttctacac tcatacctct acctctcact ggggccagca ggagttggga acccctctga
     2401 ggtgatttgc ctgagcatgg ggttccggct gtcactcagg ctcagagacc cagctgggct
     2461 gggctttgcc tttcagcatt ctgtctgtct cactggtcat gcattgttcc atagtcgccc
     2521 tcatggggtc atttcatgcc tccaggcggg gcccggaagt agtagtagta gtagtagtag
     2581 tagtagtagt agtagtagta gtagttccat gtaggggcag gatcctttgg aaaagtaccg
     2641 tatgttccta gaccccttcc ttccttcctt ccttccttcc ttctttcctt ccttccttcc
     2701 ttccttcctt ccttccttcc ttccttccct ctccctctct ccctcttcct tccttccttc
     2761 ctccctctct ccctcttcct tccttccttc cttccttcct tccttccttc cttcctccct
     2821 ccctccctct ccctctctct ctctctcttc cttccttcct tccttccttc cttccttcct
     2881 tccttctttt ctttcaaaga cttatttatt ttatgtatac gagtacactg tagctgtctt
     2941 cagacacact agaagagggc atcagattcc attacagatg gttgtgagcc gccatgtggt
     3001 tgctgggagt agaactcagg acctctggga aagcagtcag tgctcttaac cactgagcca
     3061 tctctccagc cccctagacc ccctttctta tcactcacac agacacactg tgtcttgtgt
     3121 cttgtgagtc cagcacctgg tcccaccctc agtccccatg ttagtcttgg ttgtgcctgt
     3181 ctttaaccac agcctcacag ctggtctctg gcagtggtta ggacaggcgg gagcaaccac
     3241 aatcaaacct acagggcagg ccctagggtt tgttatccca cgttcaggcc aggattagta
     3301 cagagctggt taaggctttc atttcacttc agattcagcg gtgggagagt gagctagtac
     3361 tgtcctaacc ctggcttttc agttaatgtt tccatctgtg aagcttggaa acacagctgg
     3421 gaagtttgta ttcatttact tagtagatat gtgcagagct ccttgtgtat gtctgtgact
     3481 ggttagaccc cacgcccctc actgagctcc cagttcagag gaaagccaga caattaaaca
     3541 gcagttacaa tgaaaaaaaa aaaaaaaaaa a
//
