LOCUS       NM_134017               1870 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus methionine adenosyltransferase 2 non-catalytic beta
            subunit methionine (Mat2b), transcript variant 1, mRNA.
ACCESSION   NM_134017
VERSION     NM_134017.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1870)
  AUTHORS   Imbard,A., Schwendimann,L., Lebon,S., Gressens,P., Blom,H.J. and
            Benoist,J.F.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1870)
  AUTHORS   An,Q., Sun,H., Zhang,J., Lu,Z., Peng,W., Xu,S., Zhang,Y. and Su,J.
  TITLE     Methionine Adenosyltransferase 2beta Participates in Mouse Oocyte
            Maturation by Regulating the MAPK Pathway
  JOURNAL   Reprod Sci 27 (1), 163-171 (2020)
   PUBMED   32046373
  REMARK    GeneRIF: Methionine Adenosyltransferase 2beta Participates in Mouse
            Oocyte Maturation by Regulating the MAPK Pathway.
REFERENCE   3  (bases 1 to 1870)
  AUTHORS   Partearroyo,T., Murillo-Cuesta,S., Vallecillo,N.,
            Bermudez-Munoz,J.M., Rodriguez-de la Rosa,L., Mandruzzato,G.,
            Celaya,A.M., Zeisel,S.H., Pajares,M.A., Varela-Moreiras,G. and
            Varela-Nieto,I.
  TITLE     Betaine-homocysteine S-methyltransferase deficiency causes
            increased susceptibility to noise-induced hearing loss associated
            with plasma hyperhomocysteinemia
  JOURNAL   FASEB J 33 (5), 5942-5956 (2019)
   PUBMED   30753104
REFERENCE   4  (bases 1 to 1870)
  AUTHORS   Ge,X., Li,W., Huang,S., Yin,Z., Yang,M., Han,Z., Han,Z., Chen,F.,
            Wang,H., Lei,P. and Zhang,J.
  TITLE     Increased miR-21-3p in Injured Brain Microvascular Endothelial
            Cells after Traumatic Brain Injury Aggravates Blood-Brain Barrier
            Damage by Promoting Cellular Apoptosis and Inflammation through
            Targeting MAT2B
  JOURNAL   J Neurotrauma 36 (8), 1291-1305 (2019)
   PUBMED   29695199
  REMARK    GeneRIF: Increased miR-21-3p in Injured Brain Microvascular
            Endothelial Cells after Traumatic Brain Injury Aggravates
            Blood-Brain Barrier Damage by Promoting Cellular Apoptosis and
            Inflammation through Targeting MAT2B.
REFERENCE   5  (bases 1 to 1870)
  AUTHORS   Sun,H., Kang,J., Su,J., Zhang,J., Zhang,L., Liu,X., Zhang,J.,
            Wang,F., Lu,Z., Xing,X., Chen,H. and Zhang,Y.
  TITLE     Methionine adenosyltransferase 2A regulates mouse zygotic genome
            activation and morula to blastocyst transitiondagger
  JOURNAL   Biol Reprod 100 (3), 601-617 (2019)
   PUBMED   30265288
REFERENCE   6  (bases 1 to 1870)
  AUTHORS   Tang,S., Fang,Y., Huang,G., Xu,X., Padilla-Banks,E., Fan,W., Xu,Q.,
            Sanderson,S.M., Foley,J.F., Dowdy,S., McBurney,M.W., Fargo,D.C.,
            Williams,C.J., Locasale,J.W., Guan,Z. and Li,X.
  TITLE     Methionine metabolism is essential for SIRT1-regulated mouse
            embryonic stem cell maintenance and embryonic development
  JOURNAL   EMBO J 36 (21), 3175-3193 (2017)
   PUBMED   29021282
REFERENCE   7  (bases 1 to 1870)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1870)
  AUTHORS   LeGros,H.L. Jr., Halim,A.B., Geller,A.M. and Kotb,M.
  TITLE     Cloning, expression, and functional characterization of the beta
            regulatory subunit of human methionine adenosyltransferase (MAT II)
  JOURNAL   J Biol Chem 275 (4), 2359-2366 (2000)
   PUBMED   10644686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL646055.10 and BC003457.1.
            
            On Dec 1, 2010 this sequence version replaced NM_134017.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003457.1, SRR7652917.1184958.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AL646055.10        65655-65723         c
            70-1870             BC003457.1         1-1801
FEATURES             Location/Qualifiers
     source          1..1870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 24.4 cM"
     gene            1..1870
                     /gene="Mat2b"
                     /gene_synonym="1110064C04Rik; 2410018D16Rik; MAT-II;
                     MATIIbeta; TGR"
                     /note="methionine adenosyltransferase 2 non-catalytic beta
                     subunit methionine"
                     /db_xref="GeneID:108645"
                     /db_xref="MGI:MGI:1913667"
     exon            1..205
                     /gene="Mat2b"
                     /gene_synonym="1110064C04Rik; 2410018D16Rik; MAT-II;
                     MATIIbeta; TGR"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1147
                     /gene="Mat2b"
                     /gene_synonym="1110064C04Rik; 2410018D16Rik; MAT-II;
                     MATIIbeta; TGR"
                     /EC_number="2.5.1.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     methionine adenosyltransferase 2 subunit beta; MAT II
                     beta; methionine adenosyltransferase 2 beta subunit;
                     methionine adenosyltransferase II, beta"
                     /codon_start=1
                     /product="methionine adenosyltransferase 2 subunit beta
                     isoform 1"
                     /protein_id="NP_598778.1"
                     /db_xref="CCDS:CCDS24547.1"
                     /db_xref="GeneID:108645"
                     /db_xref="MGI:MGI:1913667"
                     /translation="MVGREKELSIHFVPGCCQLVEEEVNIPSRRVLITGATGLLGRAV
                     YKEFQQSNWHTVGCGFRRARPKFEQVNLLDSEAVHHLIHDFQPHVIVHCAAERRPDVV
                     ESQPDAASQLNVGASGNLAKEAAAIGAFLIYISSDYVFDGTNPPYTEEDIPSPLNLYG
                     KTKLDGEKAVLENNLGAAVLRIPVLYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQ
                     RFPTHVKDVASVCRQLAEKRMLDPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHL
                     RPITDSPVIGAQRPKNAQLDCSKLETLGIGQRTPFRTGIKESLWPFLIDKRWRQTVFH
                     "
     exon            206..400
                     /gene="Mat2b"
                     /gene_synonym="1110064C04Rik; 2410018D16Rik; MAT-II;
                     MATIIbeta; TGR"
                     /inference="alignment:Splign:2.1.0"
     exon            401..515
                     /gene="Mat2b"
                     /gene_synonym="1110064C04Rik; 2410018D16Rik; MAT-II;
                     MATIIbeta; TGR"
                     /inference="alignment:Splign:2.1.0"
     exon            516..668
                     /gene="Mat2b"
                     /gene_synonym="1110064C04Rik; 2410018D16Rik; MAT-II;
                     MATIIbeta; TGR"
                     /inference="alignment:Splign:2.1.0"
     exon            669..862
                     /gene="Mat2b"
                     /gene_synonym="1110064C04Rik; 2410018D16Rik; MAT-II;
                     MATIIbeta; TGR"
                     /inference="alignment:Splign:2.1.0"
     exon            863..976
                     /gene="Mat2b"
                     /gene_synonym="1110064C04Rik; 2410018D16Rik; MAT-II;
                     MATIIbeta; TGR"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1857
                     /gene="Mat2b"
                     /gene_synonym="1110064C04Rik; 2410018D16Rik; MAT-II;
                     MATIIbeta; TGR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1835..1840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mat2b"
                     /gene_synonym="1110064C04Rik; 2410018D16Rik; MAT-II;
                     MATIIbeta; TGR"
                     /note="hexamer: AATAAA"
     polyA_site      1857
                     /gene="Mat2b"
                     /gene_synonym="1110064C04Rik; 2410018D16Rik; MAT-II;
                     MATIIbeta; TGR"
                     /note="major polyA site"
ORIGIN      
        1 agggcggcgg aagccggaag cggcagccgg ggtcggcctg ggcctagggg aggagggcca
       61 agggcgcggg cgctgcggcc cctggcagtg ctgcgctagt ggagcttgcg gtcgcgactg
      121 aagcggcgca aagactgcgg gcatggtggg ccgggagaag gagctctcca tccacttcgt
      181 ccccggctgc tgccagctgg tggaggagga agtgaacatc cctagccggc gggttctcat
      241 tactggtgcc actgggcttc ttggcagagc agtttacaaa gagtttcagc agagcaactg
      301 gcacaccgtt ggctgtggct ttcgaagagc aagaccaaaa ttcgaacaag tgaacctgtt
      361 ggattctgaa gctgttcatc acctcattca tgatttccag cctcatgtca tagtgcattg
      421 tgctgcagag agaagacctg atgttgttga gagtcagcca gatgctgctt cccagctgaa
      481 tgtgggtgcc tctgggaact tggcaaagga ggcagctgcg attggagcat ttctcatcta
      541 cattagctca gattatgtgt ttgatggcac aaatccccct tacacagaag aagatatacc
      601 aagtcccctg aatctatatg gaaaaacaaa attagatgga gaaaaagcag tcctggagaa
      661 taatttaggg gctgctgtgt tgagaattcc tgttctgtat ggggaagttg aaaagcttga
      721 agaaagtgct gtgactgtta tgttcgacaa ggtgcagttc agcaacaagt cagcaaacat
      781 ggaccattgg cagcagaggt tccccacaca tgtgaaagac gtagccagtg tgtgccggca
      841 gctggcagag aagaggatgc tggatccatc cattaaggga acctttcact ggtctggcaa
      901 tgagcagatg accaagtatg aaatggcgtg tgcaattgca gatgccttca acctccccag
      961 cagccactta agacctatta ctgacagtcc tgtcatagga gcacagcgcc ccaaaaatgc
     1021 tcagctcgat tgctccaaat tggagacgtt gggcattggc cagaggacac catttcgaac
     1081 tggaatcaaa gaatctctct ggcctttcct catcgacaag agatggagac agactgtctt
     1141 tcattagctc atgtgttgtg tattttttta aatgaaaagt atagtatgtg gcactttttc
     1201 aagaataaag gaaatagttt tgtatgagta ctccttaatt gtgacacatg atccttcagg
     1261 taaacaatgc tgttgcacta ggggaatgtt ggaccggctg agagcggtca tgactttctg
     1321 tggattgttt tgttttgtct ggcttacctc gctatacaag taatgtaaat tatgatctgt
     1381 aatgtccgag ggcgggatga aacagactgt tagactttgg atgaaatgca ttgttcattc
     1441 ctacagcttc ctttcttgct gttgttttgt ttgttggctc ttgtatattg atagcttcag
     1501 tgtgtgtaga atctcatgat aatcatcggt gttcattact tgctttgctt gagcccagat
     1561 caaaatgctt ggagaaaaga aaactttatt tttgcaactg taagtatggt ttttaaacgc
     1621 ttgattcttt aatgtgttat gtatatcaga acctgtatag cctgatgcct acttcatagc
     1681 actgtgtggc aaacacttga gagagtgcac gtgtgtgtat ttttttaata taaatacata
     1741 tatatgtctc tttccttcta tcttactaag tgatgtttca tacatgtggt tataataatg
     1801 agccttgtaa gtcttttgac cacttctaaa taataataaa tacttgctag catgtaaaaa
     1861 aaaaaaaaaa
//
