LOCUS       NM_133653               3486 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus methionine adenosyltransferase 1A (Mat1a), mRNA.
ACCESSION   NM_133653
VERSION     NM_133653.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3486)
  AUTHORS   Barbier-Torres,L., Chhimwal,J., Kim,S.Y., Ramani,K., Robinson,A.,
            Yang,H., Van Eyk,J., Liangpunsakul,S., Seki,E., Mato,J.M. and
            Lu,S.C.
  TITLE     S-Adenosylmethionine Negatively Regulates the Mitochondrial
            Respiratory Chain Repressor MCJ in the Liver
  JOURNAL   Int J Biol Sci 20 (4), 1218-1237 (2024)
   PUBMED   38385082
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3486)
  AUTHORS   Saenz de Urturi,D., Buque,X., Porteiro,B., Folgueira,C., Mora,A.,
            Delgado,T.C., Prieto-Fernandez,E., Olaizola,P., Gomez-Santos,B.,
            Apodaka-Biguri,M., Gonzalez-Romero,F., Nieva-Zuluaga,A., Ruiz de
            Gauna,M., Goikoetxea-Usandizaga,N., Garcia-Rodriguez,J.L.,
            Gutierrez de Juan,V., Aurrekoetxea,I., Montalvo-Romeral,V.,
            Novoa,E.M., Martin-Guerrero,I., Varela-Rey,M., Bhanot,S., Lee,R.,
            Banales,J.M., Syn,W.K., Sabio,G., Martinez-Chantar,M.L.,
            Nogueiras,R. and Aspichueta,P.
  TITLE     Methionine adenosyltransferase 1a antisense oligonucleotides
            activate the liver-brown adipose tissue axis preventing obesity and
            associated hepatosteatosis
  JOURNAL   Nat Commun 13 (1), 1096 (2022)
   PUBMED   35232994
  REMARK    GeneRIF: Methionine adenosyltransferase 1a antisense
            oligonucleotides activate the liver-brown adipose tissue axis
            preventing obesity and associated hepatosteatosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3486)
  AUTHORS   Imbard,A., Schwendimann,L., Lebon,S., Gressens,P., Blom,H.J. and
            Benoist,J.F.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3486)
  AUTHORS   Lu,L., Zhang,J., Fan,W., Li,Y., Wang,J., Li,T.W.H.,
            Barbier-Torres,L., Mato,J.M., Liu,T., Seki,E., Matsuda,M.,
            Tomasi,M.L., Bhowmick,N.A., Yang,H. and Lu,S.C.
  TITLE     Deregulated 14-3-3zeta and methionine adenosyltransferase alpha1
            interplay promotes liver cancer tumorigenesis in mice and humans
  JOURNAL   Oncogene 40 (39), 5866-5879 (2021)
   PUBMED   34349244
  REMARK    GeneRIF: Deregulated 14-3-3zeta and methionine adenosyltransferase
            alpha1 interplay promotes liver cancer tumorigenesis in mice and
            humans.
REFERENCE   5  (bases 1 to 3486)
  AUTHORS   Pascale,R.M., Peitta,G., Simile,M.M. and Feo,F.
  TITLE     Alterations of Methionine Metabolism as Potential Targets for the
            Prevention and Therapy of Hepatocellular Carcinoma
  JOURNAL   Medicina (Kaunas) 55 (6), 296 (2019)
   PUBMED   31234428
  REMARK    GeneRIF: The reproduction of these changes in MAT1A-KO mice, prone
            to develop hepatitis and HCC, demonstrates the pathogenetic role of
            MAT1A gene under-regulation associated with up-regulation of the
            MAT2A gene (MAT1A:MAT2A switch), encoding the SAM synthesizing
            enzymes, methyladenosyltransferase I/III (MATI/III) and
            methyladenosyltransferase II (MATII), respectively. This leads to a
            rise of MATII, inhibited by the reaction produc
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3486)
  AUTHORS   Chen,L., Zeng,Y., Yang,H., Lee,T.D., French,S.W., Corrales,F.J.,
            Garcia-Trevijano,E.R., Avila,M.A., Mato,J.M. and Lu,S.C.
  TITLE     Impaired liver regeneration in mice lacking methionine
            adenosyltransferase 1A
  JOURNAL   FASEB J 18 (7), 914-916 (2004)
   PUBMED   15033934
  REMARK    GeneRIF: MAT1A knockout hepatocytes have more baseline DNA
            synthesis but no mitogenic response to hepatocyte growth factor.
            MAT1A-produced SAMe has a major role in ERK signaling & cyclin D1
            regulation during liver regeneration & mitogenic signal response.
REFERENCE   7  (bases 1 to 3486)
  AUTHORS   Martinez-Chantar,M.L., Corrales,F.J., Martinez-Cruz,L.A.,
            Garcia-Trevijano,E.R., Huang,Z.Z., Chen,L., Kanel,G., Avila,M.A.,
            Mato,J.M. and Lu,S.C.
  TITLE     Spontaneous oxidative stress and liver tumors in mice lacking
            methionine adenosyltransferase 1A
  JOURNAL   FASEB J 16 (10), 1292-1294 (2002)
   PUBMED   12060674
  REMARK    GeneRIF: Spontaneous oxidative stress and liver tumors in mice
            lacking methionine adenosyltransferase 1A
REFERENCE   8  (bases 1 to 3486)
  AUTHORS   Lu,S.C., Alvarez,L., Huang,Z.Z., Chen,L., An,W., Corrales,F.J.,
            Avila,M.A., Kanel,G. and Mato,J.M.
  TITLE     Methionine adenosyltransferase 1A knockout mice are predisposed to
            liver injury and exhibit increased expression of genes involved in
            proliferation
  JOURNAL   Proc Natl Acad Sci U S A 98 (10), 5560-5565 (2001)
   PUBMED   11320206
REFERENCE   9  (bases 1 to 3486)
  AUTHORS   Dwivedi,R.S., Wang,L.J. and Mirkin,B.L.
  TITLE     S-adenosylmethionine synthetase is overexpressed in murine
            neuroblastoma cells resistant to nucleoside analogue inhibitors of
            S-adenosylhomocysteine hydrolase: a novel mechanism of drug
            resistance
  JOURNAL   Cancer Res 59 (8), 1852-1856 (1999)
   PUBMED   10213491
REFERENCE   10 (bases 1 to 3486)
  AUTHORS   Sakata,S.F., Shelly,L.L., Ruppert,S., Schutz,G. and Chou,J.Y.
  TITLE     Cloning and expression of murine S-adenosylmethionine synthetase
  JOURNAL   J Biol Chem 268 (19), 13978-13986 (1993)
   PUBMED   8314764
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC154597.2, BB871001.1,
            AK153832.1, BB807316.1 and AC124400.4.
            
            On Jan 30, 2013 this sequence version replaced NM_133653.2.
            
            Summary: This gene encodes a member of the AdoMet synthase family.
            Methionine adenosyltransferase is a product of this gene (the alpha
            form) and the beta form and catalyzes the formation of
            S-adenosylmethionine from methionine and ATP.[provided by RefSeq,
            Jan 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189682.136501.1,
                                           ERR2844020.548247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AC154597.2         189582-189760
            180-248             BB871001.1         2-70
            249-3357            AK153832.1         3-3111
            3358-3485           BB807316.1         242-369
            3486-3486           AC124400.4         66451-66451
FEATURES             Location/Qualifiers
     source          1..3486
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.36 cM"
     gene            1..3486
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /note="methionine adenosyltransferase 1A"
                     /db_xref="GeneID:11720"
                     /db_xref="MGI:MGI:88017"
     exon            1..228
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..566
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..1663
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /EC_number="2.5.1.6"
                     /note="adoMet synthetase 1; methionine adenosyltransferase
                     I, alpha"
                     /codon_start=1
                     /product="S-adenosylmethionine synthase isoform type-1"
                     /protein_id="NP_598414.1"
                     /db_xref="CCDS:CCDS26959.1"
                     /db_xref="GeneID:11720"
                     /db_xref="MGI:MGI:88017"
                     /translation="MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLD
                     AHLKQDPNAKVACETVCKTGMVLLCGEITSVAMVDYQRVVRDTIKHIGYDDSAKGFDF
                     KTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHK
                     LNTRIADLRRSGVLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEA
                     MQEALKEQVIKAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWG
                     AHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIF
                     TYGTSNKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPK
                     KLVF"
     exon            567..644
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..767
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..880
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1024
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1243
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1426
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1560
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..3486
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3328..3333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /note="hexamer: AATAAA"
     polyA_site      3359
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /note="major polyA site"
     regulatory      3451..3456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /note="hexamer: AATAAA"
     polyA_site      3473
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; Ams; MAT; MATA1; SAMS; SAMS1"
                     /note="major polyA site"
ORIGIN      
        1 agcccatacc aaatctctgg gagactttct ggctgcccat gagtaactcc aggcccccag
       61 gtctccagag tgggatggta tcccgggaac cactcagaga ttagctaagg agctgaagga
      121 agtccgaaag gcacttccgg tccgagaggc taaacagcct tcctaatctc acttagacca
      181 cagacttgcc acttgagaca tcagagctga aggctgaaat tcctcaagga gtcacctggg
      241 agcaagctgc gaccagcctg gagtgacaca tctgtattcc atccgctatc tccctctttg
      301 cccatcctta ccctgtcctc atatgctcat aggcacttag gcagaagtca tctcctcggg
      361 attctgccaa agatctgcct gttgggtttg tagggggagg ataagaaaag aaagaaaaga
      421 aaaagctctg aagttgtcac tttggagaag tgaagtcgaa aagtgtggca caatgaatgg
      481 acctgtggat ggcttgtgtg accattctct aagtgaagag ggagccttca tgttcacatc
      541 agaatctgta ggagaggggc atccagataa gatctgtgac cagattagtg atgcggtgct
      601 ggatgctcac ctcaagcaag accccaatgc caaggtggcc tgtgagacag tgtgcaagac
      661 aggtatggtg ctactgtgtg gggagatcac ctcagtggcc atggttgatt accagcgggt
      721 ggtgagagac accatcaagc acattggcta tgacgactct gccaagggct ttgacttcaa
      781 gacttgcaat gtgctagtgg ctctggagca acagtcccca gatattgccc aatgtgtcca
      841 cctagacaga aatgaagagg atgttggtgc aggagatcag ggtctgatgt ttggctatgc
      901 tactgatgag accgaggaat gcatgcccct taccatcgtg ctcgctcaca aactcaacac
      961 ccggatagca gatctgaggc gctctggtgt ccttccctgg ctgagacctg attctaagac
     1021 tcaggtaaca gttcagtaca tgcaggataa tggtgcagtc atccctgtgc gcatccacac
     1081 catcgtcatc tctgtgcaac acaatgaaga catcacactg gaggccatgc aagaggccct
     1141 gaaagagcag gtgatcaaag ctgtggtgcc agccaagtac ctggatgaag atactgttta
     1201 ccacctgcag ccaagtgggc ggtttgttat tggaggcccc cagggggatg caggtgtcac
     1261 gggccgcaag attattgtgg acacatacgg aggctggggt gcccatggtg gtggtgcctt
     1321 ctctggaaag gactacacca aggtggaccg ctcagcagct tatgctgccc gctgggtggc
     1381 caagtccctg gtaaaggctg ggctctgccg gagagtgctt gttcaggtgt cctatgccat
     1441 tggtgtggca gaacctctgt ccatttccat cttcacctac gggacctcca ataagactga
     1501 gcgggagctg ctagaggtgg tgaacaagaa ctttgacctt cggcctggtg ttattgtcag
     1561 ggacttggat ctgaaaaaac ccatctacca gaagactgcg tgctacggcc atttcgggag
     1621 aagcgagttt ccctgggagg tccccaagaa gcttgtgttt tagagccgct ggaaagttta
     1681 gctctgtccc atactcacct cttcaggatc tcaactccct ggtctcctag cctctcccag
     1741 agtgccctcc ttgccttcta ccctcagggc aaagccagct tcttctaatt ttcccctatc
     1801 cagcaatctg caaacatctt atgaatgaca tgacaggtgg ctttctggtg ctaggttatc
     1861 atgtctcctt ttgagggtag tcactgttcc ctgcctgtcc ctcagatgac agcaatgcta
     1921 attttgtgta aaagttactc ctgtttgaca ggaagtcctt ccctcacttc ctcccatagt
     1981 ctgaacctta ccaggccatc tcttcctcca ttctagatat gtacccagat gaatatattg
     2041 cacagacctc tggcttcccc tttacatctg cagccagaga ttccgagcca ttgctatcta
     2101 agggtccctc tgagactagg catctgctac ataaaatatg gtcaatgtct cctgagcatt
     2161 tgcatcgtgt gagggactga gctgtgtgtt cttcatctca gcacaataag gtgttgtctt
     2221 tattattatc cacagtaact gatggaaaac tgaggctcag agagtctatg aagctctgac
     2281 aagtttccat agccacatgt atcagagcca agaaatggat ctaggagttc tgactctaac
     2341 cctcacattt gtatcccaga caagatgttg accagagtga tgacaagtgg atcgacttga
     2401 ggctatggct acttatttaa ggcctgggtc tcctgagaat taggagatga acctagtggc
     2461 tctttgtgag ccctggacag cgttccacaa aatcaaaatg gagacatata agtgtctcat
     2521 ttgttctgga agagggttta aggaaatctg ggtatcttgg cctatcaagc tgggctggag
     2581 tctcgaacta agaggaagtt tcatggtcct ggcccccaac actgaaagat aggtgtgtga
     2641 gttctctggg catgggttct aatcatagac agccacatgt gcttccctcc tcacagagga
     2701 gaggcagctg gttgttatag cacagacaac cggcctctga aaggggaccc tgcacctttt
     2761 gaggctttct cctttcctgg acgctcatgc ttatgcaggc taagtgttcc aggtagaggg
     2821 acagcctcca agcaatcgac aagttgccaa gatctcatga gaactggctt ttaccaggta
     2881 gcctttgaaa gacatgtctg tccagcaggg ttctgggaac cacatgtttc taagtgtccc
     2941 atcataatca gtaccacatt cccaacctgt ccctagttgg gcccttctca cagcatactg
     3001 ccttcatagc tcccaagaac atgggttcag gaggggacct ggctcagaga aggttctggc
     3061 taggagaagg gctgggcagc ttcatcaaga agcagatacc ttgcatctgt gccttgactg
     3121 ggcagagatc ccagctttcc cctttccccc agcgtgagga aacagcagag ggaaaagcct
     3181 cattggccaa cagatcctga tgctgtgtgt gacttagaag cttgagtctt tccatagggt
     3241 tcggagctgc ctgggagcca agttcctcac agcagaagga aggatgggcg tgcgaaggtt
     3301 gagttcctgt aacttaagct ttatcaaaat aaaaatccag aatggtatac ttgctctaac
     3361 cctgagagta atgagcctct ttctttcctt tcaacatttc ctaggaaaga aagccattat
     3421 ttgttaatgt tacctgatga tagtatggtg aataaaatct caaggagcaa caacactgta
     3481 cttgca
//
