LOCUS       NM_175171              10671 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus microtubule associated serine/threonine kinase family
            member 4 (Mast4), mRNA.
ACCESSION   NM_175171 XM_283179 XM_915307
VERSION     NM_175171.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10671)
  AUTHORS   Lee,D.J., Kim,P., Kim,H.Y., Park,J., Lee,S.J., An,H., Heo,J.S.,
            Lee,M.J., Ohshima,H., Mizuno,S., Takahashi,S., Jung,H.S. and
            Kim,S.J.
  TITLE     MAST4 regulates stem cell maintenance with DLX3 for epithelial
            development and amelogenesis
  JOURNAL   Exp Mol Med 56 (7), 1606-1619 (2024)
   PUBMED   38945953
  REMARK    GeneRIF: MAST4 regulates stem cell maintenance with DLX3 for
            epithelial development and amelogenesis.
REFERENCE   2  (bases 1 to 10671)
  AUTHORS   Lee,S.J., Kim,K.H., Lee,D.J., Kim,P., Park,J., Kim,S.J. and
            Jung,H.S.
  TITLE     MAST4 controls cell cycle in spermatogonial stem cells
  JOURNAL   Cell Prolif 56 (4), e13390 (2023)
   PUBMED   36592615
  REMARK    GeneRIF: MAST4 controls cell cycle in spermatogonial stem cells.
REFERENCE   3  (bases 1 to 10671)
  AUTHORS   Kim,P., Park,J., Lee,D.J., Mizuno,S., Shinohara,M., Hong,C.P.,
            Jeong,Y., Yun,R., Park,H., Park,S., Yang,K.M., Lee,M.J., Jang,S.P.,
            Kim,H.Y., Lee,S.J., Song,S.U., Park,K.S., Tanaka,M., Ohshima,H.,
            Cho,J.W., Sugiyama,F., Takahashi,S., Jung,H.S. and Kim,S.J.
  TITLE     Mast4 determines the cell fate of MSCs for bone and cartilage
            development
  JOURNAL   Nat Commun 13 (1), 3960 (2022)
   PUBMED   35803931
  REMARK    GeneRIF: Mast4 determines the cell fate of MSCs for bone and
            cartilage development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10671)
  AUTHORS   Lee,S.J., Park,J., Lee,D.J., Otsu,K., Kim,P., Mizuno,S., Lee,M.J.,
            Kim,H.Y., Harada,H., Takahashi,S., Kim,S.J. and Jung,H.S.
  TITLE     Mast4 knockout shows the regulation of spermatogonial stem cell
            self-renewal via the FGF2/ERM pathway
  JOURNAL   Cell Death Differ 28 (5), 1441-1454 (2021)
   PUBMED   33219327
REFERENCE   5  (bases 1 to 10671)
  AUTHORS   Kumar,A. and Thakur,M.K.
  TITLE     Analysis of Presenilin 1 and 2 interacting proteins in mouse
            cerebral cortex during development
  JOURNAL   Int J Dev Neurosci 38, 138-146 (2014)
   PUBMED   25196998
REFERENCE   6  (bases 1 to 10671)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 10671)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 10671)
  AUTHORS   Crozet,F., el Amraoui,A., Blanchard,S., Lenoir,M., Ripoll,C.,
            Vago,P., Hamel,C., Fizames,C., Levi-Acobas,F., Depetris,D.,
            Mattei,M.G., Weil,D., Pujol,R. and Petit,C.
  TITLE     Cloning of the genes encoding two murine and human cochlear
            unconventional type I myosins
  JOURNAL   Genomics 40 (2), 332-341 (1997)
   PUBMED   9119401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124387.5, AC165290.2, AC167975.3, AC114827.4, AC112791.3 and
            AC239606.3.
            
            On or before Sep 10, 2009 this sequence version replaced
            XM_915307.3, XM_283179.6, NM_175171.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090136.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-657               AC124387.5         84122-84778
            658-811             AC165290.2         188811-188964       c
            812-936             AC165290.2         157571-157695       c
            937-968             AC167975.3         129061-129092       c
            969-1057            AC114827.4         34206-34294         c
            1058-1127           AC112791.3         194756-194825       c
            1128-1206           AC112791.3         188897-188975       c
            1207-1364           AC112791.3         182301-182458       c
            1365-1440           AC112791.3         180341-180416       c
            1441-1650           AC112791.3         178224-178433       c
            1651-1752           AC112791.3         173218-173319       c
            1753-1885           AC112791.3         171572-171704       c
            1886-1953           AC112791.3         167600-167667       c
            1954-2039           AC112791.3         165415-165500       c
            2040-2248           AC112791.3         158441-158649       c
            2249-2387           AC112791.3         156710-156848       c
            2388-2520           AC112791.3         154978-155110       c
            2521-2686           AC112791.3         154024-154189       c
            2687-2788           AC112791.3         152126-152227       c
            2789-2911           AC112791.3         145550-145672       c
            2912-3024           AC112791.3         145215-145327       c
            3025-3152           AC112791.3         143278-143405       c
            3153-3388           AC112791.3         142757-142992       c
            3389-3589           AC112791.3         138311-138511       c
            3590-3819           AC112791.3         135636-135865       c
            3820-3942           AC112791.3         134769-134891       c
            3943-4079           AC112791.3         126201-126337       c
            4080-4261           AC112791.3         123453-123634       c
            4262-9560           AC112791.3         117854-123152       c
            9561-10671          AC239606.3         159181-160291       c
FEATURES             Location/Qualifiers
     source          1..10671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 54.94 cM"
     gene            1..10671
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /note="microtubule associated serine/threonine kinase
                     family member 4"
                     /db_xref="GeneID:328329"
                     /db_xref="MGI:MGI:1918885"
     exon            1..657
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..8157
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="microtubule-associated serine/threonine-protein
                     kinase 4"
                     /protein_id="NP_780380.2"
                     /db_xref="CCDS:CCDS49349.1"
                     /db_xref="GeneID:328329"
                     /db_xref="MGI:MGI:1918885"
                     /translation="MGEKVSEAPEPVPRGCSGHGARTLVSSAAAVSSEGASSAESSSG
                     SETLSEEGEPSRFSCRSQPPRPPGGALGTRLPAAWAPARVALERGVPTLPLPHPGGAV
                     LPVPQVSSASQEEQDEELDHILSPPPMPFRKCSNPDVACGLGKSLKYKRQLSEDGKQL
                     RRGSLGGALTGRYLLPNPVAGQAWPASAETSNLVRMRSQALGQSAPSLTASLKELSLP
                     RRGSLCRTSNRKSLIGNGQSPALPRPHSPLSAHAGNSPQDSPRNFSPSASAHFSFARR
                     TDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPYQPTPDELHFLSKHFCTTE
                     SIATENRCRNTPMRPRSRSLSPGRSPACCDHEIIMMNHVYKERFPKATAQMEERLKEI
                     ITSYSPDHVLPLADGVLSFTHHQIIELARDCLDKSHQGLITSRYFFELQHKLDKLLQE
                     AHDRSESGELAFIKQLVRKILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGI
                     KTDIPRYIISQLGLNKDPLEEMAQLGNYDSRTAETPEMDESVSSSNTSLRLRRKPRES
                     DFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAE
                     NPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYL
                     HNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQ
                     VCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEI
                     NWPEKDEAPPPDAQELITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQKAEF
                     IPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFTVEIRQFSSCSHRFSKVFSSID
                     RITQNSGEDKDDSEDKTKSTTLPSTETLSWSSEYSEMQQLSTSNSSDTESNRCKLSSG
                     LLPKLAISTDGEQDEAVPCSGDPREEPEKPVPPSEECTQEEPEVTTPASTISSSTLSV
                     GSFSEHLDQINGRSECVDSTDNSSKPSSEPTSHVARQRLESTEKKKISGKVTKSLSAS
                     ALSLMIPGDMFAVSPLGSPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQPIVIHSSG
                     KNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPAYQAGLKAGDLITHINGEPVHGLV
                     HTEVIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKGRMVRRSKKSKKKESLERRR
                     SLFKKLAKQPSPLLHTSRSFSCLNRSLSSGESLPGSPTHSLSPRSPTPSYRSTPDFPS
                     GTNSSQSSSPSSSAPNSPAGSGHIRPSTLHGLAPKLSGQRYRSGRRKSAGSIPLSPLA
                     RTPSPTPQPTSPQRSPSPLLGHSLGNAKITQAFPSKMHSPPTIVRHIVRPKSAEPPRS
                     PLLKRVQSEEKLSPSYGSDKKLLCSRKHSLEVTQEEVQREQCQREVTLQSLEENVCDA
                     PSLSRARPVEQGCLKRPVSRKVGRQESVDDLDRDKLKAKVVVKKPEEKHESHQKPHSL
                     GGDSESYALFRLEEREKKVYSKGLERSGHFENTSAELPSVGSLLKDTLHKQASVRASE
                     GVTSDGAACSLTPGEHSQSLGDFKRASASGILHDSVCPISDRPAPGKVEYSEKASQAK
                     ELLRSEKLDSKLANIDYLRKKMSLDDKDDSHCAILKPKITSSAHECLPGNPIRPMAGQ
                     QETPPASENRAFINSTHTPQMSAVSFVPLKALAGRVENGGEKAGLAAPESPVRKSPSE
                     YKLEGRSVSCLKPIEGTLDIALLSGPHASKTELLSPEPAQSPSPGINVGPCVPLALPG
                     SSGKKGDSTSLREPSSANLKVNKSYLLEPRFLPPSRALQDSLAASGPEPKSKPERKLI
                     HPSARSPATVTESNLQQKEGGPATHQDRSTDTRNLPGPGQTLHNVDLPRLCTRAPLPP
                     EGTPAKEKPCLKEPSAKVKSEWSAVRDDGHRDPCAKLCPAETGKASDSSKPLPSGGRT
                     QPDFYKQTQTSEKAWAHAKTNHKDSQDEVKSLAREDSASLLYEKEIGRARKGPEPKPE
                     VPATRCPPQPPGIEGEKREKLSAAPSLQKQAPKEPDRKEQTSQRPGGSGPQQPPPTKE
                     LSNSASWQHGSSPSHTLKKEPGTKAAAAEPSTSLHDTPRSATATTTAIATTTTTTSAG
                     HSDCSSHKARPGPDPSPSKSKHQDRSLSSQKLSAGSAKGKEPVTQPLGGSIREGKGGS
                     KGPVDTFSAVLTTQGKASDVLVQGEGRVSIIVHTEECPLDAKLKNTNGGCPPEMQAKH
                     PPRQGHLSEAADQKPLIAGEKQSPSPKHPKPSTVKDYPSLCRQTDRSPSHQATTGDRK
                     AEGKKCTDALYVAAPEGYKPEASPSLHHGETGLRGSERPPMGMGKGFSEPKGKGPGPQ
                     KSLAETGKPSGMKRSPSATVQSSLRSAAPPEKSLSYSASFPEAQPGVREVPAANSSPS
                     SAKATGGTSEFPAPSSRDHRKLQSGGDGRSQMIKSDSLPSFRLSTSALESHFQDPQVP
                     IASGHRGRALSVTAATGEPKGRELAQPPPVRKQNACREATRAPPAPSTDRSLPLSSEK
                     DFVVRQRRGKETLRSSPHKKAS"
     exon            658..811
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            812..936
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            937..968
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1057
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1127
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1206
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1364
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1440
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1650
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1752
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1885
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1953
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2039
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2248
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2387
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2520
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2686
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2788
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2911
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3024
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3152
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3388
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3589
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..3819
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            3820..3942
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            3943..4079
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            4080..4261
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     exon            4262..10671
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10652..10657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /note="hexamer: AATAAA"
     polyA_site      10671
                     /gene="Mast4"
                     /gene_synonym="4930420O11Rik; mKIAA0303"
                     /note="major polyA site"
ORIGIN      
        1 gtcccggagg caggtttagc gggagaagcc gcagtcccgg cggctcgggc gcagcgcgga
       61 gcgccgatcg cggtgggcat ggccccgcgc gcgggagtcc atgtcagcag ccgagccacg
      121 gcggcagtga acttggcgac gcgctcctgt ggtccaacct ctgtcatgta gtcgccggcg
      181 gcgctccccg cagcccggga gccgcagcgc gatccagaca cagcagagca gccggggctt
      241 cttcgggagg cgccgagcgc accgccaccc ctcggacggc actttgggcc gaaaagggac
      301 atgggggaga aagtttccga ggcgcctgag cccgtgcccc ggggctgcag cggacacggc
      361 gcccggaccc tagtctcttc ggcggcagcc gtgtcctcgg agggcgcttc ctcagcggag
      421 tcatcctctg gctcggaaac tctgtcggag gaaggggagc ccagccgctt ctcctgcagg
      481 tcgcagccgc cgcggccgcc gggcggcgcc ctgggaaccc ggctacccgc cgcgtgggct
      541 cccgcgcgcg tggctctgga gcgtggagtc cctaccctgc cgctgccgca cccgggagga
      601 gcggtgctgc cggtgcccca ggtcagcagc gcatcccaag aggagcagga tgaagagctt
      661 gaccacatac tgtctccgcc acccatgccg tttcggaaat gcagcaaccc agatgtggcc
      721 tgcggcctcg gaaaatcact gaagtacaag agacagctta gtgaggatgg gaagcagctg
      781 cggcggggga gcctgggagg agccctcaca gggaggtacc tccttccaaa cccggtagca
      841 ggacaggcct ggcctgcttc ggcggagacg tccaacctcg tgcgcatgcg cagccaggcc
      901 cttggccaat cggctccctc gctcacagcc agcttgaagg agctgagcct cccccgaaga
      961 ggaagtcttt gccgaacaag caaccggaag agtttgatag gcaatggcca gtctccagca
     1021 ctgcctcgac cacactcacc tctctctgct catgcaggaa atagccctca agacagtcca
     1081 aggaatttct cccccagtgc ctcagcccat ttctcatttg cgaggagaac ggatgggcgc
     1141 cgctggtctc tggcttctct cccttcctca ggctatggga caaatacccc aagctccacc
     1201 gtctcctcat cctgttcttc ccaggagaag ttgcaccagc taccatacca gccaacccca
     1261 gatgaattac acttcttatc caaacacttc tgcacaacag aaagtatcgc cactgagaac
     1321 cggtgcagaa acacacccat gcgtccacgt tcccggagtc tcagccctgg acggtccccc
     1381 gcctgctgtg accatgaaat aattatgatg aaccatgtct acaaagaaag gttcccaaag
     1441 gccacagctc agatggaaga gcgtctgaag gagatcatca ccagctactc tccagaccat
     1501 gttctcccct tggcagatgg ggtacttagt ttcactcacc atcagatcat tgagctggct
     1561 cgggactgtt tggataaatc tcaccagggt ctcatcacgt cgagatactt ttttgagttg
     1621 cagcacaaac tggacaagtt gctccaggag gctcacgatc gctctgaaag tggagaactg
     1681 gcatttatca agcaactagt ccgaaagatc ctaattgtca ttgcccgccc cgctcggtta
     1741 ttggagtgtt tggaatttga tcctgaagaa ttttattacc tattggaagc tgcagaaggc
     1801 catgccaaag aaggccaagg aatcaaaact gacatcccta ggtatatcat cagccagctg
     1861 ggactcaata aggacccttt agaagaaatg gctcagttgg ggaattacga cagtaggaca
     1921 gcagagacac cagagatgga tgagtcagtg agtagctcaa atacttccct gagacttcga
     1981 aggaaacccc gagagagtga ttttgaaaca attaaattga tcagcaatgg agcctacggg
     2041 gcagtctact ttgttcggca caaagagtcc cgccagaggt ttgccatgaa gaagatcaac
     2101 aagcagaacc tcatccttcg gaaccagatc cagcaggcct tcgtggagcg agacatcctg
     2161 actttcgcag agaacccctt tgtggtcagc atgtattgct cctttgaaac gaggcgtcac
     2221 ttatgcatgg tcatggagta tgtagaaggg ggagactgtg cgaccctaat gaaaaacatg
     2281 ggacctctcc cagttgatat ggccagaatg tatttcgccg agaccgtctt ggccttggag
     2341 tacctgcata attacggaat cgtacacagg gacttgaagc cagacaacct gttggtcacc
     2401 tccatggggc acataaaact gactgacttc ggcttgtcta aggtgggatt aatgagcatg
     2461 accaccaatc tctatgaagg ccacatagag aaggacgctc gagagttctt agataaacag
     2521 gtctgtggta cacctgagta cattgccccc gaggtgattc tgagacaggg ctacgggaaa
     2581 cccgtggact ggtgggccat gggcattatc ctctatgaat ttctggtcgg atgtgtgcct
     2641 ttctttgggg acactccaga agagctattt ggacaagtca tcagtgatga aatcaactgg
     2701 cctgaaaagg acgaggcccc tcctccagac gctcaggagc tgattacctt gctcctcagg
     2761 cagaatccgc tggagaggct gggaacaggt ggagcctatg aagtgaagca gcatcgtttc
     2821 ttccgctcct tagactggaa cagtttgctg agacagaagg cggaatttat tccccaactg
     2881 gaatcggagg atgacacaag ttattttgat actcggtcag agaagtatca tcacatggag
     2941 acggaggagg aggacgatac aaacgatgag gacttcaccg tggagataag gcagttttct
     3001 tcctgttcac acaggttttc aaaagttttc agcagtatag atcgcataac tcaaaattca
     3061 ggagaagaca aagatgactc tgaggacaag accaaaagca caacgttgcc atccacagag
     3121 acactcagct ggagttccga atactctgaa atgcaacagt tatcgacctc caactcttca
     3181 gatactgaaa gcaacaggtg caaactcagc tctggcttgc tccccaagct ggctatttcg
     3241 acagatgggg aacaagatga ggctgtccct tgctctggag accccagaga ggagccagag
     3301 aaacctgtcc ctccctctga ggagtgtact caggaggagc ccgaggtcac caccccagcc
     3361 agcaccatca gcagttccac actgtcagtt ggcagttttt cagagcactt ggatcagata
     3421 aatgggcgaa gcgagtgtgt ggacagtaca gataattcct caaagccatc cagtgaaccc
     3481 acttctcacg tggctcgaca gcgcttagaa agcacagaga aaaagaaaat ttctgggaaa
     3541 gtcacaaagt ccctctcggc cagtgctctg tccctcatga tcccaggaga tatgttcgct
     3601 gtatctccat tgggaagccc aatgtcccca cactccctgt cttcagaccc ttcttcttca
     3661 cgggattcct ctcccagccg agactcttct gcagcatctg ccagtccgca tcagcccatt
     3721 gtcatccaca gctcaggcaa gaactatggg ttcaccatcc gtgctatccg cgtgtacgtg
     3781 ggggacagtg acatctacac agtgcaccat atcgtctgga acgtagaaga aggaagtccc
     3841 gcataccagg caggactgaa ggccggggat ctgatcacac acatcaacgg agagccggtg
     3901 cacggcctcg tccacacgga agttatcgag ctcctgctga agagtgggaa taaggtgtct
     3961 atcaccacta ctccatttga aaacacatca atcaaaacgg gaccagccag gagaaacagt
     4021 tacaagggcc ggatggtgag acgaagcaag aagtccaaga agaaggagag tctagaaagg
     4081 aggagatctc tcttcaagaa gctggccaag cagccttctc ctttgctcca caccagccga
     4141 agtttctcct gcttaaaccg gtccctgtca tctggagaga gcctcccggg ttccccaact
     4201 cacagcttgt ccccgaggtc tccaacaccc agttatcgtt ctactcccga ttttccgtca
     4261 ggtacaaatt cctcccagag cagctcccca agttcaagtg cccccaattc tccagcaggt
     4321 tcagggcaca tccggcccag caccctccat ggcctggctc ccaaactcag cgggcagcga
     4381 taccgctctg gaagacggaa gtcggctggc agcatccctc tctccccgct ggccaggaca
     4441 ccctctccca ctccacagcc tacctctcct cagcgttcac catccccact gttgggacac
     4501 tcactgggca atgccaagat cactcaggcc tttcctagca agatgcactc tccccccaca
     4561 atcgtcagac acatcgtgag gcccaagagt gcagagccgc cccgctcccc actgctgaaa
     4621 cgggtgcagt cggaggaaaa gttgtcaccc tcctatggca gtgacaagaa gcttctgtgc
     4681 tcccgcaagc atagcctaga ggtgacacaa gaggaggtac agagggagca gtgtcagcgg
     4741 gaagtgacac tgcagagcct ggaagagaat gtgtgtgacg ctccttccct cagtcgggcc
     4801 aggccagtgg agcaaggctg tctgaaacgc cccgtgtccc ggaaggtggg caggcaagag
     4861 tctgtggatg acctggaccg ggacaagctg aaagccaagg ttgtcgtaaa gaaaccagaa
     4921 gagaaacatg aatcgcacca gaaacctcac agccttggtg gtgattcgga aagctatgct
     4981 ctcttcaggc tagaggagag agagaaaaaa gtgtactcca aggggttgga aaggtcaggc
     5041 cattttgaaa acacatcagc agagttgcct tctgtgggca gcctgctgaa ggacactctt
     5101 cacaagcagg ccagcgtgag ggccagcgag ggggtgacct cagacggggc agcttgcagc
     5161 ctgacaccag gggagcacag ccagtctcta ggtgacttta agcgggcctc agcttctggc
     5221 attctccatg atagtgtgtg ccccatctct gataggcctg ctcctggaaa ggttgaatac
     5281 tcggagaagg cctctcaggc caaagagctc cttcgaagtg aaaaactaga cagcaagctg
     5341 gccaatattg attacctcag aaagaaaatg tcattggatg acaaagatga cagccactgt
     5401 gccatcctga aacccaagat aacatctagc gcccatgaat gtctgccagg gaaccccata
     5461 cggcccatgg cagggcaaca agagaccccg ccagcctctg aaaaccgggc attcatcaac
     5521 agtacccaca cacctcagat gagtgcagtt tcctttgttc ctctcaaagc cttagctggc
     5581 cgggtagaga acggagggga gaaagcaggc ttagctgctc ccgagtcccc tgtcaggaag
     5641 agcccctccg agtataagct agagggcagg tcagtttcat gtctcaagcc gatcgagggc
     5701 acactggaca ttgctctcct gtctggacct cacgcctcca aaacagagtt gctttcccca
     5761 gagcctgcac agagtcccag cccaggcatc aacgtgggac catgtgtgcc actagctctt
     5821 cctgggagca gtgggaaaaa gggagactcc accagcctga gagagccttc ctcagccaac
     5881 ttaaaagtaa ataaatctta tctgctggag cctcggttcc tacccccgag ccgggctctc
     5941 caggactctc tcgcagcctc tgggccagaa ccgaagtcaa agccggaaag gaagctcatt
     6001 catccttctg ccaggagccc agcaactgtc acagagagca atcttcagca gaaagagggt
     6061 ggtcccgcca cacaccaaga ccgctccact gacaccagga acctccctgg cccagggcag
     6121 accctacaca atgtggacct acccaggctg tgtacacgtg ccccactccc accggaaggg
     6181 acgcccgcaa aggagaagcc atgtctgaag gaaccctctg ccaaggtgaa aagcgagtgg
     6241 tctgccgtga gggatgacgg acacagagat ccctgtgcga agctgtgccc ggcagagact
     6301 ggtaaagcca gcgacagttc caaacccctg ccttccgggg ggaggaccca acccgatttc
     6361 tacaagcaga cccagacttc ggagaaagca tgggcgcatg caaaaacaaa ccacaaagat
     6421 agccaagatg aggtgaagtc cctggccagg gaggactcag cttcactttt atatgaaaag
     6481 gagataggcc gggcacgaaa aggtcctgaa cccaaaccgg aagttcctgc tacccggtgc
     6541 cctcctcagc caccaggaat tgagggtgag aagcgagaaa agctctccgc tgccccctct
     6601 ttgcagaaac aggctcccaa agagccagac aggaaggaac agacttcgca aaggcctgga
     6661 ggtagtggcc ctcaacaacc cccacccacc aaagagctgt ctaactcagc atcctggcag
     6721 cacggcagtt ctccgagtca cactttaaag aaggagcccg ggaccaaagc tgccgctgca
     6781 gaaccaagca ccagccttca tgacactccc cgatctgcta cagccaccac cactgccatt
     6841 gccaccacca ccactaccac cagtgccggg cacagtgact gcagtagcca taaggcccgg
     6901 cctggccctg accccagccc ttcaaagtct aagcaccaag acaggtccct ctcctcacag
     6961 aagctgagtg ctggctctgc aaaaggcaaa gagcctgtca ctcaacccct gggtggttcc
     7021 atcagagaag gcaagggtgg cagcaagggt ccagtggaca cattttctgc tgtcctgacc
     7081 acccagggca aagcaagtga tgtgcttgtg cagggagaag gtcgggtctc aatcattgtc
     7141 cacactgaag agtgtcctct cgatgccaaa ctgaaaaaca ccaatggagg gtgtccccca
     7201 gagatgcagg cgaagcatcc acccagacaa ggacatctca gtgaagcagc agaccagaag
     7261 ccactcattg ctggtgagaa gcaaagcccg tctccaaagc atcccaaacc atccactgtg
     7321 aaagattacc ccagtctgtg cagacagaca gacagaagcc caagccatca ggctaccact
     7381 ggggacagga aggcagaagg aaagaaatgc acagacgcac tttatgtcgc agccccagag
     7441 ggctacaagc cagaggccag cccttctctc caccacggcg agaccggact cagaggctca
     7501 gagaggccac ccatgggcat ggggaagggc ttctctgagc ccaaggggaa agggccaggt
     7561 ccccagaagt cactggctga aacaggcaag cccagcggta tgaaaaggtc accctctgcc
     7621 accgtgcaga gctctctccg ctcagctgcc cccccagaaa agtctctgag ttactcagcc
     7681 agctttcccg aggcccagcc tggagtgcga gaggtccctg cagccaacag cagcccctca
     7741 tctgccaagg ctacaggggg gacctcagag ttcccagccc ccagcagcag ggaccacagg
     7801 aagcttcagt ctggaggaga cggccgaagc caaatgataa agagtgactc tctgccctcc
     7861 ttccgcctct ccacctctgc tctggagtca catttccagg atccacaggt gcccatcgca
     7921 tcaggccacc gaggcagggc actgtcagta actgctgcca caggagaacc caaagggaga
     7981 gagctcgccc agcctccccc agtcaggaaa cagaatgcgt gcagagaggc gaccagagca
     8041 cccccagccc caagcacaga tcgctccctc cctctttcct cagagaaaga cttcgtggtt
     8101 cggcagagaa ggggcaagga gaccttaagg agcagtcctc acaaaaaggc ctcctaacag
     8161 gcagctctgg tggcatggct atgagaccca gcccaagcgt agctgggact gggtctttgt
     8221 caccttacaa accagcactg tatgggaatg tcctccatgc agagcccaga ggctcataag
     8281 gaggaggaga gacaggaaaa aaaaaaaggg aactttcttc cagatgcctt cccagtagta
     8341 accggtaaaa ctgttgccag atagtgtttg tacaaaacct gccttcccag cgatgagctg
     8401 gtgaggaaga gaagctctct gtacataacc tagcaatgtg tttgggtcgg gatgtagagt
     8461 gtgcaccttg cagctgacca ccttgctgac cgaagctttt ctagattgaa catatttgtt
     8521 tttaccacgt aaccataacg tagtaagaaa gcaaagtggt caggctgggg gaggtgtgtg
     8581 aaaaatagaa acccacccgt aactgcgtgt gtatgcctcc acctatgtgt tttggtctgt
     8641 ggtctgagaa tagttcaagg ctccatttgt agaagtagag ttaaagatga aaggaagccc
     8701 taactacagt agatggtgag gttttttttt tgtgtgtgtg tgtgtgtatg tgtgtgtgtg
     8761 tatatattta accaggattt ctgatagtac tgaatctggc tacctgtatt tctgagctgc
     8821 tgcttttgga cccctccgct aggagtggcc aggacagggg gagctgggca tctctttgac
     8881 agccctcgta agggacattt tgaccctcag gtccaagtgg cccaaaaggc aatggtcctt
     8941 gtctctgggt tatatgtctg gtcttcaccg gagggcacac agggactata aacacactgc
     9001 aggtcagctt tctttctttc tctccttcct tcctttctaa gctctaccct caggccttta
     9061 tgctgtgagt ccaagaagca catattcgtg gcaggcactg gaccagcgct gctggtgagg
     9121 aaacaggcaa gtccctggct gcacacaaat ccgctagcac ttaggtggag cgatacgcat
     9181 taggcattgg aagaggcttt aactttgctt tggttgaaga aaaggagggg ggtggatttt
     9241 ggcatcatag catatatatt aaagaataat caggacatca gatacatttt aatacatagc
     9301 tggggcctta tgttgtagat gaagcttgct gtttttagca agttcctggg tttcacattc
     9361 atttctgatg catcgagtag ctccatgcat ttcataacac aatctcttta tttgtatgca
     9421 aaaaatttac tgtattaata aagagcatca ttttgtaaca aagagactgg agctatttgg
     9481 tgcttgaatg tgaacatcct ttttactttt gctaagcctt atttaaattt tgtataccag
     9541 gaaatatgta gaacttgtca gatcatttta gctctgaggg tttttctggg ttgtttctgt
     9601 tgttgcgatg gtttttttat gttttgtttt gttttgtttc gttggtgggt ttgggttttt
     9661 gttttgtttt gttttgtttt aatggcttgt tttgaattgt aagatggcac ttgctgacta
     9721 agacacaatg cagacaaatt tttataagat gcttgggatc cataacaaga ctttgttcta
     9781 taagaggaaa aaaaaattac aaatgaataa tgaacctagc tccagacccc tcaggggtgt
     9841 cttggtatct gtacaccata ggattgttta tgtgagcaca gccctgtgga ttgtaaatca
     9901 cctagcgagg ttgtaagcac tccagaaaca aaggcatcac gtcaccatct gcctggttgc
     9961 ccttggttgc caagccagtt ggtgatggca aaaggaaagg aaaagggaga ttctgcccca
    10021 ctcctgtctc cccaccccca gacagctcca gccatccccc catcactaca ttgtgaaact
    10081 gtagaacaaa tattttttta caagaactcc aatgggtctc aaaaaacggt ctcaaagctt
    10141 acagtgcata tctggttggc agatctaaca gcctaatcct tctccactca gagatcagga
    10201 caggtctgtc caggaggtag ttcatggttt acagactttg cttttaactg tcccgttttc
    10261 tttaaagcac agccagctgc ttgtttacaa aggatatttt ttatgtatat tttgtatagt
    10321 gtattatcat ttttgccaaa tttgtttttg cattttggac gagtaaagga gtacttaagg
    10381 ttgctcacat gtgatacctg tttgttgttg tgaaatctcc ccccaaccag ctggtaggat
    10441 ttctcccgtg ttccctttgg tcagtctctg tgtggttgta agatgtgccc ctcggtagcg
    10501 ctcccagctg tagacttacc agcttcagtt tgttaggatc tgtgcaataa agtgtttgca
    10561 gtcttatttt ctctgagaac taccccccca tgaatgtcat aattgttgta tattgaacaa
    10621 atatttatac ttatgcagtt gcataacatt gaataaaaat ttagcatgaa a
//
