LOCUS       NM_001402973            5319 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus microtubule associated serine/threonine kinase 3
            (Mast3), transcript variant 1, mRNA.
ACCESSION   NM_001402973 XM_006509707
VERSION     NM_001402973.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5319)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5319)
  AUTHORS   Spinelli,E., Christensen,K.R., Bryant,E., Schneider,A.,
            Rakotomamonjy,J., Muir,A.M., Giannelli,J., Littlejohn,R.O.,
            Roeder,E.R., Schmidt,B., Wilson,W.G., Marco,E.J., Iwama,K.,
            Kumada,S., Pisano,T., Barba,C., Vetro,A., Brilstra,E.H., van
            Jaarsveld,R.H., Matsumoto,N., Goldberg-Stern,H., Carney,P.W.,
            Andrews,P.I., El Achkar,C.M., Berkovic,S., Rodan,L.H., McWalter,K.,
            Guerrini,R., Scheffer,I.E., Mefford,H.C., Mandelstam,S., Laux,L.,
            Millichap,J.J., Guemez-Gamboa,A., Nairn,A.C. and Carvill,G.L.
  CONSRTM   Undiagnosed Diseases Network (UDN)
  TITLE     Pathogenic MAST3 Variants in the STK Domain Are Associated with
            Epilepsy
  JOURNAL   Ann Neurol 90 (2), 274-284 (2021)
   PUBMED   34185323
REFERENCE   3  (bases 1 to 5319)
  AUTHORS   Tripathy,R., Leca,I., van Dijk,T., Weiss,J., van Bon,B.W.,
            Sergaki,M.C., Gstrein,T., Breuss,M., Tian,G., Bahi-Buisson,N.,
            Paciorkowski,A.R., Pagnamenta,A.T., Wenninger-Weinzierl,A.,
            Martinez-Reza,M.F., Landler,L., Lise,S., Taylor,J.C., Terrone,G.,
            Vitiello,G., Del Giudice,E., Brunetti-Pierri,N., D'Amico,A.,
            Reymond,A., Voisin,N., Bernstein,J.A., Farrelly,E., Kini,U.,
            Leonard,T.A., Valence,S., Burglen,L., Armstrong,L., Hiatt,S.M.,
            Cooper,G.M., Aldinger,K.A., Dobyns,W.B., Mirzaa,G., Pierson,T.M.,
            Baas,F., Chelly,J., Cowan,N.J. and Keays,D.A.
  TITLE     Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with
            Cerebellar Hypoplasia and Cortical Malformations
  JOURNAL   Neuron 100 (6), 1354-1368 (2018)
   PUBMED   30449657
REFERENCE   4  (bases 1 to 5319)
  AUTHORS   Andrade,E.C., Musante,V., Horiuchi,A., Matsuzaki,H., Brody,A.H.,
            Wu,T., Greengard,P., Taylor,J.R. and Nairn,A.C.
  TITLE     ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A
            Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast
            3 Kinase)
  JOURNAL   J Neurosci 37 (10), 2709-2722 (2017)
   PUBMED   28167675
  REMARK    GeneRIF: We describe a novel mechanism of signal transduction
            enriched in medium spiny neurons of striatum that likely mediates
            effects of the neurotransmitter dopamine acting on these cells. We
            find that the protein ARPP-16, which is highly expressed in
            striatal medium spiny neurons, acts as a selective inhibitor of
            certain forms of the serine/threonine protein phosphatase, PP2A,
            when phosphorylated by the kinase, MAST3.
REFERENCE   5  (bases 1 to 5319)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 5319)
  AUTHORS   Labbe,C., Goyette,P., Lefebvre,C., Stevens,C., Green,T.,
            Tello-Ruiz,M.K., Cao,Z., Landry,A.L., Stempak,J., Annese,V.,
            Latiano,A., Brant,S.R., Duerr,R.H., Taylor,K.D., Cho,J.H.,
            Steinhart,A.H., Daly,M.J., Silverberg,M.S., Xavier,R.J. and
            Rioux,J.D.
  TITLE     MAST3: a novel IBD risk factor that modulates TLR4 signaling
  JOURNAL   Genes Immun 9 (7), 602-612 (2008)
   PUBMED   18650832
  REMARK    GeneRIF: As in human immune cells, murine Mast3 is constitutively
            expressed in CD4-positive and CD8-positive T cells and
            CD19-expressing B cells.
REFERENCE   7  (bases 1 to 5319)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   8  (bases 1 to 5319)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162446.2.
            
            On Mar 24, 2022 this sequence version replaced XM_006509707.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422603.97428.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC162446.2         157155-157204       c
            51-82               AC162446.2         151670-151701       c
            83-172              AC162446.2         148925-149014       c
            173-261             AC162446.2         142209-142297       c
            262-334             AC162446.2         142060-142132       c
            335-355             AC162446.2         141895-141915       c
            356-434             AC162446.2         141418-141496       c
            435-592             AC162446.2         141091-141248       c
            593-668             AC162446.2         140939-141014       c
            669-878             AC162446.2         140342-140551       c
            879-980             AC162446.2         140080-140181       c
            981-1113            AC162446.2         139874-140006       c
            1114-1172           AC162446.2         139519-139577       c
            1173-1258           AC162446.2         139068-139153       c
            1259-1467           AC162446.2         138782-138990       c
            1468-1606           AC162446.2         138369-138507       c
            1607-1739           AC162446.2         137573-137705       c
            1740-1905           AC162446.2         136940-137105       c
            1906-2007           AC162446.2         136726-136827       c
            2008-2130           AC162446.2         136355-136477       c
            2131-2240           AC162446.2         135912-136021       c
            2241-2374           AC162446.2         135677-135810       c
            2375-2616           AC162446.2         134112-134353       c
            2617-2829           AC162446.2         133724-133936       c
            2830-3056           AC162446.2         133360-133586       c
            3057-3179           AC162446.2         133081-133203       c
            3180-3316           AC162446.2         132752-132888       c
            3317-3498           AC162446.2         132485-132666       c
            3499-5319           AC162446.2         130329-132149       c
FEATURES             Location/Qualifiers
     source          1..5319
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..5319
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /note="microtubule associated serine/threonine kinase 3"
                     /db_xref="GeneID:546071"
                     /db_xref="MGI:MGI:2683541"
     exon            1..50
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..4022
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     microtubule-associated serine/threonine-protein kinase 3"
                     /codon_start=1
                     /product="microtubule-associated serine/threonine-protein
                     kinase 3 isoform 1"
                     /protein_id="NP_001389902.1"
                     /db_xref="GeneID:546071"
                     /db_xref="MGI:MGI:2683541"
                     /translation="MDEPSLLRRRGLQKELSLPRRGRGLSPSSQSPCLLSPGSPCSPC
                     SPSLGLQPWSCRSGNRKSLVVGTPSPTLSRPLSPLSVPTAGNSPLDSPRNFSAAAAIS
                     FPFARSHLSHGDRADGRRWSLASLPSSGYGTNTPSSTVSSSSSSRERLHQLPFQPTAD
                     ELRFLSKHFRSSESVVDEDGGRSPRLRPRSRSLSPGRTSGTFDNEIVMMNHVYRERFP
                     KATAQMEGRLQDFLAAFAPGDRLALADGVLGFIHHQIVELARDCLAKSGEALVTSRYF
                     LEMQDKLERLLQDAHERSDSAEVGFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLL
                     EAAEGQAREDQGVKTDLPRYIIRQLGLAKDPLEEIQPLNDLDESQPPAPGSPESRGLG
                     GPSRRKPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVF
                     VERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARMYF
                     AETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIE
                     KDAREFVDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVILYEFLVGCVPFFGDTPEE
                     LFGQVVSDEIMWPEGDEALPLDAQDLITRLLRQSPMDRLGTGGTHEVKQHPFFLALDW
                     AGLLRHKAEFVPQLEAEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIPQFSSCSHR
                     FSKVYSSSEFLAVQPTPTFAERSFSEDREDGWGQSLGDRGRRLSADLRLRSWTPASSC
                     QPSSCQTDRGPSPSLLSTISLDVMPKFAFSSEDEGASSGPADPQKPVFILGEPDPPPP
                     TTPVTPKPCNLSADTAVLSHARLRSNSTGARHSTPRPLDAGRGRRLGGSRDPGPEKPR
                     ASPGGSGGRVPKSASVSALSLIITADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPS
                     PVCGSLRPPIVIHSSGKKYGFSLRAIRVYMGDSDVYTVHHVVWSVEEGSPAQEAGLRA
                     GDLITHINGESVLGLVHMDVVELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMA
                     RRSKRSRRRETQDRRKSLFKRISKPSSVLHTSRSFSSGLQHSLSSSESLPGSPTHSLS
                     PSPTTPCRSPAPDAPTDTASPPNVSPSSSSPASPATGHTRPSSLHGLAAKLGPPRHKS
                     GRRKSTSSIPPSPLACPPVPTPPPRSPSPLPGHIPIPARSPRLRRGQSADKLGLGTSE
                     RLDGDGGRRARGAEAELVVMRRLHLSERRDSFKKQEAVQEVSFDEEPGPPRGVPKIAV
                     QGAEATPGTPGHARKD"
     exon            51..82
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            83..172
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            173..261
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            262..334
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            335..355
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            356..434
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            435..592
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            593..668
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            669..878
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            879..980
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1113
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1172
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1258
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1467
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1606
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1739
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1905
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2007
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2130
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2240
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2374
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2616
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2829
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..3056
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3179
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3316
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3498
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     exon            3499..5319
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5295..5300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /note="hexamer: AATAAA"
     polyA_site      5319
                     /gene="Mast3"
                     /gene_synonym="mKIAA0561"
                     /note="major polyA site"
ORIGIN      
        1 aacacacagc gatggacgag ccgagcctcc tgcggcgccg tgggctccag aaggagctga
       61 gtcttccacg acgggggcgc ggtctgtcgc ccagcagcca gagcccatgc ctgttgagcc
      121 ccggcagccc gtgcagcccg tgcagcccat cgctgggcct gcaaccctgg agctgccgca
      181 gtggcaaccg taagagcttg gtcgtgggga cgccctcacc cactctctcc agacctctgt
      241 caccactctc tgtcccaact gcaggtaaca gccccctgga cagtcctcgg aacttctctg
      301 ctgcagcagc catcagtttc ccctttgccc ggagccacct ctctcacggt gacagggctg
      361 acggcagaag atggtcactt gcttccctcc cgtcctcggg ctatgggacc aacactccca
      421 gctccactgt atcgtcaagc tcgtcctccc gggagcgtct acaccagctc cccttccagc
      481 ccacagcaga cgagctgcgc ttcctgtcca agcacttccg cagctcagag agtgtggtgg
      541 acgaggacgg aggccgttct ccacgcctgc gcccacgctc acgcagcctc agccctggac
      601 gcacatcagg aaccttcgac aacgaaatag tgatgatgaa ccacgtgtac cgggagcgtt
      661 tccccaaggc cacggcgcag atggagggcc ggctgcagga cttcctggca gcatttgctc
      721 ctggcgaccg cctggcactg gcagacggtg tcttgggctt tatccaccac cagatcgtgg
      781 aactggcacg ggactgcctg gccaagtcgg gcgaggctct ggtcacttcc cgctatttcc
      841 tggagatgca ggacaagctg gagaggctgt tgcaggatgc tcacgagcgg tcggacagcg
      901 ccgaggtggg cttcatagtg cagctggtcc gaaagctgct catcatcatc tccaggccag
      961 cgcggctgct cgagtgcttg gagtttgacc cggaagaatt ctaccatctg ctggaggctg
     1021 cagaaggcca ggcccgcgag gaccagggcg tgaagactga tctgccccgc tacatcatcc
     1081 gccagctggg ccttgccaag gacccgctgg aagagatcca gcccctgaat gaccttgatg
     1141 aaagccagcc ccctgctcct ggatcccctg agagccgagg cctgggtggt ccgtctcgga
     1201 ggaagccatg tgagagcgac tttgagacca tcaagctcat tagcaatgga gcctatgggg
     1261 ccgtctacct ggtgcgccac agggatacgc ggcagcgctt cgccatcaag aaaatcaaca
     1321 agcagaattt aattctgcgc aaccagatcc aacaggtgtt tgtggagcga gacatcctca
     1381 ccttcgccga gaaccccttt gtggttggca tgttctgctc ctttgagacc cgccgccacc
     1441 tctgtatggt catggaatat gtggaagggg gtgactgcgc tacgctcctg aaaaacatgg
     1501 gcccactgcc cgtggacatg gcacgcatgt acttcgcgga gacggtgctg gcactggaat
     1561 atctgcacaa ctatggcatt gtgcaccgag atctcaaacc tgacaacctg ctcatcacct
     1621 ccctcggcca tatcaagctg acggacttcg gcctgtccaa gatcggcctc atgagcatgg
     1681 ccaccaacct gtatgaaggt cacatcgaga aggatgctcg agagtttgtg gacaagcagg
     1741 tgtgtgggac acccgagtac atcgcaccag aggtgatctt ccgccagggc tacgggaagc
     1801 cagtagactg gtgggccatg ggcgtcatcc tgtatgagtt cctggtgggc tgtgtgccat
     1861 tcttcgggga cacgcctgag gagctgttcg gacaggttgt cagtgatgag atcatgtggc
     1921 cagagggaga tgaggccctt ccccttgacg ctcaggacct gattactagg cttctgcgtc
     1981 agagcccaat ggacaggctg gggactggtg gcacccatga ggtgaaacag caccccttct
     2041 tcctggccct ggactgggca gggctcctga gacacaaggc agagtttgtc ccacagcttg
     2101 aagctgagga tgacaccagc tactttgaca ctcgctctga gcggtaccgc cacttgggct
     2161 ccgaggacga cgagacgaat gatgaggagt cctccacgga gatcccccag ttctcctcct
     2221 gttcccaccg cttcagcaag gtttacagca gctctgagtt cctggccgtc cagcccaccc
     2281 caacctttgc tgaaaggagc ttcagtgagg accgagaaga cggctggggg caaagcctcg
     2341 gggaccgtgg ccgccggctg agcgctgacc tccggctaag gtcctggaca cctgcctctt
     2401 cctgtcagcc atcttcctgt cagactgacc ggggtcctag cccgtctctc ctaagcacta
     2461 tcagtttgga tgtgatgcct aaatttgcct tctcctctga agatgaggga gcaagttcag
     2521 gacctgctga tccccaaaag cctgtcttca ttctggggga gcctgatccc ccacccccga
     2581 ccaccccagt gacacccaag ccctgcaacc tttctgctga cacagctgtc ctcagccatg
     2641 cccgccttcg aagtaacagt acaggagccc ggcactccac tcctcggccc ctggatgctg
     2701 gcagaggccg ccgcctagga ggctcaagag atcctggccc tgagaagccc cgggcctccc
     2761 ctggtggcag tgggggtcga gtgcccaagt cagcctctgt gtctgccctg tccctcatca
     2821 tcacggcaga cgacggcagc gggggccctc tcatgagccc cttgtcgccc cgctcgctgt
     2881 cctccaatcc ctcctcccga gactcctcac ccagccggga cccatcacca gtgtgtggta
     2941 gcctgcggcc tcccatcgtc atccacagct caggcaaaaa gtatggcttc agcctgcgcg
     3001 ccattcgtgt ctacatgggt gatagtgacg tgtacacggt gcaccatgtg gtctggagcg
     3061 tggaggaggg gagccctgca caggaggcag gactgcgtgc tggggacctc atcacacaca
     3121 tcaatgggga gtcagtcctg ggcctggtac acatggacgt ggtggagctg ctgctgaaga
     3181 gtggcaacaa gatctccctg cgcaccacgg ccctggagaa cacctccatc aaggtgggac
     3241 ccgcgcggaa gaacgtggcc aagggccgca tggcccgtag gagtaagcgc agccgccggc
     3301 gtgagaccca ggaccggcgg aagtctctgt ttaagaggat ctcaaagcca tcttctgtgc
     3361 tccacaccag ccgtagcttt tcctcaggcc tccagcactc tctgtcctcc agcgagagcc
     3421 tccccggatc acccactcac agcctgtctc ccagccccac cacgccctgc cgcagccctg
     3481 cccccgacgc ccccacagac acagcatccc cacccaatgt gtccccaagc tccagcagcc
     3541 ccgcttctcc agccactggt cacacccgtc ccagctccct gcatggcctg gcagccaagc
     3601 tcggaccacc tcgtcacaag agcggtcgcc gcaagtccac aagcagtatc cctccatctc
     3661 cgctggcctg cccgcccgtg cccacgcccc cgccacgctc accatccccc cttccggggc
     3721 acatccccat acccgcccgg tctcctaggc tgcgtagggg ccagtcagcc gacaagctgg
     3781 gcctaggcac cagtgagagg ctggatgggg atggaggccg gcgcgcccgg ggggccgagg
     3841 ctgagctggt cgtcatgagg aggctgcatc tatcagagcg tcgggattcc ttcaagaagc
     3901 aggaggcagt gcaggaggtg agcttcgatg aggagcctgg gccgcctcgc ggggtgccga
     3961 agatcgctgt gcagggtgca gaggccacac ctggaacccc aggacatgcc aggaaagact
     4021 gaccacctct ggctgcagtt ccttatgcag ctatcatctt caccaagtca cacctagatg
     4081 gggtgcagct atcagcctgg gactcggccg agggtgcccc cttcccagga agggctggga
     4141 tgggggtgcc agtgacttgt aaatagcaag ccctcgcgac taatttatta ctttttataa
     4201 gcaatagcca ggctggcccg cctggtggac tcggctgtct tgtccttggc ccctggagca
     4261 cagcctacag accctgttct ctgggtcaag gcaaagcact ttgggcaact tctgtgtttt
     4321 ctagtttgtc ctttccgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4381 gtgtgtgtgt gtatgtgtat gtccatccca ttcccaaccc aagacccact tgaaggcaca
     4441 caaaagctgg tccctactga gttttgacag aatttggaag ctgcacccta aagcaggcgg
     4501 atcaccaatt ctgtggcagg ctatactctg aagactacct tctgtgtctg aatagctctc
     4561 ctcagactgt ccttactcca ctctgcctgt gatcctgcat gcttcagttt aggggaagta
     4621 tgggaacaaa ggacttgggg gatgaggaat gctctggttt gaggcagaat agcccatata
     4681 ccttgcagga agtaactgac agacctaagg gccatcaagg tggggaaggt gtccactgca
     4741 gggtgggaca aagcacttgt cccaagtgag gaccatgcct gaccaccaac ccctgcacca
     4801 caaagtctat gcccatgtgc acgaggccca gcatggtgag tgccagagga ccgagtgtgg
     4861 accccagcta tgctgtgtaa ttctagagga gtgtctttcc cattctgtgc ctctttacag
     4921 gactaacccc agtgacttgc acacttcatg tgcactgagc acacctgaat tccccccagc
     4981 tttgtgtgat ccaagaagct gaggttccta aggccagagg catgtcccac aatggtccag
     5041 taagagtggc agcccaggac aggctctcct agccctactg tgagcatggc catgggggag
     5101 cccagactcc catgctgtgt gatctagcag ccatgtagta ggttgccagt ggtgcagctc
     5161 tacacactcc acgaggggaa ttcgcaggca ctcaaaccct ctgcacctcc ctgactcgca
     5221 gccagtacct tctgctggaa gggagaccaa ggctgtgcat gagtagccct ctacccatct
     5281 tggagctggc atcaaataaa gtcccatgaa gacatctga
//
