LOCUS       NM_019945               4922 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus microtubule associated serine/threonine kinase 1
            (Mast1), mRNA.
ACCESSION   NM_019945 XM_909877 XM_921477 XM_921486 XM_921493
VERSION     NM_019945.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4922)
  AUTHORS   Ding,W., Lu,Y., Zhou,A., Chen,Y., Wang,Z., Wang,L. and Tian,Y.
  TITLE     Mast1 mediates radiation-induced gastric injury via the P38 MAPK
            pathway
  JOURNAL   Exp Cell Res 409 (2), 112913 (2021)
   PUBMED   34774870
  REMARK    GeneRIF: Mast1 mediates radiation-induced gastric injury via the
            P38 MAPK pathway.
REFERENCE   2  (bases 1 to 4922)
  AUTHORS   Chai,G., Webb,A., Li,C., Antaki,D., Lee,S., Breuss,M.W., Lang,N.,
            Stanley,V., Anzenberg,P., Yang,X., Marshall,T., Gaffney,P.,
            Wierenga,K.J., Chung,B.H., Tsang,M.H., Pais,L.S., Lovgren,A.K.,
            VanNoy,G.E., Rehm,H.L., Mirzaa,G., Leon,E., Diaz,J., Neumann,A.,
            Kalverda,A.P., Manfield,I.W., Parry,D.A., Logan,C.V., Johnson,C.A.,
            Bonthron,D.T., Valleley,E.M.A., Issa,M.Y., Abdel-Ghafar,S.F.,
            Abdel-Hamid,M.S., Jennings,P., Zaki,M.S., Sheridan,E. and
            Gleeson,J.G.
  TITLE     Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause
            Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly
  JOURNAL   Neuron 109 (2), 241-256 (2021)
   PUBMED   33220177
REFERENCE   3  (bases 1 to 4922)
  AUTHORS   Tripathy,R., Leca,I., van Dijk,T., Weiss,J., van Bon,B.W.,
            Sergaki,M.C., Gstrein,T., Breuss,M., Tian,G., Bahi-Buisson,N.,
            Paciorkowski,A.R., Pagnamenta,A.T., Wenninger-Weinzierl,A.,
            Martinez-Reza,M.F., Landler,L., Lise,S., Taylor,J.C., Terrone,G.,
            Vitiello,G., Del Giudice,E., Brunetti-Pierri,N., D'Amico,A.,
            Reymond,A., Voisin,N., Bernstein,J.A., Farrelly,E., Kini,U.,
            Leonard,T.A., Valence,S., Burglen,L., Armstrong,L., Hiatt,S.M.,
            Cooper,G.M., Aldinger,K.A., Dobyns,W.B., Mirzaa,G., Pierson,T.M.,
            Baas,F., Chelly,J., Cowan,N.J. and Keays,D.A.
  TITLE     Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with
            Cerebellar Hypoplasia and Cortical Malformations
  JOURNAL   Neuron 100 (6), 1354-1368 (2018)
   PUBMED   30449657
REFERENCE   4  (bases 1 to 4922)
  AUTHORS   Sasaki,N., Kurisu,J. and Kengaku,M.
  TITLE     Sonic hedgehog signaling regulates actin cytoskeleton via
            Tiam1-Rac1 cascade during spine formation
  JOURNAL   Mol Cell Neurosci 45 (4), 335-344 (2010)
   PUBMED   20654717
REFERENCE   5  (bases 1 to 4922)
  AUTHORS   Valiente,M., Andres-Pons,A., Gomar,B., Torres,J., Gil,A.,
            Tapparel,C., Antonarakis,S.E. and Pulido,R.
  TITLE     Binding of PTEN to specific PDZ domains contributes to PTEN protein
            stability and phosphorylation by microtubule-associated
            serine/threonine kinases
  JOURNAL   J Biol Chem 280 (32), 28936-28943 (2005)
   PUBMED   15951562
REFERENCE   6  (bases 1 to 4922)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 4922)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 4922)
  AUTHORS   Krieser,R.J. and Eastman,A.
  TITLE     Deoxyribonuclease II: structure and chromosomal localization of the
            murine gene, and comparison with the genomic structure of the human
            and three C. elegans homologs
  JOURNAL   Gene 252 (1-2), 155-162 (2000)
   PUBMED   10903447
REFERENCE   9  (bases 1 to 4922)
  AUTHORS   Lumeng,C., Phelps,S., Crawford,G.E., Walden,P.D., Barald,K. and
            Chamberlain,J.S.
  TITLE     Interactions between beta 2-syntrophin and a family of
            microtubule-associated serine/threonine kinases
  JOURNAL   Nat Neurosci 2 (7), 611-617 (1999)
   PUBMED   10404183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC054524.1, AY312167.1 and BU701555.1.
            
            On Feb 10, 2007 this sequence version replaced NM_019945.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054524.1, AF077818.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3529              BC054524.1         1-3529
            3530-3824           AY312167.1         469-763
            3825-4870           BC054524.1         3825-4870
            4871-4922           BU701555.1         565-616
FEATURES             Location/Qualifiers
     source          1..4922
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.32 cM"
     gene            1..4922
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /note="microtubule associated serine/threonine kinase 1"
                     /db_xref="GeneID:56527"
                     /db_xref="MGI:MGI:1861901"
     exon            1..159
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..4789
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /EC_number="2.7.11.1"
                     /note="syntrophin associated serine/threonine kinase;
                     syntrophin-associated serine-threonine protein kinase"
                     /codon_start=1
                     /product="microtubule-associated serine/threonine-protein
                     kinase 1"
                     /protein_id="NP_064329.2"
                     /db_xref="CCDS:CCDS40415.1"
                     /db_xref="GeneID:56527"
                     /db_xref="MGI:MGI:1861901"
                     /translation="MSDSLWTALSNFSMPSFPGGSMFRRTKSCRTSNRKSLILTSTSP
                     TLPRPHSPLPGHLGSSPLDSPRNFSPNTPAHFSFASSRRADGRRWSLASLPSSGYGTN
                     TPSSTVSSSCSSQERLHQLPYQPTVDELHFLSKHFGSTESITDEDGGRRSPAVRPRSR
                     SLSPGRSPSSYDNEIVMMNHVYKERFPKATAQMEEKLRDFARAYEPDSVLPLADGVLS
                     FIHHQIIELARDCLTKSRDGLITTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVK
                     KLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKTDIPRYIIRQLGLTRDP
                     FPDVVRLEEQDSGGSNTPEQDDTSEGRSSTSKAKKPPGESDFDTIKLISNGAYGAVYL
                     VRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLC
                     MVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLIT
                     SMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGY
                     GKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTDAQLLIS
                     SLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDTSYFDTRSD
                     RYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQLSQHEPKTPVSASGASKR
                     DPSAKGPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASEASFLEGEASPPLGARR
                     RFSALLEPSRFTAPQEDEDEARLRRPPRPSSDPPSSLDTRVPKEAVQGEGTSTPGEPE
                     ATERSHPGDLGPPSKDGDPSGPRATNDLVLRRARHQQLSGDLAVEKRPSRTGGKVIKS
                     ASATALSVMIPAVDPHGGSPLASPMSPRSLSSNPSSRDSSPSRDYSPAVSGLRSPITI
                     QRSGKKYGFTLRAIRVYMGDSDVYSVHHIVWHVEEGGPAQEAGLCAGDLITHVNGEPV
                     HGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRPSAKDGQ
                     ESKKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPARSPTHSYRST
                     PDSAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQYRSARCKSAGNI
                     PLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPL
                     LKRVQSAEKLGASLGADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGETPPIE
                     GPGATRQVAVRRLGRQESPLSLGADPLLPDGVQRPMASSKEDSAGGTEACTPPRATTP
                     GSRTLERDSGCTRHQSVQTEDGPGGVARALAKAALSPVQEHETGRRSSSGEAGTPPVP
                     IVVEPARPGVKTQAPQPLGTDSKGLKEPVAQMPLMPDAPRGRERWVLEEVEERTTLSG
                     LRSKPASPKLSPDPQTPTLVPTKNVPRSAAPSVPPASLMVPGTKPEAGLNSRCPAEAV
                     TPAGLTKTGAPSPASLGP"
     exon            160..248
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            249..324
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            325..403
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            404..564
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            565..640
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            641..850
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            851..952
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1085
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1153
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1239
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1448
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1587
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1720
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1886
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1988
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2111
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2221
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2400
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2648
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2855
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..3085
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3208
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3345
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3533
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     exon            3534..4922
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4848..4853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /note="hexamer: AATAAA"
     polyA_site      4872
                     /gene="Mast1"
                     /gene_synonym="9430008B02Rik; SAST; SAST170"
                     /note="major polyA site"
ORIGIN      
        1 gctccccgcg ctgccgctgc cgctgcctct gctgctgctg ccgccgcacc tgccaccatg
       61 tcgccgccgc cgggtcatgt ctgactctct ctggaccgcg ctttccaatt tctcgatgcc
      121 ctccttcccc ggcggcagca tgtttcgccg caccaagagt tgccgtacca gcaaccggaa
      181 aagcctcatc ctgacaagca cttctccgac tctaccgcga ccccactccc cgctgccggg
      241 ccacttaggt agcagtcctt tggacagccc ccgcaacttc tctcccaaca ctcccgccca
      301 cttctcgttt gcttcttccc gaagggcgga tggacgccga tggtcgcttg cttcgctccc
      361 ttcctctggc tatggcacca acacgcccag ctcaactgtt tcatcctcct gctcctccca
      421 ggagcgcctg catcaactac cgtaccagcc caccgtggac gagctgcact ttctgtccaa
      481 acacttcggc agcaccgaga gcatcaccga cgaggatggt ggccgccgct ctcccgccgt
      541 gcgtcctcgc tctcgcagcc tcagccccgg ccgctccccc tcctcctacg acaacgaaat
      601 tgtgatgatg aaccatgtgt acaaggagcg gttcccaaag gccactgcac agatggaaga
      661 gaagctgcgg gacttcgccc gcgcctatga acctgacagc gtgctgccgc tggccgacgg
      721 cgtgctcagc ttcatccacc atcagatcat tgaactggcc cgagactgcc ttaccaagtc
      781 ccgcgatggg ctcatcacca cggtctattt ctatgaactg caggaaaacc tagagaagct
      841 gctgcaggac gcttatgaac gctcggagag cttggaggta gcctttgtca ctcagctggt
      901 gaagaaactt ctcataatca tctctcgccc tgcaaggctt ctggagtgcc tggaattcaa
      961 cccagaagag ttctaccacc ttctggaggc agccgaggga catgccaagg agggccacct
     1021 ggtcaaaact gacatccccc gatacatcat ccgacagctg ggcctcactc gggacccctt
     1081 tccagatgtg gtgcgcctgg aggagcagga cagcgggggc tccaacactc cggagcaaga
     1141 cgacacatct gagggtcgca gcagcacctc caaggccaag aaacctcccg gtgaaagtga
     1201 ctttgacact atcaagctca ttagcaatgg tgcctacgga gccgtctacc tggtgcggca
     1261 ccgggacacg aggcagcgct tcgccatgaa gaagatcaac aaacagaacc tgatcctgcg
     1321 caaccagatc cagcaggcgt ttgtggagcg cgacatcctc acgtttgcag agaacccatt
     1381 tgtggtcggc atgttctgct cctttgagac ccggcgccac ctttgcatgg tcatggagta
     1441 tgtggaaggt ggtgactgtg ccactctcct caagaacatt ggggcactgc ctgtggagat
     1501 ggcgcgaatg tattttgcag aaacagttct agcccttgag tacttacaca attatggcat
     1561 cgtgcaccgt gacctcaagc cagacaacct cctcattact tccatgggcc acatcaagct
     1621 cacggatttt ggcctctcca agatgggact catgagcctg accaccaact tatatgaggg
     1681 gcacattgag aaggatgccc gggagttcct ggacaaacag gtgtgtggga ccccagagta
     1741 catcgcaccc gaggtcatcc tgcgccaggg ctacggcaag ccagtggact ggtgggctat
     1801 ggggatcatt ctctacgagt tcctggtggg ctgtgtgcct ttcttcgggg ataccccaga
     1861 agagctcttt ggacaggtca tcagcgatga catactgtgg cctgaagggg acgaggccct
     1921 gcccacagat gcacagcttc taatatctag cctcttgcag accaaccccc tggtccggct
     1981 tggggcaggt ggtgcttttg aggtgaagca gcatagtttc ttccgagacc tggactggac
     2041 agggctactg cggcagaagg cggagttcat cccccaccta gagtcagaag atgacaccag
     2101 ctactttgac acccgctccg acaggtatca ccatgtgaac tcctatgatg aggacgacac
     2161 caccgaagag gagcccgtgg agatccgcca attctcctcc tgctcgccgc gcttcagcaa
     2221 ggtgtacagc agtatggagc agctgtctca gcacgagcct aagacccccg tctcagcatc
     2281 tggggccagc aagcgggacc caagcgctaa gggcccggag gagaaagtgg ccggcaagag
     2341 ggagggactg ggtggcctga ctctgcgtga gaagacctgg agagggggct ctccagagat
     2401 taagcgcttc tcagcgtctg aagccagttt tctggaagga gaggccagtc ccccgctggg
     2461 agcgcgcaga cgtttctcag cactgctgga gcccagccgc ttcactgccc ctcaagagga
     2521 tgaagatgag gctcgactcc gcagacctcc tcgacccagc tccgatcccc ctagctcact
     2581 ggacacacgc gtccccaaag aggcagttca aggagagggc acgtccaccc ccggggaacc
     2641 cgaggccact gagcgctcac atccaggtga cctcggccca ccctccaagg atggagaccc
     2701 atcaggccct agggccacca acgacctggt tttgcgaagg gcaaggcacc agcagctgtc
     2761 tggggatctt gctgtggaga agcgaccgtc tcgaactggg ggcaaagtta tcaagtcggc
     2821 ttcagctaca gccttgtcag tcatgattcc tgcagtggac ccacatggag gctcacccct
     2881 ggctagtccc atgtcccctc gatctctctc ctccaatcca tcctcacggg actcttcgcc
     2941 tagccgagac tactcaccag ctgtcagtgg actccgttcc cccatcacca tccaacgctc
     3001 aggcaagaaa tatgggttca cactgcgagc catccgtgtc tacatgggcg actccgatgt
     3061 ctacagtgtc caccacattg tttggcacgt ggaggaagga ggcccagccc aagaggcagg
     3121 gctctgtgct ggggacctca tcactcacgt gaatggtgag cccgtgcatg gtatggtgca
     3181 tcctgaggtg gtagagctga tcctgaagag tggcaacaaa gtagctgtga ccaccacacc
     3241 ctttgaaaac acttccatcc ggattgggcc tgccaggcgc agcagttaca aagccaaaat
     3301 ggcccgaagg aacaaaaggc cttcggccaa agacggccag gagagcaaga agcggagctc
     3361 tctctttcgg aagatcacaa agcagtcgaa cctgctgcac accagtcgat cgctgtcctc
     3421 tttgaaccgg tccttgtcgt ccagcgacag tcttccgggc tcgcccacgc acggactacc
     3481 cgcacgctcg cccacacata gctatcgctc tacacctgac tccgcctacc taggcgcctc
     3541 gtcacagagt agctcgccag cttccagcac gcctaattcc cccgcctcat ccgcctcgca
     3601 ccacatcagg cccagcacct tgcacgggct gtcaccgaaa ctacaccgcc agtaccgctc
     3661 agcgcgctgt aaatcggctg gcaacatccc gctgtcacct ctagcgcaca caccatcccc
     3721 gacgcaggcg tcgccgccgc cgctgccagg ccacacggtg ggcagctcac ataccacgca
     3781 gagcttccct gccaaactac actcatcgcc acctgtcgtg cgcccgcgcc ccaaaagtgc
     3841 agagccacca cgctcgccgt tgctcaagcg cgtgcagtca gcggagaaac taggggcttc
     3901 gctgggagca gacaagaagg gcgcactgcg caaacacagc ctggaagtgg gacaccctga
     3961 tttccgaaag gacttccatg gtgagctggc cctgcatagc ctcgctgagt ctgatggtga
     4021 gacgcctcct attgagggtc ctggggcgac ccggcaggtc gccgtgcgac gcctgggtcg
     4081 ccaggaatca cccctaagct tgggcgcgga cccgttgcta cccgatggtg tccagagacc
     4141 tatggcgtca agcaaggagg attccgcggg aggtacagag gcttgcaccc cacctcgcgc
     4201 gacaacccct gggagccgga ccctggagcg tgactcgggt tgcacaaggc accagagcgt
     4261 gcagactgag gatggcccag gtggggtggc cagggccctg gccaaggcag cgctaagtcc
     4321 agtgcaggaa catgagacag gccggcgcag tagctctggt gaggcaggca cacccccggt
     4381 gcccattgtt gtagagcctg ctcggccagg ggtcaagacc caggcacccc agcctctggg
     4441 cacagactcc aagggattga aggaacctgt agcccagatg cctctgatgc ctgatgcccc
     4501 aaggggcagg gagcgctggg tgctagagga ggtggaagag cggaccacgc taagcggact
     4561 tcgctctaag cccgcctccc ccaaactctc tcctgacccc cagactccaa ccctagtccc
     4621 aacaaagaat gtaccccgca gtgcagctcc ttcagtccca cctgcttccc tcatggtccc
     4681 aggcaccaag cctgaagcag ggttgaactc ccggtgtcct gctgaagctg tgactcctgc
     4741 aggcctcacc aaaactgggg cacctagccc tgcatctcta ggtccatagc ggagcaggct
     4801 ttcggtgctg tgctgtacag atgcctgtat acatatgtac acatataaat aaagtgccca
     4861 tgctgcctga gattcttggg gttcacacct cctctctgga caggaatggc ccttggcttc
     4921 tc
//
