LOCUS       NM_001003893            3061 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus MBL associated serine protease 2 (Masp2), transcript
            variant 1, mRNA.
ACCESSION   NM_001003893 XM_358353
VERSION     NM_001003893.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3061)
  AUTHORS   Bibert,S., Piret,J., Quinodoz,M., Collinet,E., Zoete,V.,
            Michielin,O., Menasria,R., Meylan,P., Bihl,T., Erard,V.,
            Fellmann,F., Rivolta,C., Boivin,G. and Bochud,P.Y.
  TITLE     Herpes simplex encephalitis in adult patients with MASP-2
            deficiency
  JOURNAL   PLoS Pathog 15 (12), e1008168 (2019)
   PUBMED   31869396
  REMARK    GeneRIF: that MASP-2 deficiency can increase susceptibility to
            adult Herpes simplex virus encephalitis
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3061)
  AUTHORS   Alghadban,S., Kenawy,H.I., Dudler,T., Schwaeble,W.J. and
            Brunskill,N.J.
  TITLE     Absence of the Lectin Activation Pathway of Complement Ameliorates
            Proteinuria-Induced Renal Injury
  JOURNAL   Front Immunol 10, 2238 (2019)
   PUBMED   31608060
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3061)
  AUTHORS   Hayashi,M., Machida,T., Ishida,Y., Ogata,Y., Omori,T., Takasumi,M.,
            Endo,Y., Suzuki,T., Sekimata,M., Homma,Y., Ikawa,M., Ohira,H.,
            Fujita,T. and Sekine,H.
  TITLE     Cutting Edge: Role of MASP-3 in the Physiological Activation of
            Factor D of the Alternative Complement Pathway
  JOURNAL   J Immunol 203 (6), 1411-1416 (2019)
   PUBMED   31399515
REFERENCE   4  (bases 1 to 3061)
  AUTHORS   Banda,N.K., Acharya,S., Scheinman,R.I., Mehta,G., Takahashi,M.,
            Endo,Y., Zhou,W., Farrar,C.A., Sacks,S.H., Fujita,T., Sekine,H. and
            Holers,V.M.
  TITLE     Deconstructing the Lectin Pathway in the Pathogenesis of
            Experimental Inflammatory Arthritis: Essential Role of the Lectin
            Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2
  JOURNAL   J Immunol 199 (5), 1835-1845 (2017)
   PUBMED   28739878
  REMARK    GeneRIF: this study shows that MASP-2 contributes to the
            development of collagen Ab-induced arthritis
REFERENCE   5  (bases 1 to 3061)
  AUTHORS   Gorelik,A., Sapir,T., Haffner-Krausz,R., Olender,T., Woodruff,T.M.
            and Reiner,O.
  TITLE     Developmental activities of the complement pathway in migrating
            neurons
  JOURNAL   Nat Commun 8, 15096 (2017)
   PUBMED   28462915
  REMARK    GeneRIF: It has been shown that key proteins in the lectin arm of
            this pathway, MASP1, MASP2 and C3, are expressed in the developing
            cortex and that neuronal migration is impaired in knockout and
            knockdown mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3061)
  AUTHORS   Iwaki,D. and Fujita,T.
  TITLE     Production and purification of recombinants of mouse MASP-2 and
            sMAP
  JOURNAL   J Endotoxin Res 11 (1), 47-50 (2005)
   PUBMED   15826378
  REMARK    GeneRIF: Recombinant protein of masp2 was made and purified.
REFERENCE   7  (bases 1 to 3061)
  AUTHORS   Stover,C.M., Lynch,N.J., Hanson,S.J., Windbichler,M., Gregory,S.G.
            and Schwaeble,W.J.
  TITLE     Organization of the MASP2 locus and its expression profile in mouse
            and rat
  JOURNAL   Mamm Genome 15 (11), 887-900 (2004)
   PUBMED   15672593
  REMARK    GeneRIF: Highly conserved intron sequences. Restricted expression
            contrasts with the ubiquitous expression of neighboring genes.
REFERENCE   8  (bases 1 to 3061)
  AUTHORS   Lawson,P.R. and Reid,K.B.
  TITLE     A novel PCR-based technique using expressed sequence tags and gene
            homology for murine genetic mapping: localization of the complement
            genes
  JOURNAL   Int Immunol 12 (3), 231-240 (2000)
   PUBMED   10700458
REFERENCE   9  (bases 1 to 3061)
  AUTHORS   Stover,C.M., Thiel,S., Lynch,N.J. and Schwaeble,W.J.
  TITLE     The rat and mouse homologues of MASP-2 and MAp19, components of the
            lectin activation pathway of complement
  JOURNAL   J Immunol 163 (12), 6848-6859 (1999)
   PUBMED   10586086
REFERENCE   10 (bases 1 to 3061)
  AUTHORS   Endo,Y., Takahashi,M., Nakao,M., Saiga,H., Sekine,H.,
            Matsushita,M., Nonaka,M. and Fujita,T.
  TITLE     Two lineages of mannose-binding lectin-associated serine protease
            (MASP) in vertebrates
  JOURNAL   J Immunol 161 (9), 4924-4930 (1998)
   PUBMED   9794427
  REMARK    Erratum:[J Immunol 2000 May 15;164(10):5330]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI529228.1, AK050052.1 and AL606969.26.
            
            [WARNING] On May 2, 2024 this sequence was replaced by
            NM_001003893.3.
            
            On Apr 1, 2006 this sequence version replaced NM_001003893.1.
            
            Transcript Variant: This variant (1) is the longer transcript and
            it encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013893.1, AK050052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AI529228.1         2-25
            25-2774             AK050052.1         2-2751
            2775-3061           AL606969.26        35178-35464
FEATURES             Location/Qualifiers
     source          1..3061
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.76 cM"
     gene            1..3061
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /note="MBL associated serine protease 2"
                     /db_xref="GeneID:17175"
                     /db_xref="MGI:MGI:1330832"
     exon            1..47
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2100
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /EC_number="3.4.21.104"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; mannose-binding protein-associated serine
                     protease 2; mannan-binding lectin serine protease 2;
                     mannan-binding lectin serine peptidase 2"
                     /codon_start=1
                     /product="mannan-binding lectin serine protease 2 isoform
                     1 precursor"
                     /protein_id="NP_001003893.1"
                     /db_xref="CCDS:CCDS18941.1"
                     /db_xref="GeneID:17175"
                     /db_xref="MGI:MGI:1330832"
                     /translation="MRLLIFLGLLWSLVATLLGSKWPEPVFGRLVSPGFPEKYADHQD
                     RSWTLTAPPGYRLRLYFTHFDLELSYRCEYDFVKLSSGTKVLATLCGQESTDTEQAPG
                     NDTFYSLGPSLKVTFHSDYSNEKPFTGFEAFYAAEDVDECRVSLGDSVPCDHYCHNYL
                     GGYYCSCRAGYVLHQNKHTCSALCSGQVFTGRSGYLSSPEYPQPYPKLSSCTYSIRLE
                     DGFSVILDFVESFDVETHPEAQCPYDSLKIQTDKGEHGPFCGKTLPPRIETDSHKVTI
                     TFATDESGNHTGWKIHYTSTARPCPDPTAPPNGSISPVQAIYVLKDRFSVFCKTGFEL
                     LQGSVPLKSFTAVCQKDGSWDRPMPECSIIDCGPPDDLPNGHVDYITGPEVTTYKAVI
                     QYSCEETFYTMSSNGKYVCEADGFWTSSKGEKLPPVCEPVCGLSTHTIGGRIVGGQPA
                     KPGDFPWQVLLLGQTTAAAGALIHDNWVLTAAHAVYEKRMAASSLNIRMGILKRLSPH
                     YTQAWPEEIFIHEGYTHGAGFDNDIALIKLKNKVTINGSIMPVCLPRKEAASLMRTDF
                     TGTVAGWGLTQKGLLARNLMFVDIPIADHQKCTAVYEKLYPGVRVSANMLCAGLETGG
                     KDSCRGDSGGALVFLDNETQRWFVGGIVSWGSINCGAADQYGVYTKVINYIPWIENII
                     SNF"
     exon            48..276
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..454
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            455..586
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            587..783
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            784..931
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1050
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1129
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1261
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1336
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..3061
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2756..2761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /note="putative"
     polyA_site      2774
                     /gene="Masp2"
                     /gene_synonym="MAp19; MASP-2"
                     /note="putative"
ORIGIN      
        1 aaaggtgata ggcgctggac ctgcagagct aggtggcaca ccatgaggct actcatcttc
       61 ctgggtctgc tgtggagttt ggtggccaca cttctgggtt caaagtggcc tgaacctgta
      121 ttcgggcgcc tggtgtcccc tggcttccca gagaagtatg ctgaccatca agatcgatcc
      181 tggacactga ctgcaccccc tggctaccgc ctgcgcctct acttcaccca ctttgacctg
      241 gaactctctt accgctgcga gtatgacttt gtcaagttga gctcagggac caaggtgctg
      301 gccacactgt gtgggcagga gagtacagac actgagcagg cacctggcaa tgacaccttc
      361 tactcactgg gtcccagcct aaaggtcacc ttccactccg actactccaa tgagaagccg
      421 ttcacagggt ttgaggcctt ctatgcagcg gaggatgtgg atgaatgcag agtgtctctg
      481 ggagactcag tcccttgtga ccattattgc cacaactact tgggcggcta ctattgctcc
      541 tgcagagcgg gctacgttct ccaccagaac aagcacacgt gctcagccct ttgttcaggc
      601 caggtgttca caggaagatc tgggtatctc agtagccctg agtacccaca gccatacccc
      661 aagctctcca gctgcaccta cagcatccgc ctggaggacg gcttcagtgt catcctggac
      721 ttcgtggagt ccttcgatgt ggagacgcac cctgaagccc agtgccccta tgactccctc
      781 aagattcaaa cagacaaggg ggaacacggc ccattttgtg ggaagacgct gcctcccagg
      841 attgaaactg acagccacaa ggtgaccatc acctttgcca ctgacgagtc ggggaaccac
      901 acaggctgga agatacacta cacaagcaca gcacggccct gccctgatcc aacggcgcca
      961 cctaatggca gcatttcacc tgtgcaagcc atatatgtcc tgaaggacag gttttctgtc
     1021 ttctgcaaga caggcttcga gcttctgcaa ggttctgtcc ccctgaaatc attcactgct
     1081 gtctgtcaga aagatggatc ttgggaccgg ccgatgccag agtgcagcat tattgattgt
     1141 ggccctcctg atgacctacc caatggccat gtggactata tcacaggccc tgaagtgact
     1201 acctacaaag ctgtgattca gtacagctgt gaagagactt tctacacaat gagcagcaat
     1261 ggtaaatatg tgtgtgaggc tgatggattc tggacgagct ccaaaggaga aaaactcccc
     1321 ccggtttgtg agcctgtttg tgggctgtcc acacacacta taggaggacg catagttgga
     1381 gggcagcctg caaagcctgg tgactttcct tggcaagtct tgttgctggg tcaaactaca
     1441 gcagcagcag gtgcacttat acatgacaat tgggtcctaa cagccgctca tgctgtatat
     1501 gagaaaagaa tggcagcgtc ctccctgaac atccgaatgg gcatcctcaa aaggctctca
     1561 cctcattaca ctcaagcctg gcccgaggaa atctttatac atgaaggcta cactcacggt
     1621 gctggttttg acaatgatat agcattgatt aaactcaaga acaaagtcac aatcaacgga
     1681 agcatcatgc ctgtttgcct accgcgaaaa gaagctgcat ccttaatgag aacagacttc
     1741 actggaactg tggctggctg ggggttaacc cagaaggggc ttcttgctag aaacctaatg
     1801 tttgtggaca taccaattgc tgaccaccaa aaatgtaccg ccgtgtatga aaagctctat
     1861 ccaggagtaa gagtaagcgc taacatgctc tgtgctggct tagagactgg tggcaaggac
     1921 agctgcagag gtgacagtgg gggggcatta gtgtttctag ataatgagac acagcgatgg
     1981 tttgtgggag gaatagtttc ctggggttcc attaattgtg gggcggcaga ccagtatggg
     2041 gtctacacaa aagtcatcaa ctatattccc tggattgaga acataataag taatttctaa
     2101 tttgcatcgt ccaatcattg ttcctcatat cgccaagtac ctgggaagct tagtaacaaa
     2161 cctaagaatg acagcctacc ccaaaatcag agcaggtgag attgttacag gtccaaacac
     2221 ttgccaatat cagctttgat ttgtgtttaa cagtgcttgg ccaaccccca acacagaaaa
     2281 aacaagttgt atttgattcc ctacaatcta cttattttat actggctgtt tccatttctg
     2341 gccaacaaag ggcttgttgt gtctagtgtg tagatttggt cttaatgagc tcagaaagtg
     2401 ctcttacttt ctgagtaact tctgagtggt tccagaatac cttttggaag gtaagcggaa
     2461 agcaggtgtg tgaccttcac attagatcag ctattaaatt aacaccaagt ccattccaga
     2521 atattgggat ataggcatgt tctaccagat tcaccaaatt gtcagataaa aagaacacga
     2581 aacagcattt taccctttac aagggcaatt tagcaaatca ttccaaaaac cttaacaggt
     2641 gtttcactat acccagccca cttttcttag gtgagcgttg ggctcaggga agtcaaccgt
     2701 aactgtacaa ggtacagtca tttgcttatg tatcaaaaac agtaagttat cctgaaataa
     2761 actgctcttc tgctaagatg ctgaccttaa aggtcatgtt tgattttaac tggctcttcc
     2821 aacaaggcaa gacagggtgc ctcaagatgg ggaaatagct ggcctacaac tcatttacac
     2881 caattctggg attaaaagca tgggccacca cacccacctg gagactcaaa ttttaaagga
     2941 tgaaaatgct atattgcatc ttcccacata agtcacctta acttttctag cattgtcatg
     3001 atatagaatt tttttttctt ccagtaagac tccagacact aaactgttgg tggcaagaaa
     3061 a
//
