LOCUS       NM_001359083            3953 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus MBL associated serine protease 1 (Masp1), transcript
            variant 1, mRNA.
ACCESSION   NM_001359083 XM_006521828
VERSION     NM_001359083.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3953)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3953)
  AUTHORS   Gullipalli,D., Miwa,T., Golla,M., Sato,S., Angampalli,S. and
            Song,W.C.
  TITLE     MASP3 Deficiency in Mice Reduces but Does Not Abrogate Alternative
            Pathway Complement Activity Due to Intrinsic Profactor D Activity
  JOURNAL   J Immunol 210 (10), 1543-1551 (2023)
   PUBMED   36988282
  REMARK    GeneRIF: MASP3 Deficiency in Mice Reduces but Does Not Abrogate
            Alternative Pathway Complement Activity Due to Intrinsic Profactor
            D Activity.
REFERENCE   3  (bases 1 to 3953)
  AUTHORS   Kusakari,K., Machida,T., Ishida,Y., Omori,T., Suzuki,T.,
            Sekimata,M., Wada,I., Fujita,T. and Sekine,H.
  TITLE     The complex formation of MASP-3 with pattern recognition molecules
            of the lectin complement pathway retains MASP-3 in the circulation
  JOURNAL   Front Immunol 13, 907023 (2022)
   PUBMED   36052069
  REMARK    GeneRIF: The complex formation of MASP-3 with pattern recognition
            molecules of the lectin complement pathway retains MASP-3 in the
            circulation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3953)
  AUTHORS   Whiley,P.A.F., O'Donnell,L., Moody,S.C., Handelsman,D.J.,
            Young,J.C., Richards,E.A., Almstrup,K., Western,P.S. and
            Loveland,K.L.
  TITLE     Activin A Determines Steroid Levels and Composition in the Fetal
            Testis
  JOURNAL   Endocrinology 161 (7) (2020)
   PUBMED   32274496
REFERENCE   5  (bases 1 to 3953)
  AUTHORS   Hayashi,M., Machida,T., Ishida,Y., Ogata,Y., Omori,T., Takasumi,M.,
            Endo,Y., Suzuki,T., Sekimata,M., Homma,Y., Ikawa,M., Ohira,H.,
            Fujita,T. and Sekine,H.
  TITLE     Cutting Edge: Role of MASP-3 in the Physiological Activation of
            Factor D of the Alternative Complement Pathway
  JOURNAL   J Immunol 203 (6), 1411-1416 (2019)
   PUBMED   31399515
  REMARK    GeneRIF: MASP-3 orchestrates the overall complement reaction
            through the activation of FD.
REFERENCE   6  (bases 1 to 3953)
  AUTHORS   Lawson,P.R. and Reid,K.B.
  TITLE     A novel PCR-based technique using expressed sequence tags and gene
            homology for murine genetic mapping: localization of the complement
            genes
  JOURNAL   Int Immunol 12 (3), 231-240 (2000)
   PUBMED   10700458
REFERENCE   7  (bases 1 to 3953)
  AUTHORS   Endo,Y., Takahashi,M., Nakao,M., Saiga,H., Sekine,H.,
            Matsushita,M., Nonaka,M. and Fujita,T.
  TITLE     Two lineages of mannose-binding lectin-associated serine protease
            (MASP) in vertebrates
  JOURNAL   J Immunol 161 (9), 4924-4930 (1998)
   PUBMED   9794427
  REMARK    Erratum:[J Immunol 2000 May 15;164(10):5330]
REFERENCE   8  (bases 1 to 3953)
  AUTHORS   Takada,F., Seki,N., Matsuda,Y., Takayama,Y. and Kawakami,M.
  TITLE     Localization of the genes for the 100-kDa complement-activating
            components of Ra-reactive factor (CRARF and Crarf) to human
            3q27-q28 and mouse 16B2-B3
  JOURNAL   Genomics 25 (3), 757-759 (1995)
   PUBMED   7759119
REFERENCE   9  (bases 1 to 3953)
  AUTHORS   Takayama,Y., Takada,F., Takahashi,A. and Kawakami,M.
  TITLE     A 100-kDa protein in the C4-activating component of Ra-reactive
            factor is a new serine protease having module organization similar
            to C1r and C1s
  JOURNAL   J Immunol 152 (5), 2308-2316 (1994)
   PUBMED   8133044
REFERENCE   10 (bases 1 to 3953)
  AUTHORS   Takahashi,A., Takayama,Y., Hatsuse,H. and Kawakami,M.
  TITLE     Presence of a serine protease in the complement-activating
            component of the complement-dependent bactericidal factor, RaRF, in
            mouse serum
  JOURNAL   Biochem Biophys Res Commun 190 (3), 681-687 (1993)
   PUBMED   8439319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154571.3 and AC163612.3.
            
            On Dec 20, 2017 this sequence version replaced XM_006521828.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB049755.1, AK031598.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AC154571.3         114336-114605       c
            271-517             AC154571.3         107622-107868       c
            518-695             AC154571.3         89870-90047         c
            696-827             AC154571.3         88412-88543         c
            828-1024            AC154571.3         85712-85908         c
            1025-1172           AC154571.3         79392-79539         c
            1173-1291           AC154571.3         78141-78259         c
            1292-1370           AC154571.3         77185-77263         c
            1371-1508           AC163612.3         201636-201773       c
            1509-1583           AC163612.3         200243-200317       c
            1584-3953           AC163612.3         193730-196099       c
FEATURES             Location/Qualifiers
     source          1..3953
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 14.23 cM"
     gene            1..3953
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /note="MBL associated serine protease 1"
                     /db_xref="GeneID:17174"
                     /db_xref="MGI:MGI:88492"
     exon            1..270
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..2467
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /EC_number="3.4.21.-"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; mannan-binding lectin serine peptidase 1; raRF;
                     MASP-1; serine protease 5; complement factor MASP-3;
                     ra-reactive factor serine protease p100; mannose-binding
                     protein-associated serine protease; mannose-binding
                     lectin-associated serine protease 1; complement-activating
                     component of Ra-reactive factor; mannan-binding lectin
                     serine protease 1"
                     /codon_start=1
                     /product="mannan-binding lectin serine protease 1 isoform
                     1 precursor"
                     /protein_id="NP_001346012.1"
                     /db_xref="CCDS:CCDS88904.1"
                     /db_xref="GeneID:17174"
                     /db_xref="MGI:MGI:88492"
                     /translation="MRFLSFWRLLLYHALCLALPEVSAHTVELNEMFGQIQSPGYPDS
                     YPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTD
                     TEQTPGQEVVLSPGTFMSVTFRSDFSNEERFTGFDAHYMAVDVDECKEREDEELSCDH
                     YCHNYIGGYYCSCRFGYILHTDNRTCRVECSGNLFTQRTGTITSPDYPNPYPKSSECS
                     YTIDLEEGFMVSLQFEDIFDIEDHPEVPCPYDYIKIKAGSKVWGPFCGEKSPEPISTQ
                     THSVQILFRSDNSGENRGWRLSYRAAGNECPKLQPPVYGKIEPSQAVYSFKDQVLVSC
                     DTGYKVLKDNEVMDTFQIECLKDGAWSNKIPTCKIVDCGAPAGLKHGLVTFSTRNNLT
                     TYKSEIRYSCQQPYYKMLHNTTGVYTCSAHGTWTNEVLKRSLPTCLPVCGQPSRALPN
                     LVKRIIGGRNAELGLFPWQALIVVEDTSRVPNDKWFGSGALLSESWILTAAHVLRSQR
                     RDNTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARVILHPDFNIQNYNHDIALVQLQK
                     PVPLGAHVMPICLPRPEPEGPAPHMLGLVAGWGISNPNVTVDEIILSGTRTLSDVLQY
                     VKLPVVSHAECKASYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDEMSQH
                     WVAQGLVSWGGPEECGSKQVYGVYTKVSNYVDWLWEEMNSPRAVRDLQVER"
     exon            271..517
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /inference="alignment:Splign:2.1.0"
     exon            518..695
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /inference="alignment:Splign:2.1.0"
     exon            696..827
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1024
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1172
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1291
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1370
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1508
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1583
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..3953
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3930..3935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /note="hexamer: AATAAA"
     polyA_site      3953
                     /gene="Masp1"
                     /gene_synonym="CCPII; Crarf; Masp1/3"
                     /note="major polyA site"
ORIGIN      
        1 aggaaacagt ctgtcaggtc cctccgagtg tacataagct cagacagaga gaggagagag
       61 ggaaagccag agggagaggg ggagagggga tctgttgcag gcaggagaag gcgtgacctg
      121 aatggagaat gccagccaat tccagagaca cacagggacc tcagaacaaa gataaggcat
      181 cgctgacacc acaccgggga ctgggacgag ctcacagaca agtctggcag aaggaaccaa
      241 agccaggagc tcacagagca ggaaaatgag gttcctgtct ttctggcggc tcctcctcta
      301 ccacgctctg tgcctcgccc tgccggaggt ttcagcccat accgtggagc taaacgaaat
      361 gtttggtcag atccagtcac ctggctatcc agattcctat ccaagtgact ctgaggtgac
      421 atggaatatt actgtcccgg aggggtttcg aatcaagctt tacttcatgc acttcaactt
      481 ggaatcctcc tatctttgtg aatacgacta tgtgaaggta gaaacagaag accaggtgct
      541 ggcaaccttt tgtggcaggg agaccaccga tactgagcag acccccggcc aggaagtggt
      601 tctttcgcct ggcaccttca tgtctgtcac tttccggtca gatttctcca atgaggaacg
      661 attcacaggc ttcgacgccc actacatggc tgtagatgtg gatgagtgca aggagaggga
      721 agatgaagag ctgtcctgtg accactactg tcacaactac atcggtggct actactgctc
      781 ctgccgcttt ggctacatcc tccacacaga caacaggacc tgccgagtgg aatgcagcgg
      841 caatctcttt acccagagga caggcacaat caccagcccc gattacccca acccttatcc
      901 caagagctca gaatgttcct ataccattga cctggaggaa ggcttcatgg tcagcctgca
      961 gtttgaggac atttttgaca ttgaagacca tcctgaggtg ccctgtccct atgactacat
     1021 taagattaaa gctggttcaa aagtatgggg tcccttctgt ggagagaaat ccccagaacc
     1081 aatcagcacc cagactcaca gtgtccagat cctattccgc agcgacaact caggagagaa
     1141 ccgaggctgg aggctctcct acagagcggc aggaaatgag tgcccaaagc tacagcctcc
     1201 tgtgtacggg aaaatcgagc cctcgcaggc cgtgtattcc ttcaaagacc aagtgctcgt
     1261 cagctgtgac acaggctaca aagtgctaaa ggataacgag gtgatggaca cattccaaat
     1321 tgagtgtctg aaggacggtg catggagtaa caagatcccc acctgtaaaa ttgtagactg
     1381 tggagctcct gcagggctga aacatgggct agtaaccttc tccaccagaa acaacctcac
     1441 cacatacaaa tctgagataa ggtactcctg ccaacagccc tattacaaga tgcttcacaa
     1501 taccacaggt gtatatacgt gttctgctca tgggacctgg acgaacgaag tgctcaagag
     1561 aagcctgccc acctgccttc cagtgtgtgg acagccctcc cgcgccctgc caaacctggt
     1621 gaagagaatc atcggaggtc gcaatgctga gcttggcctc ttcccatggc aggccctcat
     1681 agtggtggaa gacacatcga gggtaccaaa cgacaagtgg ttcgggagtg gggccctgct
     1741 ctctgagtcc tggatactca cagcagccca tgttctgcgt tcccagcgca gagacaacac
     1801 agtcatacct gtctcgaagg aacatgtcac cgtctatctg ggccttcatg atgttcggga
     1861 caaatcagga gctgtcaata gctctgctgc ccgagtgata ctccatccag actttaacat
     1921 ccagaactac aaccatgaca tcgctctggt acagctacag aagcctgtgc ccttgggggc
     1981 ccatgtcatg cccatctgtc taccaagacc tgagcctgaa ggtccagccc ctcacatgtt
     2041 gggactggtg gctggctggg gcatctccaa tcctaatgtg acagtggacg agatcatcct
     2101 cagtggcaca cgaaccttat cagatgtcct acagtatgtc aaattacccg tggtgtcaca
     2161 tgctgaatgc aaagccagct atgagtctcg gtcgggcaac tacagtgtca cagagaacat
     2221 gttctgtgct ggctactatg agggtggcaa ggatacgtgt cttggggata gcggtggggc
     2281 cttcgtcatc tttgatgaga tgagccagca ctgggtagcc caaggcctgg tgtcctgggg
     2341 aggacctgaa gaatgtggta gcaagcaagt gtatggagtc tacacaaagg tctccaacta
     2401 tgtggactgg ctatgggagg agatgaactc cccgagggct gtcagggacc tccaggtaga
     2461 acggtgaagg caagtacttc cctgccccag ttcaagtgag gttacaccac acactgccaa
     2521 cagcatagtc catgattctt accagatcaa ataaactgca gcacactcat gctcctgaga
     2581 tagccccaac tcccaagact ggggttagca atatgcaggg gaaatctcta ggcaagagag
     2641 tacagtccaa agctagaacc aagcctcttc ctctctctga gcctctcctc tccagtaggg
     2701 gcggagtttc cagaaggctt ggagcctctc taagtgtcaa tcactcctaa tcacttttca
     2761 aggccgtgga gcccagtgtt gatgtaagaa agcttggtcc tgatcattag gaaaggattc
     2821 cttcagctaa agtctgcatc catgtacttg cccagctcca gtttctagac ttgcactaaa
     2881 cctggttctt catctagaaa atagcaattc aggtttgggg gaccaagagc agagcccgag
     2941 ctgtccctca gagaacactg tctggaaaca cttttgttcc tgggacttgt cttaaaagct
     3001 tcctgtagtg caaggtttgt gccttgtgcc ctccgttagt ttcagacaac cgaaagatac
     3061 cacgatggct ctgctacctg aaggagaaga ccaactgcag ctctcccaag ccctgaaaca
     3121 ctgctgtcca ctccgaacac atcgggccca tgtgccactc aaataccaga gggcaccatg
     3181 aggtgtcaac acctgccact ccacacaaac acagagcagc cctccagctc tggaaagtga
     3241 cctgccccca gccacgtgta tggagactac ttgaagaaag agaagactgc cccactgtgc
     3301 cccactgtgc cccactgtgc cccactgtgc cccattgctt ctcagcagga aaacagaaga
     3361 aaatatgggc acaagacttg ccaggtcact ctaatatttg agactatgct caacccagag
     3421 cctgagctca gtagagaata taccaagtag catactccaa cccatctatc ccttgctgtt
     3481 ctgggagtca aggtcaaggg acagagtctc attggaaaga gacagagagc catgagtcct
     3541 gggttctgtc cctagctcca tcttcagctg cccatatgac ctttgccatc atttcctcct
     3601 gtgagcttca gtctcctcat ctggaaggtc ccatagggtc tgaccagtgc tctcaatggg
     3661 cactgccctg aattctagca gcatctgtag ctctcacagg ctgagtgctc gctatcccag
     3721 ggatctccat cagaaaaaaa acaaaaaagc agctggaaag gcctggagag ggaatgtgga
     3781 gggaactggg aagagtcatc aaaacacact ccaatatcta tgaatggcac atgtaaagga
     3841 tactatattt tgtgtattta atatcacggg ctctgctact ctataagggc ctctgcactc
     3901 cgtttctctt gtcaggggtc tacagtggaa ataaatctat ggataaccaa caa
//
