LOCUS       NM_008552               4639 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus MAS1 oncogene (Mas1), mRNA.
ACCESSION   NM_008552 XM_489705
VERSION     NM_008552.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4639)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4639)
  AUTHORS   Wan,T.T., Li,Y., Li,J.X., Xiao,X., Liu,L., Li,H.H. and Guo,S.B.
  TITLE     ACE2 activation alleviates sepsis-induced cardiomyopathy by
            promoting MasR-Sirt1-mediated mitochondrial biogenesis
  JOURNAL   Arch Biochem Biophys 752, 109855 (2024)
   PUBMED   38097099
  REMARK    GeneRIF: ACE2 activation alleviates sepsis-induced cardiomyopathy
            by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
REFERENCE   3  (bases 1 to 4639)
  AUTHORS   Vasam,G., S,S.J., Miyat,S.Y., Adam,H. and Jarajapu,Y.P.
  TITLE     Early onset of aging phenotype in vascular repair by Mas receptor
            deficiency
  JOURNAL   Geroscience 44 (1), 311-327 (2022)
   PUBMED   34661816
REFERENCE   4  (bases 1 to 4639)
  AUTHORS   Cao,X., Shi,T.T., Zhang,C.H., Jin,W.Z., Song,L.N., Zhang,Y.C.,
            Liu,J.Y., Yang,F.Y., Rotimi,C.N., Xu,A. and Yang,J.K.
  TITLE     ACE2 pathway regulates thermogenesis and energy metabolism
  JOURNAL   Elife 11, e72266 (2022)
   PUBMED   35014608
  REMARK    Erratum:[Elife. 2022 Mar 22;11:e78698. doi: 10.7554/eLife.78698..
            PMID: 35315773]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4639)
  AUTHORS   Zaidan,I., Tavares,L.P., Sugimoto,M.A., Lima,K.M.,
            Negreiros-Lima,G.L., Teixeira,L.C., Miranda,T.C., Valiate,B.V.,
            Cramer,A., Vago,J.P., Campolina-Silva,G.H., Souza,J.A.,
            Grossi,L.C., Pinho,V., Campagnole-Santos,M.J., Santos,R.A.,
            Teixeira,M.M., Galvao,I. and Sousa,L.P.
  TITLE     Angiotensin-(1-7)/MasR axis promotes migration of
            monocytes/macrophages with a regulatory phenotype to perform
            phagocytosis and efferocytosis
  JOURNAL   JCI Insight 7 (1), e147819 (2022)
   PUBMED   34874920
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4639)
  AUTHORS   Jones,P.S., Savory,R., Barratt,P., Bell,A.R., Gray,T.J.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Bell,D.R.
  TITLE     Chromosomal localisation, inducibility, tissue-specific expression
            and strain differences in three murine
            peroxisome-proliferator-activated-receptor genes
  JOURNAL   Eur J Biochem 233 (1), 219-226 (1995)
   PUBMED   7588749
REFERENCE   7  (bases 1 to 4639)
  AUTHORS   Villar,A.J. and Pedersen,R.A.
  TITLE     Parental imprinting of the Mas protooncogene in mouse
  JOURNAL   Nat Genet 8 (4), 373-379 (1994)
   PUBMED   7894489
REFERENCE   8  (bases 1 to 4639)
  AUTHORS   Himmelbauer,H., Harvey,R.P., Copeland,N.G., Jenkins,N.A. and
            Silver,L.M.
  TITLE     High-resolution genetic analysis of a deletion on mouse chromosome
            17 extending over the fused, tufted, and homeobox Nkx2-5 loci
  JOURNAL   Mamm Genome 5 (12), 814-816 (1994)
   PUBMED   7894168
REFERENCE   9  (bases 1 to 4639)
  AUTHORS   al-Ubaidi,M.R., Brock,D. and Siciliano,M.J.
  TITLE     Assignment of the homolog of the MAS1 oncogene to mouse chromosome
            17
  JOURNAL   Genomics 13 (2), 487 (1992)
   PUBMED   1612611
REFERENCE   10 (bases 1 to 4639)
  AUTHORS   Cebra-Thomas,J.A., Tsai,J.Y., Pilder,S.H., Copeland,N.G.,
            Jenkins,N.A. and Silver,L.M.
  TITLE     Localization of the Mas proto-oncogene to a densely marked region
            of mouse chromosome 17 associated with genomic imprinting
  JOURNAL   Genomics 13 (2), 444-446 (1992)
   PUBMED   1612602
  REMARK    Erratum:[Genomics 1992 Sep;14(1):208]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030265.1 and AL589878.12.
            
            On Jun 4, 2016 this sequence version replaced NM_008552.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030265.1, AK030261.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849381,
                                           SAMN00849382 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2401              AK030265.1         2-2402
            2402-4639           AL589878.12        195568-197805
FEATURES             Location/Qualifiers
     source          1..4639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.69 cM"
     gene            1..4639
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /note="MAS1 oncogene"
                     /db_xref="GeneID:17171"
                     /db_xref="MGI:MGI:96918"
     exon            1..45
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /inference="alignment:Splign:2.1.0"
     exon            46..160
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /inference="alignment:Splign:2.1.0"
     exon            161..330
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /inference="alignment:Splign:2.1.0"
     exon            331..457
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /inference="alignment:Splign:2.1.0"
     exon            458..658
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /inference="alignment:Splign:2.1.0"
     exon            659..690
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /inference="alignment:Splign:2.1.0"
     exon            691..734
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /inference="alignment:Splign:2.1.0"
     exon            735..909
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /inference="alignment:Splign:2.1.0"
     exon            910..4639
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /inference="alignment:Splign:2.1.0"
     CDS             946..1920
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /note="MAS proto-oncogene; angiotensin-(1-7) receptor;
                     Mas-related G protein-coupled receptor a; Mas receptor"
                     /codon_start=1
                     /product="proto-oncogene Mas"
                     /protein_id="NP_032578.2"
                     /db_xref="CCDS:CCDS28394.1"
                     /db_xref="GeneID:17171"
                     /db_xref="MGI:MGI:96918"
                     /translation="MDQSNMTSLAEEKAMNTSSRNASLGSSHPPIPIVHWVIMSISPL
                     GFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHHY
                     TIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAFVCALLWALSC
                     LVTTMEYVMCIDSGEESHSRSDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTW
                     ASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYWSAFGNLHNISLLFSTINSSANP
                     FIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRRQEGNGNTVSIETVV"
     polyA_site      2142
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /note="major polyA site"
     regulatory      2383..2388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /note="hexamer: AATAAA"
     polyA_site      2418
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /note="major polyA site"
     regulatory      2452..2457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /note="hexamer: TATAAA"
     polyA_site      2478
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
     regulatory      4619..4624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
                     /note="hexamer: ATTAAA"
     polyA_site      4639
                     /gene="Mas1"
                     /gene_synonym="Mas-1; MasR; Mgra"
ORIGIN      
        1 agattgtcac acacatgcac ctggttacat ccctggcaaa ggcaggatct attcccagaa
       61 gaatgaatcg acagaaagtg attttttttc ccacgcaaga ttgaaaaggg gagagattta
      121 gacacatgtt ataacataga tggaactaga agacaccatg ctgcttgcac ctgcttgccg
      181 agttttgctg aaggaacagg acggaggtta caagctgact agagatggag gcgttcctga
      241 acatccctcc gagaaggttg gggtataaag agaataaacg aagctgtgtc cacagtgtgg
      301 gctggaattc ctgccgtctg gtaacagcag ttaccagctc ttccagttct ctggattctc
      361 aaagtcagaa gggagccctc agctttgggg aagcgcttga ggctatcttc ctgtgatcga
      421 caatcaacat ctaggactgg gcagagcttg gttccagggt gactgactga gtttggaagc
      481 ctctgggcag cggccttcat accatgggtc agggttccgg actgaatgcg aaaaaggaag
      541 ccggctgagc ggcagcgttc attgctctcc acctcctgac tgttgatgga atgtgaccag
      601 ctgccccaag ctcctgtcct cttaccttcc ccaccacgac ggatcagacc cttgaactga
      661 ggaacgggca tgtttaagga actctggaag atgggtgtgt tttactaagc atcgtctttc
      721 agctacttct caaggaggcg cttccatgag gaacagggag gagggagcga aactctgtga
      781 tcctgccaga gccactgact aactgactaa cgatgccacc gatgccaccg agactgcccc
      841 aagcctctag ccctctgtcc ccaattgagg ttcccaccgc tgtgttcccc accaagacct
      901 gccagccaga aaatgacctg aagtgaccca gggcaagaac tcctcatgga ccagtcaaat
      961 atgacatccc ttgctgaaga gaaagccatg aatacctcca gcagaaatgc ctccctgggg
     1021 agctcacacc cacccattcc catagtgcac tgggtcatca tgagcatctc ccctctgggc
     1081 tttgtggaga atgggatcct cctctggttc ctctgcttcc ggatgaggag aaatcccttc
     1141 acggtctaca ttacccactt gtccattgct gatatctctc ttctgttctg tatttttatc
     1201 ctgtccattg actatgcttt agactatgaa ctctcttctg gccatcacta cacaatcgtg
     1261 acattatcgg tgacttttct atttggctac aacacgggcc tctatctgct gacagccatc
     1321 agtgtggaga ggtgcctatc ggtcctctac cccatatggt acagatgcca ccgccccaag
     1381 caccagtcag cattcgtctg tgcccttctg tgggcacttt cgtgcttggt gaccaccatg
     1441 gagtatgtca tgtgtattga cagcggagaa gagagtcatt ctcggagtga ctgccgggcg
     1501 gtcatcatct tcatagccat cctcagcttc ttggtcttca ctccgctcat gttagtgtcc
     1561 agcaccatct tggtggtgaa gatacggaag aacacgtggg cctcccattc ttcgaagctg
     1621 tacattgtca tcatggtcac cattatcata ttcctcatct ttgccatgcc catgcgggtc
     1681 ctctacttgc tgtactacga gtactggtca gcctttggga acctgcataa catctccttg
     1741 cttttctcca ccatcaacag cagcgccaac cctttcatct acttttttgt gggcagcagt
     1801 aagaagaagc gcttcaggga gtccttaaaa gtcgtcctga ccagggcttt caaagatgaa
     1861 atgcaaccca ggcgccagga gggcaacggc aacactgtat ccattgagac tgtggtctga
     1921 ggacagcagg ggaaattgtg gacagaaaca gtggaatgct ggaggctttt agcttgtgct
     1981 tggaatgcaa tttaagcaca tttaaatctc ctaactatga tacagaggga agcattctac
     2041 atgcatgggg gtcatgcact gatgactttg tattgttacc tatatatgtg atatgatggg
     2101 ctctgtcttt tctatcgtta tcaaagactc attcttctcg tagctgtctg gtagtgatca
     2161 acagtgaact ataaagactg ctctagcagg aagtatccca aatgtgacct ggagaacctg
     2221 gggagactgt gtaatgactg ctgtgtgctc ctatgtgaca tcaggcaagt ggctttgggg
     2281 agcctggttt cctccactca gtggaagtag tgacaacctg tagctcaggt tattgtctag
     2341 tctgatgagg taggcaaagc acccagctca ttgtcaaagt tcaataaata tccatctctc
     2401 ctcatccttt aactagaaca caaagtgctt atacaaatat tgccttgtgt ttataaatgt
     2461 tgaatgtaga tccccaaagg tcttttggct tgtagcatga aagctttttg tggtctaaca
     2521 cctccgctga gacatcggca attgttacaa tcaaggcagc cacatattgg gacatcattt
     2581 gaaattctgg aaacaaacat ttgttccctc ttggaagagt ttcacatggc tttccttagg
     2641 gaataacaca tggagtggaa gtctatgctt ggaaatcttt ttactgcata tacaatttca
     2701 caaatggaac ttaattcagg agtttctgag gacaactgtg ctcttgaaga cctgttcccc
     2761 atagtgatgg gttatttata gctaggaagt tcttgcctgc agcttcatac acatctctgc
     2821 acctgatgcc tctttttcct gaggctctgt gtgtttgtgt gcacatgtac acatgtactc
     2881 atgttgcagc ttacatacgt gtgaatgtgt gtgtctgcat atgtggtgtg tgtgtgtgtg
     2941 tgtgtgtgtg tgtgcatcta tgtgagtatg tgagtgtgca cattgtgctc atggctggac
     3001 aaggagtctt catccatcac tttccacctt attcatcgag acaggctctc tcagtggaat
     3061 ccagagtcac caactgggat ggatagtcta acgtattagc ttgctttggg gatcattgtt
     3121 tctaccttct taacacaggg cttagagaca ggctaccata cacactcagc atttgtgtgg
     3181 gtaccgggga accctgcttc tcactcttgc atggcaagtg ttttgccaca gacaccaagc
     3241 tttttgtgtc tcatcattct gagaaggggg ctcctggtga gagctaatag gataccaaca
     3301 catctttaag ggatctgaat gcttttcccc aaaaccgacc tctgaagggc ctctccactc
     3361 aggactggct caggcaagct ggttcctgct cgagttgcca ttcccagacc acatgttttg
     3421 gatttttgac tgaacactgt cttagtttat agacggatac actggggtgc caatttcctg
     3481 acattccctc agggagtctc atagagatgg cagtgcttgc tggagttctt catgcagaca
     3541 aatgtttaaa tccataaatg agccattagt atttgtctcc attgtttgtg ctcctcgggg
     3601 ctggaagatc tctggagaaa tgagtcttcc ctgctgcccg ctccaccctg tgtctttctc
     3661 aggagcaata atgacagtca cgtagggctg ctttgctgaa ggagagctgt gagtctctca
     3721 ctgagctgag accccgatgc tagccaaatt ggatgcagga cacttttcag tgggtgatgg
     3781 catctgattc agaagcgagg cagcttgtgt ttgggagtcc agatggggtg tagagcagtg
     3841 acatttacaa cgatcttgtt ttcagttgga agcggagttt ctgtactagg gaagagtgga
     3901 atataccaca cagcctggct cccctctgat tccactatct cctggatgcc atgtagcagg
     3961 tctctgtgcc attggcagag ggtcagcctt atcacatccc aaaagagatt ttgttaccca
     4021 gctttctgtc actatgacaa acacctgaga tgagccagct tatgagcagg atttatgtgg
     4081 tctcatactt caggatttca gtccacagtc acctctccct atcactttga gtccggagtg
     4141 gcataagact tcatggcagg agcatgaggt agagaagggt tgttcaacac catcccaata
     4201 tccccttcca gggcacgctt ccaatgctct aacatccttc ccctaagtcc cacccactaa
     4261 aggtgaggac caaaagtccc agtatctccc aatggagtca cacactcatg gccaaaccat
     4321 gaggaacata gggctttgtg gacattgtca agccacagag acctcaaggg aaacactctg
     4381 agctgaccag aagcctgaat atatttcctt cctgcagatg aggtgagaag actgaatgga
     4441 ctattgtgtt tgaagattcc ccaatttctc aacaagtgat gctttgtaga gaggcagggt
     4501 ttgacgttct attcgtcgtt gttgttgttg ttgtcttgtt gtttcctgga actcactctg
     4561 tagaccaagc tggccttgaa ctcagagatc ctcctgcctc tgccctccaa gcacatggat
     4621 taaaggcatg caccaccat
//
