LOCUS       NM_212447               1372 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus MARVEL (membrane-associating) domain containing 3
            (Marveld3), transcript variant 2, mRNA.
ACCESSION   NM_212447
VERSION     NM_212447.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1372)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1372)
  AUTHORS   Weiss,F., Czichos,C., Knobe,L., Voges,L., Bojarski,C., Michel,G.,
            Fromm,M. and Krug,S.M.
  TITLE     MarvelD3 Is Upregulated in Ulcerative Colitis and Has Attenuating
            Effects during Colitis Indirectly Stabilizing the Intestinal
            Barrier
  JOURNAL   Cells 11 (9), 1541 (2022)
   PUBMED   35563847
  REMARK    GeneRIF: MarvelD3 Is Upregulated in Ulcerative Colitis and Has
            Attenuating Effects during Colitis Indirectly Stabilizing the
            Intestinal Barrier.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1372)
  AUTHORS   Heymans,C., Delcorte,O., Spourquet,C., Villacorte-Tabelin,M.,
            Dupasquier,S., Achouri,Y., Mahibullah,S., Lemoine,P., Balda,M.S.,
            Matter,K. and Pierreux,C.E.
  TITLE     Spatio-temporal expression pattern and role of the tight junction
            protein MarvelD3 in pancreas development and function
  JOURNAL   Sci Rep 11 (1), 14519 (2021)
   PUBMED   34267243
  REMARK    GeneRIF: Spatio-temporal expression pattern and role of the tight
            junction protein MarvelD3 in pancreas development and function.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1372)
  AUTHORS   Steed,E., Elbediwy,A., Vacca,B., Dupasquier,S., Hemkemeyer,S.A.,
            Suddason,T., Costa,A.C., Beaudry,J.B., Zihni,C., Gallagher,E.,
            Pierreux,C.E., Balda,M.S. and Matter,K.
  TITLE     MarvelD3 couples tight junctions to the MEKK1-JNK pathway to
            regulate cell behavior and survival
  JOURNAL   J Cell Biol 204 (5), 821-838 (2014)
   PUBMED   24567356
REFERENCE   5  (bases 1 to 1372)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   6  (bases 1 to 1372)
  AUTHORS   Raleigh,D.R., Marchiando,A.M., Zhang,Y., Shen,L., Sasaki,H.,
            Wang,Y., Long,M. and Turner,J.R.
  TITLE     Tight junction-associated MARVEL proteins marveld3, tricellulin,
            and occludin have distinct but overlapping functions
  JOURNAL   Mol Biol Cell 21 (7), 1200-1213 (2010)
   PUBMED   20164257
  REMARK    GeneRIF: marvelD3, occludin, and tricellulin define the tight
            junction-associated MARVEL protein family
REFERENCE   7  (bases 1 to 1372)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY088355.1, AK007346.1, BB619320.1 and AC122807.3.
            
            On Aug 11, 2009 this sequence version replaced NM_212447.1.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The resulting isoform (b)
            has a distinct C-terminus and is longer than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025851.1, BI410804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                BY088355.1         4-83
            81-444              AK007346.1         2-365
            445-445             BB619320.1         443-443
            446-618             AK007346.1         367-539
            619-1372            AC122807.3         17719-18472
FEATURES             Location/Qualifiers
     source          1..1372
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.38 cM"
     gene            1..1372
                     /gene="Marveld3"
                     /gene_synonym="1810006A16Rik; Marvd3; Mrvldc3"
                     /note="MARVEL (membrane-associating) domain containing 3"
                     /db_xref="GeneID:73608"
                     /db_xref="MGI:MGI:1920858"
     exon            1..490
                     /gene="Marveld3"
                     /gene_synonym="1810006A16Rik; Marvd3; Mrvldc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1256
                     /gene="Marveld3"
                     /gene_synonym="1810006A16Rik; Marvd3; Mrvldc3"
                     /note="isoform b is encoded by transcript variant 2;
                     MARVEL domain-containing protein 3"
                     /codon_start=1
                     /product="MARVEL domain-containing protein 3 isoform b"
                     /protein_id="NP_997612.2"
                     /db_xref="CCDS:CCDS22656.1"
                     /db_xref="GeneID:73608"
                     /db_xref="MGI:MGI:1920858"
                     /translation="MKNTSGHREPRTRPRERDPDRRPHPDRDHHVERSRDRGGDRHRE
                     RNGDVRGNGDRRAGREQRTDRDQRQDRHRDAGHRASEQRALEKSRQSRARPEPWGPSW
                     DAAPTPGPAPWGPPELSQKHGLGRRGLESERASERYVPTYSVPALQEEEYYQSEAEGL
                     LDCHKCRYLCTGRGVVQIMEVILNAMVLICIVASYFVLAGFSASFASGSGFGNNYYSP
                     FEGTELEQVRQLDQQYTILRSPLIYGGVAVSLGLGVLTMGVLLQGAKSLRKLPRRWLL
                     LEAAFSLLAAVGYCVAIGFYLYAALRINSTDTCKTRERVYARKGLTWMNCQLAGTDGA
                     AATFACLLVILYAASVVMALRAYREQKHYKDSQEQHRNYRDVPEYLWSGTL"
     exon            491..618
                     /gene="Marveld3"
                     /gene_synonym="1810006A16Rik; Marvd3; Mrvldc3"
                     /inference="alignment:Splign:2.1.0"
     exon            619..1372
                     /gene="Marveld3"
                     /gene_synonym="1810006A16Rik; Marvd3; Mrvldc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtaccgc cccgtccttg agcttggcca cctgcctggg aaacttatgg ttggttgtcg
       61 ccctcggatc gtttccgggc ggggacagga atccggccat gaaaaatact tcggggcacc
      121 gtgagccccg gacccgtcct agagaaagag acccggaccg gcgcccgcac ccggaccgag
      181 accaccacgt cgagcggtcg cgggaccgag gcggggacag gcacagggag aggaacggtg
      241 acgtgagagg aaacggggac cgtcgggcgg gccgggaaca gagaacggac cgagaccagc
      301 gccaggacag acacagggac gcgggccatc gcgcatccga acaaagagcc ttggagaagt
      361 cccgtcaaag ccgtgcgcgg cccgagccct ggggacccag ttgggacgca gccccgactc
      421 cgggacccgc accctggggg cccccagagc tgtcgcagaa gcatggcctc gggcgccgcg
      481 ggttggagag cgaacgggct tcggaaagat acgtgcccac ctactccgtg cctgctctcc
      541 aggaagagga atattaccag tcggaagcgg agggactcct ggattgccac aaatgcagat
      601 acttgtgcac agggagaggt gtggtgcaga taatggaggt gattttgaat gccatggttc
      661 tcatatgcat cgtggcttcc tattttgtcc tggccggatt cagcgccagc tttgccagcg
      721 gcagcggctt cggaaataac tattactcac cttttgaggg caccgagttg gagcaggttc
      781 ggcagctgga ccagcagtac acgatcctgc ggtcgcccct gatctacggc ggcgtggctg
      841 tctccctggg gctgggcgtc ctcactatgg gcgttttact gcagggagct aagagtctaa
      901 ggaagctgcc caggagatgg ctgctgctgg aggccgcctt cagcctcctg gccgcggtgg
      961 gctactgcgt cgccattggc ttttacctgt atgcggcgtt gcgcatcaat tccaccgaca
     1021 cttgcaaaac cagagaaaga gtctacgccc gcaagggcct cacctggatg aactgccagc
     1081 tggcgggcac cgatggggca gcagccacct tcgcttgtct tctagtgatt ttatacgcgg
     1141 ccagcgtggt gatggccctg cgggcctacc gagaacagaa gcactacaaa gacagccagg
     1201 aacaacacag aaattaccgt gatgttccag aatacctgtg gtccgggacg ctctaaggag
     1261 agctggaacc tcctttgttc ctcccctaca agcacaacgt gatttcccat acttgattcc
     1321 taagctccct cagtgctcag gcacctgagc agagtaaagt tgtgaaagga ga
//
