LOCUS       NM_001038602            3061 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus MARVEL (membrane-associating) domain containing 2
            (Marveld2), transcript variant 1, mRNA.
ACCESSION   NM_001038602
VERSION     NM_001038602.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3061)
  AUTHORS   Siegerist,F., Kliewe,F., Hammer,E., Schakau,P., Chi Soh,J.E.,
            Weber,C., Lindenmeyer,M., Reichelt-Wurm,S., Drenic,V.,
            Chatziantoniou,C., Chadjichristos,C.E., Zhang,Y., Simm,S.,
            Banas,M.C., Nauck,M., Volker,U. and Endlich,N.
  TITLE     The role of the tricellular junction protein ILDR2 in
            glomerulopathies: Expression patterns and functional insights
  JOURNAL   iScience 27 (12), 111329 (2024)
   PUBMED   39640577
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3061)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3061)
  AUTHORS   Hofling,C., Rossner,S., Flachmeyer,B., Krueger,M., Hartig,W. and
            Michalski,D.
  TITLE     Tricellulin, alpha-Catenin and Microfibrillar-Associated Protein 5
            Exhibit Concomitantly Altered Immunosignals along with Vascular,
            Extracellular and Cytoskeletal Elements after Experimental Focal
            Cerebral Ischemia
  JOURNAL   Int J Mol Sci 24 (15), 11893 (2023)
   PUBMED   37569268
  REMARK    GeneRIF: Tricellulin, alpha-Catenin and Microfibrillar-Associated
            Protein 5 Exhibit Concomitantly Altered Immunosignals along with
            Vascular, Extracellular and Cytoskeletal Elements after
            Experimental Focal Cerebral Ischemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3061)
  AUTHORS   Kim,Y.S., Fan,R., Lith,S.C., Dicke,A.K., Drexler,H.C.A., Kremer,L.,
            Kuempel-Rink,N., Hekking,L., Stehling,M. and Bedzhov,I.
  TITLE     Rap1 controls epiblast morphogenesis in sync with the pluripotency
            states transition
  JOURNAL   Dev Cell 57 (16), 1937-1956 (2022)
   PUBMED   35998584
REFERENCE   5  (bases 1 to 3061)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   6  (bases 1 to 3061)
  AUTHORS   Kikuchi,S., Ninomiya,T., Tatsumi,H., Sawada,N. and Kojima,T.
  TITLE     Tricellulin is expressed in autotypic tight junctions of peripheral
            myelinating Schwann cells
  JOURNAL   J Histochem Cytochem 58 (12), 1067-1073 (2010)
   PUBMED   21097846
  REMARK    GeneRIF: The tricellulin may be a component to maintain the
            integrity for PNS myelin function and morphology.
REFERENCE   7  (bases 1 to 3061)
  AUTHORS   Raleigh,D.R., Marchiando,A.M., Zhang,Y., Shen,L., Sasaki,H.,
            Wang,Y., Long,M. and Turner,J.R.
  TITLE     Tight junction-associated MARVEL proteins marveld3, tricellulin,
            and occludin have distinct but overlapping functions
  JOURNAL   Mol Biol Cell 21 (7), 1200-1213 (2010)
   PUBMED   20164257
  REMARK    GeneRIF: marvelD3, occludin, and tricellulin define the tight
            junction-associated MARVEL protein family
REFERENCE   8  (bases 1 to 3061)
  AUTHORS   Ikenouchi,J., Sasaki,H., Tsukita,S., Furuse,M. and Tsukita,S.
  TITLE     Loss of occludin affects tricellular localization of tricellulin
  JOURNAL   Mol Biol Cell 19 (11), 4687-4693 (2008)
   PUBMED   18768749
  REMARK    GeneRIF: Knockdown of occludin caused mislocalization of
            tricellulin to bTJs, implying that occludin supports tricellular
            localization of tricellulin by excluding tricellulin from
            bicellular tight junctions.
REFERENCE   9  (bases 1 to 3061)
  AUTHORS   Riazuddin,S., Ahmed,Z.M., Fanning,A.S., Lagziel,A., Kitajiri,S.,
            Ramzan,K., Khan,S.N., Chattaraj,P., Friedman,P.L., Anderson,J.M.,
            Belyantseva,I.A., Forge,A., Riazuddin,S. and Friedman,T.B.
  TITLE     Tricellulin is a tight-junction protein necessary for hearing
  JOURNAL   Am J Hum Genet 79 (6), 1040-1051 (2006)
   PUBMED   17186462
  REMARK    GeneRIF: In the inner ear, tricellulin is concentrated at the
            tricellular tight-junctions in cochlear and vestibular epithelia,
            including the structurally complex and extensive junctions between
            supporting and hair cells.
REFERENCE   10 (bases 1 to 3061)
  AUTHORS   Ikenouchi,J., Furuse,M., Furuse,K., Sasaki,H., Tsukita,S. and
            Tsukita,S.
  TITLE     Tricellulin constitutes a novel barrier at tricellular contacts of
            epithelial cells
  JOURNAL   J Cell Biol 171 (6), 939-945 (2005)
   PUBMED   16365161
  REMARK    GeneRIF: In this study, we identify tricellulin, the first integral
            membrane protein that is concentrated at the vertically oriented TJ
            strands of tricellular contacts.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165159.2 and AK133741.1.
            
            On Jan 13, 2010 this sequence version replaced NM_001038602.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133741.1, SRR17784648.911963.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC165159.2         74043-74065         c
            24-2232             AK133741.1         2-2210
            2233-3061           AC165159.2         53051-53879         c
FEATURES             Location/Qualifiers
     source          1..3061
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 53.23 cM"
     gene            1..3061
                     /gene="Marveld2"
                     /gene_synonym="MARVD2; Mrvldc2; Tric; Trica; Tricb; Tricc"
                     /note="MARVEL (membrane-associating) domain containing 2"
                     /db_xref="GeneID:218518"
                     /db_xref="MGI:MGI:2446166"
     exon            1..46
                     /gene="Marveld2"
                     /gene_synonym="MARVD2; Mrvldc2; Tric; Trica; Tricb; Tricc"
                     /inference="alignment:Splign:2.1.0"
     exon            47..1198
                     /gene="Marveld2"
                     /gene_synonym="MARVD2; Mrvldc2; Tric; Trica; Tricb; Tricc"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1729
                     /gene="Marveld2"
                     /gene_synonym="MARVD2; Mrvldc2; Tric; Trica; Tricb; Tricc"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MARVEL domain-containing protein 2; tricellulin"
                     /codon_start=1
                     /product="MARVEL domain-containing protein 2 isoform 1"
                     /protein_id="NP_001033691.1"
                     /db_xref="CCDS:CCDS26732.1"
                     /db_xref="GeneID:218518"
                     /db_xref="MGI:MGI:2446166"
                     /translation="MSSSDARSRIRDRGYSEVPRDTSCPDGTIRTFQSLHSSELAVSA
                     DPLPPPPLPLQPPFGPSFYSSDTEEPAVAPDLKPVRRFVPDSWKNFFRGKKKDPEWDN
                     PVSDIRYISDGVECSPPASPARANHHPYKDPSRGSQGTFNSQHEADAMFAHDPYASLD
                     RRTQTARTYSEKVEEYNLRYAYMKSWAGLLRILGVVELLLGAGVFACVTAYIHKDNEW
                     YNLFGYTQPYGMGGLGSLGNTYGGYYYSGPKTPFVLVVAGLAWITTIIILVLGMSMYY
                     RTILLDSNWWPLTEFGVNVALFILYMAAAIVYVNDTNRGGLCYYPLFNTPMNAMFCRV
                     EGGQIAAMIFLFVTMIVYLVSALVCLKLWRHEAARRHREFLEQQEINDPSLSSKRKMC
                     EAAISDRQRDQEVNVKDLRTTTKMTPELLSGHIPPGHIPKPIVMPDYVAKYPVIQTDD
                     DRERYKAVFQDQFSEYKELSAEVQAILRKFDELDTVMSRLPHHSENRQEHERISRIHE
                     EFRKKKNDPSFLEKKERCDYLKNKLSHIKQRIQEYDKVMNWDTQGYP"
     exon            1199..1234
                     /gene="Marveld2"
                     /gene_synonym="MARVD2; Mrvldc2; Tric; Trica; Tricb; Tricc"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1383
                     /gene="Marveld2"
                     /gene_synonym="MARVD2; Mrvldc2; Tric; Trica; Tricb; Tricc"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1555
                     /gene="Marveld2"
                     /gene_synonym="MARVD2; Mrvldc2; Tric; Trica; Tricb; Tricc"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1606
                     /gene="Marveld2"
                     /gene_synonym="MARVD2; Mrvldc2; Tric; Trica; Tricb; Tricc"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..3061
                     /gene="Marveld2"
                     /gene_synonym="MARVD2; Mrvldc2; Tric; Trica; Tricb; Tricc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3039..3044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marveld2"
                     /gene_synonym="MARVD2; Mrvldc2; Tric; Trica; Tricb; Tricc"
                     /note="hexamer: ATTAAA"
     polyA_site      3059
                     /gene="Marveld2"
                     /gene_synonym="MARVD2; Mrvldc2; Tric; Trica; Tricb; Tricc"
                     /note="major polyA site"
ORIGIN      
        1 agtttcggtg cccgcggcag agcgtgctgt tccggcggcc gcgcaggtgt gaaaatcaca
       61 aatgtcgtca agtgacgcaa ggtccaggat tcgggacagg ggctatagtg aggttcccag
      121 ggacacgtct tgtccagatg gtaccataag aaccttccag tctcttcaca gcagtgagct
      181 ggcagtgagc gcagatcctc tgcctcctcc ccctctccca ttacagccac cattcggccc
      241 cagcttctac tcaagtgaca cagaggagcc agcagtggca ccagacctca agccggtaag
      301 acgctttgtt cccgactcct ggaaaaattt cttcagaggg aagaaaaagg acccagaatg
      361 ggataacccg gtgtctgata tcagatacat ctccgatggt gtggagtgtt cacctccagc
      421 ctctccagca agggcaaacc accaccctta caaagaccct tccagagggt cgcaaggcac
      481 ctttaattcc cagcacgagg cagatgccat gtttgcccac gacccctatg catccttaga
      541 ccggcgcaca cagacggcgc ggacgtattc tgagaaggta gaggaataca atctgcgcta
      601 cgcctacatg aagtcgtggg caggcctgct gagaatcctg ggtgtggtgg aactgcttct
      661 gggggccggc gtcttcgcgt gtgtcacggc ttacatccac aaggacaacg agtggtacaa
      721 cttgtttggc tatacacagc cctatggcat gggaggtctc ggcagcctcg gcaatacata
      781 tgggggttat tactacagtg gccccaagac ccccttcgta ctcgtggtgg ctggattggc
      841 ttggatcacc accattatta tcctggtgct tggcatgtcc atgtattacc gcaccatcct
      901 tttggactct aactggtggc ccctgactga gttcggagtt aacgttgcgt tgtttatcct
      961 gtacatggct gcagccatag tctatgtgaa cgataccaac cgaggtggac tctgctacta
     1021 cccgttattt aatacaccaa tgaatgcgat gttctgccgg gtagaaggag gtcagatagc
     1081 tgcaatgatc ttcctgtttg tcaccatgat agtttatctc gtcagcgccc tggtctgcct
     1141 aaagctgtgg aggcacgaag cggctcggag acatcgggag ttcctggagc agcaggagat
     1201 aaatgacccg tcgttgtcat cgaaaaggaa aatgtgtgaa gcggccatca gtgatcgaca
     1261 gagggatcag gaagttaatg tcaaagactt gagaacaaca actaaaatga ctcctgagct
     1321 gttgagtggg cacatccctc ccggccacat tccgaagcct atcgtgatgc ctgactacgt
     1381 ggcaaaatat cctgtgattc agacagatga cgatcgagaa cgctataagg ctgtgttcca
     1441 agaccagttt tcagagtaca aagagctgtc tgcggaagtg caggccatcc tgaggaagtt
     1501 tgacgagctg gacacagtga tgagcaggct cccacatcat tctgaaaacc gccaggaaca
     1561 cgagagaatt tcaagaattc atgaagagtt taggaaaaag aagaatgacc cttcgtttct
     1621 ggaaaaaaag gagcgttgcg attacctcaa gaacaaactc tctcacataa agcaaagaat
     1681 tcaagaatac gataaagtga tgaattggga tacgcaaggt tatccctaga cactgtttag
     1741 ccgctgctgc tgtgtgctgg tctcctgggt gagcagcagg cacctccagg tcatcttccg
     1801 cttggttgaa gcacatccta ggcaaacgca ctgtgacttc actcagacat ctcaaaaccg
     1861 tttcaaaccc gcgagggcct ttactgagat gagggggaca gcgtattcag ctgggatagt
     1921 ttaaggttct tctgatgaac aagggcttga agcaagatca gttgtcacac tctgtgctct
     1981 tgggcgagtt ggtcagtcct ctgtgcctgt ttcttttgta aaatgatacc tacctcatag
     2041 ggcagttatg agaccatatg tgctcacctt tatttctcaa gcatctggaa cagagcctcc
     2101 tgctgttgct gctgctgctg ctatggaaga gccacgttcg tgtggggagg gctgtgggcc
     2161 cgtttttgga ggatgagcta cacaggatga gtctcaggaa gcagtccata gtgagcaagg
     2221 gtcagcagct aaccagaggc gcgtgtccca taatgccctg gcgtttttcc gcctttagca
     2281 ctgtagcctt aagtggaagt ttcactgctg cctgtgaact gttatggccc ctcacggcct
     2341 ccatgcctgt aatcagggtc actgtgcata gatccccgtg tcccacagcc cacgctgtgt
     2401 gcatgtgaga gctaagcctt tcagtttact tggtgtctcc cctgtgattc attgccacac
     2461 ctaccccatc tgtgtgacag tttccaccca ctacagcttc cagtcaaaca attaaccaat
     2521 caatgtccga agggttttac aaagtagcga aaccaaagta attaatgagt ggagctggca
     2581 gaggcctgga aagttctggg tgctgatgac aaagttttgt tttgttttgt tttatttgtc
     2641 agtgaaacct ggcaatactc ttgcagacta acttttgtag tgagaccttg tctcagagca
     2701 cgaaacaaat aaaaacaaaa taaaggagga aaaagacaag tagtaaataa ataaaacatg
     2761 gtagcacgtg cacaccaccc tgacactcaa gagcagaggc aggagtgtgt cgagttcaaa
     2821 gccagcctgg gcttcagagc aaggaccccc tctctcttta atgcaagata ttgccgtttt
     2881 gtacatacat ttaaaaagct taggttagcg ttaaatttaa acgttaaaca cacttaactt
     2941 tgtgagactt tattttacta cagttgtaaa tgttaatctt ttaagactga tgctgtaaca
     3001 ctgatttatt ttttaatgtt ctatcaatac agaggtgtat taaaatgtca gttacctgct
     3061 g
//
