LOCUS       NM_183195               3021 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus MARVEL (membrane-associating) domain containing 1
            (Marveld1), mRNA.
ACCESSION   NM_183195 XM_915555
VERSION     NM_183195.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3021)
  AUTHORS   Sun,H., Liu,C., Han,F., Lin,X., Cao,L., Liu,C., Ji,Q., Cui,J.,
            Yao,Y., Wang,B., Liao,Y., Nie,H., Zhang,Y. and Li,Y.
  TITLE     The regulation loop of MARVELD1 interacting with PARP1 in DNA
            damage response maintains genome stability and promotes therapy
            resistance of cancer cells
  JOURNAL   Cell Death Differ 30 (4), 922-937 (2023)
   PUBMED   36750717
  REMARK    GeneRIF: The regulation loop of MARVELD1 interacting with PARP1 in
            DNA damage response maintains genome stability and promotes therapy
            resistance of cancer cells.
REFERENCE   2  (bases 1 to 3021)
  AUTHORS   Liu,W., Han,F., Qu,S., Yao,Y., Zhao,J., Akhtar,M.L., Ci,Y.,
            Zhang,H., Li,H., Zhao,Y., Yue,L., Zhang,Y., Wang,C. and Li,Y.
  TITLE     MARVELD1 depletion leads to dysfunction of motor and cognition via
            regulating glia-dependent neuronal migration during brain
            development
  JOURNAL   Cell Death Dis 9 (10), 999 (2018)
   PUBMED   30250269
  REMARK    GeneRIF: MARVELD1 regulated neuronal migration by mediating the
            formation of glial fibres and ITGB1/FAK signalling pathway. The
            depletion of MARVELD1 during mouse brain development led to the
            abnormity of motor and cognition functions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3021)
  AUTHORS   Chen,Y., Zhang,H., Han,F., Yue,L., Qiao,C., Zhang,Y., Dou,P.,
            Liu,W. and Li,Y.
  TITLE     The depletion of MARVELD1 leads to murine placenta accreta via
            integrin beta4-dependent trophoblast cell invasion
  JOURNAL   J Cell Physiol 233 (3), 2257-2269 (2018)
   PUBMED   28708243
  REMARK    GeneRIF: MARVELD1 mediated the invasion of trophoblast cells via
            regulation of the expression of integrin beta4 during placenta
            development.
REFERENCE   4  (bases 1 to 3021)
  AUTHORS   Zeng,F., Tian,Y., Shi,S., Wu,Q., Liu,S., Zheng,H., Yue,L. and Li,Y.
  TITLE     Identification of mouse MARVELD1 as a microtubule associated
            protein that inhibits cell cycle progression and migration
  JOURNAL   Mol Cells 31 (3), 267-274 (2011)
   PUBMED   21347699
  REMARK    GeneRIF: MARVELD1 is a microtubule-associated protein that plays an
            important role in cell cycle progression and migration
REFERENCE   5  (bases 1 to 3021)
  AUTHORS   Wang,S., Li,Y., Han,F., Hu,J., Yue,L., Yu,Y., Zhang,Y., He,J.,
            Zheng,H., Shi,S., Fu,X. and Wu,H.
  TITLE     Identification and characterization of MARVELD1, a novel nuclear
            protein that is down-regulated in multiple cancers and silenced by
            DNA methylation
  JOURNAL   Cancer Lett 282 (1), 77-86 (2009)
   PUBMED   19364627
REFERENCE   6  (bases 1 to 3021)
  AUTHORS   Carroll,S.F., Loredo Osti,J.C., Guillot,L., Morgan,K. and
            Qureshi,S.T.
  TITLE     Sex differences in the genetic architecture of susceptibility to
            Cryptococcus neoformans pulmonary infection
  JOURNAL   Genes Immun 9 (6), 536-545 (2008)
   PUBMED   18563168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133503.4 and AL603804.18.
            
            On Mar 3, 2022 this sequence version replaced NM_183195.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054384.1, AK132243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: PMID: 21347699
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-860               AC133503.4         1-860               c
            861-2120            AL603804.18        148532-149791       c
            2121-3021           AL603804.18        146393-147293       c
FEATURES             Location/Qualifiers
     source          1..3021
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 35.84 cM"
     gene            1..3021
                     /gene="Marveld1"
                     /gene_synonym="Mrvldc1"
                     /note="MARVEL (membrane-associating) domain containing 1"
                     /db_xref="GeneID:277010"
                     /db_xref="MGI:MGI:2147570"
     exon            1..2120
                     /gene="Marveld1"
                     /gene_synonym="Mrvldc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..731
                     /gene="Marveld1"
                     /gene_synonym="Mrvldc1"
                     /note="putative MARVEL domain-containing protein 1"
                     /codon_start=1
                     /product="MARVEL domain-containing protein 1"
                     /protein_id="NP_899018.1"
                     /db_xref="CCDS:CCDS50439.1"
                     /db_xref="GeneID:277010"
                     /db_xref="MGI:MGI:2147570"
                     /translation="MLPPPPRQPPPQARTARGSLRLQRAFLRGPLGVLRLLQLLAGAA
                     FWITIATSKYQGPVHFALFVSVLFWLLTLGLYFITLLGKQELVPVLGSRWLVVNVAHD
                     LLAAALYGAATGIMIDQTQRHSYCNLKNYRLPCAYHAFLAASVCGGLCLGLYLLSALY
                     GCCRRYQGKEEVV"
     exon            2121..3021
                     /gene="Marveld1"
                     /gene_synonym="Mrvldc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3001..3006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marveld1"
                     /gene_synonym="Mrvldc1"
                     /note="hexamer: AATAAA"
     polyA_site      3021
                     /gene="Marveld1"
                     /gene_synonym="Mrvldc1"
                     /note="major polyA site"
ORIGIN      
        1 gatgagaagc agcgctgagg acttgaagta gagggaggag ggcaggcctc ggagcagcgg
       61 gagcagcggg agcagcggga gcagcgggag cagcgggagc agcgggagca gcgggagcag
      121 cgggcccggg ctcgggccgc ccccgcgagc aaggcgccgc cattccgctg ctcggggcgc
      181 cgccgccgcc gccgccgcgt ccgggggcca tgctcccgcc gcccccgcgc cagccgccgc
      241 cccaggcgcg cacggcccgc ggctccctgc gcctgcagcg ggctttcctg cgcggcccgc
      301 tgggcgtgct gcggctgctg cagctgctgg ccggagccgc cttctggatc accattgcca
      361 ccagcaagta ccagggcccg gtgcacttcg cgctcttcgt gtccgtgctc ttctggctgc
      421 tcaccctggg gctctacttc atcacgctgt tgggcaagca ggagctggtg cccgtgctgg
      481 gctcgcgctg gctcgtggtc aacgtggcgc acgacctgct ggcggctgct ctctacgggg
      541 cggcgacggg catcatgatc gaccagacgc agcgccacag ctactgcaac ctcaagaact
      601 accggctgcc ctgcgcctac catgccttcc tggcggcctc tgtctgcggc ggcctctgcc
      661 tcggcctcta cctactctcg gcactctacg gctgctgccg tcgctaccag ggcaaggagg
      721 aggtggtgtg aggccacccg ctccaccgcg gcccagatcg gtttagggaa tccctcccga
      781 acccttcctg ccgccgccta gtgccggtgt gcccctgcac cctctccctg cctgcgtttc
      841 cactgcccgc gccctggatc cccgacgttc agttctagtc tgactgctgt accgcagctc
      901 agcccagata tcagcttcca gggacccacg cagccatccg aggcgccgac gcacacaccc
      961 agttgggccg cttcaggcga agcctggaag tccctttcct cattccctgt cgagagctag
     1021 acgtggacag gcgccgccgc gtagatccgg gggaggctcc caaattggaa ccagtctttg
     1081 gactgcgcca ttgccccctc cctcctgccc tgcagtcgga agagcatccc ttccctgccc
     1141 cctcttccag cctagggagg tgtagaatgc agtcaggcag ctgcaagagg agctggggac
     1201 aggctttagc tagtgctagg atggatgatg gatgacgtct ttagttgtag tttggctctc
     1261 tccctgcgca gccctacgtc tacgaagtct ttgggtggag tcagctacag aagtggtgga
     1321 tagcaaaggc ctgctggcta taccttactt aacgacgcaa gtcttctctc cgcctaaatc
     1381 cttggtgttc attcagattg ggccaactgt actaacttcc ctggcctctc agatgtcact
     1441 cactagcttc cgccgcactc cacctataaa tatgtttgca ttggggatcc cacgtggcca
     1501 acggcgatca ttaaggtgct gcccacctct ttgggaaccc agatcccgct cttccaaaca
     1561 gctgttctaa tattagaagc acactctttc ctctaaagca gtgggttgtc tagggagcca
     1621 gtactgtgtt acttcccaaa gaaggggtag aaggcaaacg ggtctgtcaa tggtgctgcc
     1681 ttcccgagca cattcacaat gtttgttagc acaatgcggt ctctctgaga agttctgcag
     1741 gtatcgcagc cacacatggt aattcagttc actggagtaa ctattgggcc taagccatcc
     1801 ccaccgcaag actgtgtcta tgctgtctag gtcatgccta caggttgacc cactgaaaat
     1861 taggaagctc ttttttccct aactctaact gggggtccac ccagtgacaa aggagctagg
     1921 accccctccc tagctagaga cctgagaaga gttgaatatt cattcacgtt gttggaaaca
     1981 agaagccaag gatatccaga tgatccccca attcaaagag atcctggcat tgactctgag
     2041 cagctggtgc ggtgagttct gtctgccacc aaattgagaa ctatctggac ctggggtgga
     2101 cagctggtgc cacctctaag gtttccatgt tgctgaggcc tccaagattc tcagagcagt
     2161 cagaatggcc ctgcctgatt ggctgaactg gtctccctgg gaccagcaga aggtttggca
     2221 gtcttcgctg cttcggggca gtggggaaca aacagtctct tttgcaagtg tctagtggaa
     2281 gagccgtggt agagaagact tgatttcttt cttgatacaa gaggattccc aagctcttat
     2341 gttatcattt aggcacaaga tctggtcact tgggactgaa ctctgcccat ctcccattgc
     2401 ctaaatgaca ggtgtcagtt ctggctccca ttccttacct gtttgccttt cttagatcac
     2461 cgtctaagct caggtccagt cccctcagga taggctcagt cccagcgctc tgggtctgag
     2521 gccagcacac cttactcagg agcacacgtc ttggcctctc tggtgcctca tctaccctcg
     2581 cgtgcctata gcactcggga gctcacgagc tcttctccac gtgccttcca gctttgactc
     2641 cagcagcggg catggcggtc cctccgtttg ccactcgtga gaagcacaga taagattatt
     2701 ataataccca cctttcctca aacggcatag tatgatcgcc ctgctgtggc ccagagcatt
     2761 tggaaactgg tagcactctc cctggcttat ctctctgaca ccaggactgg ggccaggcca
     2821 agaccaccca gacagctccc caccataagt ctggggtctc ttgtgggccc aggagacaat
     2881 ttctacagtg tggacaaagg ccaggcaggg tgggttttgg tgtagggagg gtagttacag
     2941 agaggggcca tgtgccttat ccagtagtgt attcatggtc accccagtat gcttttttgg
     3001 aataaagttt gttttgtctg a
//
