LOCUS       NP_758483                752 aa            linear   ROD 03-AUG-2024
DEFINITION  MAP/microtubule affinity-regulating kinase 4 isoform 1 [Mus
            musculus].
ACCESSION   NP_758483
VERSION     NP_758483.1
DBSOURCE    REFSEQ: accession NM_172279.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 752)
  AUTHORS   Wu,Y., Zhang,J., Wang,W., Wu,D., Kang,Y. and Fu,L.
  TITLE     MARK4 aggravates cardiac dysfunction in mice with STZ-induced
            diabetic cardiomyopathy by regulating ACSL4-mediated myocardial
            lipid metabolism
  JOURNAL   Sci Rep 14 (1), 12978 (2024)
   PUBMED   38839927
  REMARK    GeneRIF: MARK4 aggravates cardiac dysfunction in mice with
            STZ-induced diabetic cardiomyopathy by regulating ACSL4-mediated
            myocardial lipid metabolism.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 752)
  AUTHORS   Sultanakhmetov,G., Limlingan,S.J.M., Fukuchi,A., Tsuda,K.,
            Suzuki,H., Kato,I., Saito,T., Weitemier,A.Z. and Ando,K.
  TITLE     Mark4 ablation attenuates pathological phenotypes in a mouse model
            of tauopathy
  JOURNAL   Brain Commun 6 (3), fcae136 (2024)
   PUBMED   38712317
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 752)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 752)
  AUTHORS   Yu,X., Chen,X., Amrute-Nayak,M., Allgeyer,E., Zhao,A.,
            Chenoweth,H., Clement,M., Harrison,J., Doreth,C., Sirinakis,G.,
            Krieg,T., Zhou,H., Huang,H., Tokuraku,K., Johnston,D.S., Mallat,Z.
            and Li,X.
  TITLE     MARK4 controls ischaemic heart failure through microtubule
            detyrosination
  JOURNAL   Nature 594 (7864), 560-565 (2021)
   PUBMED   34040253
  REMARK    GeneRIF: MARK4 controls ischaemic heart failure through microtubule
            detyrosination.
REFERENCE   5  (residues 1 to 752)
  AUTHORS   Yang,K., Cai,J., Pan,M., Sun,Q. and Sun,C.
  TITLE     Mark4 Inhibited the Browning of White Adipose Tissue by Promoting
            Adipocytes Autophagy in Mice
  JOURNAL   Int J Mol Sci 21 (8), 2752 (2020)
   PUBMED   32326642
  REMARK    GeneRIF: Mark4 Inhibited the Browning of White Adipose Tissue by
            Promoting Adipocytes Autophagy in Mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 752)
  AUTHORS   Magnani,I., Novielli,C., Fontana,L., Tabano,S., Rovina,D.,
            Moroni,R.F., Bauer,D., Mazzoleni,S., Colombo,E.A., Tedeschi,G.,
            Monti,L., Porta,G., Bosari,S., Frassoni,C., Galli,R., Bello,L. and
            Larizza,L.
  TITLE     Differential signature of the centrosomal MARK4 isoforms in glioma
  JOURNAL   Anal Cell Pathol (Amst) 34 (6), 319-338 (2011)
   PUBMED   22156016
  REMARK    GeneRIF: The balance between the MARK4 isoforms is carefully
            guarded during neural differentiation but may be subverted in
            gliomagenesis.
REFERENCE   7  (residues 1 to 752)
  AUTHORS   Schneider,A., Laage,R., von Ahsen,O., Fischer,A., Rossner,M.,
            Scheek,S., Grunewald,S., Kuner,R., Weber,D., Kruger,C.,
            Klaussner,B., Gotz,B., Hiemisch,H., Newrzella,D.,
            Martin-Villalba,A., Bach,A. and Schwaninger,M.
  TITLE     Identification of regulated genes during permanent focal cerebral
            ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4
  JOURNAL   J Neurochem 88 (5), 1114-1126 (2004)
   PUBMED   15009667
  REMARK    GeneRIF: MARK4 is a functional protein kinase which specifically
            phosphorylates a cognate peptide substrate for the AMP-kinase
            family. On overexpression in heterologous cells functional
            wild-type protein, but not its kinase-dead mutant, decreased cell
            viability
REFERENCE   8  (residues 1 to 752)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (residues 1 to 752)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 752)
  AUTHORS   Lee,Y.J., Park,C.W., Hahn,Y., Park,J., Lee,J., Yun,J.H., Hyun,B.
            and Chung,J.H.
  TITLE     Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely
            linked to Peg1/Mest(1)
  JOURNAL   FEBS Lett 472 (2-3), 230-234 (2000)
   PUBMED   10788617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149052.3 and AC118017.15.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY151083.1, SRR7345562.3477673.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..752
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.78 cM"
     Protein         1..752
                     /product="MAP/microtubule affinity-regulating kinase 4
                     isoform 1"
                     /EC_number="2.7.11.1"
                     /note="MAP/microtubule affinity-regulating kinase 4L;
                     MARK4 serine/threonine protein kinase"
                     /calculated_mol_wt=82513
     Region          1..36
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CIP4.1)"
     Region          58..310
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(65..69,73,86,88,119,135..138,142,144..145,147,
                     180..181,183,185..186,188,198..199,202,215..220,222,
                     252..255,257)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(65..68,73,86,88,119,135..138,142,185..186,188,
                     198..199)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(69,142,144,180..181,183,185,202,216..220,222)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            198..220
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Site            214
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by LKB1.
                     /evidence=ECO:0000250|UniProtKB:Q96L34; propagated from
                     UniProtKB/Swiss-Prot (Q8CIP4.1)"
     Region          328..370
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          385..615
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CIP4.1)"
     Site            423
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CIP4.1)"
     Site            543
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96L34; propagated from
                     UniProtKB/Swiss-Prot (Q8CIP4.1)"
     Region          654..752
                     /region_name="MARK4_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinase 4; cd12197"
                     /db_xref="CDD:213382"
     Site            order(654,657,728,730..731)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213382"
     CDS             1..752
                     /gene="Mark4"
                     /gene_synonym="2410090P21Rik; Markl1"
                     /coded_by="NM_172279.2:350..2608"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS20903.1"
                     /db_xref="GeneID:232944"
                     /db_xref="MGI:MGI:1920955"
ORIGIN      
        1 mssrtalapg ndrnsdthgt lgsgrssdkg pswssrslga rcrnsiascp eeqphvgnyr
       61 llrtigkgnf akvklarhil tgrevaikii dktqlnpssl qklfrevrim kglnhpnivk
      121 lfevietekt lylvmeyasa gevfdylvsh grmkekeara kfrqivsavh ychqknivhr
      181 dlkaenllld aeanikiadf gfsneftlgs kldtfcgspp yaapelfqgk kydgpevdiw
      241 slgvilytlv sgslpfdghn lkelrervlr gkyrvpfyms tdcesilrrf lvlnpakrct
      301 leqimkdkwi nigyegeelk pytepeedfg dtkrievmvg mgytreeike altnqkynev
      361 tatylllgrk teeggdrgap glalarvrap sdttngtsss kgsshnkgqr assstyhrqr
      421 rhsdfcgpsp aplhpkrspt stgdtelkee rmpgrkascs avgsgsrglp psspmvssah
      481 npnkaeiper rkdststpnn lppsmmtrrn tyvcterpgs erpsllpngk enssgtsrvp
      541 paspsshsla ppsgersrla rgstirstfh ggqvrdrrag sgsgggvqng ppasptlahe
      601 aaplpsgrpr pttnlftklt skltrrvtde periggpevt schlpwdkte taprllrfpw
      661 svkltssrpp ealmaalrqa taaarcrcrq pqpfllaclh ggaggpepls hfevevcqlp
      721 rpglrgvlfr rvagtalafr tlvtrisndl el
//
