LOCUS       NM_001370744            3400 bp    mRNA    linear   ROD 03-AUG-2024
DEFINITION  Mus musculus MAP/microtubule affinity regulating kinase 3 (Mark3),
            transcript variant 3, mRNA.
ACCESSION   NM_001370744 XM_006515515
VERSION     NM_001370744.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3400)
  AUTHORS   Zhang,Q., Mesner,L.D., Calabrese,G.M., Dirckx,N., Li,Z.,
            Verardo,A., Yang,Q., Tower,R.J., Faugere,M.C., Farber,C.R. and
            Clemens,T.L.
  TITLE     Genomic variants within chromosome 14q32.32 regulate bone mass
            through MARK3 signaling in osteoblasts
  JOURNAL   J Clin Invest 131 (7) (2021)
   PUBMED   33792563
  REMARK    GeneRIF: Genomic variants within chromosome 14q32.32 regulate bone
            mass through MARK3 signaling in osteoblasts.
REFERENCE   2  (bases 1 to 3400)
  AUTHORS   Chu,Q., Yao,C., Qi,X., Stripp,B.R. and Tang,N.
  TITLE     STK11 is required for the normal program of ciliated cell
            differentiation in airways
  JOURNAL   Cell Discov 5, 36 (2019)
   PUBMED   31636950
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3400)
  AUTHORS   Calabrese,G.M., Mesner,L.D., Stains,J.P., Tommasini,S.M.,
            Horowitz,M.C., Rosen,C.J. and Farber,C.R.
  TITLE     Integrating GWAS and Co-expression Network Data Identifies Bone
            Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional
            Module
  JOURNAL   Cell Syst 4 (1), 46-59 (2017)
   PUBMED   27866947
REFERENCE   4  (bases 1 to 3400)
  AUTHORS   Kurogi,S., Sekimoto,T., Funamoto,T., Ota,T., Nakamura,S., Nagai,T.,
            Nakahara,M., Yoshinobu,K., Araki,K., Araki,M. and Chosa,E.
  TITLE     Development of an efficient screening system to identify novel bone
            metabolism-related genes using the exchangeable gene trap
            mutagenesis mouse models
  JOURNAL   Sci Rep 7, 40692 (2017)
   PUBMED   28106071
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3400)
  AUTHORS   Kwan,J., Sczaniecka,A., Heidary Arash,E., Nguyen,L., Chen,C.C.,
            Ratkovic,S., Klezovitch,O., Attisano,L., McNeill,H., Emili,A. and
            Vasioukhin,V.
  TITLE     DLG5 connects cell polarity and Hippo signaling protein networks by
            linking PAR-1 with MST1/2
  JOURNAL   Genes Dev 30 (24), 2696-2709 (2016)
   PUBMED   28087714
REFERENCE   6  (bases 1 to 3400)
  AUTHORS   Peng,C.Y., Graves,P.R., Ogg,S., Thoma,R.S., Byrnes,M.J. 3rd, Wu,Z.,
            Stephenson,M.T. and Piwnica-Worms,H.
  TITLE     C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and
            promotes 14-3-3 protein binding
  JOURNAL   Cell Growth Differ 9 (3), 197-208 (1998)
   PUBMED   9543386
REFERENCE   7  (bases 1 to 3400)
  AUTHORS   Biesecker,L.G., Gottschalk,L.R. and Emerson,S.G.
  TITLE     Identification of four murine cDNAs encoding putative protein
            kinases from primitive embryonic stem cells differentiated in vitro
  JOURNAL   Proc Natl Acad Sci U S A 90 (15), 7044-7048 (1993)
   PUBMED   8346215
REFERENCE   8  (bases 1 to 3400)
  AUTHORS   Gilardi-Hebenstreit,P., Nieto,M.A., Frain,M., Mattei,M.G.,
            Chestier,A., Wilkinson,D.G. and Charnay,P.
  TITLE     An Eph-related receptor protein tyrosine kinase gene segmentally
            expressed in the developing mouse hindbrain
  JOURNAL   Oncogene 7 (12), 2499-2506 (1992)
   PUBMED   1281307
  REMARK    Erratum:[Oncogene. 1993 Apr;8(4):1103.. PMID: 8455939]
REFERENCE   9  (bases 1 to 3400)
  AUTHORS   Wilks,A.F.
  TITLE     Two putative protein-tyrosine kinases identified by application of
            the polymerase chain reaction
  JOURNAL   Proc Natl Acad Sci U S A 86 (5), 1603-1607 (1989)
   PUBMED   2466296
REFERENCE   10 (bases 1 to 3400)
  AUTHORS   Hanks,S.K., Quinn,A.M. and Hunter,T.
  TITLE     The protein kinase family: conserved features and deduced phylogeny
            of the catalytic domains
  JOURNAL   Science 241 (4861), 42-52 (1988)
   PUBMED   3291115
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163357.5 and AC160972.4.
            
            On May 24, 2019 this sequence version replaced XM_006515515.3.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1539392.1,
                                           SRR7652917.63831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-581               AC163357.5         191361-191941
            582-773             AC163357.5         209417-209608
            774-827             AC163357.5         221351-221404
            828-876             AC163357.5         232236-232284
            877-942             AC163357.5         235158-235223
            943-1013            AC160972.4         107547-107617
            1014-1070           AC160972.4         108789-108845
            1071-1307           AC160972.4         111378-111614
            1308-1427           AC160972.4         111781-111900
            1428-1527           AC160972.4         112117-112216
            1528-1640           AC160972.4         112492-112604
            1641-1794           AC160972.4         113264-113417
            1795-2012           AC160972.4         117919-118136
            2013-2116           AC160972.4         124239-124342
            2117-2374           AC160972.4         131773-132030
            2375-2401           AC160972.4         136260-136286
            2402-2446           AC160972.4         137692-137736
            2447-3400           AC160972.4         139572-140525
FEATURES             Location/Qualifiers
     source          1..3400
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.05 cM"
     gene            1..3400
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /note="MAP/microtubule affinity regulating kinase 3"
                     /db_xref="GeneID:17169"
                     /db_xref="MGI:MGI:1341865"
     exon            1..581
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     CDS             531..2792
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /EC_number="2.7.11.1"
                     /note="isoform 3 is encoded by transcript variant 3; ELKL
                     motif kinase 2; EMK2/MARK3 serine-threonine protein
                     kinase; EMK-2; MPK-10"
                     /codon_start=1
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform 3"
                     /protein_id="NP_001357673.1"
                     /db_xref="CCDS:CCDS88407.1"
                     /db_xref="GeneID:17169"
                     /db_xref="MGI:MGI:1341865"
                     /translation="MSTRTPLPTVNERDTENHISHGDGRQEVTSRTGRSGARCRNSIA
                     SCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFR
                     EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFR
                     QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPY
                     AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM
                     STDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDI
                     MVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSAELDASDSSSSSNLSLAKVRPNSD
                     LSNSTGQSPHHKGQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGI
                     PSRKSSSSAVGGKGIAPASPMLGNAGNPNKADIPERKKSPAVPSSNTASGGMTRRNTY
                     VCSERCAADRHSVIQNGKENSAIPDERTPVASTHSISSATTPDRIRFPRGTASRSTFH
                     GQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKR
                     LPTEYERNGRYEGSSRNVSSEQKDENREAKPRSLRFTWSMKTTSSMDPSDMMREIRKV
                     LDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAF
                     KNIASKIANELKL"
     exon            582..773
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            774..827
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            828..876
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            877..942
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1013
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1070
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1307
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1427
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1527
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1640
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1794
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..2012
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2116
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2374
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2401
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2446
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..3400
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3232..3237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /note="hexamer: AATACA"
     polyA_site      3250
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /note="major polyA site"
     regulatory      3373..3378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /note="hexamer: ATTAAA"
     polyA_site      3400
                     /gene="Mark3"
                     /gene_synonym="1600015G02Rik; A430080F22Rik; C-TAK1; Emk2;
                     ETK-1; ETK1; MPK10"
                     /note="major polyA site"
ORIGIN      
        1 gagtctgtaa ggctcctgag gtgccgggag cggcggtggc agccggcagg gcgaggccgg
       61 gcggaaagcg agccggagaa gggaaagcag ccgggcgtgg gcgcctcctc cgcggctccc
      121 tccatggtcg gcgcctgcag gccgcggcgg cctgtcttgc gctccatctc cgctccatcc
      181 tcctgcgctg ctgcctcttc aggggctgcc ggccgcgccg tgtcgagccc ccggggctga
      241 gctccgcggc gctgcggctg cgagcggcga ggaggcgcgg ggcccgcgag gcccgtgagg
      301 tgccctgagg cttgcggcgg cggccagccg gcccgcttcc agtgcggccg ccggcgctgg
      361 gggagaatga gccccggggc ccgcgggcgc acggcccggg ccaggccgga gatctagact
      421 ccggccaggg agggcagggc ccggaggctc gcggccgctg ctcgccggcc gcccaaagct
      481 gggcggtttt gttttcgcct tggcgttgtg cggaatcaaa gcgcaataag atgtccacta
      541 ggaccccttt gccaacggtg aatgaacgag acactgaaaa ccacatttca catggagacg
      601 ggaggcaaga agtcacctcc cgcaccgggc gctctggagc tcggtgtaga aactcaatag
      661 cttcctgtgc agatgaacag cctcacatcg gaaactacag actgttgaaa acaatcggca
      721 aggggaactt tgcaaaagtg aaattggcga gacacatcct cacaggccga gaggttgcaa
      781 taaaaataat tgacaaaact cagttgaatc caacaagtct acaaaagctc ttcagagaag
      841 taagaataat gaagatttta aatcacccaa acatagtgaa gttgttcgaa gtcattgaaa
      901 cggaaaaaac tctctactta atcatggaat atgcaagtgg aggtgaagta tttgactatt
      961 tggttgcaca tggaagaatg aaggaaaaag aagcaagagc taaatttaga cagattgttt
     1021 ccgcagtaca gtattgccac caaaaacgga ttgttcacag agacctcaag gctgaaaatc
     1081 tgttattaga tgcggatatg aacattaaaa tagcagattt tggttttagc aatgaattta
     1141 ctgttggcag taaactagac acgttttgtg gtagtcctcc atatgcagcc cctgagctct
     1201 tccagggcaa gaagtatgac gggccagaag tcgacgtgtg gagcctcggt gtcattctct
     1261 acaccctagt cagtgggtcg cttccctttg atggtcaaaa cctgaaggaa ctgagagaga
     1321 gagtactccg cgggaagtac agaatccctt tctacatgtc cacagactgc gagaaccttc
     1381 tcaagcgctt cctggtgctg aacccagtta aacggggcac tctcgagcaa atcatgaagg
     1441 acaggtggat caatgcaggc catgaggagg atgagcttaa gccatttgtt gaaccagaac
     1501 tagacatctc agaccagaag agaatagata ttatggtggg aatgggatat tcccaagaag
     1561 aaattcaaga atctcttagc aaaatgaaat acgatgaaat cacagctact tacttgctac
     1621 tggggaggaa atctgcagag ctggacgcta gtgactccag ttctagcagc aacctttcac
     1681 ttgctaaggt gcggccaaac agtgacctca gcaatagcac tggccagtct cctcatcaca
     1741 aagggcagag aagtgtttcc tcaagtcaga agcagagacg gtacagtgac cacgctggac
     1801 cagctattcc ttcagttgtg gcatatccaa agaggagtca gaccagcact gcagatagtg
     1861 acctcaaaga agatggaatt ccctcccgaa aatcaagcag cagtgctgta ggagggaagg
     1921 ggattgctcc tgccagtccc atgcttggga atgcaggcaa tcccaataaa gccgatatcc
     1981 ctgagcgcaa gaaaagccct gctgtgccca gtagtaacac agcatctggt gggatgacac
     2041 ggcggaacac ttacgtttgc agcgagagat gtgcagcaga cagacattct gtgattcaga
     2101 acggcaaaga aaacagcgct attccagatg agagaactcc agttgcttca acccacagta
     2161 ttagcagtgc gaccacccca gatcgcatcc gctttccaag gggcacagcc agccgtagca
     2221 ctttccatgg ccaacctcgg gagcggcgaa ccgcaacata taatggccca cctgcctcac
     2281 ccagcttgtc ccatgaagcc acaccgctgt ctcagactcg aagccgaggt tccactaatc
     2341 tttttagtaa attaacttcc aaactcacaa gaagaaacat gtcattcagg tttatcaaaa
     2401 gacttccaac tgaatatgag aggaacggga gatatgaggg ctcaagtcgc aatgtgtctt
     2461 cagagcagaa ggatgagaac agagaggcca agccccgctc cctgcgcttc acctggagca
     2521 tgaagaccac gagctccatg gaccccagtg acatgatgcg ggagatccgc aaggtgctgg
     2581 acgccaataa ctgcgactac gagcagaggg agcgcttcct gctcttctgt gtccatggcg
     2641 acgggcacgc agagaacctg gtacagtggg aaatggaagt ctgtaagctg ccaagactgt
     2701 ctctgaatgg agtccggttt aagcggatat cagggacatc catagctttc aaaaatattg
     2761 cttccaaaat tgccaatgag ctaaagctgt aacccagtaa ttatggtgta aattaagtag
     2821 caatttaagg tgttttccag agcactgatg gaaatgtata gagtaatatt taggcaataa
     2881 cgtctgcatc ttctaaatca tgacattaaa gtctgaggat gaaagcgagc gcgcctggga
     2941 gcgaaggctg gccttctcta cgaatgcact acattaaagt ctgtgacccc gtgcctctgt
     3001 cttgtttcca ttgccctggg agtcagagtg taacaccatc tgcacgcggc tccttgtgtg
     3061 gtgtgagtgg atgatgtgtg gggagcactg ttttggaagc ggctcctcac acggcagcca
     3121 gctttactag tccctctgtg ggagatcatt tggtgctaaa acattacagt tgccaagaag
     3181 gaaaataact gaattactgc taagaattaa ccttaaggct agttgataat taatacaggt
     3241 ttacagttca tgcctgtggt tttgtgtttg tttcgtgatt tttttttttg cttttttttt
     3301 aagtgcaaaa ggtttaaatt tatagttgtg aacattgctt gtgtgtgttt ttctaagtag
     3361 attcacaaga taattaaaaa ttcacttttt ctcagtaaaa
//
