LOCUS       NM_001410248            4459 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus MAP/microtubule affinity regulating kinase 2 (Mark2),
            transcript variant 5, mRNA.
ACCESSION   NM_001410248 XM_030250740
VERSION     NM_001410248.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4459)
  AUTHORS   Gong,M., Li,J., Qin,Z., Machado Bressan Wilke,M.V., Liu,Y., Li,Q.,
            Liu,H., Liang,C., Morales-Rosado,J.A., Cohen,A.S.A., Hughes,S.S.,
            Sullivan,B.R., Waddell,V., van den Boogaard,M.H., van
            Jaarsveld,R.H., van Binsbergen,E., van Gassen,K.L., Wang,T.,
            Hiatt,S.M., Amaral,M.D., Kelley,W.V., Zhao,J., Feng,W., Ren,C.,
            Yu,Y., Boczek,N.J., Ferber,M.J., Lahner,C., Elliott,S., Ruan,Y.,
            Mignot,C., Keren,B., Xie,H., Wang,X., Popp,B., Zweier,C., Piard,J.,
            Coubes,C., Mau-Them,F.T., Safraou,H., Innes,A.M., Gauthier,J.,
            Michaud,J.L., Koboldt,D.C., Sylvie,O., Willems,M., Tan,W.H.,
            Cogne,B., Rieubland,C., Braun,D., McLean,S.D., Platzer,K.,
            Zacher,P., Oppermann,H., Evenepoel,L., Blanc,P., El Khattabi,L.,
            Haque,N., Dsouza,N.R., Zimmermann,M.T., Urrutia,R., Klee,E.W.,
            Shen,Y., Du,H., Rappaport,L., Liu,C.M. and Chen,X.
  TITLE     MARK2 variants cause autism spectrum disorder via the
            downregulation of WNT/beta-catenin signaling pathway
  JOURNAL   Am J Hum Genet 111 (11), 2392-2410 (2024)
   PUBMED   39419027
REFERENCE   2  (bases 1 to 4459)
  AUTHORS   Caiola,H.O., Wu,Q., Li,J., Wang,X.F., Soni,S., Monahan,K.,
            Wagner,G.C., Pang,Z.P. and Zhang,H.
  TITLE     Neuronal connectivity, behavioral, and transcriptional alterations
            associated with the loss of MARK2
  JOURNAL   FASEB J 38 (20), e70124 (2024)
   PUBMED   39436150
REFERENCE   3  (bases 1 to 4459)
  AUTHORS   Han,Y., Li,M., Zhao,B., Wang,H., Liu,Y., Liu,Z., Xu,J. and Yang,R.
  TITLE     MARK2 phosphorylates KIF13A at a 14-3-3 binding site to polarize
            vesicular transport of transferrin receptor within dendrites
  JOURNAL   Proc Natl Acad Sci U S A 121 (20), e2316266121 (2024)
   PUBMED   38709923
  REMARK    GeneRIF: MARK2 phosphorylates KIF13A at a 14-3-3 binding site to
            polarize vesicular transport of transferrin receptor within
            dendrites.
REFERENCE   4  (bases 1 to 4459)
  AUTHORS   Deng,J., Wen,C., Ding,X., Zhang,X., Hou,G., Liu,A., Xu,H., Cao,X.
            and Bai,Y.
  TITLE     LKB1-MARK2 signalling mediates lipopolysaccharide-induced
            production of cytokines in mouse macrophages
  JOURNAL   J Cell Mol Med 24 (19), 11307-11317 (2020)
   PUBMED   32841502
  REMARK    GeneRIF: LKB1-MARK2 signalling mediates lipopolysaccharide-induced
            production of cytokines in mouse macrophages.
REFERENCE   5  (bases 1 to 4459)
  AUTHORS   Chu,Q., Yao,C., Qi,X., Stripp,B.R. and Tang,N.
  TITLE     STK11 is required for the normal program of ciliated cell
            differentiation in airways
  JOURNAL   Cell Discov 5, 36 (2019)
   PUBMED   31636950
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4459)
  AUTHORS   Bessone,S., Vidal,F., Le Bouc,Y., Epelbaum,J., Bluet-Pajot,M.T. and
            Darmon,M.
  TITLE     EMK protein kinase-null mice: dwarfism and hypofertility associated
            with alterations in the somatotrope and prolactin pathways
  JOURNAL   Dev Biol 214 (1), 87-101 (1999)
   PUBMED   10491259
REFERENCE   7  (bases 1 to 4459)
  AUTHORS   Guida,L.C., Charlton,P., Gilbert,D.J., Jenkins,N.A., Copeland,N.G.
            and Nicholls,R.D.
  TITLE     Genetic mapping of the galanin-GMAP (Galn) gene to mouse chromosome
            19
  JOURNAL   Mamm Genome 9 (3), 240-242 (1998)
   PUBMED   9501310
REFERENCE   8  (bases 1 to 4459)
  AUTHORS   Fernandes,M., Lespinasse,F., Rotomondo,F., Poirier,C., Guenet,J.L.,
            Gaudray,P. and Carle,G.F.
  TITLE     Comparative mapping of two adjacent regions of MMU19 with their
            human counterpart on HSA11q13
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 237-246 (1998)
   PUBMED   9730611
REFERENCE   9  (bases 1 to 4459)
  AUTHORS   Wada,Y., Kubota,H., Maeda,M., Taniwaki,M., Hattori,M., Imamura,S.,
            Iwai,K. and Minato,N.
  TITLE     Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups
            of chromosome 19 in mouse and chromosome 11q13.3 centromeric to
            BCL1 in human
  JOURNAL   Genomics 39 (1), 66-73 (1997)
   PUBMED   9027487
REFERENCE   10 (bases 1 to 4459)
  AUTHORS   Inglis,J.D., Lee,M. and Hill,R.E.
  TITLE     Emk, a protein kinase with homologs in yeast maps to mouse
            chromosome 19
  JOURNAL   Mamm Genome 4 (7), 401-403 (1993)
   PUBMED   8358177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129188.3 and AC140307.3.
            
            On Aug 1, 2022 this sequence version replaced XM_030250740.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.1108023.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-455               AC129188.3         54656-55110         c
            456-635             AC140307.3         154033-154212       c
            636-689             AC140307.3         153746-153799       c
            690-738             AC140307.3         150760-150808       c
            739-804             AC140307.3         150431-150496       c
            805-875             AC140307.3         150264-150334       c
            876-932             AC140307.3         149999-150055       c
            933-1169            AC140307.3         149162-149398       c
            1170-1289           AC140307.3         148299-148418       c
            1290-1389           AC140307.3         148090-148189       c
            1390-1502           AC140307.3         147895-148007       c
            1503-1635           AC140307.3         146866-146998       c
            1636-1808           AC140307.3         146463-146635       c
            1809-1906           AC140307.3         146156-146253       c
            1907-2164           AC140307.3         144428-144685       c
            2165-2191           AC140307.3         143416-143442       c
            2192-2359           AC140307.3         142541-142708       c
            2360-2404           AC140307.3         141472-141516       c
            2405-4459           AC140307.3         138826-140880       c
FEATURES             Location/Qualifiers
     source          1..4459
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.32 cM"
     gene            1..4459
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /note="MAP/microtubule affinity regulating kinase 2"
                     /db_xref="GeneID:13728"
                     /db_xref="MGI:MGI:99638"
     exon            1..455
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..2765
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="isoform 5 is encoded by transcript variant 5;
                     serine/threonine-protein kinase MARK2; ELKL motif kinase
                     1; PAR1 homolog b"
                     /codon_start=1
                     /product="serine/threonine-protein kinase MARK2 isoform 5"
                     /protein_id="NP_001397177.1"
                     /db_xref="GeneID:13728"
                     /db_xref="MGI:MGI:99638"
                     /translation="MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMLRGRNSATSA
                     DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVR
                     IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIV
                     SAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAP
                     ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD
                     CENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVS
                     MGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPS
                     HKVQRSVSANPKQRRSSDQAVPAIPTSNSYSKKTQSNNAENKRPEEETGRKASSTAKV
                     PASPLPGLDRKKTTPAPSTNSVLSTSTNRSRNSPLLDRASLGQASIQNGKDSTAPQRV
                     PVASPSAHNISSSSGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGH
                     SQGRRGASGSIFSKFTSKFVRRNLSFRFARRCRLSLPKSQELDILRQGSFCRQALVEQ
                     QEAHTLLLHLPSWDRAWLVQPGHVLCRPRNLNEPESKDRVETLRPHVVGSGGTDKDKE
                     EFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHERYMLLCVHGTPG
                     HENFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL"
     exon            456..635
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            636..689
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            690..738
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            739..804
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            805..875
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            876..932
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1169
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1289
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1389
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1502
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1635
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1808
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1906
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2164
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2191
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2359
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2404
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..4459
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4435..4440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /note="hexamer: AATAAA"
     polyA_site      4459
                     /gene="Mark2"
                     /gene_synonym="Emk; EMK-1; Par-1; Par-1b"
                     /note="major polyA site"
ORIGIN      
        1 ggcggtggtg gcggccatgt tgggagcagc aggtccggcg gcggctgcct gtgtgtcggg
       61 cgcggagcag tgcggctgag ggcaggggag gagcgaggca ggcggccggc tgcggcggtt
      121 gagagtaggc ggagcggcgc ggccgggccg aaaggcggca caacccagcc gggggtcggg
      181 ggggggggtg cggtccggag ccgctcggag ccggcgaggc ctagcccgag cggtgcatca
      241 ccgggctggc gtgagccatc gcccggcctc cccgcacccc cggccggggc ccatgcagcg
      301 ggtgctcctg ctgtgagaag ccccgcccgg ccgggctcct agccttccct tccctatctt
      361 cctccaagct tctccattcc ctcccctgag ataccggcgc catgtccagc gctcggaccc
      421 ccctacccac gctgaacgaa agggacacgg agcagcccac cttgggacac cttgattcca
      481 agcccagcag taagtccaac atgctgcggg gccgcaactc agccacctct gctgacgagc
      541 agccccatat tggcaactac cggctcctta agaccattgg caagggtaac tttgccaagg
      601 tgaagttggc ccggcacatc ctgacgggga aagaggtagc tgtgaagatc atcgacaaga
      661 cccagctgaa ctcctccagc ctacagaaac tgttccgaga agtaagaata atgaaggttt
      721 tgaatcatcc caacatagtt aagttgtttg aagtgatcga gactgagaag actctctacc
      781 ttgtcatgga gtatgccagt ggcggagagg tgtttgatta cctagtggcc catggcagga
      841 tgaaagaaaa agaagctcga gccaaatttc gccagatagt gtctgctgtg cagtactgtc
      901 accagaagtt cattgttcat agagatctaa aggcagaaaa cctgctcctg gatgctgata
      961 tgaacatcaa gattgcagac tttggcttta gcaacgaatt cacctttggg aacaagctgg
     1021 atactttctg tggcagtcct ccttatgctg ccccagaact tttccagggc aaaaagtatg
     1081 atggtcctga ggtggatgtc tggagcctgg gagtcatcct ctatacactg gtcagcggat
     1141 ccctgccttt tgatggacag aacctcaagg agctgcggga acgggtactg agggggaaat
     1201 accgtattcc gttctacatg tccacggact gtgaaaatct gcttaagaaa tttctcatac
     1261 ttaatcctag taagagaggc actttagagc aaattatgaa agatcggtgg atgaacgtgg
     1321 ggcatgagga cgatgagcta aagccttatg tggaacctct ccctgactac aaggaccccc
     1381 ggcggacaga gttgatggtg tcaatgggtt acacacggga agagatccag gactcgctgg
     1441 taggccagag gtacaacgaa gtgatggcta cctatctgct ccttggctac aagagctctg
     1501 agctggaagg tgataccatc actttgaagc cccggccttc agctgatcta accaacagca
     1561 gtgccccatc tccatcccac aaggttcagc gcagcgtctc tgccaacccc aagcaacgac
     1621 gctccagtga ccaggccgtc cctgccattc ccacctcgaa ttcctactct aagaagactc
     1681 agagtaacaa cgcagaaaat aagcggcctg aggaagagac agggcggaaa gccagcagca
     1741 ccgccaaagt gcctgccagc cctctgcctg gcctggacag gaagaagacc actcctgccc
     1801 cctccacgaa cagcgtcctt tccaccagca caaaccgaag caggaactcc ccacttttgg
     1861 acagggccag ccttggccag gcctccatcc agaatggtaa agacagcaca gccccccagc
     1921 gcgtccctgt cgcctccccc tccgcccaca acatcagcag cagtagtgga gccccagacc
     1981 gaactaattt cccacggggt gtgtccagtc gaagcacctt ccatgctggg cagctccgac
     2041 aggtgcggga ccagcagaat ctaccctacg gtgtgacccc agcctctccc tctggccata
     2101 gccagggccg gcggggggcc tctggcagca tcttcagcaa gttcacctcc aagtttgtcc
     2161 gcagaaatct gtctttcagg tttgccagaa gatgtcgcct gagcctgcca aagagccaag
     2221 agctggatat tctcaggcag gggtcattct gccgccaggc cctggtggaa cagcaggagg
     2281 cccacaccct gctcctgcat ctcccttcct gggacagagc ctggcttgtt cagcctggcc
     2341 atgtcctctg caggcctagg aacctgaatg aacctgaaag caaagaccga gtggagacgc
     2401 tcagacctca cgtggtaggc agtggaggca ctgacaagga caaggaggag tttcgggagg
     2461 ccaagcctcg ctccctgcgc ttcacctgga gcatgaagac cacgagctct atggagccca
     2521 atgagatgat gcgggagatc cgcaaggtgc tggacgccaa cagctgccaa agcgagctgc
     2581 acgagcggta catgctactg tgcgtgcatg gcacaccagg ccacgagaac tttgtgcagt
     2641 gggagatgga ggtgtgcaaa ctgccccggc tgtctctcaa cggtgttcgg tttaagcgga
     2701 tatcgggcac ttccatggcc ttcaaaaaca ttgcctccaa aatagccaat gagctgaagc
     2761 tttaacaggc tgtcaggagg ggcagcagag gcccaccagt ggacttggct gcttgggcca
     2821 accctgcatc cccctgggag aaactgcagg atgaattggt gtgtctcccc tgctggcact
     2881 tgtccccttc caggcccttc tcagtttttt tcttccatgt ttgtggggga tgggaagtgg
     2941 ttcttctccc tcccacattc acccctgccc agaagtccct cccttccccc ctgcaggagg
     3001 caaaggaagg ggagggggct gggggggggc agggctcccc ctcggtactg cggttgcaca
     3061 gagtatttcg cctaaaccaa gaaaattttt attaccaaaa aagaaaaaga aaaaaaaaaa
     3121 aatcccagcg gccacctttc ctccctgccc cattgggaca gtcaagactg gatctgtggg
     3181 gctcctggga gggtggctca gggctggaac actctcaggc aagagtggtg gagttccctg
     3241 gcaggccctc cgccaggccc tctttgggct tctcccctct ccccacttct tccccccttc
     3301 aagcgaccca ccagaggtgg ccttcccctg cccccaagcc cttgggctta caggccttta
     3361 cactgaggcc cagttggggg tactgcacag ccctggagag ggtgggcggt gggaccctgg
     3421 ctccctccac accatatcct ctgtccttcc ccagagctgg gcacttcctt ccatgagctg
     3481 ctgtggggac atggttcccc ttctcagaag tctgtgccat cttcaggcag gctaaaccca
     3541 gtactggtag aggggagggg aatgggccat gggctctcag cccccagggg gcagcttggg
     3601 aacagggaca cagcttctcc gttctgggag tctttgtctg aaagcacagc ccctcaccat
     3661 ccccctactg cttccccttc cttggcatta atctgggcac cgttctcatc tcacagcctt
     3721 gccttttctt cctggcattg ccgcccctcc tctcaggaga ctgtccaggg cctccatggc
     3781 tgcctggcgg aaggctggat tgggcggcag ggccaggagt ctcttgtcct ccacagggtg
     3841 gggcaaagta actcctgctt gctaacctct gaggccagtg tgtgaatggg tggctgtagg
     3901 cgcttggctg gtggtggcca ctgcatccct taatttattt ctctgctgtt tcagttcttg
     3961 agaaattggg gaagtcctac agaggctgcc cctgccctca cctgagttgt acattttttt
     4021 tgtgatgggt tattttttat ttttattatt attgttgttt tggttttttt tttgtttgtt
     4081 tttgatttat gacaattcca ctcttggccc cagttgtcgt cctgtcactc cctcccctgt
     4141 ccatcaccct ggctcccaga ccaggctcag caacacattg agtcttgggt tccaggaacc
     4201 ttgccaacct caaccctcca gcccgtgctc cactggctat ggctcagacc aagggctcct
     4261 cctctcccct cttgccctat ggaacagccc gggtgctcca agggggccag gagggcatgg
     4321 cttggctccc aagataaggg gtccggggcc aggacaccca ggcaaggtgg cccctccctg
     4381 cctagccccc ttccccccac cctgcactta gtttctcctc tggatcaaat acgtaataaa
     4441 gagaatgttt ggaatctga
//
