LOCUS       NM_145515               4565 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus MAP/microtubule affinity regulating kinase 1 (Mark1),
            transcript variant 2, mRNA.
ACCESSION   NM_145515
VERSION     NM_145515.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4565)
  AUTHORS   Kelly-Castro,E.C., Shear,R., Dindigal,A.H., Bhagwat,M. and Zhang,H.
  TITLE     MARK1 regulates dendritic spine morphogenesis and cognitive
            functions in vivo
  JOURNAL   Exp Neurol 376, 114752 (2024)
   PUBMED   38484863
  REMARK    GeneRIF: MARK1 regulates dendritic spine morphogenesis and
            cognitive functions in vivo.
REFERENCE   2  (bases 1 to 4565)
  AUTHORS   Fumoto,K., Takigawa-Imamura,H., Sumiyama,K., Yoshimura,S.H.,
            Maehara,N. and Kikuchi,A.
  TITLE     Mark1 regulates distal airspace expansion through type I pneumocyte
            flattening in lung development
  JOURNAL   J Cell Sci 132 (24) (2019)
   PUBMED   31719161
  REMARK    GeneRIF: The results suggest that Mark1-mediated fibroblast
            activation induces AECI flattening and thereby regulates distal
            lung sacculation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4565)
  AUTHORS   Chu,Q., Yao,C., Qi,X., Stripp,B.R. and Tang,N.
  TITLE     STK11 is required for the normal program of ciliated cell
            differentiation in airways
  JOURNAL   Cell Discov 5, 36 (2019)
   PUBMED   31636950
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4565)
  AUTHORS   Fumoto,K., Takigawa-Imamura,H., Sumiyama,K., Kaneiwa,T. and
            Kikuchi,A.
  TITLE     Modulation of apical constriction by Wnt signaling is required for
            lung epithelial shape transition
  JOURNAL   Development 144 (1), 151-162 (2017)
   PUBMED   27913639
REFERENCE   5  (bases 1 to 4565)
  AUTHORS   Kwan,V., Meka,D.P., White,S.H., Hung,C.L., Holzapfel,N.T.,
            Walker,S., Murtaza,N., Unda,B.K., Schwanke,B., Yuen,R.K.C.,
            Habing,K., Milsom,C., Hope,K.J., Truant,R., Scherer,S.W., Calderon
            de Anda,F. and Singh,K.K.
  TITLE     DIXDC1 Phosphorylation and Control of Dendritic Morphology Are
            Impaired by Rare Genetic Variants
  JOURNAL   Cell Rep 17 (7), 1892-1904 (2016)
   PUBMED   27829159
REFERENCE   6  (bases 1 to 4565)
  AUTHORS   Hezel,A.F., Gurumurthy,S., Granot,Z., Swisa,A., Chu,G.C.,
            Bailey,G., Dor,Y., Bardeesy,N. and Depinho,R.A.
  TITLE     Pancreatic LKB1 deletion leads to acinar polarity defects and
            cystic neoplasms
  JOURNAL   Mol Cell Biol 28 (7), 2414-2425 (2008)
   PUBMED   18227155
REFERENCE   7  (bases 1 to 4565)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   8  (bases 1 to 4565)
  AUTHORS   Kerns,R.T., Ravindranathan,A., Hassan,S., Cage,M.P., York,T.,
            Sikela,J.M., Williams,R.W. and Miles,M.F.
  TITLE     Ethanol-responsive brain region expression networks: implications
            for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J
            mice
  JOURNAL   J Neurosci 25 (9), 2255-2266 (2005)
   PUBMED   15745951
REFERENCE   9  (bases 1 to 4565)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 4565)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ179387.1, BC112400.1, CX210969.1, AC131992.8, AK173181.1 and
            AK047140.1.
            
            On Mar 12, 2009 this sequence version replaced NM_145515.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF453686.1, BC112400.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                CJ179387.1         22-92
            72-1021             BC112400.1         1-950
            1022-1576           CX210969.1         82-636
            1577-1884           BC112400.1         1506-1813
            1885-1885           AC131992.8         48561-48561
            1886-2554           BC112400.1         1815-2483
            2555-3415           AK173181.1         2408-3268
            3416-4565           AK047140.1         506-1655
FEATURES             Location/Qualifiers
     source          1..4565
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 89.26 cM"
     gene            1..4565
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /note="MAP/microtubule affinity regulating kinase 1"
                     /db_xref="GeneID:226778"
                     /db_xref="MGI:MGI:2664902"
     exon            1..128
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2465
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serine/threonine-protein kinase MARK1; ELKL motif
                     serine-threonine protein kinase 3; PAR1 homolog c"
                     /codon_start=1
                     /product="serine/threonine-protein kinase MARK1 isoform 2"
                     /protein_id="NP_663490.2"
                     /db_xref="CCDS:CCDS35817.1"
                     /db_xref="GeneID:226778"
                     /db_xref="MGI:MGI:2664902"
                     /translation="MSARTPLPTVNERDTENHTSVDGYTETHIPPAKSSSRQNLPRCR
                     NSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ
                     KLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR
                     AKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCG
                     SPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRI
                     PFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYSEPELDLSDAK
                     RIDIMVTMGFARDEINDALVSQKYDEVMATYILLGRKPPEFEGGESLSSGSLCQRSRP
                     SSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSIPPAVSYTKRPQANSVESEQK
                     EEWGKDTARRLGSTTVGSKSEVTASPLVGPDRKKSTASPSNNVYSGGSMARRNTYVCE
                     RSTDRYAALQNGRDSSLTEMSASSMSSAGSTVASAGPSARPRHQKSMSTSGHPIKVTL
                     PTIKDGSEAYRPGAAQRVPAASPSAHSISASTPDRTRFPRGSSSRSTFHGEQLRERRS
                     AAYNGPPASPSHETGAFAHARRGTSTGIISKITSKFVRRDPSEGEASGRADTARGSSG
                     DPKERDKDEGKEAKPRSLRFTWSMKTTSSMDPNDMLREIRKVLDANTCDYEQKERFLL
                     FCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL"
     exon            129..332
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            333..386
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            387..435
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            436..501
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            502..572
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            573..629
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            630..866
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            867..986
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1086
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1199
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1353
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1547
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1648
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1813
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2065
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2110
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..4565
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2722..2727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /note="hexamer: AATAAA"
     polyA_site      2748
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
     regulatory      2884..2889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /note="hexamer: ATTAAA"
     polyA_site      2913
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
     regulatory      4170..4175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /note="hexamer: AATAAA"
     polyA_site      4200
                     /gene="Mark1"
                     /gene_synonym="B930025N23Rik; Emk3; mKIAA1477; mPar-1c;
                     Par-1c"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcccgc cctcgccgaa gccctccgcg gcccgcgacc cgccggaccc cccgctcgac
       61 cccgctgccc gcgcaagatg tcggcgcgga cgccattgcc cacggtgaac gagcgggaca
      121 cggagaacca tacgtctgtg gatggctaca ctgaaacaca tatcccgcct gccaagtcaa
      181 gtagcagaca gaaccttccc cggtgtagaa actccattac gtcagcgaca gatgaacagc
      241 ctcacatcgg aaattaccgc ttacagaaaa caatagggaa aggaaatttt gccaaagtga
      301 aattggcaag acatgttcta acaggtagag aggtcgctgt gaaaataata gacaaaactc
      361 agctaaaccc taccagtcta cagaagttgt tccgagaagt acgaataatg aagatactga
      421 accatcctaa catagtgaaa ctgtttgaag ttattgaaac agagaagaca ctctatttgg
      481 tcatggaata cgcaagtggg ggtgaagtct ttgattactt agttgcccac ggaagaatga
      541 aagagaaaga ggcccgtgcc aaattcaggc agattgtatc tgctgtacag tattgccatc
      601 aaaaatgcat tgttcaccgt gatcttaagg ctgaaaacct tctccttgat gctgatatga
      661 atattaaaat tgctgacttt ggttttagca atgaattcac agtggggaac aaattggaca
      721 cattctgtgg aagcccgcct tatgctgccc ccgagctttt ccaaggcaag aagtacgatg
      781 ggccagaagt ggatgtgtgg agtctgggcg tcattctcta cacgctggtc agtggctcgc
      841 tgccgtttga tggccagaat ctaaaggaac ttcgggagcg agtccttcga gggaagtacc
      901 gcatcccctt ctacatgtcc acagactgtg agaatctcct gaagaaactg ttagtgctga
      961 atcccataaa gcggggcagc ctggagcaaa taatgaaaga ccgatggatg aatgttggtc
     1021 atgaggaaga agagctaaag ccgtactctg agcctgagct tgatctcagc gatgcaaaaa
     1081 gaatagacat tatggtcacc atgggttttg cacgagatga aatcaatgat gccttagtaa
     1141 gtcagaaata tgatgaagtt atggctactt acatccttct aggtagaaaa ccacccgagt
     1201 tcgaaggtgg tgagtcactg tccagtggga gcttgtgcca gcggtcgcgg ccgagcagcg
     1261 acctgaacaa cagcaccctt cagtcgcctg ctcacctgaa ggtccagcgg agcatctcgg
     1321 ccaaccagaa gcagaggcgc ttcagcgacc acgccggccc ctccatcccc cctgccgtct
     1381 catacaccaa gaggcctcag gccaacagcg tggagagtga acagaaggag gagtggggca
     1441 aagacacagc ccgcagactt ggcagcacca cagtgggatc aaagagcgaa gtcacagcca
     1501 gccccttggt ggggccagac aggaaaaagt ccacagcgag cccaagtaac aacgtatatt
     1561 ctggcggtag catggcgagg aggaatacgt atgtgtgtga gaggagcaca gaccggtacg
     1621 cagccttgca gaatggaaga gacagcagcc ttacagagat gtctgccagc agcatgtcct
     1681 cggcgggctc caccgtggcc tctgctggcc cctcagcacg tccccgccac cagaaatcta
     1741 tgtcaacctc tggccaccct ataaaagtta cactgccaac cattaaagat ggctcagaag
     1801 cgtatcggcc tggtgcagct cagagagtgc ctgctgcttc tccgtctgct cacagcatca
     1861 gtgccagcac tccagacagg acccgcttcc cccgagggag ctccagccga agcactttcc
     1921 atggggaaca gctccgagag cggcgcagcg cggcttacaa cggaccaccg gcctccccat
     1981 cccacgaaac gggtgcgttt gcacatgcca gaaggggcac gtcaaccggc atcatcagca
     2041 aaatcacctc caagttcgtc cgcagggatc caagtgaagg cgaagccagc ggcagagccg
     2101 acacagccag aggttcatcg ggagatccca aagagagaga caaggacgag ggcaaagagg
     2161 ccaagccccg ctccctgcgc ttcacctgga gcatgaagac cacgagctcc atggacccca
     2221 acgacatgct gagggagatc cgcaaggtgc tggatgccaa cacctgtgac tatgagcaga
     2281 aagagaggtt cctgctcttc tgcgttcacg gagacgctcg gcaggacagc ctcgtacagt
     2341 gggagatgga ggtctgcaag ttgcctcggc tctcactcaa cggggtccgc ttcaagcgaa
     2401 tatctgggac atctattgcc tttaagaaca ttgcatccaa aatagcaaat gagcttaagc
     2461 tgtaacgatg cgtaggcttc gggatcaggg aggatgcacc acacctgagt acagtgtctg
     2521 aatgtactgg tgatacctgt gtggtcccgc tgtggatcgc ccatgtagaa attgtcctta
     2581 atgcaataag gttatacata gttatgagct gtaaaattca agtcagtatg agctataata
     2641 atcgtagctt caaaagtagg ttcacatgta caggtaagta tattgtgtat ttctgttcat
     2701 tttctgttca tagagttgta taataaaata tgattgcttt aaaacctgta tagttgtcta
     2761 gatctccaca cagaaatgta cgtttaatgc tttgagttga aaaggatttc ccctgttatt
     2821 tacattctgg tgtgttttta aaattcttac ctccatcatg ctgttttgaa aattgtgtcg
     2881 aggattaaaa gcgcacagaa atagtctcta aaattgtagc atgaagttta tagaaattat
     2941 tttaaactca catttaattt aaaccagaag ttgacagtgg gttggtgtcc cgcagtcctc
     3001 ctgctttccc agtctccgcc tgggtcagac aaggtgtggt tgggacttag agaatgtcta
     3061 cggcgtggca cccagacctc ctatacaaag ccgacacaag tcacagctct gccttgagct
     3121 aactcagaag cgcctcgagg aagagttgag tctttaccaa gcttacttgg ccctctggtt
     3181 tttctgacct gctaattagc agcagagact gaaagaatcc gtagctcacc cggccggctg
     3241 taatgaaaca acccagcact tgggtttgct gccttcggaa gacgcagggt agctgcggaa
     3301 acaggagcgt gtcgggacgt ctcatagcac aagctcatcc gtacagtgtc gatgattgcg
     3361 ttggctgaga tatgatgccg cctcaggaat tgacccgagt tgggagcatc tgccccagtg
     3421 tcctcccagc ctccaccctc ccccaccact ctcgtatctg tcagtaaccg gagaggcctg
     3481 tgagcagggc gtgctctcca tgcccgttca ctacggactt atgctgcctg gtggttcact
     3541 ctgctccctc aaaactcctt tgttttcaat attttgccca agttctcctg tttcttccac
     3601 atcattattc cagtcatgtg gagctttgta actggtcatt tgccttcttt cataattagt
     3661 gacgtatgcg acgtaaagcc actagaaaag gcacatcttt ttaatactca ttattttcta
     3721 ctgactagcc ttggaggttg actgtgcaat gttatttaat gttgtaatta ctgtaatatc
     3781 agcacacagg ccccatctgc acactcctga gaaatagaaa atgtactcag agcttgtcat
     3841 tgaaaggaaa gtaacgctgt ggtcagtgct tgacattgga aaccgcactg gaaagctgcc
     3901 ggtggagggg atgtcctggt ccacagtggc ctccacacaa agatgctctt atcttctgta
     3961 ctgtactgtg atgtagcttt cttctgtaac attctgttct aaatggtgtg ttttcttgcc
     4021 ttagggaagg gcggtgttag cggggggggg ggaagcaaca aaacagaact gtgtagcccc
     4081 tttttaacct ggtgttcatc ccaagcattc gatgcagatc tgcattcgct cactggtgca
     4141 cactgaaacc ttacttgaac aggcctcata ataaagcgtt tgtctttggc tctttctcga
     4201 gctgtgaatc acctgtttgc tgcttggaga gccctccgag tgcgttcttc cccgagctct
     4261 aagtccactc ggcaagccag ggatgggccg tgtaggttcc caggatgttg ttatgacaag
     4321 aaagtttgac cttcctatgg gaacccccgt cattgacata cttttcagaa cagaaacttt
     4381 ctatcctctg ttttatatgt tcatgataac attttgaaga gtcagaggga ttttaatata
     4441 tttgcataaa cacctggcta tatgatagca ggatttcctt ggctctgtgg aaatagtttg
     4501 tatcacttgt tagaaaatag gacatagtat tttgtttaac aacagcaaaa ataaaaaaaa
     4561 atagc
//
