LOCUS       NM_001081154            7765 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus meiosis regulator and mRNA stability 1 (Marf1), mRNA.
ACCESSION   NM_001081154 NM_153549 XM_148595
VERSION     NM_001081154.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7765)
  AUTHORS   Yao,Q., Cao,G., Li,M., Wu,B., Zhang,X., Zhang,T., Guo,J., Yin,H.,
            Shi,L., Chen,J., Yu,X., Zheng,L., Ma,J. and Su,Y.Q.
  TITLE     Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and
            genome integrity in mice
  JOURNAL   Proc Natl Acad Sci U S A 115 (44), 11250-11255 (2018)
   PUBMED   30333187
  REMARK    GeneRIF: Purified MARF1 cleaved ssRNAs in vitro.
REFERENCE   2  (bases 1 to 7765)
  AUTHORS   Cao,G.Y., Li,M.Z., Wang,H., Shi,L.Y. and Su,Y.Q.
  TITLE     Interference with the C-terminal structure of MARF1 causes
            defective oocyte meiotic division and female infertility in mice
  JOURNAL   J Biomed Res 32 (1), 58-67 (2018)
   PUBMED   29353819
REFERENCE   3  (bases 1 to 7765)
  AUTHORS   Kanemitsu,Y., Fujitani,M., Fujita,Y., Zhang,S., Su,Y.Q.,
            Kawahara,Y. and Yamashita,T.
  TITLE     The RNA-binding protein MARF1 promotes cortical neurogenesis
            through its RNase activity domain
  JOURNAL   Sci Rep 7 (1), 1155 (2017)
   PUBMED   28442784
  REMARK    GeneRIF: Here, the authors report that meiosis arrest female 1
            (MARF1) is an RBP that is expressed during neuronal
            differentiation. Cortical neurons expressed the somatic form of
            MARF1 (sMARF1) but not the oocyte form (oMARF1). sMARF1 was
            enriched in embryonic brains, and its expression level decreased as
            brain development progressed.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7765)
  AUTHORS   Fujitani,M., Zhang,S., Fujiki,R., Fujihara,Y. and Yamashita,T.
  TITLE     A chromosome 16p13.11 microduplication causes hyperactivity through
            dysregulation of miR-484/protocadherin-19 signaling
  JOURNAL   Mol Psychiatry 22 (3), 364-374 (2017)
   PUBMED   27378146
REFERENCE   5  (bases 1 to 7765)
  AUTHORS   Su,Y.Q., Sun,F., Handel,M.A., Schimenti,J.C. and Eppig,J.J.
  TITLE     Meiosis arrest female 1 (MARF1) has nuage-like function in
            mammalian oocytes
  JOURNAL   Proc Natl Acad Sci U S A 109 (46), 18653-18660 (2012)
   PUBMED   23090997
  REMARK    GeneRIF: Meiosis arrest female 1 (MARF1) has nuage-like function in
            mammalian oocytes.
REFERENCE   6  (bases 1 to 7765)
  AUTHORS   Su,Y.Q., Sugiura,K., Sun,F., Pendola,J.K., Cox,G.A., Handel,M.A.,
            Schimenti,J.C. and Eppig,J.J.
  TITLE     MARF1 regulates essential oogenic processes in mice
  JOURNAL   Science 335 (6075), 1496-1499 (2012)
   PUBMED   22442484
  REMARK    GeneRIF: MARF1 (4921513D23Rik), by suppressing levels of specific
            transcripts, is an essential regulator of important oogenic
            processes leading to female fertility and the development of
            healthy offspring
REFERENCE   7  (bases 1 to 7765)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164291.2 and AC119853.9.
            
            On Dec 18, 2010 this sequence version replaced NM_001081154.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363660.993823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC164291.2         38136-38266         c
            132-331             AC164291.2         32824-33023         c
            332-1018            AC164291.2         31018-31704         c
            1019-1193           AC164291.2         30134-30308         c
            1194-1420           AC164291.2         28008-28234         c
            1421-1538           AC119853.9         235814-235931       c
            1539-1711           AC119853.9         235007-235179       c
            1712-2137           AC119853.9         231322-231747       c
            2138-2295           AC119853.9         230978-231135       c
            2296-2454           AC119853.9         230733-230891       c
            2455-2644           AC119853.9         229273-229462       c
            2645-2823           AC119853.9         227433-227611       c
            2824-2904           AC119853.9         226028-226108       c
            2905-3141           AC119853.9         221660-221896       c
            3142-3261           AC119853.9         221450-221569       c
            3262-3437           AC119853.9         220537-220712       c
            3438-3658           AC119853.9         218736-218956       c
            3659-3801           AC119853.9         217841-217983       c
            3802-3935           AC119853.9         217601-217734       c
            3936-4138           AC119853.9         216146-216348       c
            4139-4366           AC119853.9         215032-215259       c
            4367-4597           AC119853.9         209314-209544       c
            4598-4810           AC119853.9         206373-206585       c
            4811-4871           AC119853.9         205080-205140       c
            4872-4988           AC119853.9         204815-204931       c
            4989-5159           AC119853.9         203273-203443       c
            5160-7765           AC119853.9         198256-200861       c
FEATURES             Location/Qualifiers
     source          1..7765
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 9.69 cM"
     gene            1..7765
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /note="meiosis regulator and mRNA stability 1"
                     /db_xref="GeneID:223989"
                     /db_xref="MGI:MGI:2444505"
     exon            1..131
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            132..331
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..5401
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /note="limkain-b1; meiosis arrest female protein 1;
                     meiosis arrest female 1"
                     /codon_start=1
                     /product="meiosis regulator and mRNA stability factor 1"
                     /protein_id="NP_001074623.1"
                     /db_xref="CCDS:CCDS37262.1"
                     /db_xref="GeneID:223989"
                     /db_xref="MGI:MGI:2444505"
                     /translation="MEGKGTENPCSRTLGWFHQDNDAKPWLWKFSGCFSRPEQTLPLS
                     SQTKEYMENKKAAVELKDIPSPLHVGSKFFPAVPLPDIRSLQQPKVQLSAIPKVSCCA
                     HCPNEPSTSPMRFGGGSGSSGGSGSLIHTGSLLDSPSTGTVTCQVGSGFAFQSVSSLQ
                     NASTRNNLVGLSSDFPSMCVESNLPSCKHLSCCGKLHFQSCHSNVHKLHQFQNLQGCA
                     SAGYFPCSDFPSGAPGHLEERLSHSELTPHLCTNSLHLNVAPPVCLKGSLYCEDCLNK
                     PARNSIIDAAKIWPNIPPPSTQPAPPAIPVCNGCGTKGMEKETSLLLATSLGKTASKF
                     GSPEVAVTGQVLETLPPIGVFWDIENCSVPSGRSATTVVQRIREKFFRGHREAEFICV
                     CDISKENKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFANTHTAPATVVLVST
                     DVNFALELSDLRHRHGFHIILVHKNQASEALLHHANQLIRFEEFISDLPPRLPLKIPC
                     HTLLYVYNLPANKDGKSISNRLRRLSDNCGGKVLSITGCSAILRFINQDSAERAQKRM
                     ENEDVFGNRIIVSFTPKHREFFEAKSSNAIADKVKSPKKVKNTKLCLIKDTSEQSPSV
                     KAMPGKVLQANSGSATKTTNIKSLQELCRMESKSGNRNSDHQQGHGRLAALPNSGPTA
                     SVPIVKNTGVTEPLYRSSQKKENPSSQSTVNSPVEKKKREETVFQVSYPSAFSKLIAS
                     RQVSPLLTSQSWSPRSMSPNLLNRASPLAFNIANPSSGADCPDPFANGVDIQVSNVDY
                     RLSRKELQQLLQEAFSKHGQVKSVELSPHTDYQLKAIVQMRNLHEAICAVNSLHRHKI
                     GSKKILVSLSTGAANKSLSLLSTETMSILQDAPACCLPLFKFIDIYEKKYGHKLNVSD
                     LYKLTDTIAIREQGNGRLVCLLPSNQARQSPLGSSQSHDGSSSNCSPVLFEELEYHEP
                     VCKQHCSNKDFSELVFDPDSYKIPFVVLSLKVFAPQVHSLLQTHQGTVPLLSFPDCYA
                     AEFGDLEITQDSHKGVPLEHFITCIPGVNIATAQNGVKVVKWIHNKPPPPNTDPWLLR
                     SKSPVRNPQLIQFSREVIDLLKTQPSCILPVSNFIPSYHHHFGKQCRVSDYGYSKLIE
                     LLEAVPHVLQILGMGSKRLMTLTHRAQVKRFTQDLLKLLKSQASKQVIVRDFSQAYHW
                     CFSKDWDVTEYGVCDLIDIISEIPDTTICLSQQDDDMVICIRKRERTQDEIERTKQFS
                     KDVVDLLRHQPHFRMPFNKFIPSYHHHFGRQCKLAYYGFTKLLELLEAIPEILQVLEC
                     GEEKILTLTEVERFKALAAQFVKLLRSQKGNCLMMTDLFTEYAKTFGYTFRLQDYDVS
                     SVSALTQKLCHVVKVADMESGKQIQLINRKSLRSLTAQLLVLLMSWEGDAYLPVDELR
                     RHYETTHSTPLNPCEYGFMTLTELLKSLPYLVEVCTNDKAEEYVKLTSLYLFAKNVRS
                     LLHTYHYQQIFLHEFSMAYNKYVGETLQPKTYGYSSVEELLGAIPQVVWIKGHGHKRI
                     VVLKNDMKNRLSSFDLFSVNHEDQPAVSRQILAVPESHLASELQLRTGPSQMEQELLH
                     LASSSPVDLLCAPVPSCLPSPQLRPDPVILKPADLIQFEEHPQEPLGVLVLNQEEKSE
                     VPLPVQKGNLSCDSSPSSPAASPAPPGPSSEAPRPLFSKDAVESPAKKQPKNRVKLAA
                     NFSFAPVTKL"
     exon            332..1018
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1193
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1420
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1538
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1711
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..2137
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2295
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2454
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2644
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2823
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2904
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3141
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3261
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3437
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            3438..3658
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3801
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            3802..3935
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            3936..4138
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            4139..4366
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            4367..4597
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            4598..4810
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            4811..4871
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            4872..4988
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            4989..5159
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     exon            5160..7765
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7738..7743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /note="hexamer: AATAAA"
     polyA_site      7760
                     /gene="Marf1"
                     /gene_synonym="4921513D23Rik; E030019O05; Lkap; mKIAA0430"
                     /note="major polyA site"
ORIGIN      
        1 gcggaagtgg agggagcgct tggcggcggc ggcgggagct gcggagtcgg gaatcaaaat
       61 aaagggcctg gggggggtgg ggggtaggcg gcggtgtcgg aatgtgagcc aagaaggagc
      121 tagtggctga gggtggaaga aagagaaaag aaagatgaaa gaatgttgaa ccatattgtc
      181 tggctatgtg atggaaggga aaggaactga gaacccttgc agcagaacac ttggatggtt
      241 tcaccaagat aatgatgcta agccgtggct ttggaaattc tctggttgct tttctcgtcc
      301 cgagcagaca ttgcctctta gttcccaaac gaaagagtac atggagaaca agaaagctgc
      361 tgtggagtta aaggatatac catctcccct tcatgttggc tctaaatttt tcccagcagt
      421 cccacttcct gatattcgtt ctcttcagca acctaaagta cagctctcag ctattcccaa
      481 agtaagctgc tgtgctcatt gccctaatga accctccact tcacccatgc gttttggtgg
      541 tggcagtggc agtagtggag gttctgggag cttgattcac acgggctcac tcttagactc
      601 accaagcact gggacagtca cgtgtcaagt agggtcaggt tttgctttcc agtccgtgtc
      661 ttcactgcag aatgcctcca ctaggaacaa cttggtgggc ctttcaagtg acttccccag
      721 catgtgtgta gagagtaacc taccttcctg caagcacctg tcgtgttgtg ggaagctcca
      781 tttccagtca tgtcacagta atgtacacaa gctgcatcag ttccagaatc ttcagggctg
      841 tgcctctgct ggctatttcc cctgttccga tttcccaagt ggggctcctg ggcatttgga
      901 agagcgcctt tcccattcag agcttacacc tcacttgtgc accaactctc ttcacctaaa
      961 tgtggcacct ccggtttgtt taaagggctc actttactgt gaagactgtc taaacaagcc
     1021 agcaagaaat agtataattg atgctgctaa aatctggcca aatataccac ctccaagtac
     1081 tcagcctgca cctccagcta ttcctgtgtg taatggctgt ggaacaaaag gcatggaaaa
     1141 ggagacctca ttgttgttgg caaccagtct aggcaaaact gcttcgaaat ttgggtcacc
     1201 agaagttgca gtcactggac aggtgctgga gaccctcccc cccattggcg ttttctggga
     1261 tattgaaaac tgctcagtcc cctctggccg gtcagcaaca actgttgtac agagaatccg
     1321 tgagaagttt tttagaggac acagagaagc agagtttatc tgtgtgtgtg acatcagtaa
     1381 agaaaacaag gaagttattc aagagctgaa taattgtcag gtaaccgttg ctcacataaa
     1441 tgctactgca aagaatgctg ctgatgataa actccgtcag agcctgcgaa ggttcgcaaa
     1501 cacgcacact gctccagcta ctgtggttct tgtgtcaact gatgtcaatt ttgcgttgga
     1561 actcagtgat cttaggcacc ggcacggttt ccacatcatt ttggtacata aaaaccaggc
     1621 ctctgaagcc ttgttacatc atgctaacca gctgatcaga tttgaagagt tcatttctga
     1681 tctcccccct cggttaccac tgaagattcc ttgccacact ctactctatg tttataacct
     1741 gccagcaaat aaagatggca agagcatcag caacaggctc aggcgcctct ctgataactg
     1801 tggtggcaag gtgctgagta tcacaggctg cagcgcaatt ctccgcttca taaaccagga
     1861 cagtgcagag cgggcccaga agcgaatgga aaatgaagat gtctttggca acaggatcat
     1921 cgtgtccttt actccaaaac atagagaatt ctttgaagcc aagagttcaa atgctattgc
     1981 cgacaaagtg aagtctccca aaaaagttaa gaacacaaaa ttgtgcctca tcaaagacac
     2041 aagtgaacag tcacccagtg tcaaagccat gccagggaaa gtgttgcagg caaattctgg
     2101 atctgctaca aaaaccacaa acattaaaag tttacaggag ctgtgccgaa tggagtcaaa
     2161 gtctggcaat agaaacagtg accatcagca aggccatggg aggctggcag cactgcctaa
     2221 cagtggtcca actgcttcag tgcccatcgt gaagaacaca ggtgtgacag agccacttta
     2281 cagaagcagt cagaaaaaag agaaccccag ttcccagagc actgtcaact ctcctgtaga
     2341 gaagaagaag agagaggaga ctgtcttcca agtaagctac ccatccgcat tcagcaagct
     2401 gatcgcctca aggcaagtca gccctctgct cacctctcag tcttggtctc cgaggagtat
     2461 gtctccaaac cttttgaata gagcctcacc acttgctttc aacattgcca atcccagcag
     2521 cggtgctgac tgcccagacc catttgcaaa tggtgttgac atccaggtca gcaatgtgga
     2581 ctacaggctg tcccggaagg agctgcagca gctcctccag gaagcctttt ccaagcatgg
     2641 ccaggtgaag agtgttgagc tcagtcccca tactgattac cagctcaagg ccattgtgca
     2701 gatgagaaac ctgcacgaag caatctgtgc agtgaacagc ctccataggc acaaaattgg
     2761 cagcaagaag atactggtct cactctccac aggagctgcc aacaagtcac tctctttact
     2821 aagcacagaa acaatgtcta ttcttcagga tgctcctgcc tgttgcttgc ctctctttaa
     2881 atttatagac atctatgaaa agaagtatgg acacaagtta aatgtgtctg atttatataa
     2941 attaacagac actattgcaa tccgtgaaca gggaaacggg cgattggtgt gtctcttacc
     3001 tagtaatcag gcccgccaga gccccctggg ctcttcccag tcacatgatg gctcctcctc
     3061 aaactgcagc ccagttctgt ttgaagagtt ggagtatcac gaacctgtct gcaagcagca
     3121 ctgctctaac aaggacttca gtgaacttgt gtttgatcca gactcttaca agattccttt
     3181 tgtggttctc tctttgaaag tgttcgcacc tcaagttcat agtcttctgc agacccacca
     3241 gggcactgtg cctttgctaa gctttccaga ttgctatgct gcggagtttg gtgacctaga
     3301 aattacgcaa gacagccaca agggtgtccc cttagagcac ttcatcacct gcattccagg
     3361 agtgaacatt gccactgctc agaatggcgt caaagtagtg aagtggattc acaacaagcc
     3421 cccacctccc aacactgacc cttggcttct tcgttctaaa agtcctgtga gaaatcccca
     3481 gctgattcag ttcagcagag aggtcattga tttactgaag acccagccat cgtgtatact
     3541 acccgtcagc aatttcatcc cttcatacca tcaccacttt ggaaagcagt gcagggtttc
     3601 agactatggt tattccaagc tgattgaact cctagaagct gtgcctcatg tgttgcagat
     3661 tcttggtatg ggctccaagc gtctgatgac ccttactcac agggcccagg tgaagcgctt
     3721 tactcaggat ttactaaaac ttcttaagtc ccaggccagc aagcaggtca tcgtgagaga
     3781 cttttcacag gcttatcatt ggtgtttctc aaaggactgg gatgtcacgg aatatggtgt
     3841 ttgtgacttg attgatataa tatcagagat cccagacaca actatttgct tgtcccaaca
     3901 agatgacgac atggtcattt gtatccgaaa aagagaacga actcaggatg aaatagaaag
     3961 gacaaagcag ttctccaaag atgttgtgga cttgctgcgc caccagcccc atttcagaat
     4021 gcccttcaac aagttcattc cctcttacca ccaccacttt ggccgacagt gtaaacttgc
     4081 atactatgga tttaccaagc tgcttgaact tttggaagcc atacctgaga ttttacaagt
     4141 gttggaatgt ggagaagaaa aaatcctgac tttgactgaa gtggagcgat tcaaagctct
     4201 agccgcccag tttgttaagc ttctgcggtc ccaaaagggt aactgcctta tgatgacaga
     4261 tctgtttaca gaatatgcta aaacttttgg ttatacattt cgtctccaag actatgatgt
     4321 cagttcagtc tcagctttga cacagaagct ctgccatgtt gtaaaggttg ctgatatgga
     4381 gtctggtaaa cagatccagc tgatcaatag gaagtctctg cggtctctca ctgctcagtt
     4441 gctggtcttg ttgatgtctt gggaagggga tgcttatctt cctgttgatg agctcaggag
     4501 acattatgaa accactcaca gcactcctct caacccctgt gaatatggat tcatgaccct
     4561 gactgagcta ctgaagagtc tgccgtactt agtagaggtt tgtacgaacg ataaggcaga
     4621 agagtatgtg aagctcacaa gcctgtactt gtttgcaaag aatgtgaggt ctttgcttca
     4681 tacctatcac taccagcaga tttttcttca tgaattttcc atggcctata acaaatatgt
     4741 tggagaaaca ctacagccca aaacttatgg ctacagtagt gtggaggaat tactgggagc
     4801 catcccacag gtggtctgga taaaaggaca tggtcataag agaattgtag tgttaaaaaa
     4861 tgacatgaaa aaccgcctaa gctcatttga ccttttctct gtcaatcatg aagaccagcc
     4921 tgcagtgagc aggcagatcc tggcggtgcc agaatcccat ctagcctcag aactccagct
     4981 ccgaacagga cccagccaga tggagcagga gcttctgcac ctggccagca gctcccccgt
     5041 tgacctgctc tgtgctcctg ttccttcatg cctgccatcc cctcagctaa gaccagatcc
     5101 tgtcatcctg aagcccgctg atctcattca gtttgaggaa caccctcaag agcctttggg
     5161 agttttagtt ttaaaccaag aagaaaaatc agaagttcca ctaccagtgc aaaagggaaa
     5221 cctgtcctgt gactcctcac ccagcagccc agcagcttct cctgctcctc ctggcccctc
     5281 ctcagaagcc cccaggccac ttttcagcaa ggatgcagtg gaaagcccag ccaaaaagca
     5341 gcccaaaaat agagtcaaat tggcagccaa cttttctttt gcacctgtaa ccaagcttta
     5401 actcccattt gaacatggaa ttaaattagg atgggggaaa actgtctgac tctacacaca
     5461 aaaatgggct taaaaacctc attttatatc ttgaccccag aagccacttt cattaatggc
     5521 acctagggaa atggttgggt ttttgttgtt gttgttgttt tttgtttgtt tgtttttgtt
     5581 tttgttttat ttttaaactt ttagataaac atgttcttcc tttatttctc ccacttattt
     5641 gaaagaactc ttccattaag gaatctgtaa tatttcacca aatttttcta gactgttgtg
     5701 aattgtggtg gttgggaaga aattcgcaga gatcactcag caggaagtgg cttgagtccc
     5761 attgagcaat ctccatcatt tgtttaagca aatggatttg tggttgttcg agaagccaag
     5821 catgcccatg agcctgtggg tcacacactg gggaatgagt gagtggcagg agagccattt
     5881 ttaggctgac aggaaagttc ctggcttcta ggtgacttgt tggtgtgcct tgttttttat
     5941 gtaactatgt ctggttaacc agtgtagctt catcccattt ttttaaacat ttgcatttgg
     6001 ggattccatt taagagcttt ctagaaagtt atttcatgct tcccttctct gtctgtccca
     6061 gtttgataag gataaggtta aggagaggag atggcctcga tgtcatgtat ttaaagtcag
     6121 ggtttaaatg acacattgtg tgttgagagg tggcaatggt aagagtctga tttttttaaa
     6181 ctatgcatta aatgtataaa ttgtaaatca gctgaagtgc ttcaagaggc gtgggttaga
     6241 tactattgcc actaagaaga gaccagagtt ctatctgtaa tgtgaaggcc aagtttgatc
     6301 agcctatcct tgttcttgcg atttaaaagt tggctgtaaa tctgggaagc tctccatgtg
     6361 aagatgtgtg tccatgttag ttcatctgga cgtctctcaa tagtgtgtgg tcttttctgt
     6421 cacttctcac tattggaagc gcgtttgggt ttttgttttg tttttttgtg gtgtctgatg
     6481 ttggcatttg agaaaagcca gcctttgtgg gcactgcctt gtggaatggc cttctctctg
     6541 ggtgcctgag gtatccactt atgagtggcc tctcacccgt gttagagaga cctgacattt
     6601 acaatggatt gtatctgttg ggcgaaaaag gcaaatccat tcatgagcag aaagaaactg
     6661 ttggcacaca gtcttccact agttagatga cttctttggt gggaaatgtt tataattttt
     6721 ttctagaaag ccagaaaatg gattctgatt tcatagccag cattttgata aaaatgtcac
     6781 aaaattaaag gctgtagaga gatttttttt ttacaagttg attttttttt tttttttttt
     6841 tttttttttt tttttttttt gccaaaatct tttaaatgaa gccattgatt cccagttctt
     6901 agtaatatga cctgccccgg atgagctgca ctggaaatgt tgtgcaggct tgccactctt
     6961 tctgtgcaag cctgaaggta ctttctgtgc aggcctggaa gcacttcttt ctgaggcctg
     7021 atagcacttc ctctttaagg cctcatggca cttcctctgc gattttagtg cataggaagc
     7081 aaaatggcac atgtgcaatt tctttaaggc ttttaagccg tataatagag ttggtgttga
     7141 gagtgtgagt tgccttattt gcagatatcc tatggctaag cctgcctgct cagacttcag
     7201 gtttgcaagc atagagggat tatggatttg aaaacactag atgccactaa agttacttgg
     7261 agtcatctca aaggtcaggt tctatgggca gcaaagaata gttgtgtaca gtgaacgggt
     7321 atgtgtttgc catttgctgg agttgcccat atgtttggag tgtgtgtgac taacccttac
     7381 tatttaaaga tgtgaagact tgattggaag cacgctgagt gtggtgtgcc cacagtggcc
     7441 agtccaatca ctatttcatc atccagaggc ttagataatg atgctatgat gtatgcacgt
     7501 ggagatgatg agacactttt tctgcgtgga aggatgtacc agattaaatt tatctgttga
     7561 aaagacaaaa gttatcacca gaatcccctt tccatcttcc catcttatac tgtttgcttt
     7621 tgatgaggct tgggggacaa gtttttctta actgtctact ttgtttgaac atttttgggg
     7681 ggtggagggg gcggggaggt tcaagtgctg tttgtgtgtt gggaccaaac agttgtcaat
     7741 aaactttatg agcaatcatc tgtaa
//
