LOCUS       NM_010766               1963 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus macrophage receptor with collagenous structure
            (Marco), mRNA.
ACCESSION   NM_010766
VERSION     NM_010766.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1963)
  AUTHORS   Onyishi,C.U., Jeon,Y., Fejer,G., Mukhopadhyay,S., Gordon,S. and
            May,R.C.
  TITLE     Loss of the scavenger receptor MARCO results in uncontrolled
            vomocytosis of fungi from macrophages
  JOURNAL   Eur J Immunol 54 (6), e2350771 (2024)
   PUBMED   38494423
  REMARK    GeneRIF: Loss of the scavenger receptor MARCO results in
            uncontrolled vomocytosis of fungi from macrophages.
REFERENCE   2  (bases 1 to 1963)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1963)
  AUTHORS   Carpentier,K.S., Sheridan,R.M., Lucas,C.J., Davenport,B.J.,
            Li,F.S., Lucas,E.D., McCarthy,M.K., Reynoso,G.V., May,N.A.,
            Tamburini,B.A.J., Hesselberth,J.R., Hickman,H.D. and Morrison,T.E.
  TITLE     MARCO+ lymphatic endothelial cells sequester arthritogenic
            alphaviruses to limit viremia and viral dissemination
  JOURNAL   EMBO J 40 (22), e108966 (2021)
   PUBMED   34618370
  REMARK    GeneRIF: MARCO(+) lymphatic endothelial cells sequester
            arthritogenic alphaviruses to limit viremia and viral
            dissemination.
REFERENCE   4  (bases 1 to 1963)
  AUTHORS   Wang,L., Yang,H.Y., Zang,C.X., Shang,J.M., Liu,H., Zhang,Z.H.,
            Yuan,F.Y., Ju,C., Li,F.Y., Bao,X.Q. and Zhang,D.
  TITLE     TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting
            with the SRCR Domain
  JOURNAL   Mol Neurobiol 58 (11), 5743-5755 (2021)
   PUBMED   34398403
  REMARK    GeneRIF: TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by
            Interacting with the SRCR Domain.
REFERENCE   5  (bases 1 to 1963)
  AUTHORS   Kanno,S., Hirano,S., Sakamoto,T., Furuyama,A., Takase,H., Kato,H.,
            Fukuta,M. and Aoki,Y.
  TITLE     Scavenger receptor MARCO contributes to cellular internalization of
            exosomes by dynamin-dependent endocytosis and macropinocytosis
  JOURNAL   Sci Rep 10 (1), 21795 (2020)
   PUBMED   33311558
  REMARK    GeneRIF: Scavenger receptor MARCO contributes to cellular
            internalization of exosomes by dynamin-dependent endocytosis and
            macropinocytosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1963)
  AUTHORS   Brannstrom,A., Sankala,M., Tryggvason,K. and Pikkarainen,T.
  TITLE     Arginine residues in domain V have a central role for
            bacteria-binding activity of macrophage scavenger receptor MARCO
  JOURNAL   Biochem Biophys Res Commun 290 (5), 1462-1469 (2002)
   PUBMED   11820786
  REMARK    GeneRIF: An arginine-rich segment in domain V of MARCO and
            particularly its RXR motifs play a critical role in high affinity
            bacterial binding.
REFERENCE   7  (bases 1 to 1963)
  AUTHORS   Elshourbagy,N.A., Li,X., Terrett,J., Vanhorn,S., Gross,M.S.,
            Adamou,J.E., Anderson,K.M., Webb,C.L. and Lysko,P.G.
  TITLE     Molecular characterization of a human scavenger receptor, human
            MARCO
  JOURNAL   Eur J Biochem 267 (3), 919-926 (2000)
   PUBMED   10651831
REFERENCE   8  (bases 1 to 1963)
  AUTHORS   Kangas,M., Brannstrom,A., Elomaa,O., Matsuda,Y., Eddy,R.,
            Shows,T.B. and Tryggvason,K.
  TITLE     Structure and chromosomal localization of the human and murine
            genes for the macrophage MARCO receptor
  JOURNAL   Genomics 58 (1), 82-89 (1999)
   PUBMED   10331948
REFERENCE   9  (bases 1 to 1963)
  AUTHORS   Iwama,A., Zhang,P., Darlington,G.J., McKercher,S.R., Maki,R. and
            Tenen,D.G.
  TITLE     Use of RDA analysis of knockout mice to identify myeloid genes
            regulated in vivo by PU.1 and C/EBPalpha
  JOURNAL   Nucleic Acids Res 26 (12), 3034-3043 (1998)
   PUBMED   9611252
REFERENCE   10 (bases 1 to 1963)
  AUTHORS   Elomaa,O., Kangas,M., Sahlberg,C., Tuukkanen,J., Sormunen,R.,
            Liakka,A., Thesleff,I., Kraal,G. and Tryggvason,K.
  TITLE     Cloning of a novel bacteria-binding receptor structurally related
            to scavenger receptors and expressed in a subset of macrophages
  JOURNAL   Cell 80 (4), 603-609 (1995)
   PUBMED   7867067
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC132338.1 and AA185896.1.
            
            On Feb 14, 2018 this sequence version replaced NM_010766.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137939.1, AK169230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1849              BC132338.1         1-1849
            1850-1963           AA185896.1         227-340
FEATURES             Location/Qualifiers
     source          1..1963
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 52.71 cM"
     gene            1..1963
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /note="macrophage receptor with collagenous structure"
                     /db_xref="GeneID:17167"
                     /db_xref="MGI:MGI:1309998"
     exon            1..356
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1804
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /codon_start=1
                     /product="macrophage receptor MARCO"
                     /protein_id="NP_034896.1"
                     /db_xref="CCDS:CCDS15234.1"
                     /db_xref="GeneID:17167"
                     /db_xref="MGI:MGI:1309998"
                     /translation="MGSKELLKEEDFLGSTEDRADFDQAMFPVMETFEINDPVPKKRN
                     GGTFCMAVMAIHLILLTAGTALLLIQVLNLQEQLQMLEMCCGNGSLAIEDKPFFSLQW
                     APKTHLVPRAQGLQALQAQLSWVHTSQEQLRQQFNNLTQNPELFQIKGERGSPGPKGA
                     PGAPGIPGLPGPAAEKGEKGAAGRDGTPGVQGPQGPPGSKGEAGLQGLTGAPGKQGAT
                     GAPGPRGEKGSKGDIGLTGPKGEHGTKGDKGDLGLPGNKGDMGMKGDTGPMGSPGAQG
                     GKGDAGKPGLPGLAGSPGVKGDQGKPGVQGVPGPQGAPGLSGAKGEPGRTGLPGPAGP
                     PGIAGNPGIAGVKGSKGDTGIQGQKGTKGESGVPGLVGRKGDTGSPGLAGPKGEPGRV
                     GQKGDPGMKGSSGQQGQKGEKGQKGESFQRVRIMGGTNRGRAEVYYNNEWGTICDDDW
                     DNNDATVFCRMLGYSRGRALSSYGGGSGNIWLDNVNCRGTENSLWDCSKNSWGNHNCV
                     HNEDAGVECS"
     exon            357..458
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            459..677
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            678..713
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            714..812
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            813..857
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..902
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1010
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1109
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1145
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1244
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1307
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1352
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1451
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1496
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1673
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1925
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1902..1907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /note="hexamer: AATAAA"
     polyA_site      1925
                     /gene="Marco"
                     /gene_synonym="Ly112; Scara2"
                     /note="major polyA site"
ORIGIN      
        1 taacaggcag cttccccaca caacagtttc acatgtgaac agcctgatat ttaagcaaaa
       61 atcagttcta cactaaggag cagccgggtc cccacagcca ggaaacattg tgcaaattga
      121 aaaatcattg ccaaagggaa gttgtatgca tctccagcta gctgccgcag ttaaatggga
      181 gccctgcttc ctcctagggg agagtttctg ctggctccag ggctttggcc acctataaag
      241 cttagcaatg ggaagtaaag aactcctcaa agaggaagac ttcttgggca gcacagaaga
      301 cagagccgat tttgaccaag ctatgttccc tgtgatggag accttcgaaa tcaatgatcc
      361 agtgcccaag aagagaaatg gggggacctt ctgcatggca gtcatggcca tccacctgat
      421 cctgctcacg gcaggtactg cactgctgct gattcaagtt ctcaatctgc aggagcagct
      481 ccagatgcta gagatgtgct gtggcaatgg atcactagct atcgaggaca agcccttctt
      541 ctcgctgcag tgggcaccca aaacacacct ggtacctaga gcacaggggc tgcaagcctt
      601 gcaggcccag ctcagctggg tccataccag ccaggagcaa ctccgtcagc agttcaacaa
      661 cctcactcaa aatccagagt tgttccagat taaaggtgaa cgaggctctc caggtccaaa
      721 aggggccccg ggtgctcctg gaatccccgg gctgcctggg ccagctgctg agaagggaga
      781 aaagggggct gcaggtcgtg atggaacccc aggtgtccaa ggaccccagg gcccaccagg
      841 cagcaaggga gaggcaggcc tccagggact tacgggtgca ccagggaagc aaggagcaac
      901 tggtgctcca ggacctcgag gagagaaggg cagcaaaggt gacataggtc tcactggccc
      961 caagggggaa catggcacca agggagacaa aggggaccta ggccttccag gaaacaaagg
     1021 ggacatgggc atgaagggag acacggggcc catggggtcc cctggagctc agggaggtaa
     1081 aggtgatgct ggaaaaccag gcctaccagg tttggctgga tctccaggag tcaaaggtga
     1141 ccaaggaaaa cctggagtgc agggtgttcc aggccctcaa ggtgcaccag gactttcagg
     1201 tgccaagggt gagccaggac gcactggtct tcctgggcca gcaggacccc cgggaattgc
     1261 tgggaatcca gggattgcag gtgtgaaagg aagcaagggt gacacaggaa ttcaaggaca
     1321 gaaaggcaca aaaggagaat caggagtccc aggtcttgta ggcagaaagg gagacactgg
     1381 aagccctggg ctggcaggtc ccaaaggaga acctggacga gtcggtcaga agggagaccc
     1441 ggggatgaaa gggtcttctg gccagcaagg acaaaaggga gaaaagggtc aaaaaggcga
     1501 atctttccaa cgcgtccgga tcatgggtgg caccaacaga ggccgagctg aagtttacta
     1561 taacaatgag tgggggacaa tttgtgatga tgattgggat aataatgatg cgactgtctt
     1621 ctgtcgcatg ctcggttact ccagagggag agcacttagc agctatggag gtggctctgg
     1681 gaacatctgg ctggacaatg tgaattgtcg gggcacagag aacagtttgt gggactgcag
     1741 taagaactcc tggggcaatc acaattgcgt acataatgaa gatgcgggtg tggaatgctc
     1801 ctgacttggg agcccgagag gtcatcagtg tgtccccagg tgtctttggg ttccacccac
     1861 atggaaatct gtgggcttgc taactctgtt gaggggaagt taataaagct caagtgggga
     1921 tctgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
