LOCUS       NM_010807               1611 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus MARCKS-like 1 (Marcksl1), mRNA.
ACCESSION   NM_010807
VERSION     NM_010807.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1611)
  AUTHORS   Fazilaty,H., Brugger,M.D., Valenta,T., Szczerba,B.M., Berkova,L.,
            Doumpas,N., Hausmann,G., Scharl,M. and Basler,K.
  TITLE     Tracing colonic embryonic transcriptional profiles and their
            reactivation upon intestinal damage
  JOURNAL   Cell Rep 36 (5), 109484 (2021)
   PUBMED   34348153
REFERENCE   2  (bases 1 to 1611)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1611)
  AUTHORS   Song,C., Yue,Q., Moseley,A., Al-Khalili,O., Wynne,B.M., Ma,H.,
            Wang,L. and Eaton,D.C.
  TITLE     Myristoylated alanine-rich C kinase substrate-like protein-1
            regulates epithelial sodium channel activity in renal distal
            convoluted tubule cells
  JOURNAL   Am J Physiol Cell Physiol 319 (3), C589-C604 (2020)
   PUBMED   32639874
  REMARK    GeneRIF: Myristoylated alanine-rich C kinase substrate-like
            protein-1 regulates epithelial sodium channel activity in renal
            distal convoluted tubule cells.
REFERENCE   4  (bases 1 to 1611)
  AUTHORS   Tanaka,T., Shimizu,S., Ueno,M., Fujihara,Y., Ikawa,M. and Miyata,S.
  TITLE     MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the
            Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors
  JOURNAL   EBioMedicine 30, 62-73 (2018)
   PUBMED   29580842
  REMARK    GeneRIF: MARCKSL1 expression in the amygdala plays an important
            role in anxiety-like behaviors.
REFERENCE   5  (bases 1 to 1611)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 1611)
  AUTHORS   Stumpo,D.J., Bock,C.B., Tuttle,J.S. and Blackshear,P.J.
  TITLE     MARCKS deficiency in mice leads to abnormal brain development and
            perinatal death
  JOURNAL   Proc Natl Acad Sci U S A 92 (4), 944-948 (1995)
   PUBMED   7862670
REFERENCE   7  (bases 1 to 1611)
  AUTHORS   Reichert,F., Saada,A. and Rotshenker,S.
  TITLE     Peripheral nerve injury induces Schwann cells to express two
            macrophage phenotypes: phagocytosis and the galactose-specific
            lectin MAC-2
  JOURNAL   J Neurosci 14 (5 Pt 2), 3231-3245 (1994)
   PUBMED   8182468
REFERENCE   8  (bases 1 to 1611)
  AUTHORS   Li,J. and Aderem,A.
  TITLE     MacMARCKS, a novel member of the MARCKS family of protein kinase C
            substrates
  JOURNAL   Cell 70 (5), 791-801 (1992)
   PUBMED   1516135
REFERENCE   9  (bases 1 to 1611)
  AUTHORS   Blackshear,P.J., Verghese,G.M., Johnson,J.D., Haupt,D.M. and
            Stumpo,D.J.
  TITLE     Characteristics of the F52 protein, a MARCKS homologue
  JOURNAL   J Biol Chem 267 (19), 13540-13546 (1992)
   PUBMED   1618855
REFERENCE   10 (bases 1 to 1611)
  AUTHORS   Umekage,T. and Kato,K.
  TITLE     A mouse brain cDNA encodes a novel protein with the protein kinase
            C phosphorylation site domain common to MARCKS
  JOURNAL   FEBS Lett 286 (1-2), 147-151 (1991)
   PUBMED   1864362
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX243729.1, AK083913.1 and CD802500.1.
            
            On Sep 9, 2009 this sequence version replaced NM_010807.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX243729.1, X61399.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                CX243729.1         1-50
            51-1523             AK083913.1         2-1474
            1524-1591           AK083913.1         1476-1543
            1592-1611           CD802500.1         9-28                c
FEATURES             Location/Qualifiers
     source          1..1611
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.26 cM"
     gene            1..1611
                     /gene="Marcksl1"
                     /gene_synonym="D4Bc1; F52; MacMARCKS; Macs2; Macs3; Mlp;
                     Mrp"
                     /note="MARCKS-like 1"
                     /db_xref="GeneID:17357"
                     /db_xref="MGI:MGI:97143"
     exon            1..336
                     /gene="Marcksl1"
                     /gene_synonym="D4Bc1; F52; MacMARCKS; Macs2; Macs3; Mlp;
                     Mrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..852
                     /gene="Marcksl1"
                     /gene_synonym="D4Bc1; F52; MacMARCKS; Macs2; Macs3; Mlp;
                     Mrp"
                     /note="mac-MARCKS; brain protein F52; MARCKS-like protein
                     1; macrophage myristoylated alanine-rich C kinase
                     substrate"
                     /codon_start=1
                     /product="MARCKS-related protein"
                     /protein_id="NP_034937.1"
                     /db_xref="CCDS:CCDS18695.1"
                     /db_xref="GeneID:17357"
                     /db_xref="MGI:MGI:97143"
                     /translation="MGSQSSKAPRGDVTAEEAAGASPAKANGQENGHVRSNGDLTPKG
                     EGESPPVNGTDEAAGATGDAIEPAPPSQEAEAKGEVAPKETPKKKKKFSFKKPFKLSG
                     LSFKRNRKEGGGDSSASSPTEEEQEQGEMSACSDEGTAQEGKAAATPESQEPQAKGAE
                     ASAASKEGDTEEEAGPQAAEPSTPSGPESGPTPASAEQNE"
     exon            337..1601
                     /gene="Marcksl1"
                     /gene_synonym="D4Bc1; F52; MacMARCKS; Macs2; Macs3; Mlp;
                     Mrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1577..1582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marcksl1"
                     /gene_synonym="D4Bc1; F52; MacMARCKS; Macs2; Macs3; Mlp;
                     Mrp"
                     /note="hexamer: AATAAA"
     polyA_site      1595
                     /gene="Marcksl1"
                     /gene_synonym="D4Bc1; F52; MacMARCKS; Macs2; Macs3; Mlp;
                     Mrp"
                     /note="major polyA site"
ORIGIN      
        1 cgccccgagc ctcgggcgcg tacatatagg cggctcggcg ggcggcgggc ggcattctgg
       61 cgcggagcgc agcagcagtg ggcgcagcta gcgggtcggc tgcggagcgg gggtgcagtg
      121 cgctttgccc cccgtacccc tccccctcgg acgcagcccc acccctctgc ccgccgggcc
      181 gtcccagccg aactatcccc tgcggcgcca gcgcggggcg gctccgggcg cccccagcag
      241 acccccatca tgggcagcca gagctctaag gctccccggg gcgacgtgac cgccgaggag
      301 gcagcgggcg cttcccccgc gaaggccaac ggacaggaga atggccacgt gagaagcaat
      361 ggagacttaa cccccaaggg tgaaggggag tcaccacccg tgaacggaac agatgaggca
      421 gctggggcta ctggtgatgc catcgagcca gcgcccccta gccaggaagc tgaggccaag
      481 ggggaggtcg cccccaagga gacccccaag aagaagaaga aattctcttt caagaagcct
      541 ttcaaattga gtggcctgtc cttcaagaga aatcggaagg agggtggggg tgattcctca
      601 gcctcctcgc caacagagga agagcaggag cagggcgaga tgagcgcctg cagcgacgag
      661 ggcactgccc aagaagggaa ggccgctgcc acccctgaga gccaagagcc ccaggccaag
      721 ggggcagagg ctagtgctgc ctccaaggaa ggagacacag aagaggaggc agggccccag
      781 gctgcagagc catccactcc ctcgggccca gagagtggcc ccacacctgc cagtgctgag
      841 cagaatgagt aggggtgggg acaggtgggt gatctctaag ctgcaaaaac tgtgctgtcc
      901 ttgtgaggtc actgcctgga ccttgtgccc tggctgcctt cctgtgccca gaaaggaagg
      961 ggcttgttgc cccctcccag ccacgctccc ttttcgccct cctgtggatt ctcccatcag
     1021 ccatttggtc ttactcttaa ggccagttga agatggtccc ttacggtttc ccaagttagg
     1081 ttagtgatgt gagatgccct gtccctacct ctttcccgag ccccatccct gcagaaggca
     1141 attgctgggt ttccaattct tttccaagtt cgttttgttt atcctgcttc tcaaccccct
     1201 gagccagaag tgggggctta tactcccaaa ccctgagtgt ccagcctttc ccctgttgaa
     1261 ttcttagtct cttgtgctgt gcctagtggc acctgggctg gggaggacat tgccccatct
     1321 gggtttttat aaatgtctta ctcaagttca aacctccagc ttgtgaaatc aaccatgtct
     1381 ctgacttgat aagcaagtgt taggcttcag gagggaggga ggtctgtaat gtgaaacaac
     1441 ttcttgttgt cttttttttt ccccctccca ttgttgtaaa taacttttaa tggccaaacc
     1501 ccagatttgt actttttttt tttctaactg ctaaaaccat tcttccaccc ggatttactg
     1561 taacatttgg aaaaggaata aatgtcgtcc ctttagtgat gaaaaaaaaa a
//
