LOCUS       NM_001418488            3676 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus membrane associated ring-CH-type finger 7 (Marchf7),
            transcript variant 2, mRNA.
ACCESSION   NM_001418488 XM_036162426
VERSION     NM_001418488.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3676)
  AUTHORS   Thompson,L.H., Whiston,R.A., Rakhimov,Y., Taccioli,C., Liu,C.G.,
            Croce,C. and Metcalfe,S.M.
  TITLE     A LIF/Nanog axis is revealed in T lymphocytes that lack MARCH-7, a
            RINGv E3 ligase that regulates the LIF-receptor
  JOURNAL   Cell Cycle 9 (20), 4213-4221 (2010)
   PUBMED   20962578
  REMARK    GeneRIF: Data demonstrate that T cells retain responsiveness to a
            LIF/Nanog axis and that this axis is linked to MARCH-7, a RINGv E3
            ligase that regulates the LIF-receptor.
REFERENCE   2  (bases 1 to 3676)
  AUTHORS   Mollah,M.B. and Ishikawa,A.
  TITLE     A wild derived quantitative trait locus on mouse chromosome 2
            prevents obesity
  JOURNAL   BMC Genet 11, 84 (2010)
   PUBMED   20860848
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3676)
  AUTHORS   Nathan,J.A., Sengupta,S., Wood,S.A., Admon,A., Markson,G.,
            Sanderson,C. and Lehner,P.J.
  TITLE     The ubiquitin E3 ligase MARCH7 is differentially regulated by the
            deubiquitylating enzymes USP7 and USP9X
  JOURNAL   Traffic 9 (7), 1130-1145 (2008)
   PUBMED   18410486
REFERENCE   4  (bases 1 to 3676)
  AUTHORS   Muthukumarana,P.A., Lyons,G.E., Miura,Y., Thompson,L.H., Watson,T.,
            Green,C.J., Shurey,S., Hess,A.D., Rosengard,B.R. and Metcalfe,S.M.
  TITLE     Evidence for functional inter-relationships between FOXP3,
            leukaemia inhibitory factor, and axotrophin/MARCH-7 in
            transplantation tolerance
  JOURNAL   Int Immunopharmacol 6 (13-14), 1993-2001 (2006)
   PUBMED   17161353
  REMARK    GeneRIF: Data suggest that thymic Foxp3+T cell development is
            influenced by axotrophin.
REFERENCE   5  (bases 1 to 3676)
  AUTHORS   Chen,H.W., Chen,J.J., Yu,S.L., Li,H.N., Yang,P.C., Su,C.M.,
            Au,H.K., Chang,C.W., Chien,L.W., Chen,C.S. and Tzeng,C.R.
  TITLE     Transcriptome analysis in blastocyst hatching by cDNA microarray
  JOURNAL   Hum Reprod 20 (9), 2492-2501 (2005)
   PUBMED   15919778
REFERENCE   6  (bases 1 to 3676)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   7  (bases 1 to 3676)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
REFERENCE   8  (bases 1 to 3676)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3676)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 3676)
  AUTHORS   Baker,R.K., Haendel,M.A., Swanson,B.J., Shambaugh,J.C.,
            Micales,B.K. and Lyons,G.E.
  TITLE     In vitro preselection of gene-trapped embryonic stem cell clones
            for characterizing novel developmentally regulated genes in the
            mouse
  JOURNAL   Dev Biol 185 (2), 201-214 (1997)
   PUBMED   9187083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935326.13.
            
            On Mar 21, 2023 this sequence version replaced XM_036162426.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.216867.1,
                                           SRR13862051.1765621.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AL935326.13        45043-45201
            160-260             AL935326.13        59887-59987
            261-425             AL935326.13        64035-64199
            426-621             AL935326.13        64801-64996
            622-789             AL935326.13        67317-67484
            790-1888            AL935326.13        69016-70114
            1889-2061           AL935326.13        71871-72043
            2062-2171           AL935326.13        76060-76169
            2172-2285           AL935326.13        78674-78787
            2286-2334           AL935326.13        80329-80377
            2335-2359           AL935326.13        82605-82629
            2360-3676           AL935326.13        83007-84323
FEATURES             Location/Qualifiers
     source          1..3676
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 34.46 cM"
     gene            1..3676
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /note="membrane associated ring-CH-type finger 7"
                     /db_xref="GeneID:57438"
                     /db_xref="MGI:MGI:1931053"
     exon            1..159
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            160..260
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            261..425
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..2372
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 2;
                     axotrophin; E3 ubiquitin-protein ligase MARCH7; MARCH-VII;
                     membrane-associated RING-CH protein VII;
                     membrane-associated RING finger protein 7;
                     membrane-associated ring finger (C3HC4) 7; gene trap ROSA
                     b-geo 17; RING-type E3 ubiquitin transferase MARCH7;
                     RING-type E3 ubiquitin transferase MARCHF7; E3
                     ubiquitin-protein ligase MARCHF7"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF7 isoform a"
                     /protein_id="NP_001405417.1"
                     /db_xref="GeneID:57438"
                     /db_xref="MGI:MGI:1931053"
                     /translation="MESKPSRIPRRISVQPSGSLSTRMVSGNRGTSLNDSYHSRDSSF
                     RLDSEYQSASASACASPCQPAWYSESEIPQGARARAQTQQRDHDSKRPKLSCTNCAST
                     SAGRNGGSGLNTVSDSSWRHSQVPRSSSMVLGSFGTDLMRERRDLDRRRESSISNLMD
                     YNHRSGDFTTSSYVQERVPSSYSQGARPKENAVSTLQLNSSSTNHQLPSDHQTVPSSR
                     DSSRSSFRSHFSPRQSESFRNSSHPAFSYFSSRNETPTISNSERGSSQRPYRESSDNE
                     GRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLSSENYISPRTLTSQSRNNGTSSS
                     SDVSEGRAAEASQGFRFLRRRWGLSSLSQNHSSEPEAENFNQESEGRNSGPWLSSSLR
                     NRCTPLFSRRRREGRDESSRMSTSDVPPRSHIFRRDSNEVVHLEAQGDSLGAAANRPQ
                     ASGASSSAAAGGSTPELPQGGRNPGLTGILPGSLFRFAVPPALGSNLADNVMITVDII
                     PSGWNSTDGKNDKAKSAPSRDPEKLQKIKESLLLEDSDDEEEGDLCRICQMAAASSSN
                     LLIEPCKCTGSLQYVHQECMKKWLQAKINSGSSLEAVTTCELCKEKLQLNLEDFDIHE
                     LHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTIEPSTRVRFINLARTLQAH
                     MEDLETVISQILLSFRG"
     exon            426..621
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            622..789
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1888
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2061
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2171
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2285
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2334
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2359
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..3676
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3653..3658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /note="hexamer: AATAAA"
     polyA_site      3676
                     /gene="Marchf7"
                     /gene_synonym="Axo; Axot; Gtrgeo17; March7"
                     /note="major polyA site"
ORIGIN      
        1 acttctgcgg cgcatccgga ggggcggccg ccattgtgct tcgtcgccga cttctctgcc
       61 ggtagcccga gagccgagcc gagcccagcg aggaaggcgg cggcggtgtg gctgcggcga
      121 gcgcgacact ccctgcagcg gagtgctcgg tggaagaggg tcagggctgc atcatttatt
      181 ggattggtgt ttttgataaa cctatatgct tggtgtttct gatatgattt gatatgttca
      241 tgtatccctg atttattttg gaaaccttaa gaatggagtc taaaccttcc aggattccaa
      301 gaagaatttc tgttcaaccc tctggctctt taagcactag gatggtgtct ggaaacagag
      361 gaaccagttt aaatgattca tatcattcta gagactcctc ctttagactg gattctgaat
      421 atcagtctgc atcagcatca gcgtgtgcat caccatgtca gcctgcctgg tacagtgagt
      481 ctgagatacc tcagggagcg cgggcacgag cacagaccca gcagcgggat catgactcaa
      541 agagacccaa gctttcctgt acaaactgtg catctacctc agctgggagg aacggtggga
      601 gtgggttaaa tacagtgtca gattcttctt ggaggcatag tcaagttccc agatcttcat
      661 caatggtact tggttcattt ggaacagact tgatgagaga aaggagagat ttggacagga
      721 gaagagagtc ctccatcagc aatcttatgg attataatca ccgaagtggt gatttcacaa
      781 cttcatcata tgttcaagaa agagttcctt cttcatattc acagggagca agaccaaaag
      841 agaatgcagt gagcacttta cagttgaatt catcatccac caatcaccaa ttgccttctg
      901 accatcagac agtaccaagt tctagggact ccagtagaag ttctttcaga tcacattttt
      961 ctccaagaca atcagaatct tttcgcaaca gttcacatcc tgcattttca tatttttcaa
     1021 gtagaaatga aactccaact ataagcaatt cagaaagggg ttcatctcag agaccatatc
     1081 gagaatcttc tgacaatgaa ggtaggcgta caactaggag attgctgtca cggatagctt
     1141 ctagcatgtc atctactttt ttctcacgaa gatctagtca agattccttg aatacaagat
     1201 ctttgagttc tgaaaattat atttctccga gaaccctgac ttcacagtct cggaataatg
     1261 gaacctcctc gtcctctgac gtcagtgagg gcagggcagc tgaagcatct cagggattta
     1321 gatttcttag gcgaagatgg gggttgtcgt cgctcagcca aaatcatagc tctgaaccag
     1381 aggcagaaaa ttttaaccaa gaatcagaag gtagaaattc aggaccatgg ttgtcttctt
     1441 cacttagaaa tagatgcaca cctttgttct cgagaaggag gcgagaggga agggatgagt
     1501 cttcaagaat gtctacgtca gatgtaccac ctagatctca tattttcaga agagattcaa
     1561 atgaagtagt tcatcttgaa gcacagggtg actcccttgg ggctgctgcc aaccgaccac
     1621 aagcatctgg agcgtcaagc agtgctgctg caggtggctc caccccagag ttgcctcagg
     1681 gtggaagaaa tccaggacta acagggattc ttcctggctc cttgttccgg tttgcagtcc
     1741 caccagcact cggcagtaat ctggctgaca atgtcatgat tactgtagat attattcctt
     1801 ctggttggaa ttcaactgat gggaaaaatg ataaagctaa aagtgcacct tcaagagacc
     1861 cagaaaaact tcagaaaatc aaagaaagcc tccttttaga ggactctgat gatgaagaag
     1921 aaggggactt atgtagaatt tgtcagatgg cagcagcgtc atcatctaat ttattgatag
     1981 agccgtgcaa atgcacaggg agcctgcagt acgtccatca agagtgtatg aaaaagtggt
     2041 tacaagccaa aattaattct ggctcttcat tagaggctgt gactacctgt gaactctgta
     2101 aagagaagtt gcaacttaac ctggaggatt ttgatattca tgaactacat agagctcatg
     2161 caaatgaaca agctgagtat gagtttatca gctctggtct ctacctagtt gtcttactgc
     2221 acttgtgtga acaaagcttt tctgatatga tgggaaatac aattgaacca agcactcgtg
     2281 tccgatttat taaccttgca agaactcttc aggcacatat ggaagatctc gaaacggtaa
     2341 taagccagat tctactcagc ttcagaggat gaattctgaa gaagatggag accataagag
     2401 aatgcttgat attgcctaac ttcatttaag aaaaaaaaaa aaaggatgat ctgtgaacat
     2461 gtttattaaa actggcaatt aagtatggat aatttcatgg ggtaatgcct agtagattaa
     2521 ttgactatac ataaaatgaa tatatatata tacatgtata aatgtaaata tatattcatt
     2581 ctcaagtatt gctgaactga aattcttgag ctggaccctt taacactggc cagcgaatct
     2641 catgtttata atatgtaatc caagcatttt tccttttggt gagtgggaaa gcattaccct
     2701 tgtttgaaat atctaaacag tgctcatcaa ctttcttctt tgttgcaatt actgtagtca
     2761 tatttatggg aaaaaaatgt ttgtgtatta gtctcttgct agtgaaaaaa agtcagataa
     2821 aatgtccttt tgaaataaaa tgccaatggc acctaattag tttttcctct ttaaatgcct
     2881 taagttacag ccacattttg ataatcattt acttccagtg tttaaaattt ttttaaaaga
     2941 atgggaagtt tgaagagcat tattgtatta ggtttccaaa tttaatttga attctaaatc
     3001 cacttagcaa taaaacctaa tttttaagga aaaaaagtat gtaaaagatg tagtaatgat
     3061 ggataacttt tgtattgatt tgcaaaaaat gcagattata tttgataggc catggtatgt
     3121 aggtattcct ttcaggaata ttacagctgt aaattatatc agaattgcca gtcaaatgat
     3181 acttggttaa aaattactga aaatctcaag ttaacagaat atttttttaa aacccacatt
     3241 caaagtttaa aacactggtt ttcaatgtgt ttttagtatt gtcacttctt tatagagaaa
     3301 tataatataa ataacctatt tggatcctgg tcatttttag gtgttccttg ataattctga
     3361 gcatttattt gatgattgtt aatatttttc actacctttg caaaacagat aaattactta
     3421 ttcaacatta atgagtttgc actatggtct tgagctgtgt aaacttgcgt aatgatttcc
     3481 actgtcagca cccttaggat atatattaca atttcgggtg gtttcagatt agtccaatgt
     3541 tgtggcaaca actcactttc aaaacctaaa tagaaaccat gtacgttgtc aaatgtgaat
     3601 ggacagtttg cctacattta gtttgttggt gttaatgtaa aacctggctt gaaataaagt
     3661 gatactgatt gattta
//
