LOCUS       NM_001402879            6240 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus membrane associated ring-CH-type finger 6 (Marchf6),
            transcript variant 2, mRNA.
ACCESSION   NM_001402879 XM_011245351
VERSION     NM_001402879.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6240)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6240)
  AUTHORS   Mun,S.H., Lee,C.S., Kim,H.J., Kim,J., Lee,H., Yang,J., Im,S.H.,
            Kim,J.H., Seong,J.K. and Hwang,C.S.
  TITLE     Marchf6 E3 ubiquitin ligase critically regulates endoplasmic
            reticulum stress, ferroptosis, and metabolic homeostasis in POMC
            neurons
  JOURNAL   Cell Rep 42 (7), 112746 (2023)
   PUBMED   37421621
  REMARK    GeneRIF: Marchf6 E3 ubiquitin ligase critically regulates
            endoplasmic reticulum stress, ferroptosis, and metabolic
            homeostasis in POMC neurons.
REFERENCE   3  (bases 1 to 6240)
  AUTHORS   Nguyen,K.T., Mun,S.H., Yang,J., Lee,J., Seok,O.H., Kim,E., Kim,D.,
            An,S.Y., Seo,D.Y., Suh,J.Y., Lee,Y. and Hwang,C.S.
  TITLE     The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the
            regulation of ferroptosis
  JOURNAL   Nat Cell Biol 24 (8), 1239-1251 (2022)
   PUBMED   35941365
  REMARK    GeneRIF: The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor
            for the regulation of ferroptosis.
REFERENCE   4  (bases 1 to 6240)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6240)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   6  (bases 1 to 6240)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115735.8.
            
            On Mar 23, 2022 this sequence version replaced XM_011245351.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.17429.1,
                                           SRR10223969.16026.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               AC115735.8         11033-11256
            225-321             AC115735.8         32237-32333
            322-395             AC115735.8         36301-36374
            396-539             AC115735.8         39196-39339
            540-612             AC115735.8         41071-41143
            613-781             AC115735.8         43317-43485
            782-971             AC115735.8         45866-46055
            972-1033            AC115735.8         47927-47988
            1034-1066           AC115735.8         49288-49320
            1067-1118           AC115735.8         51432-51483
            1119-1177           AC115735.8         53209-53267
            1178-1258           AC115735.8         55624-55704
            1259-1327           AC115735.8         55909-55977
            1328-1402           AC115735.8         56061-56135
            1403-1537           AC115735.8         56979-57113
            1538-1657           AC115735.8         59136-59255
            1658-1758           AC115735.8         59461-59561
            1759-1896           AC115735.8         61637-61774
            1897-2098           AC115735.8         63563-63764
            2099-2168           AC115735.8         66244-66313
            2169-2365           AC115735.8         70246-70442
            2366-2500           AC115735.8         72382-72516
            2501-2590           AC115735.8         74280-74369
            2591-2723           AC115735.8         76673-76805
            2724-2859           AC115735.8         79982-80117
            2860-6240           AC115735.8         82780-86160
FEATURES             Location/Qualifiers
     source          1..6240
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 12.95 cM"
     gene            1..6240
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /note="membrane associated ring-CH-type finger 6"
                     /db_xref="GeneID:223455"
                     /db_xref="MGI:MGI:2442773"
     exon            1..224
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2950
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2; E3
                     ubiquitin-protein ligase MARCH6; membrane-associated ring
                     finger (C3HC4) 6; MARCH-VI; membrane-associated RING-CH
                     protein VI; membrane-associated RING finger protein 6;
                     RING-type E3 ubiquitin transferase MARCH6; RING-type E3
                     ubiquitin transferase MARCHF6; E3 ubiquitin-protein ligase
                     MARCHF6"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF6 isoform 2"
                     /protein_id="NP_001389808.1"
                     /db_xref="GeneID:223455"
                     /db_xref="MGI:MGI:2442773"
                     /translation="MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWL
                     KHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFA
                     WLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISL
                     VWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPVGGNGAENPAADQPANPAGENAVL
                     GENPDAQDGQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNALEWDRAAEELTWER
                     MLGLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLI
                     TTIVGYILLAITLIICHALATLVKFHRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGW
                     WLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLLREVLRPGV
                     LWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRIIKSLLPN
                     FLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGYLLDL
                     HSYLLGDQEENENSANQQVNNNQPARNNNAVPAGEGLHAAHQAILQQGGPVGFQPYRR
                     PLNFPLRIFLLIVFMCITLLIASLICLTLPAFLFSVFAGRWLMSFWTGTAKIHELYTA
                     ACGLYVCWLTIRAVTVLVAWMPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGVVPLLLG
                     LLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYA
                     NGIRNIDLHYIIRKLAAPVISVLLLSLCVPYVIASGAVPLLGVTAEMQNLVHRRIYPF
                     LLMVVVLMGILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGPSTPPPVSSQE
                     "
     exon            225..321
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            322..395
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            396..539
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            540..612
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            613..781
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            782..971
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1033
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1066
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1118
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1177
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1258
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1327
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1402
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1537
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1657
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1758
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1896
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2098
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2168
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2365
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2500
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2590
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2723
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2859
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..6240
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3194..3199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /note="hexamer: ATTAAA"
     polyA_site      3224
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /note="major polyA site"
     regulatory      3242..3247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /note="hexamer: ATTAAA"
     polyA_site      3263
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
     regulatory      5432..5437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /note="hexamer: ATTAAA"
     polyA_site      5454
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
ORIGIN      
        1 ggcgctcgct ttctgtcagt cgctgtccct gtccccctcg cccgcgaccg gcttcctctc
       61 gcacccgagc gcacgcactt gcccggcccg cgtcctcttc ctcctccact cctcccgccc
      121 gcccgcccgc ctttcccttc gggccccgag gctctgccgg gtcgcgggcg cctcgcggct
      181 gcgtcaccgc cgccccccag acaagatgga caccgccgag gaagatatat gtagagtgtg
      241 tcggtcagaa ggaacacctg agaaacctct ttatcatcct tgtgtatgta ctggcagtat
      301 taaatttatt catcaagaat gcttagttca gtggttgaaa catagtcgga aagaatactg
      361 tgaattatgc aagcacagat ttgctttcac accaatttat tctccagata tgccttcacg
      421 gctaccaatc caagacatat ttgctggact ggttacaagt attggcactg caatacgata
      481 ctggtttcat tacacacttg tggcctttgc atggctggga gttgttcctc ttacagcatg
      541 ccgcatctac aagtgcttgt ttactggctc cgtgagctca ctactgacac tgccactaga
      601 catgctgtca acggaaaatt tgttggcgga ttgcttgcag ggctgttttg tggtgacgtg
      661 cacactttgt gcgttcatca gcctggtgtg gttacgagag cagatagtcc acgggggagc
      721 cccaatttgg ctggagcatg ctgctccacc cttcaatgct gctggacacc accaaaatga
      781 ggctcctgta ggaggaaatg gtgcagaaaa ccctgctgct gatcagccag ctaacccagc
      841 aggtgagaat gcagttctgg gtgaaaaccc tgatgcccag gacggtcaag cagaagagga
      901 agaggaggac aatgaggagg aagatgatgc gggtgtagaa gatgctgctg atgccaacaa
      961 tggagcccaa gacgacatga actggaatgc tttagagtgg gaccgggctg cagaagagct
     1021 tacttgggaa agaatgcttg gacttgatgg atcactagtt ttcctggaac acgtgttctg
     1081 ggtggtgtct ttaaatacat tgttcattct tgtttttgca ttttgtcctt accacatcgg
     1141 ccatttctcc cttgttggct tggggtttga ggagcatgtc caagcatctc attttgaagg
     1201 tctaatcaca acgattgttg gatatatact tttagcaata acactgataa tttgtcatgc
     1261 attggcaact cttgttaaat ttcataggtc tcgtcgcttg ctgggcgtct gctatattgt
     1321 ggttaaggtc tctttgttag ttgtggtaga aatcggagtg ttccctctca tttgtggctg
     1381 gtggctggat atctgttctc tggaaatgtt tgatgctact ctgaaagatc gagagctgag
     1441 ctttcagtca gctccaggga ccacgatgtt tctgcactgg ttggtgggaa tggtgtatgt
     1501 gttctacttt gcctccttca tcctgttact gagagaggta cttcgacctg gtgtcttatg
     1561 gtttctgagg aatttgaacg atccagattt taatccagta caggaaatga ttcacttgcc
     1621 catttataga catctccgaa gatttatttt gtcagtgatt gtctttggct ccattgtcct
     1681 tctgatgctc tggcttccta tacgtataat taagagtctc ttgcctaatt ttcttcctta
     1741 caatgtcatg ctctacagtg atgctccggt gagtgagctg tcccttgagc tgctcctact
     1801 gcaggttgtc ttgccagcat tgctggaaca gggacacacg aggcagtggc tgaaggggct
     1861 tgtgcgtgca tggactgtta ctgctggata cttgctggac cttcattcct acttactggg
     1921 agatcaggaa gaaaacgaga acagtgcaaa tcagcaggtc aacaataacc agcctgcacg
     1981 aaacaataat gctgttcctg ccggggaagg tctgcatgca gcccaccaag ccatactcca
     2041 gcagggagga cctgttggct ttcagcctta ccgccggcct ttaaatttcc cactcaggat
     2101 atttctgctg attgtcttca tgtgcataac attgctaatt gccagcctca tttgccttac
     2161 tttaccagcc tttctatttt cagtatttgc tggccgttgg ttaatgtcat tttggacggg
     2221 gactgccaaa atccatgagc tgtacacagc tgcttgtggt ctctatgtgt gttggctaac
     2281 cataagggct gtgacggtgc tggtggcctg gatgccccag ggacgaagag tgattttcca
     2341 gaaggttaaa gagtggtccc tcatgataat gaagacgttg atagttgctg tgctgctggc
     2401 tggggtcgtc ccactgctcc tcgggctcct gtttgagctg gttattgttg ctcctctgag
     2461 ggtccctctt gatcagactc cccttttcta cccttggcag gactgggcgc tgggagtgct
     2521 gcatgccaaa attatcgcag ctataactct tatgggtcct cagtggtggt tgaaaactgt
     2581 cattgaacag gtttacgcaa atggcattcg taacatcgac cttcactata tcatccgtaa
     2641 gctggcagcc ccggtgatct ctgtgctctt actttccctg tgtgtaccgt atgtcatagc
     2701 ttctggcgcg gttcctctac taggtgttac tgcagagatg cagaacttag ttcaccggcg
     2761 gatttaccca tttttattga tggtcgttgt gctgatggga atcctgtcct tccaggtccg
     2821 ccagtttaag cgcctttatg aacacattaa aaatgacaag taccttgtgg ggcagcgcct
     2881 ggtgaactat gagcgcaaat ccggcaagca aggcccgtct acaccgcctc cggtgtcgtc
     2941 ccaagaataa agtgcttgtc tcagctcctt gagcttctcc ttgccttttc gtgtcctttg
     3001 ttgtggactt ctcacttgga gattctcctg tgatctcagc gttgtttaag ttaaatgtac
     3061 ttgacttgtc tcctcagcat tcagagagca gcgcatccgg cactactgct cctccctgca
     3121 tctgccgaca tcactgctgt cttgagatct gtacatgtgt aaataggagt tccttgatgc
     3181 cctaaaacct tggattaaac agaatgtgca ttgtacatct ttaacaaatg tatattaatt
     3241 tattaaatct agttgtcact ttattttgga cctgctgtga tctcgacagg aaatgtgcca
     3301 cagagcagta gtgtataggc gagactttga gtgacatctt ttggagcaca gtgcatggtg
     3361 ttgccagcag ttctcaccag gtaactgcat cctgtccttg gctggtcagt ccttccttac
     3421 caggagccga atgggcagtg gagcctgtgg taggggactg gacggagtgc ctcacagaca
     3481 gtcgtatttg gaaattatta catgtaacac caaagctgtt gtacattttc tactgcctga
     3541 ttgttttcat gtgtctgtgt ttgtaatatt gtatagtata ttgtgctaga tgaggaaatt
     3601 atttttaatt ttgataattt aatattccta gtgatcagca ttgggagttg gggtttttgt
     3661 gcttgttagg ggcatgtcta tacttagaaa gataaactac aaatgaagat ttttttattg
     3721 acctcctccc cttccataca gctctttctt tttgtcaaca gtggccaaaa gtgtcatgcc
     3781 ggatgagaaa tctaagggga tgtcatcacc aacaggacca gtagtgacag gtcaaggccc
     3841 taggccgtgg aatgaggccg actgcatcag ggacgatgag tagaacatcc tgccgtgctg
     3901 gcagcacatt gcagctgagg ctcagttaat ataccaggaa acccctgttc ctaaggcatg
     3961 gtgtttacag taaaccgcaa ataaaaccaa gttttatttg tttgaaagga agcagactga
     4021 gttggccttc gccataggaa agagttgcat tggagaaatg ctgtgagatt ttagagaatt
     4081 taatactcag aggaagcctg gttcccctag cccaagcttc atgtttaaag tttaaaagat
     4141 taggatggtt gtacgtcatt caagtgttta atggtaaagg tgtattataa ggatagtgct
     4201 agaagctttc atagactgta aagagttcca tggagtatta aacccatagt tggaaaggtc
     4261 tgagggccca cccccacctc taaatacaaa gccaaacaaa agattaagag caatgctttc
     4321 tggttttgtt cctttcttga ttttgtcttt ttgtcgttct taaattcact aagtaataag
     4381 caaatacttt gttttaaagc agcattatat ttaaaaaaca aaaacagtct tgccatggat
     4441 ccagtgttaa cactgtcatt ttgtaacagc ctttctctcc tgtagcaagc ctaccttcac
     4501 tctcagactt tgtccttcca taaagaatta gcattttaaa atgcagtgcc acctgtcaat
     4561 gggaatatgt ctataaagcc taatcttttg atgctggtat attggacata taacattcag
     4621 gtttcatttt taatttttaa acaatttatg gatctaccac aaaaagctaa gcattctcag
     4681 tcatctggaa ttgtaagtga gcttactgga tgcttttctg agaacaacca caaacagcgc
     4741 cgattgccaa ggtgggcccc atctcactgg cagggcctgc tctcctgtgt gctttgtcca
     4801 gtggctttca ggaagatgat gtcctcgtgg ggatttattg tgcataacat ttgctagggt
     4861 gacatacagg ttttattcaa caatatcata aacatttaaa accctcaatt cagaaggtgt
     4921 tcctatttgc tgccggtctt tacaggaaat ttatagagat gtgcatcatt ttgaattagg
     4981 ctaacaccca gtcttcaagg gagtttacta ggaaagacct ttgtgcttta ttattgataa
     5041 tttgaagaca aatcaccact tgggattagt tttacatgac cagttatcag atggtcactt
     5101 cgaaatgtat agttgttcat tattaacaaa ttatggtttg atttttaaac tacaaagtac
     5161 taatagttta gatgaaaact gaagaaaatg ccaatgtaaa atttgtgtgt agctagcctt
     5221 aatgttccat gtttatagtt gtggttccag cccccactcc cgttctccgg gggtagggta
     5281 gggagataag acatgtattg aacagtaatt tttgttttaa cagtcagtat agctgttatt
     5341 actgtgaatt ctcaagatgg tccctcccct caagggacaa tcctcctatg agtttatcag
     5401 acatgtcgct tctgtgtcgc acaaatgctt tattaaagta tattcctaaa ttcaggttga
     5461 gttgatgaat ttttaagaca aacacaaaat acgcattgga catttgtacc ctgttgtgtt
     5521 tgcagacaca ggagccagtg ccattatgca agaacttggc acttggcacg gtgctccaaa
     5581 ttagttcctt cctctcctct ctggggtgga gaatatcagg ctagttactg tgatgcctca
     5641 ttttacattg tgatgctcaa agttcttgtt taaaacaatc ctctaggatc gtaactgttc
     5701 agtcattatc aaggggagag atgacatagt accactgaag tgttactaga gacctcatct
     5761 gtgaagggtc tttaaattct ttgcttaaat tgccctgtag cggggcactt aatttgccct
     5821 gtcaatcaga tgttttgttt cagcttattg ctgttgttgt caaagattta aaacagctgt
     5881 cgtgagtaag ggcttcttca gatactctcc aataatagct ttggcattaa tataaaaata
     5941 agacagtata catgtgtatg tatgtctcca ttcctgtcta tctgtctgag tgcctcattt
     6001 tgtaatcatg acaatcctat agaaccttag atggaaatga gtgactaagg cctaggggtg
     6061 tctgtttagg agtgaattag aacacttagt gatgtgggag gtcggttttc tattacagta
     6121 aacacctgta cccagatcaa ttttatgtgt atatattcaa aaatgctccc ttttttatgt
     6181 ggtcatttgt tgccttccga gttaagagaa cagaattgaa taaagtgaat gttagttgta
//
