LOCUS       NP_001389808             914 aa            linear   ROD 01-MAY-2025
DEFINITION  E3 ubiquitin-protein ligase MARCHF6 isoform 2 [Mus musculus].
ACCESSION   NP_001389808 XP_011243653
VERSION     NP_001389808.1
DBSOURCE    REFSEQ: accession NM_001402879.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 914)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 914)
  AUTHORS   Mun,S.H., Lee,C.S., Kim,H.J., Kim,J., Lee,H., Yang,J., Im,S.H.,
            Kim,J.H., Seong,J.K. and Hwang,C.S.
  TITLE     Marchf6 E3 ubiquitin ligase critically regulates endoplasmic
            reticulum stress, ferroptosis, and metabolic homeostasis in POMC
            neurons
  JOURNAL   Cell Rep 42 (7), 112746 (2023)
   PUBMED   37421621
  REMARK    GeneRIF: Marchf6 E3 ubiquitin ligase critically regulates
            endoplasmic reticulum stress, ferroptosis, and metabolic
            homeostasis in POMC neurons.
REFERENCE   3  (residues 1 to 914)
  AUTHORS   Nguyen,K.T., Mun,S.H., Yang,J., Lee,J., Seok,O.H., Kim,E., Kim,D.,
            An,S.Y., Seo,D.Y., Suh,J.Y., Lee,Y. and Hwang,C.S.
  TITLE     The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the
            regulation of ferroptosis
  JOURNAL   Nat Cell Biol 24 (8), 1239-1251 (2022)
   PUBMED   35941365
  REMARK    GeneRIF: The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor
            for the regulation of ferroptosis.
REFERENCE   4  (residues 1 to 914)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 914)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   6  (residues 1 to 914)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115735.8.
            
            On Mar 23, 2022 this sequence version replaced XP_011243653.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.17429.1,
                                           SRR10223969.16026.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..914
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 12.95 cM"
     Protein         1..914
                     /product="E3 ubiquitin-protein ligase MARCHF6 isoform 2"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase MARCH6;
                     membrane-associated ring finger (C3HC4) 6; MARCH-VI;
                     membrane-associated RING-CH protein VI;
                     membrane-associated RING finger protein 6; RING-type E3
                     ubiquitin transferase MARCH6; RING-type E3 ubiquitin
                     transferase MARCHF6; E3 ubiquitin-protein ligase MARCHF6"
                     /calculated_mol_wt=102708
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:O60337; propagated from
                     UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Region          8..57
                     /region_name="RING_CH-C4HC3_MARCH6"
                     /note="RING-CH finger, H2 subclass (C4HC3-type), found in
                     membrane-associated RING-CH6 (MARCH6); cd16702"
                     /db_xref="CDD:438362"
     Site            92..112
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Site            143..163
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Region          186..256
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Site            284..304
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Site            337..357
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Site            377..397
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Site            422..442
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Site            481..501
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Site            520..540
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Site            632..652
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Site            683..703
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Site            726..746
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Site            769..789
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Site            820..840
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     Site            853..873
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQ89.2)"
     CDS             1..914
                     /gene="Marchf6"
                     /gene_synonym="3830408G03; F830029L24Rik; March6;
                     mKIAA0597"
                     /coded_by="NM_001402879.1:206..2950"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:223455"
                     /db_xref="MGI:MGI:2442773"
ORIGIN      
        1 mdtaeedicr vcrsegtpek plyhpcvctg sikfihqecl vqwlkhsrke ycelckhrfa
       61 ftpiyspdmp srlpiqdifa glvtsigtai rywfhytlva fawlgvvplt acriykclft
      121 gsvsslltlp ldmlstenll adclqgcfvv tctlcafisl vwlreqivhg gapiwlehaa
      181 ppfnaaghhq neapvggnga enpaadqpan pagenavlge npdaqdgqae eeeedneeed
      241 dagvedaada nngaqddmnw nalewdraae eltwermlgl dgslvflehv fwvvslntlf
      301 ilvfafcpyh ighfslvglg feehvqashf eglittivgy illaitliic halatlvkfh
      361 rsrrllgvcy ivvkvsllvv veigvfplic gwwldicsle mfdatlkdre lsfqsapgtt
      421 mflhwlvgmv yvfyfasfil llrevlrpgv lwflrnlndp dfnpvqemih lpiyrhlrrf
      481 ilsvivfgsi vllmlwlpir iiksllpnfl pynvmlysda pvselslell llqvvlpall
      541 eqghtrqwlk glvrawtvta gylldlhsyl lgdqeenens anqqvnnnqp arnnnavpag
      601 eglhaahqai lqqggpvgfq pyrrplnfpl rifllivfmc itlliaslic ltlpaflfsv
      661 fagrwlmsfw tgtakihely taacglyvcw ltiravtvlv awmpqgrrvi fqkvkewslm
      721 imktlivavl lagvvplllg llfelvivap lrvpldqtpl fypwqdwalg vlhakiiaai
      781 tlmgpqwwlk tvieqvyang irnidlhyii rklaapvisv lllslcvpyv iasgavpllg
      841 vtaemqnlvh rriypfllmv vvlmgilsfq vrqfkrlyeh ikndkylvgq rlvnyerksg
      901 kqgpstpppv ssqe
//
