LOCUS       NM_027314               4113 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus membrane associated ring-CH-type finger 5 (Marchf5),
            transcript variant 1, mRNA.
ACCESSION   NM_027314 XM_974595
VERSION     NM_027314.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4113)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4113)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4113)
  AUTHORS   Ma,W., Ahmad,S.A.I., Hashimoto,M., Khalilnezhad,A., Kataoka,M.,
            Arima,Y., Tanaka,Y., Yanagi,S., Umemoto,T. and Suda,T.
  TITLE     MITOL deficiency triggers hematopoietic stem cell apoptosis via ER
            stress response
  JOURNAL   EMBO J 43 (3), 339-361 (2024)
   PUBMED   38238476
  REMARK    GeneRIF: MITOL deficiency triggers hematopoietic stem cell
            apoptosis via ER stress response.
REFERENCE   4  (bases 1 to 4113)
  AUTHORS   Lu,L., Shao,Y., Xiong,X., Ma,J., Zhai,M., Lu,G., Jiang,L., Jin,P.,
            Tang,J., Yang,J., Liu,Y., Duan,W. and Liu,J.
  TITLE     Irisin improves diabetic cardiomyopathy-induced cardiac remodeling
            by regulating GSDMD-mediated pyroptosis through MITOL/STING
            signaling
  JOURNAL   Biomed Pharmacother 171, 116007 (2024)
   PUBMED   38171238
  REMARK    GeneRIF: Irisin improves diabetic cardiomyopathy-induced cardiac
            remodeling by regulating GSDMD-mediated pyroptosis through
            MITOL/STING signaling.
REFERENCE   5  (bases 1 to 4113)
  AUTHORS   Liu,R., Zeng,L.W., Li,H.F., Shi,J.G., Zhong,B., Shu,H.B. and Li,S.
  TITLE     PD-1 signaling negatively regulates the common cytokine receptor
            gamma chain via MARCH5-mediated ubiquitination and degradation to
            suppress anti-tumor immunity
  JOURNAL   Cell Res 33 (12), 923-939 (2023)
   PUBMED   37932447
  REMARK    GeneRIF: PD-1 signaling negatively regulates the common cytokine
            receptor gamma chain via MARCH5-mediated ubiquitination and
            degradation to suppress anti-tumor immunity.
REFERENCE   6  (bases 1 to 4113)
  AUTHORS   Park,Y.Y., Nguyen,O.T., Kang,H. and Cho,H.
  TITLE     MARCH5-mediated quality control on acetylated Mfn1 facilitates
            mitochondrial homeostasis and cell survival
  JOURNAL   Cell Death Dis 5 (4), e1172 (2014)
   PUBMED   24722297
  REMARK    GeneRIF: A fine balance of Mfn1 levels is maintained by
            MARCH5-mediated quality control on acetylated Mfn1.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4113)
  AUTHORS   Sugiura,A., Nagashima,S., Tokuyama,T., Amo,T., Matsuki,Y.,
            Ishido,S., Kudo,Y., McBride,H.M., Fukuda,T., Matsushita,N.,
            Inatome,R. and Yanagi,S.
  TITLE     MITOL regulates endoplasmic reticulum-mitochondria contacts via
            Mitofusin2
  JOURNAL   Mol Cell 51 (1), 20-34 (2013)
   PUBMED   23727017
REFERENCE   8  (bases 1 to 4113)
  AUTHORS   Yonashiro,R., Kimijima,Y., Shimura,T., Kawaguchi,K., Fukuda,T.,
            Inatome,R. and Yanagi,S.
  TITLE     Mitochondrial ubiquitin ligase MITOL blocks S-nitrosylated
            MAP1B-light chain 1-mediated mitochondrial dysfunction and neuronal
            cell death
  JOURNAL   Proc Natl Acad Sci U S A 109 (7), 2382-2387 (2012)
   PUBMED   22308378
REFERENCE   9  (bases 1 to 4113)
  AUTHORS   Shi,H.X., Liu,X., Wang,Q., Tang,P.P., Liu,X.Y., Shan,Y.F. and
            Wang,C.
  TITLE     Mitochondrial ubiquitin ligase MARCH5 promotes TLR7 signaling by
            attenuating TANK action
  JOURNAL   PLoS Pathog 7 (5), e1002057 (2011)
   PUBMED   21625535
  REMARK    GeneRIF: MARCH5 is an authentic E3 ubiquitin ligase and catalyzes
            K63-linked polyubiquitination of TANK. MARCH5 modulates TLR7
            signaling via releasing the inhibitory action of TANK toward TRAF6.
REFERENCE   10 (bases 1 to 4113)
  AUTHORS   Yonashiro,R., Sugiura,A., Miyachi,M., Fukuda,T., Matsushita,N.,
            Inatome,R., Ogata,Y., Suzuki,T., Dohmae,N. and Yanagi,S.
  TITLE     Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and
            attenuates mutant SOD1-induced reactive oxygen species generation
  JOURNAL   Mol Biol Cell 20 (21), 4524-4530 (2009)
   PUBMED   19741096
  REMARK    GeneRIF: Results indicate that MITOL plays a protective role
            against mitochondrial dysfunction caused by the mitochondrial
            accumulation of mSOD1 via the ubiquitin-proteasome pathway.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009364.1, BY070559.1, BC132455.1, AK003478.1, AC161238.7 and
            AK017741.1.
            
            On Aug 28, 2009 this sequence version replaced NM_027314.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009364.1, BC064752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AK009364.1         2-163
            163-170             BY070559.1         56-63
            171-236             AK009364.1         170-235
            237-1344            BC132455.1         1-1108
            1345-1807           AK003478.1         390-852
            1808-3311           AC161238.7         122504-124007       c
            3312-4108           AK017741.1         852-1648
            4109-4113           AC161238.7         121702-121706       c
FEATURES             Location/Qualifiers
     source          1..4113
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 32.2 cM"
     gene            1..4113
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
                     /note="membrane associated ring-CH-type finger 5"
                     /db_xref="GeneID:69104"
                     /db_xref="MGI:MGI:1915207"
     exon            1..360
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..1162
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; ring
                     finger protein 153; E3 ubiquitin-protein ligase MARCH5;
                     membrane-associated RING-CH protein V; membrane-associated
                     RING finger protein 5; RING-type E3 ubiquitin transferase
                     MARCH5; membrane-associated ring finger (C3HC4) 5;
                     RING-type E3 ubiquitin transferase MARCHF5; E3
                     ubiquitin-protein ligase MARCHF5"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF5 isoform 1"
                     /protein_id="NP_081590.3"
                     /db_xref="CCDS:CCDS29776.1"
                     /db_xref="GeneID:69104"
                     /db_xref="MGI:MGI:1915207"
                     /translation="MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQ
                     ACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAA
                     GIMVGSIYWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIR
                     WEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPT
                     IATIVGKLMFSSVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQE
                     EA"
     exon            361..563
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
                     /inference="alignment:Splign:2.1.0"
     exon            564..694
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
                     /inference="alignment:Splign:2.1.0"
     exon            695..878
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1045
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..4113
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1458..1463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
                     /note="hexamer: ATTAAA"
     polyA_site      1478
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
                     /note="major polyA site"
     regulatory      1629..1634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
                     /note="hexamer: AATAAA"
     polyA_site      1653
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
     regulatory      1770..1775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
                     /note="hexamer: ATTAAA"
     polyA_site      1795
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
     regulatory      4089..4094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
                     /note="hexamer: AATAAA"
     polyA_site      4113
                     /gene="Marchf5"
                     /gene_synonym="1810015H18Rik; 2310008I22Rik;
                     2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V;
                     March5; Marchv; MITOL; Rnf153"
ORIGIN      
        1 acagaggtag ctcctccgcc ggcagcagct cggcgccccg gcggtccatg gaccggaacc
       61 ctgggcggac cggcaggaac ccgggccgcg accgccgcct cccggcccca ggctcctcct
      121 cctcactccc cgccgccctc tgcggtcgcc cgccggccgc gcagcgccac cgcgggcctc
      181 tgggagccac gccgggaggc tgtgtggcgg gtccgcggcc gccgcgggac tgaggcctac
      241 tccgccgcct ctcagtgcta ttgtcccggg gcctggccct gagcggggct gcgggcgagg
      301 gccgagctcg ccggctccgc ggaagatgcc ggaccaagcc cttcaacaga tgctggacag
      361 aagttgctgg gtgtgctttg ccaccgatga agatgataga acagctgagt gggtgagacc
      421 atgcaggtgc agaggatcta ctaagtgggt tcaccaggct tgtctccagc gctgggtaga
      481 tgaaaagcaa agaggaaaca gcacagccag agtggcctgt cctcagtgca acgccgagta
      541 cttaatagtg tttccaaagc tgggtccagt ggtttatgtc ttggatcttg cagatagact
      601 gatctcaaaa gcttgccctt ttgctgcagc aggaataatg gttggatcta tctattggac
      661 agccgtgact tatggagcag tgacagtgat gcaggttgta ggccataaag aagggctgga
      721 tgttatggag cgagctgacc ctttatttct tttgattgga cttcctacta ttcctgtcat
      781 gctgatacta ggcaaaatga ttcgctggga ggactatgtg cttagactat ggcgcaaata
      841 ctcaaataaa ctacaaatct tgaacagtat atttccaggg attggttgtc ctgttcctcg
      901 aattccagct gaagctaacc ctttagcaga ccacgtctct gctaccagaa ttttgtgtgg
      961 agcccttgtc tttcctacta ttgcgacaat agttggtaaa ctgatgttca gtagtgttaa
     1021 ctcaaattta caaaggacaa tcttgggtgg aattgctttt gttgccataa aaggagcatt
     1081 taaggtttac ttcaaacagc agcaatattt acgtcaggca caccgcaaaa tcctaaatta
     1141 tccagagcaa gaagaagcat aaaactgact tctggttgtt ctgaggcctc tcatcctgac
     1201 gagtctgttg tgttctgatt ccatcattaa tgcgctagtg gagacttgtg acgctgctcc
     1261 tatattctaa gagatacaat aaagcacgca gggccggggc aagccgccca gtaatcacgg
     1321 acctaaggac acgcgtcagc tctgtcattt gtatgttcta cttttatggc agtcggctaa
     1381 accattattt tagcatggga aacctgagtt tgttcatatt tttccagaca agaatgtaaa
     1441 gataaaactg tacaaacatt aaaagtggac atgttttatt ctgacgcctc ttttgtatat
     1501 actcagttca gtgttttctt aggaatagca actcgatgaa ggaactgtga gggcttttct
     1561 cattggtgta attgattgta tgctacaaag gagcctctgt taacaggagg aagtgtaaac
     1621 tagttctgaa taaataacaa acccagaaat gtatgtcagc attgaagtga ttatctgaac
     1681 aaaagagatt ttgttttctt ttcctaaacc catgtgacat ctcagatgtg aagggtcagt
     1741 ttccagggct tccaaagcac tttttcacta ttaaacttta tttatgcaat gttgacatct
     1801 catagttcat agtgtacttt tgactcgtag tcgtcctgtg tgtgtggtgt gagggtgtgt
     1861 gtgtgagcgg ggaaggggac ttcagaaaga aggtaggagg gagggaagca gaggatagtg
     1921 atagggaaat gaggtggaag gcccttttat cacttagtat gtttttaaat ttgtatttct
     1981 acaaattaga actactgatt cataggttaa gcagagaaca acttgcaaaa aatgataata
     2041 aaattattgg gtttctgttg attccgttat tcagatattt gttaactggc tcccacttac
     2101 ctagtcactg tgcaggtgct atgggataga gttggggaac ttgttcagag agtctgcagt
     2161 ctaatagaac aagcactgat tgaacccaag ggagctcttg aatatcagtg aggtaattat
     2221 ggagtattga tcagggtcat tggtttccac tttatctgtt tataggatag ccaatactgt
     2281 ttttagggta tcttgttttt gaatcagggt ctctagcata gctaacctca gacttcctgt
     2341 gtatctgaag gtggccttga gctcctgatc cctgagcctc ctaactacag gtgagcacca
     2401 caacacctgc ttttctaact taatgctgtg gattgaacct agggccttac acatgctagg
     2461 tatacactac atcaccagcc ctccttttag attttagttg tcatattaag ggggcgatct
     2521 ccttactagt cattgtttaa ctagttttat attcattgtt caaaagcaat tatttaggtc
     2581 atgtttaata gtgaccatta caatgttcag caatctgatt agaatgaaaa atttttttta
     2641 aagatttatt tatttattat atgtaagtac actgtagctg tcttcagaca ctccagaaga
     2701 gggagtcaga tctcattatg ggtggttgtg agccaccatg tggttgctgg gatttgaact
     2761 ccggaccttc ggaagaacag tcgggtgctc ttacccgctg agccatctca ccagccccta
     2821 gaatgaaaat ttttaaagtt taaaaaataa tgctgttcac agtatatgat gcatgataat
     2881 gctccccctt tctgcgaaat ggatacttct ctttagaagt gtaacaaata tagattgagc
     2941 tgtgttagat tgtaaataaa tattttagta aagactggta tctttctcta ggttggttat
     3001 ctcagttttg agttttacgg tgtctgtggg aatgactctt ttgaacatcc agagttgtaa
     3061 ttatctaggg tataaggggc aatttgactg agttaacctt aacactgctg ttattctgta
     3121 gagaaaatgt gaaccctgat tatatataaa aataactaag atctacagct gtaattatga
     3181 aattggcttc catcattgcc agtgtgaaaa tatatatatt ctgacatttc ctggatactc
     3241 ctgttaagtt gagcagcttt tacacagcca caagccctca gctccctgtg tactacttta
     3301 atttccgggg tggtggtggg gggtggggag ctgcttggat cgatctattg gcatcaaggc
     3361 ccgtgaaggc agaggtttat agagctatgg ggagggagcc acacttgtct gcagtccaga
     3421 gtgaacacta gccctgctgc atttgaacac cacatgacag gcctccctgg aaccacaaat
     3481 caaaagacat gggcagactg aaagctgaat aggttacgtt gagctcccat caagttttag
     3541 tagctgtagt gtataacctt ggccaggtgg ctattcagcc acagttacgt tcatctctaa
     3601 aatgcaagtc acacctagac actttctagg atttggttga gaaaagacag gtactttcgg
     3661 cctcagtagc tcctaaaggt ggtcgtccca tctaggacag ggcagtaacc aagggtaggg
     3721 ccctcgagga cagagccagc acagacttga ggatttgtga gtatgctgtt ctccgatttt
     3781 ctttcttttt cttccttcct tccttccttc cttccttcct tccttccttc cttccttcct
     3841 ttctttttgt cctagaaatg tcacatttaa accttttttt aaaaaaatta gaattcagtg
     3901 attagtaaaa ttctattgta gaagttaact ccatctaagt tggctgaaaa tgttcattac
     3961 ttaccaaatg gttgaagaat atataattaa gtggcttcat tagtcactgc cttgctaatt
     4021 ttgctgtatt tttttttcta attccttgtt tttaatatag aaaactcaat actggctgaa
     4081 ataggttgaa taaacaattt ttatgctctc taa
//
