LOCUS       NM_001045533            4782 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus membrane associated ring-CH-type finger 4 (Marchf4),
            transcript variant 1, mRNA.
ACCESSION   NM_001045533 XM_619638 XM_910671 XM_991541
VERSION     NM_001045533.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4782)
  AUTHORS   Li,Q., Wang,H.Y., Chepelev,I., Zhu,Q., Wei,G., Zhao,K. and
            Wang,R.F.
  TITLE     Stage-dependent and locus-specific role of histone demethylase
            Jumonji D3 (JMJD3) in the embryonic stages of lung development
  JOURNAL   PLoS Genet 10 (7), e1004524 (2014)
   PUBMED   25079229
  REMARK    Erratum:[PLoS Genet. 2023 Mar 30;19(3):e1010701. doi:
            10.1371/journal.pgen.1010701.. PMID: 36996023]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4782)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163484.4 and AC114629.12.
            
            On Jan 29, 2019 this sequence version replaced NM_001045533.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098191.1, AK122502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2535              AC163484.4         153868-156402
            2536-2691           AC114629.12        110238-110393       c
            2692-2884           AC114629.12        104952-105144       c
            2885-4782           AC114629.12        84908-86805         c
FEATURES             Location/Qualifiers
     source          1..4782
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.54 cM"
     gene            1..4782
                     /gene="Marchf4"
                     /gene_synonym="MARCH-IV; March4; mKIAA1399"
                     /note="membrane associated ring-CH-type finger 4"
                     /db_xref="GeneID:381270"
                     /db_xref="MGI:MGI:2683550"
     exon            1..2535
                     /gene="Marchf4"
                     /gene_synonym="MARCH-IV; March4; mKIAA1399"
                     /inference="alignment:Splign:2.1.0"
     CDS             2023..3252
                     /gene="Marchf4"
                     /gene_synonym="MARCH-IV; March4; mKIAA1399"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; E3 ubiquitin-protein ligase MARCH4;
                     membrane-associated RING-CH protein IV;
                     membrane-associated RING finger protein 4; RING-type E3
                     ubiquitin transferase MARCH4; membrane-associated ring
                     finger (C3HC4) 4; RING-type E3 ubiquitin transferase
                     MARCHF4; E3 ubiquitin-protein ligase MARCHF4"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF4 isoform 1
                     precursor"
                     /protein_id="NP_001038998.1"
                     /db_xref="CCDS:CCDS15034.1"
                     /db_xref="GeneID:381270"
                     /db_xref="MGI:MGI:2683550"
                     /translation="MLMPLGGLLWWWCCCCGWYSCGLCTPAPQMLRHQGLLKCRCRML
                     FNDLKVFLLRRPPPAPLPMHGDPQLPGVAANNNTLPALGAGGWAGWRGPREAVGRETP
                     PLPPPPPLPPSGDDDWDGPATGPPASLLSSASSDEFCKEKTEDCYSLGSSLDSGMRTP
                     LCRICFQGPEQGELLSPCRCDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAIST
                     KNPLQWQAISLTVIEKVQIAAAILGSLFLIASISWLIWSTFSPSAKWQRQDLLFQICY
                     GMYGFMDVVCIGLIIHEGPSVYRIFKRWQAVNQQWKVLNYDKTKDLEDQKSGGRTNLQ
                     TSSSAQANLPSAEEEAASPPAREEGPTRAASHPSGPVSQHHCAYTILHILSHLRPHDQ
                     RSTQGSGRELVMRVTTV"
     exon            2536..2691
                     /gene="Marchf4"
                     /gene_synonym="MARCH-IV; March4; mKIAA1399"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2884
                     /gene="Marchf4"
                     /gene_synonym="MARCH-IV; March4; mKIAA1399"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..4782
                     /gene="Marchf4"
                     /gene_synonym="MARCH-IV; March4; mKIAA1399"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4761..4766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marchf4"
                     /gene_synonym="MARCH-IV; March4; mKIAA1399"
                     /note="hexamer: AATAAA"
     polyA_site      4782
                     /gene="Marchf4"
                     /gene_synonym="MARCH-IV; March4; mKIAA1399"
                     /note="major polyA site"
ORIGIN      
        1 actcacccag gtgctgaacg cagcagcggc ttcacggccg ctcgggtggg agtagctggg
       61 tgccttctcc gctctaagaa ggttgtttcc agtcctcgga ccgccagcct accgcccggc
      121 acctcccttc cagcaccacc cctttgggaa ctgagccagg ggggcagcag tcgcggcggc
      181 gggtgctgag caaccgcgga agacaacacc tggcagcagg ctagaatctg atttgtttcc
      241 ttttcggctt ttctaagaga tatatttata tacggttctg gggagtctcc aggaccaagc
      301 tggagccaag tgccgtctgt ctgaccatct cgaccacacc gtctctattc ctcctcccca
      361 ccttcagctt acaccgcaaa caagccttac ctcggtgcat ctgggagagg tagcaacagc
      421 aagcgagcct agccagccag aggcagccgg aggaaggagg ggcggcgtgg gggtgggagc
      481 aaagagcggg ccgaggccgc ccaaggtggg gggagcgggg gcagagctgt cgacaggacc
      541 tgacagccgc cctcctccac ccccacccac cagaagcact ctttcctgat tatccgagaa
      601 ctgaattgtt ccattagtat tattttattt tttattctcc ccatcacttc cccaccgccc
      661 ctacccccac gcctgcctcg tctgtggttg catggcagca ctgcccgggt gcgggggctc
      721 agggccagcc cctcgggaag gaagaggagg aggatcatga agcctggagt cgcgaccgcg
      781 ctggaccgcg ggcagcagcc agaggaccag ctggagcagc ccccgcctgg gagacaccag
      841 gacgcagacc agcagtcgct tctgccgcca cagcagcagc gccgggcgcg tgcagaccca
      901 gagcaggagg aggagggcga cagcgaccca gaagaggacg aggaggagaa agcgaagcca
      961 ctctccagcc cggacctgcc cattttccag ctctcgaacc tcgcccgaag ggacctttga
     1021 tggaaccaag gggaggggcc tccgacttac agactgcagc tggagtgggc tgggggctga
     1081 gatcatgtaa ctattcccct ttactctccc ctcccacaag cccctcttcg ctacctcctt
     1141 tctcagatcc ttctgtcacc ttctcaaccc caaacacaca cccttcctct attcaggacc
     1201 ttaagctctg gaaggcagca gccctccgag ggttaaggat ctctttttcc tccatccttt
     1261 cccggtccac cgccctatat cccacctctt ctgtgtagcc ttttggctgc ataggcgaag
     1321 cacaaggcga agctctttgc ccaatttcac ccacaaccag cccccctaat tcctctctta
     1381 aaagcaactc tggtgctgct ggaggtcaat tgtcctggtt ttctgcccaa gagaattagg
     1441 acgtcttcta cccccaccca atcttgcctt tccccaacca cttcatacta cctgagacag
     1501 tctgtctttc tctctctctc atgtgcaatt ctcaattctt tactgagctg agttccctaa
     1561 gctgctccaa atttgattta tatccaccgt ttttatataa aagagattta ccacagccta
     1621 gagaattgag aagaacctag caaccctttc tttgggaact tttaactatt agacattggt
     1681 catgcatccc agccccgatg cttctgttgc cctactccca gcagtgttca ggggtcaaag
     1741 acagaaagga gacagcagcc agaactaagt ctgaggttgg ggcggggctg ctagagcaag
     1801 aaaaactttt tttactttgc atttccttag tagcgttcag aatcattgac tcacagttgt
     1861 cagtccaaga gggtaattta tttgctgctt ggaggggtta taagaagagc caataagaaa
     1921 ggttcctcca taacacagga acactgtgga ccccaagccc caccctaccc acctcttcaa
     1981 agactccagc tgcccctctc cagtcctctg cttccctatc acatgctcat gcccctgggt
     2041 gggctgctgt ggtggtggtg ctgctgctgc ggctggtaca gctgtggact gtgcacccca
     2101 gctccccaga tgttgcgcca ccagggtctc ctcaagtgcc gctgtcgaat gctcttcaat
     2161 gacctgaagg ttttcctact gaggcgcccc cctccagcgc ccctgcccat gcacggcgac
     2221 cctcagctcc ctggtgtggc ggccaacaac aacacccttc cggctctggg tgccgggggg
     2281 tgggcaggct ggaggggccc ccgagaagcg gtgggcaggg agacccctcc tctgccacct
     2341 ccaccacctt tgcctccttc tggggatgat gactgggatg gcccagccac agggccacct
     2401 gcctccctgc tcagcagtgc ttcctctgat gaattctgta aggagaaaac tgaggactgc
     2461 tactctctgg gaagtagctt ggacagtggt atgagaactc ccctctgccg catctgtttc
     2521 cagggaccag aacagggaga gctgctaagc ccatgccgtt gtgatggttc agtcaaatgt
     2581 acacaccagc catgtctcat caaatggatc agtgaaaggg gctgctggag ttgtgagctg
     2641 tgctactaca agtaccatgt catcgccata agcacaaaga atcctctaca gtggcaggcc
     2701 atatccctga cggtcatcga gaaggttcaa attgcagccg ccatcttggg ttctctcttc
     2761 ctcatcgcca gtatctcttg gctcatctgg tcgaccttca gtccctcagc aaaatggcaa
     2821 cgtcaagacc tcctcttcca gatctgctat gggatgtatg gcttcatgga cgtggtgtgc
     2881 ataggcctca tcatccacga agggccctcg gtatatcgca tctttaaacg ctggcaggct
     2941 gtaaaccagc agtggaaagt gctgaactat gacaagacaa aagacttaga ggatcaaaaa
     3001 tcaggaggca ggacaaacct acagacttcc tcatctgccc aagccaacct accctctgcg
     3061 gaagaggagg cagccagccc gcctgcccgt gaagagggcc ccaccagggc cgccagccac
     3121 ccctcaggcc ctgtgtccca acaccactgt gcttacacca tcctacacat cctgagtcac
     3181 ttgagacctc atgaccagcg gagcacccag ggcagcggcc gagagcttgt catgagagtc
     3241 accacagtgt gaaaggaggc ctgggaggca ggttgagacc acatacacac cacaagagtc
     3301 tgggccagga ggggcccagg gatcaggaat ggtgggcctc aaggggagct atgggggaga
     3361 ccgcctgagg gagagccctt acgattccca gtccattggt tccacagcaa gggaaaacca
     3421 acacaaactt cacaacaatg ggtgggacaa atggaatctg ccctaagaaa acaacccctc
     3481 ccagagaacc acaagtagca agacacccag aaaagggtgg gcagaaaatg gtggctggta
     3541 cctggggtac ctgctgtgcc tgggggtcta agggcagcaa agagagaaaa caaagggcca
     3601 cctgggtgct gctgcttcct agcactgagt aactgagaga caagagagag agagagagag
     3661 agagagagag agagagagag agagagagac cttgtgagct ggtggtccta atgtttgctg
     3721 aaggcctcta cactctgtaa aattccagtg actcaaatgg ctttagggat cccctggaga
     3781 cggttcagga agggagttgt tggtatgcca ggccagagaa atggggttgg gtcccccagg
     3841 aagaactttc ctagctgtaa catgaactca aagaaggctg aggtttagac atggagatct
     3901 ttttgtttcc ttgtttacct tacggtgatt tggctcaaag atgtttacag gatgtggggg
     3961 actcatgtac atacatgtgc atgtggagag acgtgaagac ttctcatgag tggctcaagc
     4021 acacttccgc tgctgtggcg tcagccttca aagctgtcag gccagggatg attttcctca
     4081 ttactgagcc ccgtctataa ccaggataat gcagtgccat gtccttttcg cattggcatt
     4141 ctcacaggca ggcccgcaag cacacacgca tatgtatgca cgcatgcacg catgcgtgtg
     4201 cgagcaaatg cctgtgaaca cacacacaaa gacacagaga gaaacacaca cgcattcacg
     4261 tgcttgagcg cgcacacaca cacacacaca cacacacaca cacacacata cacacacaca
     4321 cacacagaca cacacacaca cacatctggg tctgctgcag tgtggggtga cactggcctg
     4381 tgtatctcaa ggaaggcgtg aacacctaac taagtattcc tagctgcttg gtactggtcc
     4441 cctccctaaa gaggcagttt gccttgtgat ctgggctatg tgctctgggc tatgtgctcc
     4501 tggtccttct ggtgcagcca ggcacaccaa ggaggcagtc agggagcact gtcgtaggag
     4561 cccaccagtg tgttccagga ccctgccagg gaaggccact gggtggtcac ctgcagagtt
     4621 tcttactgtc attgcacaat ggacatgcca tccttgggta ttaaatggac actgtcaagt
     4681 acttttttaa actagttttt agggtttttt tttaaaaaaa aaactctctg ttgtttgtaa
     4741 tattctctta aaagcttgga aataaaattt ctttccctag ca
//
