LOCUS       NP_001038998             409 aa            linear   ROD 11-FEB-2025
DEFINITION  E3 ubiquitin-protein ligase MARCHF4 isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_001038998 XP_619638 XP_915764 XP_996635
VERSION     NP_001038998.1
DBSOURCE    REFSEQ: accession NM_001045533.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 409)
  AUTHORS   Li,Q., Wang,H.Y., Chepelev,I., Zhu,Q., Wei,G., Zhao,K. and
            Wang,R.F.
  TITLE     Stage-dependent and locus-specific role of histone demethylase
            Jumonji D3 (JMJD3) in the embryonic stages of lung development
  JOURNAL   PLoS Genet 10 (7), e1004524 (2014)
   PUBMED   25079229
  REMARK    Erratum:[PLoS Genet. 2023 Mar 30;19(3):e1010701. doi:
            10.1371/journal.pgen.1010701.. PMID: 36996023]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 409)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163484.4 and AC114629.12.
            
            On or before Sep 2, 2006 this sequence version replaced
            XP_915764.1, XP_619638.1, XP_996635.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098191.1, AK122502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.54 cM"
     Protein         1..409
                     /product="E3 ubiquitin-protein ligase MARCHF4 isoform 1
                     precursor"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase MARCH4;
                     membrane-associated RING-CH protein IV;
                     membrane-associated RING finger protein 4; RING-type E3
                     ubiquitin transferase MARCH4; membrane-associated ring
                     finger (C3HC4) 4; RING-type E3 ubiquitin transferase
                     MARCHF4; E3 ubiquitin-protein ligase MARCHF4"
                     /calculated_mol_wt=43247
     sig_peptide     1..17
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q80TE3.3)"
                     /calculated_mol_wt=1973
     mat_peptide     18..409
                     /product="E3 ubiquitin-protein ligase MARCHF4.
                     /id=PRO_0000055931"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TE3.3)"
                     /calculated_mol_wt=43247
     Region          92..133
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TE3.3)"
     Region          156..211
                     /region_name="RING_CH-C4HC3_MARCH4"
                     /note="RING-CH finger, H2 subclass (C4HC3-type), found in
                     membrane-associated RING-CH4 (MARCH4); cd16824"
                     /db_xref="CDD:438473"
     Site            242..262
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TE3.3)"
     Site            271..291
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TE3.3)"
     Region          323..372
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TE3.3)"
     Region          389..409
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TE3.3)"
     CDS             1..409
                     /gene="Marchf4"
                     /gene_synonym="MARCH-IV; March4; mKIAA1399"
                     /coded_by="NM_001045533.2:2023..3252"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS15034.1"
                     /db_xref="GeneID:381270"
                     /db_xref="MGI:MGI:2683550"
ORIGIN      
        1 mlmplggllw wwccccgwys cglctpapqm lrhqgllkcr crmlfndlkv fllrrpppap
       61 lpmhgdpqlp gvaannntlp algaggwagw rgpreavgre tpplpppppl ppsgdddwdg
      121 patgppasll ssassdefck ektedcyslg ssldsgmrtp lcricfqgpe qgellspcrc
      181 dgsvkcthqp clikwiserg cwscelcyyk yhviaistkn plqwqaislt viekvqiaaa
      241 ilgslflias iswliwstfs psakwqrqdl lfqicygmyg fmdvvcigli ihegpsvyri
      301 fkrwqavnqq wkvlnydktk dledqksggr tnlqtsssaq anlpsaeeea asppareegp
      361 traashpsgp vsqhhcayti lhilshlrph dqrstqgsgr elvmrvttv
//
