LOCUS       NM_001374227            1830 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus membrane associated ring-CH-type finger 3 (Marchf3),
            transcript variant 1, mRNA.
ACCESSION   NM_001374227 XM_006526019
VERSION     NM_001374227.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1830)
  AUTHORS   Zeng,L.W., Feng,L., Liu,R., Lin,H., Shu,H.B. and Li,S.
  TITLE     The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target
            IL-5 receptor alpha to negatively regulate eosinophilic airway
            inflammation
  JOURNAL   Cell Mol Immunol 19 (10), 1117-1129 (2022)
   PUBMED   35982175
  REMARK    GeneRIF: The membrane-associated ubiquitin ligases MARCH2 and
            MARCH3 target IL-5 receptor alpha to negatively regulate
            eosinophilic airway inflammation.
REFERENCE   3  (bases 1 to 1830)
  AUTHORS   Feng,L., Li,C., Zeng,L.W., Gao,D., Sun,Y.H., Zhong,L., Lin,H.,
            Shu,H.B. and Li,S.
  TITLE     MARCH3 negatively regulates IL-3-triggered inflammatory response by
            mediating K48-linked polyubiquitination and degradation of
            IL-3Ralpha
  JOURNAL   Signal Transduct Target Ther 7 (1), 21 (2022)
   PUBMED   35075102
  REMARK    GeneRIF: MARCH3 negatively regulates IL-3-triggered inflammatory
            response by mediating K48-linked polyubiquitination and degradation
            of IL-3Ralpha.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1830)
  AUTHORS   Lin,H., Gao,D., Hu,M.M., Zhang,M., Wu,X.X., Feng,L., Xu,W.H.,
            Yang,Q., Zhong,X., Wei,J., Xu,Z.S., Zhang,H.X., Song,Z.M., Zhou,Q.,
            Ye,W., Liu,Y., Li,S. and Shu,H.B.
  TITLE     MARCH3 attenuates IL-1beta-triggered inflammation by mediating
            K48-linked polyubiquitination and degradation of IL-1RI
  JOURNAL   Proc Natl Acad Sci U S A 115 (49), 12483-12488 (2018)
   PUBMED   30442668
REFERENCE   5  (bases 1 to 1830)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1830)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109152.14 and AC158763.6.
            
            On Sep 13, 2019 this sequence version replaced XM_006526019.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.5153718.1,
                                           SRR10662773.1608601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC109152.14        44336-44544
            210-453             AC158763.6         163830-164073       c
            454-658             AC158763.6         159662-159866       c
            659-868             AC158763.6         135017-135226       c
            869-1830            AC158763.6         127145-128106       c
FEATURES             Location/Qualifiers
     source          1..1830
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 30.92 cM"
     gene            1..1830
                     /gene="Marchf3"
                     /gene_synonym="6330411I15Rik; A530081L18Rik; MARCH-III;
                     March3"
                     /note="membrane associated ring-CH-type finger 3"
                     /db_xref="GeneID:320253"
                     /db_xref="MGI:MGI:2443667"
     exon            1..209
                     /gene="Marchf3"
                     /gene_synonym="6330411I15Rik; A530081L18Rik; MARCH-III;
                     March3"
                     /inference="alignment:Splign:2.1.0"
     exon            210..453
                     /gene="Marchf3"
                     /gene_synonym="6330411I15Rik; A530081L18Rik; MARCH-III;
                     March3"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..1027
                     /gene="Marchf3"
                     /gene_synonym="6330411I15Rik; A530081L18Rik; MARCH-III;
                     March3"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase MARCH3; membrane-associated
                     RING-CH protein III; membrane-associated ring finger
                     (C3HC4) 3; membrane-associated RING finger protein 3;
                     RING-type E3 ubiquitin transferase MARCH3; RING-type E3
                     ubiquitin transferase MARCHF3; E3 ubiquitin-protein ligase
                     MARCHF3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF3 isoform 1"
                     /protein_id="NP_001361156.1"
                     /db_xref="CCDS:CCDS89244.1"
                     /db_xref="GeneID:320253"
                     /db_xref="MGI:MGI:2443667"
                     /translation="MTTSRCSHLPEVLPDCTSSAAPVVKTVEDCGSLVNGQPQYVMQV
                     SAKDGQLLSTVVRTLATQSPFNDRPMCRICHEGSSQEDLLSPCECTGTLGTIHRSCLE
                     HWLSSSNTSYCELCHFRFAVERKPRPLVEWLRNPGPQHEKRTLFGDMVCFLFITPLAT
                     ISGWLCLRGAVDHLHFSSRLEAVGLIALTVALFTIYLFWTLVSFRYHCRLYNEWRRTN
                     QRVILLIPKSVNVPSNQQSLLGLHSVKRNSKETIV"
     exon            454..658
                     /gene="Marchf3"
                     /gene_synonym="6330411I15Rik; A530081L18Rik; MARCH-III;
                     March3"
                     /inference="alignment:Splign:2.1.0"
     exon            659..868
                     /gene="Marchf3"
                     /gene_synonym="6330411I15Rik; A530081L18Rik; MARCH-III;
                     March3"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1830
                     /gene="Marchf3"
                     /gene_synonym="6330411I15Rik; A530081L18Rik; MARCH-III;
                     March3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1798..1803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marchf3"
                     /gene_synonym="6330411I15Rik; A530081L18Rik; MARCH-III;
                     March3"
                     /note="hexamer: AATAAA"
     polyA_site      1825
                     /gene="Marchf3"
                     /gene_synonym="6330411I15Rik; A530081L18Rik; MARCH-III;
                     March3"
                     /note="major polyA site"
ORIGIN      
        1 attcgctgag cgggtccgtg gtttgccagc gcgctctggg cgactgctga gccaggcgac
       61 cgccgagctt gcggcgatcc ccgtcaggtg ccccgcagag ccaatgcgcc caggtgcggc
      121 ggggcaagag cagccggcgg ttccgggcaa cttgggactg aggatctgct gcaggggcgt
      181 ggatttggcg tctctactgg gccaggagga tggacgtcct ctatgaatgt ggaagccatt
      241 aaccgagtaa ttgctgtctg ttgccatgac aaccagtcgc tgcagtcacc tgcccgaagt
      301 cttgccagac tgcaccagct cagccgcgcc tgtggtgaag acggtggagg attgtggcag
      361 cctagtgaat gggcagccac agtatgtcat gcaagtttca gccaaggacg ggcagctgct
      421 gtcaacagta gtgcggactc ttgccaccca gagccccttc aatgaccggc caatgtgcag
      481 gatctgccat gagggaagca gccaagagga cttactctct ccgtgtgaat gtactgggac
      541 cttggggacc atccatcgga gctgcctgga gcactggctg tcatcctcaa ataccagcta
      601 ctgtgaactc tgccacttca ggtttgcagt ggagcgcaaa cccaggccgt tagtggagtg
      661 gcttagaaac cctggccccc agcatgagaa gcggactctg tttggagata tggtgtgctt
      721 cttgtttata acgcccctgg ctaccatctc aggctggctg tgcctgcggg gggccgtgga
      781 tcacctgcac tttagtagcc ggctggaggc cgtcggactc attgccctca ctgtggcact
      841 cttcaccatt tacctcttct ggacactagt gtcgtttagg taccactgtc gattgtacaa
      901 tgaatggcgt cggaccaatc agagggtgat tctcctcatt ccaaagtctg tcaacgtacc
      961 ttctaaccag cagtccttgc tggggctcca ctcagtcaag aggaactcaa aggagacaat
     1021 tgtttgatgt ctgtgtggtt agttggtgga ctcgtcgttt ggggtttgga agtctctgca
     1081 ctggggccat gcgctgagcc accccaaagc ccatccttta gtctttgggt ctaagaacat
     1141 ctggagccat gttaccacat tgcctgagtg aggaactcgg ccagaaggaa acaatgctgt
     1201 ttgacttcga aatcatggat gctgcactca tatgatactt gctaagctgc caaacatgtc
     1261 tatttagcag atactgtatg gaattttcca aacacctctt taacatatga ggaaggttgt
     1321 cctgctgagg atgcgattca attcttcctt ttttattact atctcagata tatatatata
     1381 tatatatata tatatatata tatataaata tataatttag atgataatca aacttggaaa
     1441 gccaatgtac aaactggttt cttggtttgg atgggtttta tttgggttag tttattcatt
     1501 tccccggttt ctactgtgga ttctttggtg gctaacttga tagcctgagt ggtctttttc
     1561 atctctttta tgtcccttat tcaaggagac agcataatta ctgcagaaca agacacattt
     1621 gaagggtgtt ttctactaaa cctcattcag ttattcagtt tttaaaaggg aaaaaaggcg
     1681 tggcggctca ccacgcggtg agctgtttat ttaaacattg aggaggaagc cagcagtgag
     1741 atgttccctc ctttcaactt gtttggtact gacagctgat agaagctatt ttctaataat
     1801 aaatacctgg tgtgtgaaag gcaaacctta
//
