LOCUS       NM_001252480            1415 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus membrane associated ring-CH-type finger 2 (Marchf2),
            transcript variant 2, mRNA.
ACCESSION   NM_001252480
VERSION     NM_001252480.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1415)
  AUTHORS   Zeng,L.W., Feng,L., Liu,R., Lin,H., Shu,H.B. and Li,S.
  TITLE     The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target
            IL-5 receptor alpha to negatively regulate eosinophilic airway
            inflammation
  JOURNAL   Cell Mol Immunol 19 (10), 1117-1129 (2022)
   PUBMED   35982175
  REMARK    GeneRIF: The membrane-associated ubiquitin ligases MARCH2 and
            MARCH3 target IL-5 receptor alpha to negatively regulate
            eosinophilic airway inflammation.
REFERENCE   2  (bases 1 to 1415)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1415)
  AUTHORS   Sandow,J.J., Webb,A.I., Stockwell,D., Kershaw,N.J., Tan,C.,
            Ishido,S., Alexander,W.S., Hilton,D.J., Babon,J.J. and Nicola,N.A.
  TITLE     Proteomic analyses reveal that immune integrins are major targets
            for regulation by Membrane-Associated Ring-CH (MARCH) proteins
            MARCH2, 3, 4 and 9
  JOURNAL   Proteomics 21 (11-12), e2000244 (2021)
   PUBMED   33945654
  REMARK    GeneRIF: Proteomic analyses reveal that immune integrins are major
            targets for regulation by Membrane-Associated Ring-CH (MARCH)
            proteins MARCH2, 3, 4 and 9.
REFERENCE   4  (bases 1 to 1415)
  AUTHORS   Chathuranga,K., Kim,T.H., Lee,H., Park,J.S., Kim,J.H.,
            Chathuranga,W.A.G., Ekanayaka,P., Choi,Y.J., Lee,C.H., Kim,C.J.,
            Jung,J.U. and Lee,J.S.
  TITLE     Negative regulation of NEMO signaling by the ubiquitin E3 ligase
            MARCH2
  JOURNAL   EMBO J 39 (21), e105139 (2020)
   PUBMED   32935379
  REMARK    GeneRIF: Negative regulation of NEMO signaling by the ubiquitin E3
            ligase MARCH2.
REFERENCE   5  (bases 1 to 1415)
  AUTHORS   Han,S.O., Xiao,K., Kim,J., Wu,J.H., Wisler,J.W., Nakamura,N.,
            Freedman,N.J. and Shenoy,S.K.
  TITLE     MARCH2 promotes endocytosis and lysosomal sorting of
            carvedilol-bound beta(2)-adrenergic receptors
  JOURNAL   J Cell Biol 199 (5), 817-830 (2012)
   PUBMED   23166351
REFERENCE   6  (bases 1 to 1415)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030732.13, AK079234.1 and AV336582.1.
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. The encoded isoform (2) is shorter and has a distinct
            C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002144.1, AK079234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                CT030732.13        29989-30012         c
            25-1341             AK079234.1         2-1318
            1342-1415           AV336582.1         164-237
FEATURES             Location/Qualifiers
     source          1..1415
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..1415
                     /gene="Marchf2"
                     /gene_synonym="9530046H09Rik; MARCH-II; March2"
                     /note="membrane associated ring-CH-type finger 2"
                     /db_xref="GeneID:224703"
                     /db_xref="MGI:MGI:1925915"
     exon            1..132
                     /gene="Marchf2"
                     /gene_synonym="9530046H09Rik; MARCH-II; March2"
                     /inference="alignment:Splign:2.1.0"
     exon            133..360
                     /gene="Marchf2"
                     /gene_synonym="9530046H09Rik; MARCH-II; March2"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..925
                     /gene="Marchf2"
                     /gene_synonym="9530046H09Rik; MARCH-II; March2"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2; E3
                     ubiquitin-protein ligase MARCH2; membrane-associated
                     RING-CH protein II; membrane-associated RING finger
                     protein 2; RING-type E3 ubiquitin transferase MARCH2;
                     membrane-associated ring finger (C3HC4) 2; RING-type E3
                     ubiquitin transferase MARCHF2; E3 ubiquitin-protein ligase
                     MARCHF2; RING finger protein 172"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF2 isoform 2"
                     /protein_id="NP_001239409.1"
                     /db_xref="CCDS:CCDS57064.1"
                     /db_xref="GeneID:224703"
                     /db_xref="MGI:MGI:1925915"
                     /translation="MTTGDCCHLPGSLCDCSSSPAFSKVVEATGLGPPQYVAQVTSRD
                     GRLLSTVIRALDSQSDCPFCRICHEGANGENLLSPCGCTGTLGAVHKSCLEKWLSSSN
                     TSYCELCHTEFAVEKRPRPLTEWLKDPGPRTEKRTLCCDMVCFVFITPLAAISGWLCL
                     RGAQDHLRLHSRLEAVGLIALTIALFTIYVLWTLVSFRYHCQLYSEWRKTNQKVRLKI
                     READGSEDPHHSLLATGLLKKVAEETPV"
     exon            361..556
                     /gene="Marchf2"
                     /gene_synonym="9530046H09Rik; MARCH-II; March2"
                     /inference="alignment:Splign:2.1.0"
     exon            557..766
                     /gene="Marchf2"
                     /gene_synonym="9530046H09Rik; MARCH-II; March2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..1415
                     /gene="Marchf2"
                     /gene_synonym="9530046H09Rik; MARCH-II; March2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1368..1373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marchf2"
                     /gene_synonym="9530046H09Rik; MARCH-II; March2"
                     /note="hexamer: AATAAA"
     polyA_site      1405
                     /gene="Marchf2"
                     /gene_synonym="9530046H09Rik; MARCH-II; March2"
                     /note="major polyA site"
ORIGIN      
        1 ggcgggcggt gcccggacgc aggtgctcgc cggagccgga gcaagccgct gctgacgggc
       61 cgggccgggc cgggacccgg gccagggaga accgaggggc ctgcgcggtc gcccggcccg
      121 gccgcggaac aggtttctgg gaccatgggc ctcaggccct gaggacagga ggctccctgt
      181 ggccatgacg acaggtgact gttgccacct ccctggctcc ctatgtgact gttcgagcag
      241 ccctgccttt tccaaggttg tagaggccac agggcttggg ccacctcaat atgtagcaca
      301 agtgacttca cgggatggcc ggctgctctc aactgtcatc cgggctttgg attcacagag
      361 tgactgtccc ttctgccgaa tctgccacga gggagcaaat ggggagaact tgctgtcccc
      421 atgtggctgc acgggcacac tgggagctgt gcacaagagc tgcctggaga aatggctgtc
      481 ttcctccaac accagctact gtgagctgtg tcacactgag tttgcagtgg aaaagcggcc
      541 ccgacctctc acagagtggc taaaggaccc agggccgcgc actgagaagc gaacactgtg
      601 ctgtgacatg gtgtgctttg tgttcatcac accactggct gccatctcag gctggctttg
      661 cctgcgaggg gcccaggacc acctccgtct gcatagccgg ctggaagctg taggtctcat
      721 tgccctcacc atcgccctct ttaccatcta tgtgctctgg acactggtct ctttccgata
      781 ccattgccag ctgtactcgg aatggaggaa gacaaatcag aaagtccgcc tgaagattcg
      841 ggaagcagat ggctccgagg atccacatca ctccttgctg gctactggac tcttaaaaaa
      901 ggtggcagag gagacccctg tgtgaaggcc tggctggcag ggctcagagg tagtagacag
      961 accagagtca gatggcaatg cagctggcat ttggaaagat ggaggctgcc tgacttttca
     1021 tgcacagcta tgatgcttct caggcccgta gccacagcca gcagagcctg ctctgtgatc
     1081 ccgtgtgaac atattttcaa gggttttgtt ttgcacattg ttgtatatga caagcacaga
     1141 tggacagatt tgagctttgg atggagtagg cacctctgtc tcattttgag atctgtttga
     1201 caccttttgc acagcagctt tagcgctggt gtcaagggcg cccgttggac tagaaggttc
     1261 cagcaagctt cttgcgttac tctgcaccta gctggcttgc tttactggca ctcttgactt
     1321 ataatcttat aaagttgcac tgcatttcaa aaacccaccc ctgaatgaat aaaaggagcc
     1381 cttgctggct aatatggacg catcagttat gtttc
//
