LOCUS       NM_001403873            5164 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus membrane associated ring-CH-type finger 1 (Marchf1),
            transcript variant 8, mRNA.
ACCESSION   NM_001403873
VERSION     NM_001403873.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5164)
  AUTHORS   Guo,H., Li,W., Yang,Z. and Xing,X.
  TITLE     E3 ubiquitin ligase MARCH1 reduces inflammation and pyroptosis in
            cerebral ischemia-reperfusion injury via PCSK9 downregulation
  JOURNAL   Mamm Genome 35 (3), 346-361 (2024)
   PUBMED   39115562
  REMARK    GeneRIF: E3 ubiquitin ligase MARCH1 reduces inflammation and
            pyroptosis in cerebral ischemia-reperfusion injury via PCSK9
            downregulation.
REFERENCE   2  (bases 1 to 5164)
  AUTHORS   Kozono,Y., Kuramochi,M., Sasaki,Y.C. and Kozono,H.
  TITLE     Ubiquitination of Major Histocompatibility Complex II Changes Its
            Immunological Recognition Structure
  JOURNAL   Int J Mol Sci 24 (23), 17083 (2023)
   PUBMED   38069406
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5164)
  AUTHORS   He,X., Liu,J., Xiao,X., Zhang,S., Wang,X., Liu,J., Liu,Z., Wang,J.,
            Liu,X., Li,G. and Yang,P.
  TITLE     Targeting psychological stress-steroid-MARCH1 signaling pathway
            promotes the efficacy of specific allergen immunotherapy
  JOURNAL   Theranostics 12 (18), 7717-7728 (2022)
   PUBMED   36451862
  REMARK    GeneRIF: Targeting psychological stress-steroid-MARCH1 signaling
            pathway promotes the efficacy of specific allergen immunotherapy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5164)
  AUTHORS   Castellanos,C.A., Hiam-Galvez,K.J., Ishido,S., Satpathy,A.T. and
            Shin,J.S.
  TITLE     MARCH1 Controls an Exhaustion-like Program of Effector CD4+ T Cells
            Promoting Allergic Airway Inflammation
  JOURNAL   Immunohorizons 6 (9), 684-692 (2022)
   PUBMED   36100368
  REMARK    GeneRIF: MARCH1 Controls an Exhaustion-like Program of Effector
            CD4(+) T Cells Promoting Allergic Airway Inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5164)
  AUTHORS   Liu,H., Wilson,K.R., Firth,A.M., Macri,C., Schriek,P., Blum,A.B.,
            Villar,J., Wormald,S., Shambrook,M., Xu,B., Lim,H.J.,
            McWilliam,H.E.G., Hill,A.F., Edgington-Mitchell,L.E., Caminschi,I.,
            Lahoud,M.H., Segura,E., Herold,M.J., Villadangos,J.A. and
            Mintern,J.D.
  TITLE     Ubiquitin-like protein 3 (UBL3) is required for MARCH
            ubiquitination of major histocompatibility complex class II and
            CD86
  JOURNAL   Nat Commun 13 (1), 1934 (2022)
   PUBMED   35411049
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5164)
  AUTHORS   Tze,L.E., Horikawa,K., Domaschenz,H., Howard,D.R., Roots,C.M.,
            Rigby,R.J., Way,D.A., Ohmura-Hoshino,M., Ishido,S., Andoniou,C.E.,
            Degli-Esposti,M.A. and Goodnow,C.C.
  TITLE     CD83 increases MHC II and CD86 on dendritic cells by opposing
            IL-10-driven MARCH1-mediated ubiquitination and degradation
  JOURNAL   J Exp Med 208 (1), 149-165 (2011)
   PUBMED   21220452
  REMARK    GeneRIF: found that the transmembrane domain of CD83 enhances MHC
            class II and CD86 expression by blocking MHC class II association
            with the ubiquitin ligase MARCH1
REFERENCE   7  (bases 1 to 5164)
  AUTHORS   Walseng,E., Furuta,K., Bosch,B., Weih,K.A., Matsuki,Y., Bakke,O.,
            Ishido,S. and Roche,P.A.
  TITLE     Ubiquitination regulates MHC class II-peptide complex retention and
            degradation in dendritic cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (47), 20465-20470 (2010)
   PUBMED   21059907
  REMARK    GeneRIF: Selective ubiquitination of MHC-II in immature dendritic
            cells by the E3 ubiquitin ligase March-I results in the selective
            degradation of internalized pMHC-II.
REFERENCE   8  (bases 1 to 5164)
  AUTHORS   Ohmura-Hoshino,M., Matsuki,Y., Mito-Yoshida,M., Goto,E.,
            Aoki-Kawasumi,M., Nakayama,M., Ohara,O. and Ishido,S.
  TITLE     Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination
            for the maintenance of conventional dendritic cells
  JOURNAL   J Immunol 183 (11), 6893-6897 (2009)
   PUBMED   19917682
  REMARK    GeneRIF: MARCH-I may function as a housekeeper of conventional
            dendritic cell in the steady state.
REFERENCE   9  (bases 1 to 5164)
  AUTHORS   Jabbour,M., Campbell,E.M., Fares,H. and Lybarger,L.
  TITLE     Discrete domains of MARCH1 mediate its localization, functional
            interactions, and posttranscriptional control of expression
  JOURNAL   J Immunol 183 (10), 6500-6512 (2009)
   PUBMED   19880452
  REMARK    GeneRIF: MARCH1 expression is regulated at a posttranscriptional
            level by trafficking within the endolysosomal pathway where MARCH1
            is proteolyzed.
REFERENCE   10 (bases 1 to 5164)
  AUTHORS   Matsuki,Y., Ohmura-Hoshino,M., Goto,E., Aoki,M., Mito-Yoshida,M.,
            Uematsu,M., Hasegawa,T., Koseki,H., Ohara,O., Nakayama,M.,
            Toyooka,K., Matsuoka,K., Hotta,H., Yamamoto,A. and Ishido,S.
  TITLE     Novel regulation of MHC class II function in B cells
  JOURNAL   EMBO J 26 (3), 846-854 (2007)
   PUBMED   17255932
  REMARK    GeneRIF: The function of MHC II in B cells is regulated through
            ubiquitination by MARCH-I.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139159.3, AC114634.14, AC140272.3 and AC122800.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.23045.1,
                                           SRR17784645.176436.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164138,
                                           SAMN01164139 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AC139159.3         62729-62918
            191-399             AC139159.3         63135-63343
            400-548             AC114634.14        124796-124944
            549-599             AC140272.3         128829-128879
            600-679             AC122800.3         29980-30059
            680-1432            AC122800.3         30349-31101
            1433-1613           AC122800.3         62356-62536
            1614-1761           AC122800.3         99593-99740
            1762-5164           AC122800.3         111772-115174
FEATURES             Location/Qualifiers
     source          1..5164
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.06 cM"
     gene            1..5164
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /note="membrane associated ring-CH-type finger 1"
                     /db_xref="GeneID:72925"
                     /db_xref="MGI:MGI:1920175"
     exon            1..190
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..399
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..548
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /inference="alignment:Splign:2.1.0"
     CDS             438..2060
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /EC_number="2.3.2.27"
                     /note="isoform 6 is encoded by transcript variant 8; E3
                     ubiquitin-protein ligase MARCH1; membrane-associated RING
                     finger protein 1; MARCH-I; membrane-associated RING-CH
                     protein I; RING-type E3 ubiquitin transferase MARCH1;
                     membrane-associated ring finger (C3HC4) 1; RING-type E3
                     ubiquitin transferase MARCHF1; E3 ubiquitin-protein ligase
                     MARCHF1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF1 isoform 6"
                     /protein_id="NP_001390802.1"
                     /db_xref="GeneID:72925"
                     /db_xref="MGI:MGI:1920175"
                     /translation="MLGWCEAIARNPHRIPNTTRTPETSGDVADASQTSTLNEKSPGR
                     SASRSSNISKASSPTTGTAPRSQSRLSVCPSTQDICRSSLLHDMSEDEHCTPVVVLSH
                     ARKESGKKPVRQNPRRRRRVSQRYEHAEEQAKEKRNDFHLQISSPRWRELDMESSDSS
                     STDESQWVQAKRQAQVKFRLSRRRRNNKPCGSLTESSTSDRIELVDLGSKEEKHQELT
                     ECGSHTLNICRGKVIRYQECSHPPPRGSLVERTPAESHSGSKGKYCHRDPQLLHTLNQ
                     KETIKKRFSETDFNTEILAAVERDECGEDTGLQLNTSTQKPPAAYDDGSDNFEVCRIC
                     HCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRK
                     WEKLQMTTSERRKIFCSVTFHVIAVTCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWT
                     KLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTANKLEKNFPCNVN
                     TEIKDAVVVPVPQTGSNTLPTAEGAPPEVIPV"
     exon            549..599
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /inference="alignment:Splign:2.1.0"
     exon            600..679
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..1432
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1613
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1761
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..5164
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3938..3943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /note="hexamer: AATAAA"
     polyA_site      3963
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /note="major polyA site"
     regulatory      5142..5147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /note="hexamer: AATAAA"
     polyA_site      5164
                     /gene="Marchf1"
                     /gene_synonym="2900024D24Rik; March1"
                     /note="major polyA site"
ORIGIN      
        1 agccttctgc ttatttacct tgtcagcagg atgcatgtct ctgggtgctc cacagactcc
       61 taggggtctg ggtagaaaca aaagcccatg tcagtcgctg caaatgtggg agtctgtgcc
      121 attaaaagga gcagttgtta ataagggccc gtgagacctg ggtttccttg gtttccatga
      181 cagttattag atccaagttt ggcaaagcaa ggatatgaac agttctgcag gagggtttct
      241 cagggcgagt gaagccataa ggcatccaat caggatttgg ccacctgcag cccagccagt
      301 atgcccctcc accagatttc tgtaatccca gcccgggaga cagccagcaa tgggagaagt
      361 tcaatgggca gaaacaaaga gaagaacaag gaagttgaga atttcaggaa ttgaaaaggg
      421 aaaagaggaa ggagaaaatg ctgggctggt gtgaagcgat agcccgtaac cctcacagaa
      481 tcccaaacac cacgcggaca ccagagacct caggggatgt ggccgatgcc tctcaaacct
      541 ccacgctgaa tgaaaagtcc ccagggcgat ctgcaagtcg atcaagtaac atatcaaaag
      601 caagcagccc aacgacaggg acagctccca ggagccagtc aaggttgtct gtctgtccat
      661 ctactcagga catctgcaga tcttcactct tgcatgacat gtcagaagac gagcactgca
      721 cccctgttgt agtgttgagc catgctagaa aagagtctgg taagaaacca gtaagacaga
      781 atcctaggag gaggaggagg gtttctcaga gatatgaaca tgcagaagag caagccaaag
      841 agaaaagaaa tgactttcac ctccagatct caagtcccag gtggagagaa cttgatatgg
      901 agtcttcaga ttcgtcttcc acagatgaga gtcaatgggt tcaggcaaaa aggcaagccc
      961 aggttaaatt cagactgtct cggcgaagga gaaataacaa gccatgtgga agcttgactg
     1021 agtcttctac ttctgacaga attgaacttg ttgatctggg atccaaagag gaaaagcacc
     1081 aggagctgac agaatgtggg agtcacactt taaacatctg tagaggaaaa gtcataaggt
     1141 accaagaatg cagtcatcca ccgccaaggg ggtccttggt ggagaggaca cctgcagaga
     1201 gccactcagg gagtaaaggc aaatactgcc acagagatcc tcagctcttg catacactta
     1261 atcaaaaaga aacaatcaag aaaagatttt cagaaactga tttcaatact gaaatcctgg
     1321 cagctgtaga aagggacgag tgtggggaag acacagggct ccagctgaat acctctaccc
     1381 agaagcctcc tgctgcctat gatgatggct ctgataattt cgaagtgtgc aggatctgtc
     1441 actgcgaagg agatgaagag agcccactca tcacaccctg tcgctgcaca ggaaccttgc
     1501 gctttgtcca ccagtcctgc ctccaccaat ggatcaagag ctcagacaca cgatgctgtg
     1561 agctctgcaa gtatgacttc ataatggaga ccaagctcaa gccccttcgg aagtgggaaa
     1621 agctccagat gaccacgagc gaaaggagga aaatattctg ctctgtcacg ttccacgtca
     1681 tcgccgtcac ctgtgtggtg tggtccttgt atgtgttgat agatcggaca gcggaggaaa
     1741 tcaagcaagg taacgacaat ggtgtgctgg aatggccatt ttggacaaaa ctggttgtgg
     1801 tggctattgg cttcacggga ggtctcgtct tcatgtatgt acagtgtaaa gtctacgtcc
     1861 aactgtggcg ccggctgaag gcctacaacc gtgtgatctt tgtgcagaat tgcccagaca
     1921 ctgccaacaa actggagaag aacttcccgt gtaatgtgaa cacggaaatc aaggatgctg
     1981 tggttgtgcc tgtgccacag acaggttcaa atacactgcc aactgcagag ggagccccac
     2041 ctgaggttat accagtctga tggaactaga ggggaacttc ttcacagaag gatttttgca
     2101 gcccccagcc actaccaaca gaagtgcttc tgctctggtg gcttcttaat cttctccttt
     2161 cccctactgt cttgtttgtc ctgacttgga gcaaaaagga aatgagaaga aaataacaca
     2221 tgaccaggat ctcaagaagc agagccgtcg gtgggacctg gaaaggcaga gtgtcttggg
     2281 gaatgagttc ataaggaatg gttggtacac gccagtcttc cagagtgatg gacatgtgat
     2341 acgccttcaa gtagtgcaga ggaatccctt aacagacttc aattgcaatg tatgcttctt
     2401 tgtagggttc tgtaatgtta gccttctcca ctggaaatga cacacacaca cgcacacaca
     2461 cacaaaacaa aaaatttggt cttaagcctg aaagtgtgtg cgttatccct aagtcacacc
     2521 agaagcaaac ttggaggact tgagagggtt ttttttttat actttgacag ctgatttttt
     2581 ctggctattg tgaagtctgg ttattttgac agatgcatgt ttttaaatgg atgcaataca
     2641 catttgatga tagaaatgtt taaaattttg tttaaatgat ggaagaagag attttcaggg
     2701 cattgtggaa tttagctttc actgtttttt ggaccactat catgccatgt ttttgttttt
     2761 gtttttgttt ttgtttttgt ttttttctgg tccctcttac acagtgctca acaacagata
     2821 tataacacga gctacaaagg caaccacagt tgtaaatttt aaatctccta gtgtgccaca
     2881 ttaggaaaag taaaaataaa taggtcaatt attttcataa tttagttaac tctacatata
     2941 caagttattt catgtcatca atgaaaacag ttaaaagata gctttcatta ttttcttgaa
     3001 ccaagtcttc aaaattctgc atgtatttat gacacacctc aatatgaata aagtgtgtca
     3061 gacaggattt aattaagaat attggttagc agagcccttg cattagaaac tacatctgtt
     3121 tcatttaagt tggttatttt aaaacagcag tttaatctgt gattctgttt ttcagtttca
     3181 tttaaaggtt acaatttaca aagcactaaa ctcaccacat taagtattct ggcttgattt
     3241 caaccaactt tcaaaggggc ggaaaaaaaa accacaaaag tataggaagt cagtaaaatg
     3301 tgtagcaatg ttatgaagtc aacttctgta tagaagctat aaagtaatta tgatagggaa
     3361 aattattttg ccactaaatc aggtgtgtta aggtttttaa atccacatgg agggtcaacg
     3421 tgacatgggt accttaatta aggatcttaa cccagtgttt aaacctgaca gtatttccct
     3481 cactcagctc aaaagtaaaa atattcaata cattccatgg tgagagataa gataggctgt
     3541 cggttcaaca gctgactact gtgctctaca cagactcaaa tcaactgata tgaatgataa
     3601 ctgcaatgag ctgggtaaat actcacaaac agtagttagc tgtcgaaaga aagatgacca
     3661 cattttttaa agtgactttt gttgttgttg ttgttgttgt tgttgttgtt gttgttgtta
     3721 gctgtcatta tttattatcc tgaagaggca gagatggccc taagaaccaa agcacgggca
     3781 tcacgttgca cacatctggg atccatatcc atgaactttg taataatcag tgtttgttct
     3841 tcgtgggtga taaaggaaaa ggaaagacaa aatgatcttt caatgagaag agtatttgta
     3901 gtgactgaca ctgggtccaa atcgtcccac ccttagaaat aaagacacag taaacaatgt
     3961 caattgtgta tgacctgtat attcatgtat atatgcaaga gaaatgttaa ggtcaagtca
     4021 agtcaaacaa caaaaggtta aatactcatc tttcttaaaa cctgtaggag ggacatggat
     4081 taaatatgca cggacaaagc aatggacata actaatccgg accaggcctt cagcacaaat
     4141 aactggaact ttgtattaac ttcctgcaaa gttttcattt taaatattta aaaagaatag
     4201 gacagcaaag gaaggaagga tggatggatt gcccgtgact tcacacaaag gggttgacca
     4261 tcattcaatt tttctgtata gttccccttg ctcttcctat gatgataatt tgtcgtctac
     4321 caatactgca caagaagaga tagatctacc tcttcttgca agtgcaaact aaaaatgatt
     4381 taccttttta ccacaggaag aaatgagtta aataccttaa ttaccacaga aaatactgtt
     4441 tacaaccaag atggatattt gagtagcttg tttcatagag gaaggtggtt ggctacaact
     4501 aattttccaa ggtggatacc agtactaaaa caaagagaat aaaaagcaga gacaagcttt
     4561 gctacaacaa taagaaaaga tagcacattg ttttaaagta atagctaaac gcttcaagtt
     4621 aactatggtg agctttgttt ttaaatgagt atatgataga attctgaaca gcgtatgtac
     4681 cacacagtga ttattctgat atattttgat gctttaaaac ccacattttt tcctctaaat
     4741 tattacctga aattactatt tatgattcaa accatctgcc ctaactattc atatatacaa
     4801 cagtggtgtt ggagccgggc atagtaggta cacacctgta atcccaacac tctggaagct
     4861 taggacttca gggttatcct ctcctacata gtgaatccca actaaaggct agcctaggct
     4921 gcatgagagc tttcttcaaa agtcaaacaa acaaacaagg tttaaaactc aatgaataaa
     4981 tccagtaatg aaaatatctt ttcacattgt gtggtaatgg tgttttccct taataacaat
     5041 gaaaggtttg gctttgatgg cctgacttac tgctcaagga gaaaaaccag cttgacagaa
     5101 tgacattgtc ttcaagtgtg tttacctgct ctcatggaaa aaataaagtg aaattaaaac
     5161 aaaa
//
