LOCUS       NM_001403999            5158 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus microtubule-associated protein tau (Mapt), transcript
            variant 22, mRNA.
ACCESSION   NM_001403999
VERSION     NM_001403999.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5158)
  AUTHORS   Chapman,P.D., Kulkarni,A.S., Trevisan,A.J., Han,K., Hinton,J.M.,
            Deltuvaite,P., Fenno,L.E., Ramakrishnan,C., Patton,M.H.,
            Schwarz,L.A., Zakharenko,S.S., Deisseroth,K. and Bikoff,J.B.
  TITLE     A brain-wide map of descending inputs onto spinal V1 interneurons
  JOURNAL   Neuron 113 (4), 524-538 (2025)
   PUBMED   39719703
REFERENCE   2  (bases 1 to 5158)
  AUTHORS   Sitko,A.A., Frank,M.M., Romero,G.E., Hunt,M. and Goodrich,L.V.
  TITLE     Lateral olivocochlear neurons modulate cochlear responses to noise
            exposure
  JOURNAL   Proc Natl Acad Sci U S A 122 (4), e2404558122 (2025)
   PUBMED   39854232
REFERENCE   3  (bases 1 to 5158)
  AUTHORS   Trevisan,A.J., Han,K., Chapman,P., Kulkarni,A.S., Hinton,J.M.,
            Ramirez,C., Klein,I., Gatto,G., Gabitto,M.I., Menon,V. and
            Bikoff,J.B.
  TITLE     The transcriptomic landscape of spinal V1 interneurons reveals a
            role for En1 in specific elements of motor output
  JOURNAL   bioRxiv (2024)
   PUBMED   39345580
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5158)
  AUTHORS   Sala-Jarque,J., Gil,V., Andres-Benito,P., Martinez-Soria,I.,
            Picon-Pages,P., Hernandez,F., Avila,J., Lanciego,J.L., Nuvolone,M.,
            Aguzzi,A., Gavin,R., Ferrer,I. and Del Rio,J.A.
  TITLE     The cellular prion protein does not affect tau seeding and
            spreading of sarkosyl-insoluble fractions from Alzheimer's disease
  JOURNAL   Sci Rep 14 (1), 21622 (2024)
   PUBMED   39284839
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5158)
  AUTHORS   Nishida,I., Yamada,K., Sakamoto,A., Wakabayashi,T. and Iwatsubo,T.
  TITLE     Chronic Neuronal Hyperexcitation Exacerbates Tau Propagation in a
            Mouse Model of Tauopathy
  JOURNAL   Int J Mol Sci 25 (16), 9004 (2024)
   PUBMED   39201689
  REMARK    GeneRIF: Chronic Neuronal Hyperexcitation Exacerbates Tau
            Propagation in a Mouse Model of Tauopathy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5158)
  AUTHORS   Charriere-Bertrand,C. and Nunez,J.
  TITLE     Regulation of tubulin, Tau and microtubule associated protein 2
            expression during mouse brain development
  JOURNAL   Neurochem Int 21 (4), 535-541 (1992)
   PUBMED   1303735
REFERENCE   7  (bases 1 to 5158)
  AUTHORS   Larcher,J.C., Boucher,D., Ginzburg,I., Gros,F. and Denoulet,P.
  TITLE     Heterogeneity of Tau proteins during mouse brain development and
            differentiation of cultured neurons
  JOURNAL   Dev Biol 154 (1), 195-204 (1992)
   PUBMED   1426626
REFERENCE   8  (bases 1 to 5158)
  AUTHORS   Couchie,D., Mavilia,C., Georgieff,I.S., Liem,R.K., Shelanski,M.L.
            and Nunez,J.
  TITLE     Primary structure of high molecular weight tau present in the
            peripheral nervous system
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4378-4381 (1992)
   PUBMED   1374898
REFERENCE   9  (bases 1 to 5158)
  AUTHORS   Brion,J.P., Guilleminot,J. and Nunez,J.
  TITLE     Dendritic and axonal distribution of the microtubule-associated
            proteins MAP2 and tau in the cerebellum of the nervous mutant mouse
  JOURNAL   Brain Res Dev Brain Res 44 (2), 221-232 (1988)
   PUBMED   3147150
REFERENCE   10 (bases 1 to 5158)
  AUTHORS   Lee,G., Cowan,N. and Kirschner,M.
  TITLE     The primary structure and heterogeneity of tau protein from mouse
            brain
  JOURNAL   Science 239 (4837), 285-288 (1988)
   PUBMED   3122323
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596383.8 and AL593843.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.965058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AL596383.8         82334-82462
            130-242             AL593843.9         173623-173735       c
            243-329             AL593843.9         166109-166195       c
            330-395             AL593843.9         161179-161244       c
            396-445             AL593843.9         153693-153742       c
            446-578             AL593843.9         149345-149477       c
            579-844             AL593843.9         145569-145834       c
            845-926             AL593843.9         134671-134752       c
            927-1039            AL593843.9         133563-133675       c
            1040-5158           AL593843.9         124013-128131       c
FEATURES             Location/Qualifiers
     source          1..5158
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 67.79 cM"
     gene            1..5158
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /note="microtubule-associated protein tau"
                     /db_xref="GeneID:17762"
                     /db_xref="MGI:MGI:97180"
     exon            1..129
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            130..242
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1255
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /note="isoform 22 is encoded by transcript variant 22;
                     paired helical filament-tau; neurofibrillary tangle
                     protein"
                     /codon_start=1
                     /product="microtubule-associated protein tau isoform 22"
                     /protein_id="NP_001390928.1"
                     /db_xref="GeneID:17762"
                     /db_xref="MGI:MGI:97180"
                     /translation="MADPRQEFDTMEDHAGDYTLLQDQEGDMDHGLKDVTAPLVDERA
                     PDKQAAAQPHTEIPEGITAEEAGIGDTPNQEDQAAGHVTQARVASKDRTGNDEKKAKG
                     ADGKTGAKIATPRGAASPAQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGYSSP
                     GSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRS
                     KIGSTENLKHQPGGGKVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFK
                     DRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSP
                     RHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL"
     exon            243..329
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            330..395
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            396..445
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            446..578
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            579..844
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            845..926
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1039
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..5158
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5091..5096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /note="hexamer: AACAAA"
     polyA_site      5136
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /note="major polyA site"
ORIGIN      
        1 agtctccgcc acccaccagc tccagcacca gcagcagcgc cgccgccacc gcccaccttc
       61 tgccgccgcc gccacaacca ccttctcctc cgctgtcctc ttctgtcctc gccttctgtc
      121 gattatcagg ctttgaacca gtatggctga ccctcgccag gagtttgaca caatggaaga
      181 ccatgctgga gattacactc tgctccaaga ccaagaagga gacatggacc atggcttaaa
      241 agacgtgact gcgcccctag tggatgagag agctcccgac aagcaggccg ctgcccagcc
      301 ccacacggag atcccagaag gaattacagc cgaagaagca ggcatcggag acaccccgaa
      361 ccaggaggac caagccgctg ggcatgtgac tcaagctcgt gtggccagca aagacaggac
      421 aggaaatgac gagaagaaag ccaagggcgc tgatggcaaa accggggcga agatcgccac
      481 acctcgggga gcagcctctc cggcccagaa gggcacgtcc aacgccacca ggatcccggc
      541 caagaccacg cccagcccta agactcctcc agggtcaggt gaaccaccaa aatccggaga
      601 acgaagcggc tacagcagcc ccggctctcc cggaacgcct ggcagtcgct cgcgcacccc
      661 atccctacca acaccgccca cccgggagcc caagaaggtg gcagtggtcc gcactccccc
      721 taagtcacca tcagctagta agagccgcct gcagactgcc cctgtgccca tgccagacct
      781 aaagaatgtc aggtcgaaga ttggctctac tgagaacctg aagcaccagc caggaggtgg
      841 caaggtgcaa atagtctaca agccggtgga cctgagcaaa gtgacctcca agtgtggctc
      901 gttagggaac atccatcaca agccaggagg tggccaggtg gaagtaaaat cagagaagct
      961 ggacttcaag gacagagtcc agtcgaagat tggctccttg gataatatca cccacgtccc
     1021 tggaggaggg aataagaaga ttgaaaccca caagctgacc ttcagggaga atgccaaagc
     1081 caagacagac catggagcag aaattgtgta taagtcaccc gtggtgtctg gggacacatc
     1141 tccacggcac ctcagcaatg tgtcttccac gggcagcatc gacatggtgg actcaccaca
     1201 gcttgccaca ctagccgatg aagtgtctgc ttccttggcc aagcagggtt tgtgatcagg
     1261 ctcccagggc agtcaataat catggagaga agagagagtg agagtgtgga aaaaaaaaaa
     1321 aaaaaagaat gatctggccc cttgccctct gccctccccg ctgctcctca tagacaggct
     1381 gacctgcttg tcacctaacc tgcttttgtg gctcggattt ggctcgggac ttcaaaatca
     1441 gtgatgggaa aagtacattt catctttcca aattgatttg tgggctaaaa ataaaacata
     1501 tttaagggaa aaaaaaacat gtaaaaacat ggccaaaaaa tttccttggg caattgctaa
     1561 ttgatttccc ccccctgacc ccgccctccc tctctgagta ttagagggtg aagaaggctc
     1621 tggaggctgc ttctggggag tggctgaggg actagggcag ctaattgccc atagccccat
     1681 cctaggggct tcagggacag tggcagcaat gagagatttg agacttggtg tgttcgtggg
     1741 gccgtaggca ggtgctgtta acttgtgtgg gtgtgagtgg ggactgaaac agcgacagcg
     1801 aaggctgaga gatggatggg tggactgagt tagaggacag aggtgaggaa ggcaggttgg
     1861 gagaggggac actggctcct tgccaagtag cttggggagg acagggtgct gcagctgcct
     1921 gcagcagtcc tagctagctc agatgcctgc ttgataaagc actgtggggg taacgtgggt
     1981 gtgtgtgccc cttctgcagg gcagcctgtg ggagaagggg tattgggcag aaggaaggta
     2041 agccagcagg tggtaccttg tagattggtt ctcttgaagg ctgctcttga catcccaggg
     2101 cactggcttc ttcctccctc cccgcaaggt gggaggtcct gagcgaggtg tttcccttcg
     2161 ctcccacagg aaaagctgct ttactgagtt ctcaagtttg gaactacagc catgatttgg
     2221 ccaccattac agacctggga ctttagggct aaccagatct ttgtaaggac ttgtgcctct
     2281 tgggggacct ctgcctgttc tcatgcttgg ccctctggca cttctgtagt gggagggatg
     2341 gggggtggta ttctgggatg tgggtcccag gcctcccatc cctcacacag ccactgtatc
     2401 ccctctctct gtcctatcat gcccacgtct gccacgagag ctagtcactg ccgtccgtac
     2461 atcacgtctc actgtcctga gtgccatgcc tctcccagcc cccatccctg gcccctgggt
     2521 agatatgggc aatatctgct ctacactagg ggttggagtc cagggaaggc aaagatttgg
     2581 gcctcagtct ctagtcctac gttccacgaa tccaaccagt gtgcctccca caaggaacct
     2641 tacgaccttg tttggttcac tccattactt cctatcctgg atgggaactg gtgtgtgcct
     2701 gcctggggat gaccttggac ctctgccttt tcttttatct aagtggatgc ctcctaggcc
     2761 tgactccttg tgttgagctg gaggcagcca agtcaggtgc caatgtcttg gcatcagtaa
     2821 gaacagtcaa gagtcccagg gcagggccac acttctccca tctttcgctt ccaccccagc
     2881 ttgtgatcgc tagcctccca gagctcagct gccattaagt ccccatgcac gtaatcagtc
     2941 tccacacccc agtttgggga acataccccc ttgattgaag tgtttttttc ctccggtccc
     3001 atggaaacca tgctgcctgc cctgctggag cagacggcca cctccataga tgcagccctt
     3061 tctttcccgt cttcgccctg ttacgttgta gttggatttg tctgtttgtc tgggttcacc
     3121 agagtgacta tgatagtgaa aagaaaagaa agaaaaagaa aaaaaaaaaa aaaaagaaaa
     3181 agaaaaagga aaaaaaaaag gacgcatgta tcttgaaata tttgtcaaaa ggttctagcc
     3241 caccacgtga tggagagtct ggatatctcc ttcctgacgt ggctccaggc cagtgcagtg
     3301 ctaacctgct gggacatccc atgttttgaa gggtttcttc tgcatctggg acctcacaga
     3361 cactggattg tgacattgga ggtctgtgac attggaggtc aatggcattg gccaaggcct
     3421 gaagcacagg accagctaga ggcagcaggc tccgagtgcc agggagagct tgtggctggc
     3481 ctgttttgta tgaagatggt cctttctgat cacgacttca aatcccacag tagccctgaa
     3541 agacatctaa gaactcctgc atcacaagag aaaaggacac cagtaccagc agggagagct
     3601 gtgaccctag aaattccatg acgacccagt agatatcctt gggccctctc caagcctggg
     3661 ccttttcacc atagagtttg ggatggactg tcccactgat gaaggggaca tcttaggaga
     3721 ctcccttggt ttccaagctg tcagccccct gaacttgcac gacctcctac agcttcaggg
     3781 actaggcctt tgaagattag gaacctcagg cccacatcag ccacttctga tgtacagtta
     3841 aggacaatgt ggagactagg aggaagcagc cagcctttcc cattaaagaa ctcttgagtg
     3901 cccagggcta cctattgtga gcttccccac tgataagact ttagctgtcc atagaagtga
     3961 gtccgaggga ggaaaagtgt ggtttcttca tcatggttac ctgtcgtggt tctctctctt
     4021 acacccattt acccatcccg cagttcctgt ccttgaatgg ggggtggggt gctctgccta
     4081 tctcttgtgg ggtgatcagc ccaaaaatca tgatttggag tgatctgatc agtgctgata
     4141 ggcagtttac aaagggattc tggcttgtga cttcagtgag gacaatcccc cagggccctt
     4201 tctttccatg cctctccaac tcagagccaa tgtctttggg tgggctagat agatagggca
     4261 tacaattggc ctggttcctc caagctctta attcacttta tcaatagttc catttaaatt
     4321 gacttcaatg ataagagtgt atcccatttg agattgcttg cgttgtgggg gagggggagg
     4381 aggaacacat taagataatt cacatgggca aagggaggtc ttggagtgta gccgttaagc
     4441 catcttgtaa ccccattcat gattttgacc acctgctaga gagaagaggt gccaagagac
     4501 tagaacttgg aggcttggct gtcccactaa taggctttcg caaggcagag gtagccagct
     4561 aggtccctgc cttcccagcc aggtacagct ctcaggtttg tggaggtaat ctgtgaactt
     4621 ctcttcctgc tgccttcttg tgatgtccag agcccacagt caaatacctc ctaagaaccc
     4681 tggcttcctt ccctctaatc cactggcaca tgactatcac ctctggattg acctcagatc
     4741 catagcctac acactgctag cagtggccaa gatcacttcc tttatctcca tctgttctgt
     4801 tctccaggaa agtaagtggg gatgagggtg gaggtggtaa tcaactgtag atctgtggct
     4861 ttatgagcct tcagacttct ctctggcttc ttctggaagg gttactattg gcagtattgc
     4921 aatctcaccc tcctgatgaa ctgtagcctg tgccgttact gtgctgggca tgatctccag
     4981 tgcttgcaag tcccatgatt tctttggtga ttttgagggt ggggggaggg acacaaatca
     5041 gcttagctta gcttcctgtc tgtgaatgtc catatagtgt attgtgtttt aacaaatgat
     5101 ctacactgac tgttgctgta aaagtgaatt tggaaataaa gttattactc tgaataaa
//
