LOCUS       NM_001403980            5923 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus microtubule-associated protein tau (Mapt), transcript
            variant 11, mRNA.
ACCESSION   NM_001403980 XM_036156389
VERSION     NM_001403980.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5923)
  AUTHORS   Chapman,P.D., Kulkarni,A.S., Trevisan,A.J., Han,K., Hinton,J.M.,
            Deltuvaite,P., Fenno,L.E., Ramakrishnan,C., Patton,M.H.,
            Schwarz,L.A., Zakharenko,S.S., Deisseroth,K. and Bikoff,J.B.
  TITLE     A brain-wide map of descending inputs onto spinal V1 interneurons
  JOURNAL   Neuron 113 (4), 524-538 (2025)
   PUBMED   39719703
REFERENCE   2  (bases 1 to 5923)
  AUTHORS   Sitko,A.A., Frank,M.M., Romero,G.E., Hunt,M. and Goodrich,L.V.
  TITLE     Lateral olivocochlear neurons modulate cochlear responses to noise
            exposure
  JOURNAL   Proc Natl Acad Sci U S A 122 (4), e2404558122 (2025)
   PUBMED   39854232
REFERENCE   3  (bases 1 to 5923)
  AUTHORS   Trevisan,A.J., Han,K., Chapman,P., Kulkarni,A.S., Hinton,J.M.,
            Ramirez,C., Klein,I., Gatto,G., Gabitto,M.I., Menon,V. and
            Bikoff,J.B.
  TITLE     The transcriptomic landscape of spinal V1 interneurons reveals a
            role for En1 in specific elements of motor output
  JOURNAL   bioRxiv (2024)
   PUBMED   39345580
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5923)
  AUTHORS   Sala-Jarque,J., Gil,V., Andres-Benito,P., Martinez-Soria,I.,
            Picon-Pages,P., Hernandez,F., Avila,J., Lanciego,J.L., Nuvolone,M.,
            Aguzzi,A., Gavin,R., Ferrer,I. and Del Rio,J.A.
  TITLE     The cellular prion protein does not affect tau seeding and
            spreading of sarkosyl-insoluble fractions from Alzheimer's disease
  JOURNAL   Sci Rep 14 (1), 21622 (2024)
   PUBMED   39284839
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5923)
  AUTHORS   Nishida,I., Yamada,K., Sakamoto,A., Wakabayashi,T. and Iwatsubo,T.
  TITLE     Chronic Neuronal Hyperexcitation Exacerbates Tau Propagation in a
            Mouse Model of Tauopathy
  JOURNAL   Int J Mol Sci 25 (16), 9004 (2024)
   PUBMED   39201689
  REMARK    GeneRIF: Chronic Neuronal Hyperexcitation Exacerbates Tau
            Propagation in a Mouse Model of Tauopathy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5923)
  AUTHORS   Charriere-Bertrand,C. and Nunez,J.
  TITLE     Regulation of tubulin, Tau and microtubule associated protein 2
            expression during mouse brain development
  JOURNAL   Neurochem Int 21 (4), 535-541 (1992)
   PUBMED   1303735
REFERENCE   7  (bases 1 to 5923)
  AUTHORS   Larcher,J.C., Boucher,D., Ginzburg,I., Gros,F. and Denoulet,P.
  TITLE     Heterogeneity of Tau proteins during mouse brain development and
            differentiation of cultured neurons
  JOURNAL   Dev Biol 154 (1), 195-204 (1992)
   PUBMED   1426626
REFERENCE   8  (bases 1 to 5923)
  AUTHORS   Couchie,D., Mavilia,C., Georgieff,I.S., Liem,R.K., Shelanski,M.L.
            and Nunez,J.
  TITLE     Primary structure of high molecular weight tau present in the
            peripheral nervous system
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4378-4381 (1992)
   PUBMED   1374898
REFERENCE   9  (bases 1 to 5923)
  AUTHORS   Brion,J.P., Guilleminot,J. and Nunez,J.
  TITLE     Dendritic and axonal distribution of the microtubule-associated
            proteins MAP2 and tau in the cerebellum of the nervous mutant mouse
  JOURNAL   Brain Res Dev Brain Res 44 (2), 221-232 (1988)
   PUBMED   3147150
REFERENCE   10 (bases 1 to 5923)
  AUTHORS   Lee,G., Cowan,N. and Kirschner,M.
  TITLE     The primary structure and heterogeneity of tau protein from mouse
            brain
  JOURNAL   Science 239 (4837), 285-288 (1988)
   PUBMED   3122323
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596383.8 and AL593843.9.
            
            On Apr 7, 2022 this sequence version replaced XM_036156389.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.205349.1,
                                           SRR17784647.234725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AL596383.8         82334-82462
            130-242             AL593843.9         173623-173735       c
            243-308             AL593843.9         161179-161244       c
            309-1067            AL593843.9         156847-157605       c
            1068-1117           AL593843.9         153693-153742       c
            1118-1250           AL593843.9         149345-149477       c
            1251-1516           AL593843.9         145569-145834       c
            1517-1609           AL593843.9         137854-137946       c
            1610-1691           AL593843.9         134671-134752       c
            1692-1804           AL593843.9         133563-133675       c
            1805-5923           AL593843.9         124013-128131       c
FEATURES             Location/Qualifiers
     source          1..5923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 67.79 cM"
     gene            1..5923
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /note="microtubule-associated protein tau"
                     /db_xref="GeneID:17762"
                     /db_xref="MGI:MGI:97180"
     exon            1..129
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            130..242
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2020
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /note="isoform 11 is encoded by transcript variant 11;
                     paired helical filament-tau; neurofibrillary tangle
                     protein"
                     /codon_start=1
                     /product="microtubule-associated protein tau isoform 11"
                     /protein_id="NP_001390909.1"
                     /db_xref="GeneID:17762"
                     /db_xref="MGI:MGI:97180"
                     /translation="MADPRQEFDTMEDHAGDYTLLQDQEGDMDHGLKAEEAGIGDTPN
                     QEDQAAGHVTQEPEKVEIFSQSLLVEPGRREGQAPDLGTSDWTRQQVSSMSGAPLLPQ
                     GLREATCQPSGTRPEDIEKSHPASELLRRGPPQKEGWGQDRLGSEEEVDEDLTVDESS
                     QDSPPSQASLTPGRAAPQAGSGSVCGETASVPGLPTEGSVPLPADFFSKVSAETQASQ
                     PEGPGTGPMEEGHEAAPEFTFHVEIKASTPKEQDLEGATVVGVPGEEQKAQTQGPSVG
                     KGTKEASLQEPPGKQPAAGLPGRPVSRVPQLKARVASKDRTGNDEKKAKGADGKTGAK
                     IATPRGAASPAQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPGS
                     RSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENL
                     KHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGS
                     LGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENA
                     KAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQG
                     L"
     exon            243..308
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            309..1067
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1117
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1250
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1516
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1609
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1691
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1804
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..5923
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5856..5861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /note="hexamer: AACAAA"
     polyA_site      5901
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /note="major polyA site"
ORIGIN      
        1 agtctccgcc acccaccagc tccagcacca gcagcagcgc cgccgccacc gcccaccttc
       61 tgccgccgcc gccacaacca ccttctcctc cgctgtcctc ttctgtcctc gccttctgtc
      121 gattatcagg ctttgaacca gtatggctga ccctcgccag gagtttgaca caatggaaga
      181 ccatgctgga gattacactc tgctccaaga ccaagaagga gacatggacc atggcttaaa
      241 agccgaagaa gcaggcatcg gagacacccc gaaccaggag gaccaagccg ctgggcatgt
      301 gactcaagaa ccggagaagg tcgagatttt ctcacaaagt ttgcttgtcg aaccagggcg
      361 tcgtgaaggc caggccccag atttggggac ctcagactgg acccgccaac aggtgtctag
      421 catgtctggg gctcccctcc tgccacaagg cctcagagag gctacatgtc aaccttcggg
      481 aacaagacct gaggacatag agaaaagcca cccggcctct gagctgctgc ggcgagggcc
      541 acctcagaag gaaggctggg gccaagacag gctggggagt gaggaagagg tggatgaaga
      601 tctcaccgtg gatgaatcat cccaggattc ccctccctcc caggcctccc tgacccctgg
      661 cagggcagcc cctcaggccg gctccggctc tgtctgcggg gagaccgcca gcgtgcctgg
      721 gctcccaact gagggttccg tcccacttcc tgctgatttc ttctccaaag tctccgcaga
      781 gacccaggcc tcacagcccg aagggcctgg cacggggccc atggaggaag ggcacgaggc
      841 tgcccctgag ttcacgttcc acgtggaaat caaagccagc acgccgaagg aacaggattt
      901 ggaaggggct acagtggtgg gggtccccgg agaggagcaa aaggcccaga cccagggccc
      961 ctctgtggga aagggcacca aagaggctag ccttcaggaa cctcctggca agcaacctgc
     1021 agccggcctg cccgggaggc cagtcagtcg ggttcctcaa cttaaagctc gtgtggccag
     1081 caaagacagg acaggaaatg acgagaagaa agccaagggc gctgatggca aaaccggggc
     1141 gaagatcgcc acacctcggg gagcagcctc tccggcccag aagggcacgt ccaacgccac
     1201 caggatcccg gccaagacca cgcccagccc taagactcct ccagggtcag gtgaaccacc
     1261 aaaatccgga gaacgaagcg gctacagcag ccccggctct cccggaacgc ctggcagtcg
     1321 ctcgcgcacc ccatccctac caacaccgcc cacccgggag cccaagaagg tggcagtggt
     1381 ccgcactccc cctaagtcac catcagctag taagagccgc ctgcagactg cccctgtgcc
     1441 catgccagac ctaaagaatg tcaggtcgaa gattggctct actgagaacc tgaagcacca
     1501 gccaggaggt ggcaaggtgc agataattaa taagaagctg gatcttagca acgtccagtc
     1561 caagtgtggc tcgaaggata atatcaaaca cgtcccgggt ggaggcagtg tgcaaatagt
     1621 ctacaagccg gtggacctga gcaaagtgac ctccaagtgt ggctcgttag ggaacatcca
     1681 tcacaagcca ggaggtggcc aggtggaagt aaaatcagag aagctggact tcaaggacag
     1741 agtccagtcg aagattggct ccttggataa tatcacccac gtccctggag gagggaataa
     1801 gaagattgaa acccacaagc tgaccttcag ggagaatgcc aaagccaaga cagaccatgg
     1861 agcagaaatt gtgtataagt cacccgtggt gtctggggac acatctccac ggcacctcag
     1921 caatgtgtct tccacgggca gcatcgacat ggtggactca ccacagcttg ccacactagc
     1981 cgatgaagtg tctgcttcct tggccaagca gggtttgtga tcaggctccc agggcagtca
     2041 ataatcatgg agagaagaga gagtgagagt gtggaaaaaa aaaaaaaaaa agaatgatct
     2101 ggccccttgc cctctgccct ccccgctgct cctcatagac aggctgacct gcttgtcacc
     2161 taacctgctt ttgtggctcg gatttggctc gggacttcaa aatcagtgat gggaaaagta
     2221 catttcatct ttccaaattg atttgtgggc taaaaataaa acatatttaa gggaaaaaaa
     2281 aacatgtaaa aacatggcca aaaaatttcc ttgggcaatt gctaattgat ttcccccccc
     2341 tgaccccgcc ctccctctct gagtattaga gggtgaagaa ggctctggag gctgcttctg
     2401 gggagtggct gagggactag ggcagctaat tgcccatagc cccatcctag gggcttcagg
     2461 gacagtggca gcaatgagag atttgagact tggtgtgttc gtggggccgt aggcaggtgc
     2521 tgttaacttg tgtgggtgtg agtggggact gaaacagcga cagcgaaggc tgagagatgg
     2581 atgggtggac tgagttagag gacagaggtg aggaaggcag gttgggagag gggacactgg
     2641 ctccttgcca agtagcttgg ggaggacagg gtgctgcagc tgcctgcagc agtcctagct
     2701 agctcagatg cctgcttgat aaagcactgt gggggtaacg tgggtgtgtg tgccccttct
     2761 gcagggcagc ctgtgggaga aggggtattg ggcagaagga aggtaagcca gcaggtggta
     2821 ccttgtagat tggttctctt gaaggctgct cttgacatcc cagggcactg gcttcttcct
     2881 ccctccccgc aaggtgggag gtcctgagcg aggtgtttcc cttcgctccc acaggaaaag
     2941 ctgctttact gagttctcaa gtttggaact acagccatga tttggccacc attacagacc
     3001 tgggacttta gggctaacca gatctttgta aggacttgtg cctcttgggg gacctctgcc
     3061 tgttctcatg cttggccctc tggcacttct gtagtgggag ggatgggggg tggtattctg
     3121 ggatgtgggt cccaggcctc ccatccctca cacagccact gtatcccctc tctctgtcct
     3181 atcatgccca cgtctgccac gagagctagt cactgccgtc cgtacatcac gtctcactgt
     3241 cctgagtgcc atgcctctcc cagcccccat ccctggcccc tgggtagata tgggcaatat
     3301 ctgctctaca ctaggggttg gagtccaggg aaggcaaaga tttgggcctc agtctctagt
     3361 cctacgttcc acgaatccaa ccagtgtgcc tcccacaagg aaccttacga ccttgtttgg
     3421 ttcactccat tacttcctat cctggatggg aactggtgtg tgcctgcctg gggatgacct
     3481 tggacctctg ccttttcttt tatctaagtg gatgcctcct aggcctgact ccttgtgttg
     3541 agctggaggc agccaagtca ggtgccaatg tcttggcatc agtaagaaca gtcaagagtc
     3601 ccagggcagg gccacacttc tcccatcttt cgcttccacc ccagcttgtg atcgctagcc
     3661 tcccagagct cagctgccat taagtcccca tgcacgtaat cagtctccac accccagttt
     3721 ggggaacata cccccttgat tgaagtgttt ttttcctccg gtcccatgga aaccatgctg
     3781 cctgccctgc tggagcagac ggccacctcc atagatgcag ccctttcttt cccgtcttcg
     3841 ccctgttacg ttgtagttgg atttgtctgt ttgtctgggt tcaccagagt gactatgata
     3901 gtgaaaagaa aagaaagaaa aagaaaaaaa aaaaaaaaaa gaaaaagaaa aaggaaaaaa
     3961 aaaaggacgc atgtatcttg aaatatttgt caaaaggttc tagcccacca cgtgatggag
     4021 agtctggata tctccttcct gacgtggctc caggccagtg cagtgctaac ctgctgggac
     4081 atcccatgtt ttgaagggtt tcttctgcat ctgggacctc acagacactg gattgtgaca
     4141 ttggaggtct gtgacattgg aggtcaatgg cattggccaa ggcctgaagc acaggaccag
     4201 ctagaggcag caggctccga gtgccaggga gagcttgtgg ctggcctgtt ttgtatgaag
     4261 atggtccttt ctgatcacga cttcaaatcc cacagtagcc ctgaaagaca tctaagaact
     4321 cctgcatcac aagagaaaag gacaccagta ccagcaggga gagctgtgac cctagaaatt
     4381 ccatgacgac ccagtagata tccttgggcc ctctccaagc ctgggccttt tcaccataga
     4441 gtttgggatg gactgtccca ctgatgaagg ggacatctta ggagactccc ttggtttcca
     4501 agctgtcagc cccctgaact tgcacgacct cctacagctt cagggactag gcctttgaag
     4561 attaggaacc tcaggcccac atcagccact tctgatgtac agttaaggac aatgtggaga
     4621 ctaggaggaa gcagccagcc tttcccatta aagaactctt gagtgcccag ggctacctat
     4681 tgtgagcttc cccactgata agactttagc tgtccataga agtgagtccg agggaggaaa
     4741 agtgtggttt cttcatcatg gttacctgtc gtggttctct ctcttacacc catttaccca
     4801 tcccgcagtt cctgtccttg aatggggggt ggggtgctct gcctatctct tgtggggtga
     4861 tcagcccaaa aatcatgatt tggagtgatc tgatcagtgc tgataggcag tttacaaagg
     4921 gattctggct tgtgacttca gtgaggacaa tcccccaggg ccctttcttt ccatgcctct
     4981 ccaactcaga gccaatgtct ttgggtgggc tagatagata gggcatacaa ttggcctggt
     5041 tcctccaagc tcttaattca ctttatcaat agttccattt aaattgactt caatgataag
     5101 agtgtatccc atttgagatt gcttgcgttg tgggggaggg ggaggaggaa cacattaaga
     5161 taattcacat gggcaaaggg aggtcttgga gtgtagccgt taagccatct tgtaacccca
     5221 ttcatgattt tgaccacctg ctagagagaa gaggtgccaa gagactagaa cttggaggct
     5281 tggctgtccc actaataggc tttcgcaagg cagaggtagc cagctaggtc cctgccttcc
     5341 cagccaggta cagctctcag gtttgtggag gtaatctgtg aacttctctt cctgctgcct
     5401 tcttgtgatg tccagagccc acagtcaaat acctcctaag aaccctggct tccttccctc
     5461 taatccactg gcacatgact atcacctctg gattgacctc agatccatag cctacacact
     5521 gctagcagtg gccaagatca cttcctttat ctccatctgt tctgttctcc aggaaagtaa
     5581 gtggggatga gggtggaggt ggtaatcaac tgtagatctg tggctttatg agccttcaga
     5641 cttctctctg gcttcttctg gaagggttac tattggcagt attgcaatct caccctcctg
     5701 atgaactgta gcctgtgccg ttactgtgct gggcatgatc tccagtgctt gcaagtccca
     5761 tgatttcttt ggtgattttg agggtggggg gagggacaca aatcagctta gcttagcttc
     5821 ctgtctgtga atgtccatat agtgtattgt gttttaacaa atgatctaca ctgactgttg
     5881 ctgtaaaagt gaatttggaa ataaagttat tactctgaat aaa
//
