LOCUS       NM_001403975            6097 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus microtubule-associated protein tau (Mapt), transcript
            variant 6, mRNA.
ACCESSION   NM_001403975 XM_030245631
VERSION     NM_001403975.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6097)
  AUTHORS   Chapman,P.D., Kulkarni,A.S., Trevisan,A.J., Han,K., Hinton,J.M.,
            Deltuvaite,P., Fenno,L.E., Ramakrishnan,C., Patton,M.H.,
            Schwarz,L.A., Zakharenko,S.S., Deisseroth,K. and Bikoff,J.B.
  TITLE     A brain-wide map of descending inputs onto spinal V1 interneurons
  JOURNAL   Neuron 113 (4), 524-538 (2025)
   PUBMED   39719703
REFERENCE   2  (bases 1 to 6097)
  AUTHORS   Sitko,A.A., Frank,M.M., Romero,G.E., Hunt,M. and Goodrich,L.V.
  TITLE     Lateral olivocochlear neurons modulate cochlear responses to noise
            exposure
  JOURNAL   Proc Natl Acad Sci U S A 122 (4), e2404558122 (2025)
   PUBMED   39854232
REFERENCE   3  (bases 1 to 6097)
  AUTHORS   Trevisan,A.J., Han,K., Chapman,P., Kulkarni,A.S., Hinton,J.M.,
            Ramirez,C., Klein,I., Gatto,G., Gabitto,M.I., Menon,V. and
            Bikoff,J.B.
  TITLE     The transcriptomic landscape of spinal V1 interneurons reveals a
            role for En1 in specific elements of motor output
  JOURNAL   bioRxiv (2024)
   PUBMED   39345580
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6097)
  AUTHORS   Sala-Jarque,J., Gil,V., Andres-Benito,P., Martinez-Soria,I.,
            Picon-Pages,P., Hernandez,F., Avila,J., Lanciego,J.L., Nuvolone,M.,
            Aguzzi,A., Gavin,R., Ferrer,I. and Del Rio,J.A.
  TITLE     The cellular prion protein does not affect tau seeding and
            spreading of sarkosyl-insoluble fractions from Alzheimer's disease
  JOURNAL   Sci Rep 14 (1), 21622 (2024)
   PUBMED   39284839
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6097)
  AUTHORS   Nishida,I., Yamada,K., Sakamoto,A., Wakabayashi,T. and Iwatsubo,T.
  TITLE     Chronic Neuronal Hyperexcitation Exacerbates Tau Propagation in a
            Mouse Model of Tauopathy
  JOURNAL   Int J Mol Sci 25 (16), 9004 (2024)
   PUBMED   39201689
  REMARK    GeneRIF: Chronic Neuronal Hyperexcitation Exacerbates Tau
            Propagation in a Mouse Model of Tauopathy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6097)
  AUTHORS   Charriere-Bertrand,C. and Nunez,J.
  TITLE     Regulation of tubulin, Tau and microtubule associated protein 2
            expression during mouse brain development
  JOURNAL   Neurochem Int 21 (4), 535-541 (1992)
   PUBMED   1303735
REFERENCE   7  (bases 1 to 6097)
  AUTHORS   Larcher,J.C., Boucher,D., Ginzburg,I., Gros,F. and Denoulet,P.
  TITLE     Heterogeneity of Tau proteins during mouse brain development and
            differentiation of cultured neurons
  JOURNAL   Dev Biol 154 (1), 195-204 (1992)
   PUBMED   1426626
REFERENCE   8  (bases 1 to 6097)
  AUTHORS   Couchie,D., Mavilia,C., Georgieff,I.S., Liem,R.K., Shelanski,M.L.
            and Nunez,J.
  TITLE     Primary structure of high molecular weight tau present in the
            peripheral nervous system
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4378-4381 (1992)
   PUBMED   1374898
REFERENCE   9  (bases 1 to 6097)
  AUTHORS   Brion,J.P., Guilleminot,J. and Nunez,J.
  TITLE     Dendritic and axonal distribution of the microtubule-associated
            proteins MAP2 and tau in the cerebellum of the nervous mutant mouse
  JOURNAL   Brain Res Dev Brain Res 44 (2), 221-232 (1988)
   PUBMED   3147150
REFERENCE   10 (bases 1 to 6097)
  AUTHORS   Lee,G., Cowan,N. and Kirschner,M.
  TITLE     The primary structure and heterogeneity of tau protein from mouse
            brain
  JOURNAL   Science 239 (4837), 285-288 (1988)
   PUBMED   3122323
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596383.8 and AL593843.9.
            
            On Apr 7, 2022 this sequence version replaced XM_030245631.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995047.1982280.1,
                                           SRR17784650.708625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AL596383.8         82334-82462
            130-242             AL593843.9         173623-173735       c
            243-329             AL593843.9         168894-168980       c
            330-416             AL593843.9         166109-166195       c
            417-482             AL593843.9         161179-161244       c
            483-1241            AL593843.9         156847-157605       c
            1242-1291           AL593843.9         153693-153742       c
            1292-1424           AL593843.9         149345-149477       c
            1425-1690           AL593843.9         145569-145834       c
            1691-1783           AL593843.9         137854-137946       c
            1784-1865           AL593843.9         134671-134752       c
            1866-1978           AL593843.9         133563-133675       c
            1979-6097           AL593843.9         124013-128131       c
FEATURES             Location/Qualifiers
     source          1..6097
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 67.79 cM"
     gene            1..6097
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /note="microtubule-associated protein tau"
                     /db_xref="GeneID:17762"
                     /db_xref="MGI:MGI:97180"
     exon            1..129
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            130..242
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2194
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /note="isoform 6 is encoded by transcript variant 6;
                     paired helical filament-tau; neurofibrillary tangle
                     protein"
                     /codon_start=1
                     /product="microtubule-associated protein tau isoform 6"
                     /protein_id="NP_001390904.1"
                     /db_xref="GeneID:17762"
                     /db_xref="MGI:MGI:97180"
                     /translation="MADPRQEFDTMEDHAGDYTLLQDQEGDMDHGLKESPPQPPADDG
                     AEEPGSETSDAKSTPTAEDVTAPLVDERAPDKQAAAQPHTEIPEGITAEEAGIGDTPN
                     QEDQAAGHVTQEPEKVEIFSQSLLVEPGRREGQAPDLGTSDWTRQQVSSMSGAPLLPQ
                     GLREATCQPSGTRPEDIEKSHPASELLRRGPPQKEGWGQDRLGSEEEVDEDLTVDESS
                     QDSPPSQASLTPGRAAPQAGSGSVCGETASVPGLPTEGSVPLPADFFSKVSAETQASQ
                     PEGPGTGPMEEGHEAAPEFTFHVEIKASTPKEQDLEGATVVGVPGEEQKAQTQGPSVG
                     KGTKEASLQEPPGKQPAAGLPGRPVSRVPQLKARVASKDRTGNDEKKAKGADGKTGAK
                     IATPRGAASPAQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPGS
                     RSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENL
                     KHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGS
                     LGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENA
                     KAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQG
                     L"
     exon            243..329
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            330..416
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            417..482
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            483..1241
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1291
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1424
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1690
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1783
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1865
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1978
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..6097
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6030..6035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /note="hexamer: AACAAA"
     polyA_site      6075
                     /gene="Mapt"
                     /gene_synonym="Mtapt; PHF-tau; Tau"
                     /note="major polyA site"
ORIGIN      
        1 agtctccgcc acccaccagc tccagcacca gcagcagcgc cgccgccacc gcccaccttc
       61 tgccgccgcc gccacaacca ccttctcctc cgctgtcctc ttctgtcctc gccttctgtc
      121 gattatcagg ctttgaacca gtatggctga ccctcgccag gagtttgaca caatggaaga
      181 ccatgctgga gattacactc tgctccaaga ccaagaagga gacatggacc atggcttaaa
      241 agagtctccc ccacagcccc ccgccgatga tggagcggag gaaccagggt cggagacctc
      301 cgatgctaag agcactccaa ctgctgaaga cgtgactgcg cccctagtgg atgagagagc
      361 tcccgacaag caggccgctg cccagcccca cacggagatc ccagaaggaa ttacagccga
      421 agaagcaggc atcggagaca ccccgaacca ggaggaccaa gccgctgggc atgtgactca
      481 agaaccggag aaggtcgaga ttttctcaca aagtttgctt gtcgaaccag ggcgtcgtga
      541 aggccaggcc ccagatttgg ggacctcaga ctggacccgc caacaggtgt ctagcatgtc
      601 tggggctccc ctcctgccac aaggcctcag agaggctaca tgtcaacctt cgggaacaag
      661 acctgaggac atagagaaaa gccacccggc ctctgagctg ctgcggcgag ggccacctca
      721 gaaggaaggc tggggccaag acaggctggg gagtgaggaa gaggtggatg aagatctcac
      781 cgtggatgaa tcatcccagg attcccctcc ctcccaggcc tccctgaccc ctggcagggc
      841 agcccctcag gccggctccg gctctgtctg cggggagacc gccagcgtgc ctgggctccc
      901 aactgagggt tccgtcccac ttcctgctga tttcttctcc aaagtctccg cagagaccca
      961 ggcctcacag cccgaagggc ctggcacggg gcccatggag gaagggcacg aggctgcccc
     1021 tgagttcacg ttccacgtgg aaatcaaagc cagcacgccg aaggaacagg atttggaagg
     1081 ggctacagtg gtgggggtcc ccggagagga gcaaaaggcc cagacccagg gcccctctgt
     1141 gggaaagggc accaaagagg ctagccttca ggaacctcct ggcaagcaac ctgcagccgg
     1201 cctgcccggg aggccagtca gtcgggttcc tcaacttaaa gctcgtgtgg ccagcaaaga
     1261 caggacagga aatgacgaga agaaagccaa gggcgctgat ggcaaaaccg gggcgaagat
     1321 cgccacacct cggggagcag cctctccggc ccagaagggc acgtccaacg ccaccaggat
     1381 cccggccaag accacgccca gccctaagac tcctccaggg tcaggtgaac caccaaaatc
     1441 cggagaacga agcggctaca gcagccccgg ctctcccgga acgcctggca gtcgctcgcg
     1501 caccccatcc ctaccaacac cgcccacccg ggagcccaag aaggtggcag tggtccgcac
     1561 tccccctaag tcaccatcag ctagtaagag ccgcctgcag actgcccctg tgcccatgcc
     1621 agacctaaag aatgtcaggt cgaagattgg ctctactgag aacctgaagc accagccagg
     1681 aggtggcaag gtgcagataa ttaataagaa gctggatctt agcaacgtcc agtccaagtg
     1741 tggctcgaag gataatatca aacacgtccc gggtggaggc agtgtgcaaa tagtctacaa
     1801 gccggtggac ctgagcaaag tgacctccaa gtgtggctcg ttagggaaca tccatcacaa
     1861 gccaggaggt ggccaggtgg aagtaaaatc agagaagctg gacttcaagg acagagtcca
     1921 gtcgaagatt ggctccttgg ataatatcac ccacgtccct ggaggaggga ataagaagat
     1981 tgaaacccac aagctgacct tcagggagaa tgccaaagcc aagacagacc atggagcaga
     2041 aattgtgtat aagtcacccg tggtgtctgg ggacacatct ccacggcacc tcagcaatgt
     2101 gtcttccacg ggcagcatcg acatggtgga ctcaccacag cttgccacac tagccgatga
     2161 agtgtctgct tccttggcca agcagggttt gtgatcaggc tcccagggca gtcaataatc
     2221 atggagagaa gagagagtga gagtgtggaa aaaaaaaaaa aaaaagaatg atctggcccc
     2281 ttgccctctg ccctccccgc tgctcctcat agacaggctg acctgcttgt cacctaacct
     2341 gcttttgtgg ctcggatttg gctcgggact tcaaaatcag tgatgggaaa agtacatttc
     2401 atctttccaa attgatttgt gggctaaaaa taaaacatat ttaagggaaa aaaaaacatg
     2461 taaaaacatg gccaaaaaat ttccttgggc aattgctaat tgatttcccc cccctgaccc
     2521 cgccctccct ctctgagtat tagagggtga agaaggctct ggaggctgct tctggggagt
     2581 ggctgaggga ctagggcagc taattgccca tagccccatc ctaggggctt cagggacagt
     2641 ggcagcaatg agagatttga gacttggtgt gttcgtgggg ccgtaggcag gtgctgttaa
     2701 cttgtgtggg tgtgagtggg gactgaaaca gcgacagcga aggctgagag atggatgggt
     2761 ggactgagtt agaggacaga ggtgaggaag gcaggttggg agaggggaca ctggctcctt
     2821 gccaagtagc ttggggagga cagggtgctg cagctgcctg cagcagtcct agctagctca
     2881 gatgcctgct tgataaagca ctgtgggggt aacgtgggtg tgtgtgcccc ttctgcaggg
     2941 cagcctgtgg gagaaggggt attgggcaga aggaaggtaa gccagcaggt ggtaccttgt
     3001 agattggttc tcttgaaggc tgctcttgac atcccagggc actggcttct tcctccctcc
     3061 ccgcaaggtg ggaggtcctg agcgaggtgt ttcccttcgc tcccacagga aaagctgctt
     3121 tactgagttc tcaagtttgg aactacagcc atgatttggc caccattaca gacctgggac
     3181 tttagggcta accagatctt tgtaaggact tgtgcctctt gggggacctc tgcctgttct
     3241 catgcttggc cctctggcac ttctgtagtg ggagggatgg ggggtggtat tctgggatgt
     3301 gggtcccagg cctcccatcc ctcacacagc cactgtatcc cctctctctg tcctatcatg
     3361 cccacgtctg ccacgagagc tagtcactgc cgtccgtaca tcacgtctca ctgtcctgag
     3421 tgccatgcct ctcccagccc ccatccctgg cccctgggta gatatgggca atatctgctc
     3481 tacactaggg gttggagtcc agggaaggca aagatttggg cctcagtctc tagtcctacg
     3541 ttccacgaat ccaaccagtg tgcctcccac aaggaacctt acgaccttgt ttggttcact
     3601 ccattacttc ctatcctgga tgggaactgg tgtgtgcctg cctggggatg accttggacc
     3661 tctgcctttt cttttatcta agtggatgcc tcctaggcct gactccttgt gttgagctgg
     3721 aggcagccaa gtcaggtgcc aatgtcttgg catcagtaag aacagtcaag agtcccaggg
     3781 cagggccaca cttctcccat ctttcgcttc caccccagct tgtgatcgct agcctcccag
     3841 agctcagctg ccattaagtc cccatgcacg taatcagtct ccacacccca gtttggggaa
     3901 cataccccct tgattgaagt gtttttttcc tccggtccca tggaaaccat gctgcctgcc
     3961 ctgctggagc agacggccac ctccatagat gcagcccttt ctttcccgtc ttcgccctgt
     4021 tacgttgtag ttggatttgt ctgtttgtct gggttcacca gagtgactat gatagtgaaa
     4081 agaaaagaaa gaaaaagaaa aaaaaaaaaa aaaagaaaaa gaaaaaggaa aaaaaaaagg
     4141 acgcatgtat cttgaaatat ttgtcaaaag gttctagccc accacgtgat ggagagtctg
     4201 gatatctcct tcctgacgtg gctccaggcc agtgcagtgc taacctgctg ggacatccca
     4261 tgttttgaag ggtttcttct gcatctggga cctcacagac actggattgt gacattggag
     4321 gtctgtgaca ttggaggtca atggcattgg ccaaggcctg aagcacagga ccagctagag
     4381 gcagcaggct ccgagtgcca gggagagctt gtggctggcc tgttttgtat gaagatggtc
     4441 ctttctgatc acgacttcaa atcccacagt agccctgaaa gacatctaag aactcctgca
     4501 tcacaagaga aaaggacacc agtaccagca gggagagctg tgaccctaga aattccatga
     4561 cgacccagta gatatccttg ggccctctcc aagcctgggc cttttcacca tagagtttgg
     4621 gatggactgt cccactgatg aaggggacat cttaggagac tcccttggtt tccaagctgt
     4681 cagccccctg aacttgcacg acctcctaca gcttcaggga ctaggccttt gaagattagg
     4741 aacctcaggc ccacatcagc cacttctgat gtacagttaa ggacaatgtg gagactagga
     4801 ggaagcagcc agcctttccc attaaagaac tcttgagtgc ccagggctac ctattgtgag
     4861 cttccccact gataagactt tagctgtcca tagaagtgag tccgagggag gaaaagtgtg
     4921 gtttcttcat catggttacc tgtcgtggtt ctctctctta cacccattta cccatcccgc
     4981 agttcctgtc cttgaatggg gggtggggtg ctctgcctat ctcttgtggg gtgatcagcc
     5041 caaaaatcat gatttggagt gatctgatca gtgctgatag gcagtttaca aagggattct
     5101 ggcttgtgac ttcagtgagg acaatccccc agggcccttt ctttccatgc ctctccaact
     5161 cagagccaat gtctttgggt gggctagata gatagggcat acaattggcc tggttcctcc
     5221 aagctcttaa ttcactttat caatagttcc atttaaattg acttcaatga taagagtgta
     5281 tcccatttga gattgcttgc gttgtggggg agggggagga ggaacacatt aagataattc
     5341 acatgggcaa agggaggtct tggagtgtag ccgttaagcc atcttgtaac cccattcatg
     5401 attttgacca cctgctagag agaagaggtg ccaagagact agaacttgga ggcttggctg
     5461 tcccactaat aggctttcgc aaggcagagg tagccagcta ggtccctgcc ttcccagcca
     5521 ggtacagctc tcaggtttgt ggaggtaatc tgtgaacttc tcttcctgct gccttcttgt
     5581 gatgtccaga gcccacagtc aaatacctcc taagaaccct ggcttccttc cctctaatcc
     5641 actggcacat gactatcacc tctggattga cctcagatcc atagcctaca cactgctagc
     5701 agtggccaag atcacttcct ttatctccat ctgttctgtt ctccaggaaa gtaagtgggg
     5761 atgagggtgg aggtggtaat caactgtaga tctgtggctt tatgagcctt cagacttctc
     5821 tctggcttct tctggaaggg ttactattgg cagtattgca atctcaccct cctgatgaac
     5881 tgtagcctgt gccgttactg tgctgggcat gatctccagt gcttgcaagt cccatgattt
     5941 ctttggtgat tttgagggtg gggggaggga cacaaatcag cttagcttag cttcctgtct
     6001 gtgaatgtcc atatagtgta ttgtgtttta acaaatgatc tacactgact gttgctgtaa
     6061 aagtgaattt ggaaataaag ttattactct gaataaa
//
