LOCUS       NM_133350               2021 bp    mRNA    linear   ROD 08-AUG-2023
DEFINITION  Mus musculus microtubule-associated protein, RP/EB family, member 3
            (Mapre3), transcript variant 1, mRNA.
ACCESSION   NM_133350 XM_131982
VERSION     NM_133350.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2021)
  AUTHORS   Ruiz-Reig N, Chehade G, Hakanen J, Aittaleb M, Wierda K, De Wit J,
            Nguyen L, Gailly P and Tissir F.
  TITLE     KIF2A deficiency causes early-onset neurodegeneration
  JOURNAL   Proc Natl Acad Sci U S A 119 (46), e2209714119 (2022)
   PUBMED   36343267
REFERENCE   2  (bases 1 to 2021)
  AUTHORS   Wen Q, Weng H, Liu T, Yu L, Zhao T, Qin J, Li S, Wu Q, Tissir F, Qu
            Y and Zhou L.
  TITLE     Inactivating Celsr2 promotes motor axon fasciculation and
            regeneration in mouse and human
  JOURNAL   Brain 145 (2), 670-683 (2022)
   PUBMED   34983065
REFERENCE   3  (bases 1 to 2021)
  AUTHORS   Pchitskaya E, Rakovskaya A, Chigray M and Bezprozvanny I.
  TITLE     Cytoskeleton Protein EB3 Contributes to Dendritic Spines
            Enlargement and Enhances Their Resilience to Toxic Effects of
            Beta-Amyloid
  JOURNAL   Int J Mol Sci 23 (4), 2274 (2022)
   PUBMED   35216391
  REMARK    GeneRIF: Cytoskeleton Protein EB3 Contributes to Dendritic Spines
            Enlargement and Enhances Their Resilience to Toxic Effects of
            Beta-Amyloid.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2021)
  AUTHORS   Crapster JA, Rack PG, Hellmann ZJ, Le AD, Adams CM, Leib RD, Elias
            JE, Perrino J, Behr B, Li Y, Lin J, Zeng H and Chen JK.
  TITLE     HIPK4 is essential for murine spermiogenesis
  JOURNAL   Elife 9, e50209 (2020)
   PUBMED   32163033
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2021)
  AUTHORS   Pchitskaya E, Kraskovskaya N, Chernyuk D, Popugaeva E, Zhang H,
            Vlasova O and Bezprozvanny I.
  TITLE     Stim2-Eb3 Association and Morphology of Dendritic Spines in
            Hippocampal Neurons
  JOURNAL   Sci Rep 7 (1), 17625 (2017)
   PUBMED   29247211
  REMARK    GeneRIF: The authors propose that EB3 is involved in regulation of
            dendritic spines morphology, in part due to its association with
            STIM2, and that modulation of EB3 expression is a potential way to
            overcome synaptic loss during Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2021)
  AUTHORS   Patel-Hett S, Richardson JL, Schulze H, Drabek K, Isaac NA,
            Hoffmeister K, Shivdasani RA, Bulinski JC, Galjart N, Hartwig JH
            and Italiano JE Jr.
  TITLE     Visualization of microtubule growth in living platelets reveals a
            dynamic marginal band with multiple microtubules
  JOURNAL   Blood 111 (9), 4605-4616 (2008)
   PUBMED   18230754
REFERENCE   7  (bases 1 to 2021)
  AUTHORS   Dragestein KA, van Cappellen WA, van Haren J, Tsibidis GD,
            Akhmanova A, Knoch TA, Grosveld F and Galjart N.
  TITLE     Dynamic behavior of GFP-CLIP-170 reveals fast protein turnover on
            microtubule plus ends
  JOURNAL   J Cell Biol 180 (4), 729-737 (2008)
   PUBMED   18283108
  REMARK    GeneRIF: Two +TIPs, CLIP-170 and end-binding protein 3 (EB3), turn
            over rapidly on MT ends. Diffusion of CLIP-170 and EB3 appears to
            be rate limiting for their binding to MT plus ends.
REFERENCE   8  (bases 1 to 2021)
  AUTHORS   Straube A and Merdes A.
  TITLE     EB3 regulates microtubule dynamics at the cell cortex and is
            required for myoblast elongation and fusion
  JOURNAL   Curr Biol 17 (15), 1318-1325 (2007)
   PUBMED   17658256
REFERENCE   9  (bases 1 to 2021)
  AUTHORS   Hsieh PC, Chang JC, Sun WT, Hsieh SC, Wang MC and Wang FF.
  TITLE     p53 downstream target DDA3 is a novel microtubule-associated
            protein that interacts with end-binding protein EB3 and activates
            beta-catenin pathway
  JOURNAL   Oncogene 26 (34), 4928-4940 (2007)
   PUBMED   17310996
  REMARK    GeneRIF: DDA3 is a novel microtubule-associated protein that binds
            to EB3, and results implicate DDA3 and EB3 in the
            beta-catenin-mediated growth signaling.
REFERENCE   10 (bases 1 to 2021)
  AUTHORS   Komarova Y, Lansbergen G, Galjart N, Grosveld F, Borisy GG and
            Akhmanova A.
  TITLE     EB1 and EB3 control CLIP dissociation from the ends of growing
            microtubules
  JOURNAL   Mol Biol Cell 16 (11), 5334-5345 (2005)
   PUBMED   16148041
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY270434.1, BY237685.1, CX241498.1, CV560388.1, BQ570892.1,
            CJ290673.1, AI848896.1 and AC109606.11.
            
            [WARNING] On Nov 24, 2023 this sequence was replaced by
            NM_133350.3.
            
            On Jul 15, 2015 this sequence version replaced NM_133350.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057918.1, AF468005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                BY270434.1         2-93
            93-520              BY237685.1         2-429
            521-831             CX241498.1         401-711
            832-1160            CV560388.1         181-509
            1161-1560           BQ570892.1         205-604
            1561-1977           CJ290673.1         139-555
            1978-2018           AI848896.1         15-55               c
            2019-2021           AC109606.11        89922-89924
FEATURES             Location/Qualifiers
     source          1..2021
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 16.9 cM"
     gene            1..2021
                     /gene="Mapre3"
                     /gene_synonym="EB2; EB3; EBF3; RP3"
                     /note="microtubule-associated protein, RP/EB family,
                     member 3"
                     /db_xref="GeneID:100732"
                     /db_xref="MGI:MGI:2140967"
     exon            1..258
                     /gene="Mapre3"
                     /gene_synonym="EB2; EB3; EBF3; RP3"
                     /inference="alignment:Splign:2.1.0"
     exon            259..386
                     /gene="Mapre3"
                     /gene_synonym="EB2; EB3; EBF3; RP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..1111
                     /gene="Mapre3"
                     /gene_synonym="EB2; EB3; EBF3; RP3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     end-binding protein 3; EB1 protein family member 3"
                     /codon_start=1
                     /product="microtubule-associated protein RP/EB family
                     member 3 isoform 1"
                     /protein_id="NP_579928.1"
                     /db_xref="CCDS:CCDS19163.1"
                     /db_xref="GeneID:100732"
                     /db_xref="MGI:MGI:2140967"
                     /translation="MAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAY
                     CQFMDMLFPGCVHLRKVKFQAKLEHEYIHNFKVLQAAFKKMGVDKIIPVEKLVKGKFQ
                     DNFEFIQWFKKFFDANYDGKDYNPLLARQGQDVAPPPNPGDQIFNKSKKLIGTAVPQR
                     TSPTGPKNMQTSGRLSNVAPPCILRKNPPSARNGGHEADAQILELNQQLLDLKLTVDG
                     LEKERDFYFSKLRDIELICQEHESENSPVISGIIGILYATEEGFAPPEDDEIEEHQQE
                     DQDEY"
     exon            387..532
                     /gene="Mapre3"
                     /gene_synonym="EB2; EB3; EBF3; RP3"
                     /inference="alignment:Splign:2.1.0"
     exon            533..734
                     /gene="Mapre3"
                     /gene_synonym="EB2; EB3; EBF3; RP3"
                     /inference="alignment:Splign:2.1.0"
     exon            735..889
                     /gene="Mapre3"
                     /gene_synonym="EB2; EB3; EBF3; RP3"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1042
                     /gene="Mapre3"
                     /gene_synonym="EB2; EB3; EBF3; RP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..2021
                     /gene="Mapre3"
                     /gene_synonym="EB2; EB3; EBF3; RP3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccgcttct ggccgcccgg ttgcctggag acggcgggtg ccctggctcc gccccgctgg
       61 tcctgacagc cccggccgca tcgcgcctgc gcagtgctct cgtcccccgc agtctcggtg
      121 cttttaagcc ggagaccgcg gcggcctctg ctaggaccct ccgccccgga gccgccggcc
      181 ggagccgcag cctctgccgc agcgcccccg cctcccatcc cctcccctgc cgtctcagcc
      241 ggagccgcct cccgcactct ggggtatggc tgtcaatgtg tactccactt ctgtgaccag
      301 tgagaatctg agtcgccatg atatgcttgc atgggtcaat gactctctgc acctcaatta
      361 taccaagatt gaacagctct gttcaggggc agcctactgc cagttcatgg acatgctctt
      421 ccctggctgt gttcacttga ggaaggtcaa gttccaggcc aaactagaac acgagtacat
      481 ccacaacttc aaggtgctgc aagcagcttt caagaagatg ggtgttgaca aaatcattcc
      541 cgtagagaag ttagtgaaag gaaaattcca agataatttt gagtttatac agtggtttaa
      601 gaaattcttt gacgcaaact atgatggaaa ggattacaac cctctgctgg cgcggcaggg
      661 ccaggacgta gcaccacctc ctaacccagg tgatcagatc ttcaacaaat ccaagaaact
      721 cattggcaca gcagttccgc agaggacgtc ccccacaggc cccaagaaca tgcagacctc
      781 tggacgactc agcaacgtgg ctccgccctg catcctccgg aagaatcccc cctcagcccg
      841 aaacggtggc catgaggctg acgcccagat cctcgagctt aaccagcagc tgctggactt
      901 gaagctgacc gtagacgggc ttgagaaaga acgagatttc tatttcagca aattgcgaga
      961 catcgagctg atctgccagg aacatgagag cgagaacagc cccgtcatct cgggcatcat
     1021 tggcattctc tatgccacgg aggagggatt tgcaccccct gaggatgatg agattgaaga
     1081 acaccaacag gaagaccagg acgagtactg agggaggcgc cagccctggc tgaccacagc
     1141 ttccctgccc acctccactc tgcccacccc aactatgccc accccacatt atagtccttt
     1201 cctttcagcc agtcagccag ctgggtgctt tgtgtcagtg ccacagcatt agggagccgg
     1261 acgagtgggg ttcagggtgg tgggggaggc ttgggcaggt gagaggacga ggccctgtct
     1321 gggtcccccg agtggcactg gcccagggga cgtccaggac ccctgtccac tccccactcc
     1381 tatttatttc cgttgtctct atgctgtgtt ggccaacact ttccagggtg ccgctgtacc
     1441 ccacaagcca gccacctgct ccctggcagc cagcagctgt atatttgaca aagtcattgg
     1501 tatattttta cttactggat tgcccttgca ctttacctgt tcttttccag ggctgacagc
     1561 agggcttggg gtagtctttc tggcttggct ccccttccct agagccgaga ctgggacagg
     1621 actcacccat tcttatttat tttgtctttt gacttctctc tcagtagatg agggaaaggc
     1681 tgatatgagg aaagggaagg gaagctgagg aggcagtgct ctgggtccag ggagcatgcg
     1741 agagtagaca tgacctccag gcactgggct cccccaccaa gcccctgcct cagcaccaac
     1801 acccagcact gccccaggct tcctagccac tccctcctgc agcctagtta gaccacacag
     1861 actctgcctg gcccccattg tctgtctgtc ccccattctc tcacccccac ctttgcccct
     1921 tgggcaccag cctgcatatc tgttcagttt tatttaaata aatttgtgtg gcaagccatg
     1981 atttcctcaa ttgacccaca gcaaggggtc agaacatagc a
//
