LOCUS       NM_011941               6954 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus mitogen-activated protein kinase binding protein 1
            (Mapkbp1), transcript variant 2, mRNA.
ACCESSION   NM_011941
VERSION     NM_011941.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6954)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6954)
  AUTHORS   Ho,U.Y., Feng,C.A., Yeap,Y.Y., Bain,A.L., Wei,Z., Shohayeb,B.,
            Reichelt,M.E., Homer,H., Khanna,K.K., Bowles,J. and Ng,D.C.H.
  TITLE     WDR62 is required for centriole duplication in spermatogenesis and
            manchette removal in spermiogenesis
  JOURNAL   Commun Biol 4 (1), 645 (2021)
   PUBMED   34059773
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6954)
  AUTHORS   Shohayeb,B., Ho,U., Yeap,Y.Y., Parton,R.G., Millard,S.S., Xu,Z.,
            Piper,M. and Ng,D.C.H.
  TITLE     The association of microcephaly protein WDR62 with CPAP/IFT88 is
            required for cilia formation and neocortical development
  JOURNAL   Hum Mol Genet 29 (2), 248-263 (2020)
   PUBMED   31816041
REFERENCE   4  (bases 1 to 6954)
  AUTHORS   Macia,M.S., Halbritter,J., Delous,M., Bredrup,C., Gutter,A.,
            Filhol,E., Mellgren,A.E.C., Leh,S., Bizet,A., Braun,D.A., Gee,H.Y.,
            Silbermann,F., Henry,C., Krug,P., Bole-Feysot,C., Nitschke,P.,
            Joly,D., Nicoud,P., Paget,A., Haugland,H., Brackmann,D., Ahmet,N.,
            Sandford,R., Cengiz,N., Knappskog,P.M., Boman,H., Linghu,B.,
            Yang,F., Oakeley,E.J., Saint Mezard,P., Sailer,A.W., Johansson,S.,
            Rodahl,E., Saunier,S., Hildebrandt,F. and Benmerah,A.
  TITLE     Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent
            Nephronophthisis
  JOURNAL   Am J Hum Genet 100 (2), 323-333 (2017)
   PUBMED   28089251
  REMARK    GeneRIF: We identified mutations in MAPKBP1 as a genetic cause of
            juvenile or late-onset and cilia-independent nephronophthisis.
            Erratum:[Am J Hum Genet. 2017 Feb 2;100(2):372. doi:
            10.1016/j.ajhg.2017.01.025. PMID: 28157543]
REFERENCE   5  (bases 1 to 6954)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   6  (bases 1 to 6954)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 6954)
  AUTHORS   Yamaguchi,T., Miyashita,C., Koyano,S., Kanda,H., Yoshioka,K.,
            Shiba,T., Takamatsu,N. and Ito,M.
  TITLE     JNK-binding protein 1 regulates NF-kappaB activation through TRAF2
            and TAK1
  JOURNAL   Cell Biol Int 33 (3), 364-368 (2009)
   PUBMED   19385034
  REMARK    GeneRIF: The Mapkbp1 protein could enhance the NF-kappaB activation
            induced by MAP kinase kinase kinase 7 and TNF Receptor-Associated
            Factor 2 , and could promote TNF Receptor-Associated Factor 2
            polyubiquitination.
REFERENCE   8  (bases 1 to 6954)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 6954)
  AUTHORS   Koyano,S., Ito,M., Takamatsu,N., Shiba,T., Yamamoto,K. and
            Yoshioka,K.
  TITLE     A novel Jun N-terminal kinase (JNK)-binding protein that enhances
            the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase
            1
  JOURNAL   FEBS Lett 457 (3), 385-388 (1999)
   PUBMED   10471813
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070449.1, CX569009.1, AI152107.1 and BQ174980.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_011941.4.
            
            On Nov 18, 2008 this sequence version replaced NM_011941.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070449.1, SRR9219381.211953.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-554               BC070449.1         1-554
            555-555             CX569009.1         275-275
            556-5843            BC070449.1         556-5843
            5844-5847           AI152107.1         15-18
            5848-6930           BC070449.1         5844-6926
            6931-6954           BQ174980.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..6954
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.03 cM"
     gene            1..6954
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /note="mitogen-activated protein kinase binding protein 1"
                     /db_xref="GeneID:26390"
                     /db_xref="MGI:MGI:1347004"
     exon            1..470
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            471..562
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            563..625
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            626..683
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            684..854
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            855..992
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1175
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1336
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1526
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1673
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1849
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1941
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2067
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2138
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2260
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2336
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2448
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2512
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2647
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2784
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2840
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..3077
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3244
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3390
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            3391..3585
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3670
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3954
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            3955..4551
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            4552..4637
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     exon            4638..6937
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6909..6914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /note="hexamer: AATAAA"
     polyA_site      6930
                     /gene="Mapkbp1"
                     /gene_synonym="2810483F24Rik; JNKBP-1; Jnkbp1; mKIAA0596"
                     /note="major polyA site"
ORIGIN      
        1 gggaacactt gggctgtaac cggcgcccga ctggtcacta gttcatccga ttcttcagtt
       61 aaacgcctct ggcaggtgtg ggcctgacat ttcttcactc caggggtcgt cctccccttg
      121 taaaaaaaaa tctagcaggc tagggtgggg atggggagtg ggaaagcgca gggcaatgcc
      181 cagagtaaga gttggtgaca agcagaagac acctactgtg atgataaggt tgcttctgcc
      241 atctcaggcc agtgaaagtg catatccgaa ggctgtgttg aacgagaagg cagtaccgct
      301 gttgagacaa gtccaaaggc taggccaggg actgtcctta ggggctcctc gttatgatgg
      361 ctggagaagg gtcaaccatt actagccgta tcaagaactt gctgaggtct ccatccatca
      421 aattacgcag aagtaaagca ggaaaccgga gagaggacct cagctccaag gtaaccttgg
      481 agaaggtcct gggagtaaca gtatctggag gaagaggact tgcttgtgac ccccgatctg
      541 gcttagttgc ctacccagca gggtgtgtgg tcgtcctctt caatccccgg aagcacaaac
      601 agcaccacat cctcaacagc tccaggaaaa ccattactgc ccttgccttc tcccctgatg
      661 gcaagtactt ggtcactgga gagagtgggc acatgcctgc cgtgcgggtt tgggatgtgg
      721 ctgaacgtag ccaggtggca gagctacagg agcataagta tggtgtggct tgtgtggctt
      781 tctccccaag tgccaagtac attgtgtctg tgggctacca gcatgacatg attgtcaacg
      841 tgtgggcctg gaagaaaaac attgtagtgg cctccaacaa agtatccagt cgggtaaccg
      901 cagtgtcctt ttctgaagac tgcagctact ttgtcactgc aggcaaccgg cacatcaaat
      961 tctggtacct ggatgacagt aagacctcaa aggtgaacgc cactgtgccc ctgctgggcc
     1021 gctcggggct gctgggggag ctgaggaaca acctgttcac tgatgtggcc tgtggccgag
     1081 gggaaaaggc tgatagcact ttctgtatca cgtcgtcggg gctgctgtgc gagttcagcg
     1141 atcgcaggct tctggacaaa tgggtggagc taaggaccac tgtggcccac tgcatctctg
     1201 tcacccaaga atacatcttc tgtggctgtg ctgatggcac ggtgcgcctt ttcaatcctt
     1261 ccaacctgca cttcctcagt accctaccta gaccccatgc tcttggaaca gacattgcca
     1321 gcatcactga ggccagtcgc ctcttttctg gaggggtcaa tgcaaggtac ccagacacca
     1381 ttgccttgac cttcgatcca actaatcagt ggctatcttg tgtatacaac gaccacagca
     1441 tatatgtttg ggatgtgagg gaccccaaga aagtggggaa ggtgtactcc gctctgtatc
     1501 actcctcctg tgtctggagt gtggaggtct accctgagat caaggacagt caccaggcct
     1561 gtcttccccc cagttccttt attacttgct cctcagacaa caccatccgc ctgtggaaca
     1621 cagagagctc tggggtacat ggctctaccc tgcaccgtaa catcctcagc aatgatctca
     1681 ttaagatcat ctatgtggat gggaacactc aggctttgtt ggacactgag ctgcctggag
     1741 gagacaaagc tgatgggtcg ctgatggacc cccgagtggg catccggtcc gtgtgtatta
     1801 gccccaatgg acagcacctg gcctccggag accgcatggg gacacttagg atacatgaac
     1861 tgcagtccct gagtgagatg ctgaaagtgg aggcccacga ctctgagatc ttgtgcctgg
     1921 agtactctaa gccagacaca ggtttgaaac tgctagcatc ggcaagccgg gaccgtctga
     1981 tccacgtgct ggatgctggc cgggaatata gtctacagca gacactggat gagcattcat
     2041 cttccatcac tgctgtcaag tttgcagcca gtgatgggca agtgcgaatg atcagctgtg
     2101 gtgcagacaa gagcatttac ttccgaactg cacagaagtc tggagaagga gtacagttta
     2161 cacgaacgca ccacgtggta cggaagacaa ctctctatga catggacgtg gagcccagct
     2221 ggaagtacac ggccatcggc tgccaagacc ggaatattcg gatctttaac attagcagcg
     2281 gaaagcagaa aaagctgttt aaagggtcac agggtgaaga tggcactctc attaaggtgc
     2341 agacagaccc ctcagggatc tacattgcca ctagctgttc cgataagaat ctctccattt
     2401 ttgacttctc ctcaggcgag tgtgtggcca ccatgtttgg ccactcagag attgtcactg
     2461 gcatgaaatt tagtaacgat tgcaaacatc tcatctctgt gtcaggggac agctgcatct
     2521 ttgtctggcg tctgagctct gagatgacca tcagcatgag gcagcgcttg gctgagctgc
     2581 ggcagcgcca gcgagggatc aagcagcaag gaccaacctc tccccagagg gcttctggag
     2641 ccaagcagca ccatgctcca gtggtacccc cttctggacc agctctttcc tcagacagtg
     2701 acaaggaggg agaagatgag ggtactgaag aagaagaact gccagctctg cccatcctta
     2761 gcaagagcac caagaaagaa ctagcctcag gctctagtcc agccttgctc cgaagcctgt
     2821 cccactggga aatgagtcgg gcacaagaga ccatggagta cctggaccca gctcctgtag
     2881 ctaacacagg acctaaaaga agagggcgct gggctcagcc aggcgtggag ctgagtgttc
     2941 gctccatgtt ggacctgaga cagatagaga ccttagcccc aagccctcga ggccccagcc
     3001 aggactcact ggctgtgtcc ccagctggtc ctgggaagca tggtccacag ggccctgagc
     3061 tgtcatgtgt cagtcagaat gaaagggccc ctcggcttca gacctcccaa ccctgctcct
     3121 gcccccacat tatccaattg ttgtcacaag aggaaggagt ctttgcccaa gatctggagc
     3181 ctgcacccat tgaagatggt attgtctacc cggaacccag tgacagccct accatggata
     3241 ccagtgcgtt tcaggtgcag gctccaaccg gaggatccct aggaagaatg tacccaggca
     3301 gcaggggctc agaaaagcac agtcctgaca gtgcatgctc tgtggattac agcagcagcc
     3361 ggctttccag ccctgaacac cctaatgaag actctgagag cacagagccc ctaagtgtgg
     3421 atggcatctc ctcagacctg gaagagccag ccgagggtga tgaagacgag gaagaagagg
     3481 gaggcactgg cctctgtggg ctacaagaag gcggccctca taccccagat caggaacagt
     3541 ttctaaaaca gcactttgag actctggcca atgggactgc tccagggggc ccagcacggg
     3601 tgctagagag gacagagtct cagagcatct catcacgatt ccttctgcaa gtgcagacct
     3661 ccccactcag ggaaccatcc ctatcctcct caggcttggc cctgacgtcc agacctgacc
     3721 aggtatcaca ggtgtctggt gagcagctga aaggcagtgg tgccactcct ccaggagcac
     3781 ccccagaaat ggaaccctct tctggcaact ctggccccaa gcaggtggct cctgtgctgt
     3841 tgacacgacg gcataacaac ttggacaaca gctgggcctc caagaaaatg gctgcaaccc
     3901 ggcctttagc tggactccag aaagcccagt ctgtgcatag tttggtacca caggatgagg
     3961 tgccttcatc acgtccactg ctcttccagg aggcagagac ccagggcagc ttaggatccc
     4021 tgccacaagc tggtggctgc tcatctcagc cccactccta ccagaaccac accaccagtt
     4081 ctatggccaa gctagcgcgt agtatttctg ttggcgagaa tccgggcctg gcaactgaac
     4141 ctcaagctcc tgtaccgatc cgaatctcac cattcaacaa actagctctg cctagcaggg
     4201 ctcaccttgt cctggacatc cccaaaccac ttcctgaccg tcctactctg accacattct
     4261 cacctgtatc caagggcctg gcccacaatg aaacagaaca atcgggcccc ttggtgagcc
     4321 taggaaaggc tcatactaca gttgaaaagc actcctgttt aggggagggt actactcata
     4381 aatctaggac agagtgccag gcttatcctg gacccaacca cccctgtgcc cagcaactgc
     4441 cagtcaacaa ccttctccaa ggccctgaga gcttgcagcc cctgtcccct gagaagactc
     4501 gtaacccagt ggaaagcagc aggccagggg tagccctgag ccaggactca gaactggcct
     4561 tgagtctgca acagtgtgaa cagctcgtgg cagagctcca ggggaatgta cgccaggcag
     4621 tggagctcta ccgagcggtg accagctata agacaccttc ggcagagcaa agtcacatca
     4681 cccgtctcct gagagacacc ttctcttcgg tgcgacagga gctcgaggtt ctggctgggg
     4741 cggtgctgtc cagcccaggt ggcagccctg gggctgtggg ggctgagcag acgcaggccc
     4801 tgttggagca atactccgag ctactgctaa gagctgtgga gcggcgcatg gagcgtagac
     4861 tctgagttcc tgaagcctgt cccaagagaa atgctctcca ttccaaactg tatccctgct
     4921 tccactcaag aaaaggtggg aatgtctgga gtggacagca gtgatcagtg ttgagaggca
     4981 aagcagcctt cccagccgcc ctcatggagc ccctgtattt attaatttat ttccctgact
     5041 ttgcctcact tccttgggac tcctgcctct aaagcccagc ctggggctca cagcagggca
     5101 agtcttgagt ctacatcatc ttggtgctgt gaggggtagg agggcagcct gcctcccctg
     5161 gggacatcgg gaagggctgg ccttctcttc ttagaagcca tttgaagttt ctgcagggat
     5221 gagctccctg gggcggagca tccacagggt actctgggat agagatgaaa ggtaatgtgg
     5281 tatttagtgt cctaaagcca actgtagacc tttacctcta ctcccacacc agctgcactc
     5341 ccctgcctgc cagagcaggg gtagtttccc cccaactcct ggcagtgaga cagctgcctg
     5401 gcctccaggg tattcccagc cattagaaaa cttgagttgg tatcaggaac tgagccccca
     5461 cattccaatc ccatgttccc tgcaagagag ccctagtgtt ttttctggcc ccatcccttt
     5521 tcccccttgt ggagctagtt gtgggatttt tgctgcagga cagtgaaacc cctctgctgg
     5581 gcagacagca aagcctggcc tactttcctc agccccttag gcttccttgt tctctatccc
     5641 tggtccccag cagactgttg aatccctggg gaccactttc tccctacatc ctgggcaatg
     5701 cgcaatcaga aacctgtatt gggagtaccc ttatggttta cagggcactg gcccaccttc
     5761 ctagaacctt ggccacacac acacacacac acacacacac acacacacac acacacacac
     5821 acacacacac acacacacac acacacaaat catatgcaca gttgagtgct cattttagaa
     5881 cacttgcctg gctggtatgc acctggtttc ctcacatttt tgcctcagcg tcactagcct
     5941 ggattaattg gaattctgat ccagaaacac aaaaagggat gggtacacta aacacaaaaa
     6001 gggatggata cactagactg aaattctgga gttgtggtgt ccacagccag gctgaccgga
     6061 gatggcctat gggtcacctg gctcatggag gaggctcttt tcaaaggcag tattgagtgc
     6121 ccagaaatac tggacactgg agattgtgga atgaaggcac tgggcaagag accactggaa
     6181 aagtaatagc cggacaggta ggtggcagag gtagggatag agttaaggta acggttagag
     6241 agtagcaaaa agagagagaa gctgtatgtt ggaagaagtg gtgaggtggt tgcagaattg
     6301 gagtgagtat gtctttgggc ctgggccctc ctttcctctg catcagggaa ggcagagtag
     6361 tgacatttca ccaggtttag ataacacaaa cctgtcgaaa cctcaacgcc acttcccagc
     6421 tctgaatgca gaggctagca ggaaactagg tttaatgggt gcttagcttt gttggttcaa
     6481 cctgagtgtt gagtataccc aaaccatgtg aatacccaaa ccatgtgttc ccatttttct
     6541 accacacgca tagtcaaact cctagcccaa agaaccgaag ccacttgagg tgggcccctt
     6601 ggcagtgtgg gggttagaag tcggcccact gccctgacct ccaccaggtt ttagaggtct
     6661 ttatgccagc ctgcccttct agagaaagcg ccactaccct gcatgggtgg ggtcttgtgg
     6721 cctgtggcac tttgtcctct tctgcatgtc tgaggccact ggcaattgct gcccatgtcc
     6781 agatttgtcc tatcccagtt ttgaaagccc cttatttata acttttatac tgtggcgcct
     6841 gtctcctccc cggctgtacg gggtgggact gttttaacgt ttcgtttgta cggatgtatg
     6901 aaattgtcaa taaacacaat catttgttaa cctgctaaaa aaaaaaaaaa aaaa
//
