LOCUS       NM_010765               2229 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus MAP kinase-activated protein kinase 5 (Mapkapk5),
            mRNA.
ACCESSION   NM_010765 XM_916067 XM_924080 XM_924084 XM_924091
VERSION     NM_010765.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2229)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2229)
  AUTHORS   Zhao,Z., Wang,Y., Gao,Y., Ju,Y., Zhao,Y., Wu,Z., Gao,S., Zhang,B.,
            Pang,X., Zhang,Y. and Wang,W.
  TITLE     The PRAK-NRF2 axis promotes the differentiation of Th17 cells by
            mediating the redox homeostasis and glycolysis
  JOURNAL   Proc Natl Acad Sci U S A 120 (19), e2212613120 (2023)
   PUBMED   37126714
  REMARK    GeneRIF: The PRAK-NRF2 axis promotes the differentiation of Th17
            cells by mediating the redox homeostasis and glycolysis.
REFERENCE   3  (bases 1 to 2229)
  AUTHORS   Peng,Z., Ouyang,X., Wang,Y. and Fan,Q.
  TITLE     MAPKAPK5-AS1 drives the progression of hepatocellular carcinoma via
            regulating miR-429/ZEB1 axis
  JOURNAL   BMC Mol Cell Biol 23 (1), 21 (2022)
   PUBMED   35468721
  REMARK    GeneRIF: MAPKAPK5-AS1 drives the progression of hepatocellular
            carcinoma via regulating miR-429/ZEB1 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2229)
  AUTHORS   Du,J., Zhao,Y.T., Wang,H., Zhang,L.X., Qin,G., Zhuang,S., Kadin,M.,
            Chin,Y.E., Liu,P.Y. and Zhao,T.C.
  TITLE     The Essential Role of PRAK in Preserving Cardiac Function and
            Insulin Resistance in High-Fat Diet-Induced Diabetes
  JOURNAL   Int J Mol Sci 22 (15), 7995 (2021)
   PUBMED   34360761
  REMARK    GeneRIF: The Essential Role of PRAK in Preserving Cardiac Function
            and Insulin Resistance in High-Fat Diet-Induced Diabetes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2229)
  AUTHORS   Mi,L., Wang,Y., Xu,H., Wang,Y., Wu,J., Dai,H. and Zhang,Y.
  TITLE     PRAK Promotes the Pathogen Clearance by Macrophage Through
            Regulating Autophagy and Inflammasome Activation
  JOURNAL   Front Immunol 12, 618561 (2021)
   PUBMED   33936034
  REMARK    GeneRIF: PRAK Promotes the Pathogen Clearance by Macrophage Through
            Regulating Autophagy and Inflammasome Activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2229)
  AUTHORS   Seternes,O.M., Mikalsen,T., Johansen,B., Michaelsen,E.,
            Armstrong,C.G., Morrice,N.A., Turgeon,B., Meloche,S., Moens,U. and
            Keyse,S.M.
  TITLE     Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a
            novel signal transduction pathway
  JOURNAL   EMBO J 23 (24), 4780-4791 (2004)
   PUBMED   15577943
  REMARK    GeneRIF: Results demonstrate a specific interaction between
            extracellular signal-regulated kinase 3 (ERK3) and
            mitogen-activated protein kinase-activated protein kinase-5 (MK5).
            Erratum:[EMBO J. 2005 Feb 23;24(4):873]
REFERENCE   7  (bases 1 to 2229)
  AUTHORS   Schumacher,S., Laass,K., Kant,S., Shi,Y., Visel,A., Gruber,A.D.,
            Kotlyarov,A. and Gaestel,M.
  TITLE     Scaffolding by ERK3 regulates MK5 in development
  JOURNAL   EMBO J 23 (24), 4770-4779 (2004)
   PUBMED   15538386
  REMARK    GeneRIF: Data show that extracellular-regulated kinase 3 (ERK3)
            specifically interacts with the MAPK-activated protein kinase 5
            (MK5 or PRAK) in vitro and in vivo.
REFERENCE   8  (bases 1 to 2229)
  AUTHORS   Shi,Y., Kotlyarov,A., Laabeta,K., Gruber,A.D., Butt,E., Marcus,K.,
            Meyer,H.E., Friedrich,A., Volk,H.D. and Gaestel,M.
  TITLE     Elimination of protein kinase MK5/PRAK activity by targeted
            homologous recombination
  JOURNAL   Mol Cell Biol 23 (21), 7732-7741 (2003)
   PUBMED   14560018
  REMARK    GeneRIF: Data suggest that the differences between the phenotypes
            of MK5- and MK2-deficient mice result from clearly different
            functional properties of both enzymes.
REFERENCE   9  (bases 1 to 2229)
  AUTHORS   Seternes,O.M., Johansen,B., Hegge,B., Johannessen,M., Keyse,S.M.
            and Moens,U.
  TITLE     Both binding and activation of p38 mitogen-activated protein kinase
            (MAPK) play essential roles in regulation of the nucleocytoplasmic
            distribution of MAPK-activated protein kinase 5 by cellular stress
  JOURNAL   Mol Cell Biol 22 (20), 6931-6945 (2002)
   PUBMED   12242275
  REMARK    GeneRIF: Both binding and activation of p38 mitogen-activated
            protein kinase (MAPK) play essential roles in regulation of the
            nucleocytoplasmic distribution of MAPK-activated protein kinase 5
            by cellular stress.
REFERENCE   10 (bases 1 to 2229)
  AUTHORS   Ni,H., Wang,X.S., Diener,K. and Yao,Z.
  TITLE     MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated
            protein kinase, is a substrate of the extracellular-regulated
            kinase (ERK) and p38 kinase
  JOURNAL   Biochem Biophys Res Commun 243 (2), 492-496 (1998)
   PUBMED   9480836
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF039840.1 and BY722898.1.
            
            On Aug 14, 2009 this sequence version replaced NM_010765.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF039840.1, SRR1660811.8468.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               AF039840.1         15-458
            445-445             BY722898.1         30-30
            446-2229            AF039840.1         460-2243
FEATURES             Location/Qualifiers
     source          1..2229
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 61.84 cM"
     gene            1..2229
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /note="MAP kinase-activated protein kinase 5"
                     /db_xref="GeneID:17165"
                     /db_xref="MGI:MGI:1333110"
     exon            1..728
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             693..2114
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /EC_number="2.7.11.1"
                     /note="MAPKAPK-5; MAPKAP kinase 5; MAPK-activated protein
                     kinase 5"
                     /codon_start=1
                     /product="MAP kinase-activated protein kinase 5"
                     /protein_id="NP_034895.1"
                     /db_xref="CCDS:CCDS39248.1"
                     /db_xref="GeneID:17165"
                     /db_xref="MGI:MGI:1333110"
                     /translation="MSEDSDMEKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKST
                     QERFALKILLDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVM
                     EMMEGGELFHRISQHRHFTEKQASQVTKQIALALQHCHLLNIAHRDLKPENLLFKDNS
                     LDAPVKLCDFGFAKVDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTY
                     NKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRKKIMTGSFEFPEEEWSQISEM
                     AKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHA
                     EQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDGIYIHDHENGTEDSNVALEK
                     LRDVIAQCILPQAGKGENEDEKLNEVMQEAWKYNRECKLLRDALQSFSWNGRGFTDKV
                     DRLKLAEVVKQVIEEQTLPHEPQ"
     exon            729..802
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /inference="alignment:Splign:2.1.0"
     exon            803..878
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /inference="alignment:Splign:2.1.0"
     exon            879..976
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1085
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1175
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1271
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1352
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1540
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1661
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1792
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1914
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2019
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2208
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2187..2192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /note="hexamer: AATAAA"
     polyA_site      2207
                     /gene="Mapkapk5"
                     /gene_synonym="MK5; PRAK"
                     /note="major polyA site"
ORIGIN      
        1 gcacatccac cgcgcggctc gggaaagcct cagaaaggcc ggcggatgcc ggcgagaggc
       61 gcgcggggct gggtggtcgc agagccccgc ggcagcatgg ctggcgtgaa gctgcagagg
      121 gtgaggcgcg ggcgggcggc cggcgggctg cccggcgcag gcgtcccggc gatgtgtggc
      181 gctggagcgg cagtgggagc ggcggcggcg gcggcggcgg cggcggcggc agcggcggcg
      241 ggctcggctt cggcttcgct acggtgctgg tgccggcggc ggcggggaag gcggaggcgg
      301 cggcgcaggc ttctcctcag gagctggcga acccaggcct aagcggcggc cccgccaaag
      361 ccccgcacgg cgctccaggc cgggcccctc cccgcctcgc cctgccccgg gagcctgcct
      421 ccccggccgg ggatgaggcc gggaagcggc tgcgcggggc ccagcacaaa ggcttgtccc
      481 caggggccgc cgccgctgcc gccgccaccg ccgccaccag cttagagccg cctgcggaag
      541 ccgagccggc acccggacct tcatcccctc cgctccctag gggcgggcgc tgcccgtctc
      601 cccgagctcc gagccctttg cttcctcggc tgccagggga cgggacagcc gcgcagcctc
      661 cgccgcttcg ggctgtggga gcccagcgga gcatgtcgga ggacagcgac atggagaaag
      721 ccatcaagga gacctccatt ttagaagaat atagtatcaa ttggactcag aaactgggag
      781 ccggaattag tggtccagtt agagtctgtg tgaagaaatc cactcaagaa cggtttgcac
      841 tgaaaattct tcttgatcgt ccaaaagcta gaaatgaggt gcgcctgcac atgatgtgtg
      901 ccacacaccc caacatagtt cagattattg aagtgtttgc taacagtgta cagttccctc
      961 atgagtccag ccccagggct cgactcttaa ttgtaatgga gatgatggaa gggggagagc
     1021 tatttcacag aatcagccag caccggcact ttacagagaa gcaagccagc caagtaacaa
     1081 agcagatagc cctggctcta cagcactgtc acttgctaaa cattgcgcac agagacctca
     1141 agcctgaaaa tctgcttttc aaggataact ctctggacgc ccctgtgaaa ttatgtgact
     1201 ttgggtttgc taaagttgac caaggtgatt tgatgacacc ccagtttacc ccttactatg
     1261 tagcacctca ggtactggaa gcgcagagac ggcaccagaa ggagaagtct ggcatcatac
     1321 ctacctcgcc aacaccctac acttacaaca agagctgtga cttgtggtcc ctaggggtga
     1381 taatttatgt gatgctgtgc ggatatcctc ctttttactc caaacaccat agtcggacta
     1441 tcccaaagga tatgcggaaa aagatcatga caggaagttt cgagttccca gaagaagagt
     1501 ggagccagat ctcagagatg gctaaagatg ttgtgaggaa gcttctgaag gtcaaaccag
     1561 aggaaagact cacaatcgag ggagtgttgg accatccctg gctcaactcg acagaggccc
     1621 tggataatgt gctaccctct gcccagctga tgatggataa ggcggtggtt gcggggatcc
     1681 agcaggcgca cgccgagcag ctggcaaaca tgaggatcca ggacctcaag gtcagcctca
     1741 aacccctgca ctctgtcaac aaccccattc tcaggaagag gaagctgctg ggcaccaagc
     1801 caaaggacgg tatttatata cacgaccatg agaatggaac tgaggactca aatgttgcct
     1861 tggaaaagct tcgagatgtc attgcccagt gtatcctccc ccaggctggt aaaggagaga
     1921 atgaagatga gaagctgaat gaggtaatgc aggaggcctg gaagtacaac cgcgaatgca
     1981 agctcctgag ggatgctctg cagagtttta gctggaatgg ccgtggattc acagataaag
     2041 ttgaccgatt gaagctggca gaggtggtaa agcaggtgat cgaagagcag acccttcccc
     2101 acgagcccca gtagtaacag cttaaaactg tttttaacaa ttggaaaaat tattccttaa
     2161 tgtaaaaagt aatttttatg taaattaata aatcataatt tcatttccaa aaaaaaaaaa
     2221 aaaaaaaaa
//
