LOCUS       NM_178907               2816 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus mitogen-activated protein kinase-activated protein
            kinase 3 (Mapkapk3), transcript variant 1, mRNA.
ACCESSION   NM_178907
VERSION     NM_178907.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2816)
  AUTHORS   Drube S, Muller S, Weber F, Wegner P, Bottcher-Loschinski R,
            Gaestel M, Hutloff A, Kamradt T and Andreas N.
  TITLE     IL-3 is essential for ICOS-L stabilization on mast cells, and
            sustains the IL-33-induced RORgammat+ Treg generation via enhanced
            IL-6 induction
  JOURNAL   Immunology 163 (1), 86-97 (2021)
   PUBMED   33427298
REFERENCE   2  (bases 1 to 2816)
  AUTHORS   Helbig C, Weber F, Andreas N, Herdegen T, Gaestel M, Kamradt T and
            Drube S.
  TITLE     The IL-33-induced p38-/JNK1/2-TNFalpha axis is antagonized by
            activation of beta-adrenergic-receptors in dendritic cells
  JOURNAL   Sci Rep 10 (1), 8152 (2020)
   PUBMED   32424229
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2816)
  AUTHORS   Firulli BA, George RM, Harkin J, Toolan KP, Gao H, Liu Y, Zhang W,
            Field LJ, Liu Y, Shou W, Payne RM, Rubart-von der Lohe M and
            Firulli AB.
  TITLE     HAND1 loss-of-function within the embryonic myocardium reveals
            survivable congenital cardiac defects and adult heart failure
  JOURNAL   Cardiovasc Res 116 (3), 605-618 (2020)
   PUBMED   31286141
REFERENCE   4  (bases 1 to 2816)
  AUTHORS   Andreas N, Weber F, Meininger I, Templin N, Gaestel M, Kamradt T
            and Drube S.
  TITLE     IL-33-activated murine mast cells control the dichotomy between
            RORgammat+ and Helios+ Tregs via the MK2/3-mediated IL-6 production
            in vitro
  JOURNAL   Eur J Immunol 49 (12), 2159-2171 (2019)
   PUBMED   31334837
  REMARK    GeneRIF: IL-33-activated murine mast cells control the dichotomy
            between RORgammat(+) and Helios(+) Tregs via the MK2/3-mediated
            IL-6 production in vitro
REFERENCE   5  (bases 1 to 2816)
  AUTHORS   Ronkina N, Shushakova N, Tiedje C, Yakovleva T, Tollenaere MAX,
            Scott A, Batth TS, Olsen JV, Helmke A, Bekker-Jensen SH, Clark AR,
            Kotlyarov A and Gaestel M.
  TITLE     The Role of TTP Phosphorylation in the Regulation of Inflammatory
            Cytokine Production by MK2/3
  JOURNAL   J Immunol 203 (8), 2291-2300 (2019)
   PUBMED   31527197
  REMARK    GeneRIF: The MK2/3 are the only LPS-induced kinases for S52 and
            S178 of TTP and the role of MK2 and MK3 in the regulation of TNF
            biosynthesis is not restricted to phosphorylation of TTP at
            S52/S178 but includes independent processes, which could involve
            other TTP phosphorylations.
REFERENCE   6  (bases 1 to 2816)
  AUTHORS   Schwermann J, Rathinam C, Schubert M, Schumacher S, Noyan F, Koseki
            H, Kotlyarov A, Klein C and Gaestel M.
  TITLE     MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic
            stem cells
  JOURNAL   EMBO J 28 (10), 1392-1406 (2009)
   PUBMED   19369945
REFERENCE   7  (bases 1 to 2816)
  AUTHORS   Zaru R, Ronkina N, Gaestel M, Arthur JS and Watts C.
  TITLE     The MAPK-activated kinase Rsk controls an acute Toll-like receptor
            signaling response in dendritic cells and is activated through two
            distinct pathways
  JOURNAL   Nat Immunol 8 (11), 1227-1235 (2007)
   PUBMED   17906627
  REMARK    Erratum:[Nat Immunol. 2008 Jan;9(1):105]
REFERENCE   8  (bases 1 to 2816)
  AUTHORS   Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E,
            Milarski K, Askew R, Marusic S, Lin LL, Gaestel M and Telliez JB.
  TITLE     The mitogen-activated protein kinase (MAPK)-activated protein
            kinases MK2 and MK3 cooperate in stimulation of tumor necrosis
            factor biosynthesis and stabilization of p38 MAPK
  JOURNAL   Mol Cell Biol 27 (1), 170-181 (2007)
   PUBMED   17030606
REFERENCE   9  (bases 1 to 2816)
  AUTHORS   Taniwaki T, Haruna K, Nakamura H, Sekimoto T, Oike Y, Imaizumi T,
            Saito F, Muta M, Soejima Y, Utoh A, Nakagata N, Araki M, Yamamura K
            and Araki K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   10 (bases 1 to 2816)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672070.12 and AK151881.1.
            
            [WARNING] On May 16, 2023 this sequence was replaced by
            NM_178907.4.
            
            On Oct 24, 2009 this sequence version replaced NM_178907.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031467.1, AK151881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AL672070.12        100709-100790       c
            83-2188             AK151881.1         6-2111
            2189-2816           AL672070.12        65840-66467         c
FEATURES             Location/Qualifiers
     source          1..2816
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..2816
                     /gene="Mapkapk3"
                     /gene_synonym="3PK; MAPKAP-K3; MAPKAP3; MapkKapk3; MK-3;
                     MK3"
                     /note="mitogen-activated protein kinase-activated protein
                     kinase 3"
                     /db_xref="GeneID:102626"
                     /db_xref="MGI:MGI:2143163"
     exon            1..353
                     /gene="Mapkapk3"
                     /gene_synonym="3PK; MAPKAP-K3; MAPKAP3; MapkKapk3; MK-3;
                     MK3"
                     /inference="alignment:Splign:2.1.0"
     exon            354..630
                     /gene="Mapkapk3"
                     /gene_synonym="3PK; MAPKAP-K3; MAPKAP3; MapkKapk3; MK-3;
                     MK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..1560
                     /gene="Mapkapk3"
                     /gene_synonym="3PK; MAPKAP-K3; MAPKAP3; MapkKapk3; MK-3;
                     MK3"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; MAP
                     kinase-activated protein kinase 3; MAPKAPK-3; MAPKAP
                     kinase 3; MAPK-activated protein kinase 3"
                     /codon_start=1
                     /product="MAP kinase-activated protein kinase 3 isoform 1"
                     /protein_id="NP_849238.1"
                     /db_xref="CCDS:CCDS23487.1"
                     /db_xref="GeneID:102626"
                     /db_xref="MGI:MGI:2143163"
                     /translation="MDGETAGEKGSLVPPPGALGGSALGGAPAPGVRREPKKYAVTDD
                     YQLSKQVLGLGVNGKVLECYHRRSGQKCALKLLYDSPKARQEVDHHWQASGGPHIVRI
                     LDVYENMHHGKRCLLIVMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLH
                     SRNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGP
                     EKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYSFPNPEWLDVS
                     EDAKQLIRLLLKTDPTERLTIMQFMNHPWINQSMVVPQTPLYTARVLQEDKDHWDDVK
                     EEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRKKQAGSSSASQGCNNQ"
     exon            631..770
                     /gene="Mapkapk3"
                     /gene_synonym="3PK; MAPKAP-K3; MAPKAP3; MapkKapk3; MK-3;
                     MK3"
                     /inference="alignment:Splign:2.1.0"
     exon            771..835
                     /gene="Mapkapk3"
                     /gene_synonym="3PK; MAPKAP-K3; MAPKAP3; MapkKapk3; MK-3;
                     MK3"
                     /inference="alignment:Splign:2.1.0"
     exon            836..915
                     /gene="Mapkapk3"
                     /gene_synonym="3PK; MAPKAP-K3; MAPKAP3; MapkKapk3; MK-3;
                     MK3"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1039
                     /gene="Mapkapk3"
                     /gene_synonym="3PK; MAPKAP-K3; MAPKAP3; MapkKapk3; MK-3;
                     MK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1115
                     /gene="Mapkapk3"
                     /gene_synonym="3PK; MAPKAP-K3; MAPKAP3; MapkKapk3; MK-3;
                     MK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1240
                     /gene="Mapkapk3"
                     /gene_synonym="3PK; MAPKAP-K3; MAPKAP3; MapkKapk3; MK-3;
                     MK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1326
                     /gene="Mapkapk3"
                     /gene_synonym="3PK; MAPKAP-K3; MAPKAP3; MapkKapk3; MK-3;
                     MK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1407
                     /gene="Mapkapk3"
                     /gene_synonym="3PK; MAPKAP-K3; MAPKAP3; MapkKapk3; MK-3;
                     MK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..2816
                     /gene="Mapkapk3"
                     /gene_synonym="3PK; MAPKAP-K3; MAPKAP3; MapkKapk3; MK-3;
                     MK3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctggcct gcccaacccg gactagcctg gccctttaag gttgacctag cggggcccca
       61 agtctgaatg acgcgacgag aagcgggggt ggggggtcac gtgggacgcg ggcggcgaga
      121 ctctgggtcc agggctccgg tcctcagcgg actccaggga tcactatctc ttgcccactc
      181 tcgcctgcac catgattttc gtgtagtgct ttgccaccaa gtgcgccttc gcctggtccg
      241 cctttcttgg gtctctgtat ggctggttct caagaccttg ttgctataca gcgccggact
      301 ccttcctaat ttgacacgtg cctgggctga gggatcacct ccccctgctg tacgtgcctc
      361 tggacgcgcc aggctggggc tacctccgag cgccccgtgg gggccatgga tggcgagaca
      421 gcaggggaga aggggagtct tgtgcccccg ccaggtgcgc tcggcgggtc cgccttgggt
      481 ggtgctccgg ccccaggtgt gcgacgggaa cccaagaagt acgcggtgac tgatgactac
      541 cagttgtcca agcaagtgct gggtctgggt gtgaacggca aggtactgga gtgctaccat
      601 cggcgctctg gccagaagtg tgccctgaag ctcctgtatg acagccccaa ggcccggcag
      661 gaggtggacc accactggca ggcgtcaggc ggcccccaca tcgtgcgcat cctggacgtg
      721 tatgagaata tgcaccacgg caagcgctgt ctcctcattg tcatggaatg catggagggt
      781 ggtgagctgt tcagcaggat tcaggagcgt ggtgaccagg ctttcactga gagagaggct
      841 gcagagataa tgcgggacat tggcactgcc atccagttct tgcacagccg gaacattgcc
      901 caccgagatg tcaagcctga aaacctactc tatacatcca aggagaagga tgctgtactt
      961 aaactcaccg attttggctt tgccaaggaa accacccaaa atgccctcca gacaccctgc
     1021 tacactccct attatgtggc tcctgaggtc ctgggtccag agaagtatga caagtcctgt
     1081 gatatgtggt ccctgggcgt catcatgtac atccttttgt gtggattccc acccttctac
     1141 tccaacaccg gccaggccat ctctccagga atgaaaagaa ggattcgctt gggccagtat
     1201 agcttcccta accctgaatg gttagatgtc tctgaggatg ccaagcagct aatccgcctg
     1261 ctcctgaaga cagatcccac agagaggcta acgatcatgc agtttatgaa ccatccttgg
     1321 atcaatcaat ccatggtggt cccacagacc ccactctaca cagcccgagt gctccaggaa
     1381 gacaaagatc actgggatga cgtcaaggaa gagatgacca gtgccctggc cactatgcgg
     1441 gtagactatg accaggtgaa gatcaaggac ctgaagacct ctaacaaccg gctcctcaac
     1501 aagaggagga aaaagcaggc aggcagctcc tcagcctcac aaggatgcaa caaccagtaa
     1561 ctcatggtgc cttggagaag ccaggctgac agactgtaat gtcctgaggc tctggccagg
     1621 aggggctgga gtcgttctta taacaaaagg acaattttgt tgtcttatgt gtcacattga
     1681 acttggggat aaagagcttg gcccaagaat cccagcctaa gtctcaggct ctagcaagct
     1741 gcaggtgaca gggatgggag ccctctgcga cagctggagc aactttgcac accagcttga
     1801 ctgaggccac agctctgttc tgcctcagga agcagcctta cttctaggcc actgggtgtt
     1861 gtggcggata tacccgtttt tctataaagg atgtgtcctg ctgtgtgggc agatgggtct
     1921 ggccttgagg aaggtattgg gccattggtt gctatggtga ccagaggcca tgttgctgtc
     1981 tgagaatact gaacacagga ggaaggaggg acaatcaagg gtctaccttc ttggggaggt
     2041 ctgtctctct cacactggat gtccctcccc aggctctctc ctctggtctg ctagaggctg
     2101 cagagtcctg attgcttgct ttcctgggtg gtccagccct gccttactgt agcaagagcc
     2161 catgtaacac tcagagagcc actagagtcc ctgggccaag catcctctcc attaccccct
     2221 gatccaaaag gtaacttctc atctcaactg aaggtgtgga tatgtatgtt gggggtgggt
     2281 atccttaacc tttttccagt ttggaaacct cactgtgaca aaagccccca cctcttcctg
     2341 ctcaccagat ctcaggtagg aaagccagtc tctgctgaca gcacgggatc tcaggtagga
     2401 aagtccgtct ctgctgacag cacgggcaac cttgggactt acttttgtga aaggtcgcac
     2461 ttggctccct gtttgttatc taggaccttt tctggtactc tggatcagac ctggctggtg
     2521 aagggctgct gagccgtgct tacaaggtct ggtcctggct ttagcagaat tggagcagag
     2581 agggttttcc ttggctgatc ccagacttag ccagctctgc cctgtcctgc ccagggcagc
     2641 atccaggtgc tgagtggttg attggtgacc tgacaagtgc ctggcaccca gcctacttcc
     2701 tagatcctag atcctggccc ttctcactgg ctgggaaacc ttagatctta tcaattacaa
     2761 tgctgctggg ttttatattc tgatatcaat aaacacattt ttaacatttt tcaatg
//
