LOCUS       NM_008551               2884 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus MAP kinase-activated protein kinase 2 (Mapkapk2),
            mRNA.
ACCESSION   NM_008551 XM_203771
VERSION     NM_008551.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2884)
  AUTHORS   Dong,M.Z., Ouyang,Y.C., Gao,S.C., Gu,L.J., Guo,J.N., Sun,S.M.,
            Wang,Z.B. and Sun,Q.Y.
  TITLE     Protein phosphatase 4 maintains the survival of primordial
            follicles by regulating autophagy in oocytes
  JOURNAL   Cell Death Dis 15 (9), 658 (2024)
   PUBMED   39245708
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2884)
  AUTHORS   Chulkina,M., Rohmer,C., McAninch,S., Panganiban,R.P., Villeger,R.,
            Portolese,A., Ciocirlan,J., Yang,W., Cohen,C., Koltun,W.,
            Valentine,J.F., Cong,Y., Yochum,G., Beswick,E.J. and Pinchuk,I.V.
  TITLE     Increased Activity of MAPKAPK2 within Mesenchymal Cells as a Target
            for Inflammation-Associated Fibrosis in Crohn's Disease
  JOURNAL   J Crohns Colitis 18 (7), 1147-1161 (2024)
   PUBMED   38224550
  REMARK    GeneRIF: Increased Activity of MAPKAPK2 within Mesenchymal Cells as
            a Target for Inflammation-Associated Fibrosis in Crohn's Disease.
REFERENCE   3  (bases 1 to 2884)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2884)
  AUTHORS   Xu,Y., Jia,Y., Wu,N., Wang,J., He,L. and Yang,D.
  TITLE     CD93 Ameliorates Diabetic Wounds by Promoting Angiogenesis via the
            p38MAPK/MK2/HSP27 Axis
  JOURNAL   Eur J Vasc Endovasc Surg 66 (5), 707-721 (2023)
   PUBMED   37295599
  REMARK    GeneRIF: CD93 Ameliorates Diabetic Wounds by Promoting Angiogenesis
            via the p38MAPK/MK2/HSP27 Axis.
REFERENCE   5  (bases 1 to 2884)
  AUTHORS   Jacenik,D., Lebish,E.J. and Beswick,E.J.
  TITLE     MK2 drives progression of pancreas and colon cancers by suppressing
            CD8+ T cell cytotoxic function and is a potential immunotherapy
            target
  JOURNAL   Front Immunol 14, 1212100 (2023)
   PUBMED   37415974
  REMARK    GeneRIF: MK2 drives progression of pancreas and colon cancers by
            suppressing CD8[+] T cell cytotoxic function and is a potential
            immunotherapy target.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2884)
  AUTHORS   Lee,C.K., Klopp,R.G., Weindruch,R. and Prolla,T.A.
  TITLE     Gene expression profile of aging and its retardation by caloric
            restriction
  JOURNAL   Science 285 (5432), 1390-1393 (1999)
   PUBMED   10464095
REFERENCE   7  (bases 1 to 2884)
  AUTHORS   Kotlyarov,A., Neininger,A., Schubert,C., Eckert,R., Birchmeier,C.,
            Volk,H.D. and Gaestel,M.
  TITLE     MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis
  JOURNAL   Nat Cell Biol 1 (2), 94-97 (1999)
   PUBMED   10559880
REFERENCE   8  (bases 1 to 2884)
  AUTHORS   Engel,K., Kotlyarov,A. and Gaestel,M.
  TITLE     Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is
            regulated by phosphorylation
  JOURNAL   EMBO J 17 (12), 3363-3371 (1998)
   PUBMED   9628873
REFERENCE   9  (bases 1 to 2884)
  AUTHORS   Plath,K., Engel,K., Schwedersky,G. and Gaestel,M.
  TITLE     Characterization of the proline-rich region of mouse MAPKAP kinase
            2: influence on catalytic properties and binding to the c-abl SH3
            domain in vitro
  JOURNAL   Biochem Biophys Res Commun 203 (2), 1188-1194 (1994)
   PUBMED   8093038
REFERENCE   10 (bases 1 to 2884)
  AUTHORS   Engel,K., Plath,K. and Gaestel,M.
  TITLE     The MAP kinase-activated protein kinase 2 contains a proline-rich
            SH3-binding domain
  JOURNAL   FEBS Lett 336 (1), 143-147 (1993)
   PUBMED   8262198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513351.26, CB249442.1, BC063064.1 and BE979119.1.
            
            On Aug 27, 2015 this sequence version replaced NM_008551.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063064.1, SRR7345562.694856.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL513351.26        44654-44682
            30-300              CB249442.1         30-300
            301-2867            BC063064.1         1-2567
            2868-2884           BE979119.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2884
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     gene            1..2884
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /note="MAP kinase-activated protein kinase 2"
                     /db_xref="GeneID:17164"
                     /db_xref="MGI:MGI:109298"
     exon            1..555
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..1479
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /EC_number="2.7.11.1"
                     /note="MAPK-activated protein kinase 2; MAPKAP kinase 2"
                     /codon_start=1
                     /product="MAP kinase-activated protein kinase 2"
                     /protein_id="NP_032577.1"
                     /db_xref="CCDS:CCDS15266.1"
                     /db_xref="GeneID:17164"
                     /db_xref="MGI:MGI:109298"
                     /translation="MLSGSPGQTPPAPFPSPPPPAPAQPPPPFPQFHVKSGLQIRKNA
                     ITDDYKVTSQVLGLGINGKVLRIFDKRTQQKFALKMLQDCPKARREVELHWRASQCPH
                     IVHIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI
                     QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAP
                     EVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE
                     WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKER
                     WEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARAVEDAALAH"
     exon            556..695
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..760
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..840
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..967
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1043
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1168
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1254
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1335
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..2871
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2848..2853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /note="hexamer: ACTAAA"
     regulatory      2852..2857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /note="hexamer: AACAAA"
     polyA_site      2867
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /note="major polyA site"
     polyA_site      2871
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /note="major polyA site"
ORIGIN      
        1 gagcagcctg tgacgcggcc gccgcccccg ggctggtact tctcggcgcg gcgattcctc
       61 cggccgggcc ctgccgtccc gcgttccccg gagcgcacgt ctccgggggg agggagcagg
      121 gctggtgggc gcccgcggcg cacagcggga cccacggggc cccgcgacca gccgagcctg
      181 gagccgggcc ggggcggggc agccggctcc agcccggagc aaacttcgcc gccgggcggg
      241 gcgtggcggg gacccgggcc cgagccggag gagggggcgg ccgcggcccc tgcctctgcg
      301 cgcgagtcgc cgggcaccat gctgtcgggc tctccgggcc agactccgcc ggcgcctttc
      361 cccagccctc caccgccagc cccggcccag ccgccgccgc cgttccccca gttccacgtc
      421 aagtcgggcc tgcagatccg aaagaacgcc atcaccgacg actacaaggt caccagccaa
      481 gtgcttggcc tgggcatcaa cgggaaggtg ctgcggatct tcgacaagag aacccagcaa
      541 aaattcgccc taaagatgct ccaggactgt ccgaaggcgc gcagagaggt ggagctgcac
      601 tggagggcct cccagtgccc acacattgtg cacatcgtgg atgtctatga gaacctgtat
      661 gccgggagga agtgcctgct gattgtcatg gagtgtctcg atggtggaga gctctttagt
      721 cgaatccagg accgaggaga ccaggcattc acagaaagag aggcgtcaga gatcatgaag
      781 agcatcggcg aggccatcca gtacctgcac tcgatcaaca ttgctcaccg ggatgtcaag
      841 cctgagaacc tcttatatac ttccaaaagg cccaatgcca ttttgaaact cactgatttt
      901 ggctttgcca aggaaaccac cagtcacaac tctttgacca ctccgtgtta tacaccatac
      961 tatgtggctc cggaagtcct gggcccggag aagtatgaca agtcctgtga catgtggtcc
     1021 ttgggtgtca tcatgtatat tttgctgtgt gggtatcccc ccttctattc caatcacggc
     1081 cttgccatct ctccgggcat gaagactcgt attcgaatgg gccagtatga atttcctaac
     1141 ccggagtggt cagaagtatc agaagaagtg aagatgctta tccggaatct gctaaaaaca
     1201 gagcccaccc agagaatgac catcacagaa ttcatgaacc acccctggat catgcaatct
     1261 acgaaggtcc ctcagactcc actgcacacc agccgtgtcc tgaaggagga caaggaacga
     1321 tgggaggatg tcaaggagga gatgaccagt gccttggcca cgatgcgtgt tgactatgag
     1381 cagatcaaga taaagaagat agaagacgca tccaaccctc tgcttctcaa gaggcggaag
     1441 aaagctcgtg ctgtggagga tgcggctctc gcccactgag ccgctctgtc tcccacccac
     1501 tggaggacaa gcaataactc tacatgaata tattttttag acaaagagac acaagttgcc
     1561 caatgctgcc tcctgttctc ttgggctgcg tggcgcccag aaatgcctcc ggctttattc
     1621 tgcccttggc tctggctccc ccgaggtggg ggctggagga tgtgtgaggg gcaaggtgct
     1681 cctgagcccg ttgctccttt gcattttatc tgtaatttgg cgtagagttt ttatggaacc
     1741 tgtcttcttg tccttttccc cactcctcac tccttcccca ggtcctttcc catctacaaa
     1801 ggctgaggct tatccacagg tgttgtggaa gttgttatag ggaaagtccc taggttgccc
     1861 tatctgtctc ctctggcctc ccactgtaac gtggggtcct cactggctct agaatctggg
     1921 agttccaggg agaaggcagc agagtggcag taggtggccc ttgcctcccg ctgaagccct
     1981 tagacatcac cagtgtgcac aacagagcag cacatgtgtg tgcatgtgtg tgtatgcctg
     2041 gatccatgcc agcgactggg cattggaggg tctagggaag gcggggctac agggactcct
     2101 gcttgaactg agcctgccta aatgcctagg tagcttgtct agatccagag ccaggtaatt
     2161 gtggcctctg tgttagctgg gcaggggagg cagtgagggg ttggggggca ctgacagcca
     2221 tcaggaggac tgggtcccct caggacccct ttccctgctg gtcccagatc cctgaggcac
     2281 tgatctactg agtagcctct gcttgccctt cttgccacga ttaacccact cttgtcgagt
     2341 tctctgaaat ttttagccat ttctcaatgg gctgtccact cccacggtga gcctgggaag
     2401 gttctatgcc tggaaaggca gttgcatttc atgcatctcc cctgatctct ggggtacctg
     2461 ccaacctccc ttcgacaagg gcaggaccac gtgtggtctt cctggatttc caccatgtgg
     2521 tctggtggat gggacagtct tcgcaccaaa gatgtcttga ctctgtccct gcccactagc
     2581 caccttaccc tctaactact caacctgggt gggggctccc caggattgag gaggagcagg
     2641 cggggaagag tctttgtgcc atggtccccc atgcccctcc tgctggagga ggggtgtctc
     2701 cctcaggggt tggtggagga ggggctcttg ggcatccctg ggcctggggc agggcccaga
     2761 tgtctgcagc tcctcccatg tctttgatgg tgtgttcaac actcagactg ttgtaaactc
     2821 tcgttttgta tgagcaaaat tgtctttact aaacaaattt aatagttgaa aaaaaaaaaa
     2881 aaaa
//
