LOCUS       NM_207692               4677 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus mitogen-activated protein kinase 9 (Mapk9), transcript
            variant alpha2, mRNA.
ACCESSION   NM_207692
VERSION     NM_207692.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4677)
  AUTHORS   Ishibashi,R., Itani,M., Kawashima,A., Arakawa,Y. and Aoki,T.
  TITLE     JNK2-MMP-9 axis facilitates the progression of intracranial
            aneurysms
  JOURNAL   Sci Rep 14 (1), 19458 (2024)
   PUBMED   39169203
  REMARK    GeneRIF: JNK2-MMP-9 axis facilitates the progression of
            intracranial aneurysms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4677)
  AUTHORS   Wang,J., Xiao,B., Kimura,E., Mongan,M., Hsu,W.W., Medvedovic,M.,
            Puga,A. and Xia,Y.
  TITLE     Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment
            interactions that block developmental tissue closure
  JOURNAL   J Biol Chem 300 (7), 107486 (2024)
   PUBMED   38897570
REFERENCE   3  (bases 1 to 4677)
  AUTHORS   Guo,Y., Xiang,P., Sun,X., Liu,W., Zhou,J., Yin,B., Hou,L.,
            Qiang,B., Li,H., Shu,P. and Peng,X.
  TITLE     Docking protein 6 (DOK6) selectively docks the neurotrophic
            signaling transduction to restrain peripheral neuropathy
  JOURNAL   Signal Transduct Target Ther 9 (1), 32 (2024)
   PUBMED   38351062
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4677)
  AUTHORS   Wang,X., Zhang,Y., Yu,J., Ma,Y., Xu,Y., Shi,J., Qi,Z. and Liu,X.
  TITLE     Identification and analysis of key circRNAs in the mouse embryonic
            ovary provides insight into primordial follicle development
  JOURNAL   BMC Genomics 25 (1), 139 (2024)
   PUBMED   38310234
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4677)
  AUTHORS   Wang,K., Lu,Q., Luo,Y., Yu,G., Wang,Z., Lin,J., Tan,Z., Lao,Y.,
            Liu,S. and Yang,H.
  TITLE     Circ_MAPK9 promotes STAT3 and LDHA expression by silencing
            miR-642b-3p and affects the progression of hepatocellular carcinoma
  JOURNAL   Biol Direct 19 (1), 4 (2024)
   PUBMED   38163874
  REMARK    GeneRIF: Circ_MAPK9 promotes STAT3 and LDHA expression by silencing
            miR-642b-3p and affects the progression of hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4677)
  AUTHORS   Kuan,C.Y., Yang,D.D., Samanta Roy,D.R., Davis,R.J., Rakic,P. and
            Flavell,R.A.
  TITLE     The Jnk1 and Jnk2 protein kinases are required for regional
            specific apoptosis during early brain development
  JOURNAL   Neuron 22 (4), 667-676 (1999)
   PUBMED   10230788
REFERENCE   7  (bases 1 to 4677)
  AUTHORS   Sabapathy,K., Hu,Y., Kallunki,T., Schreiber,M., David,J.P.,
            Jochum,W., Wagner,E.F. and Karin,M.
  TITLE     JNK2 is required for efficient T-cell activation and apoptosis but
            not for normal lymphocyte development
  JOURNAL   Curr Biol 9 (3), 116-125 (1999)
   PUBMED   10021384
REFERENCE   8  (bases 1 to 4677)
  AUTHORS   Wisdom,R., Johnson,R.S. and Moore,C.
  TITLE     c-Jun regulates cell cycle progression and apoptosis by distinct
            mechanisms
  JOURNAL   EMBO J 18 (1), 188-197 (1999)
   PUBMED   9878062
REFERENCE   9  (bases 1 to 4677)
  AUTHORS   Yang,D.D., Conze,D., Whitmarsh,A.J., Barrett,T., Davis,R.J.,
            Rincon,M. and Flavell,R.A.
  TITLE     Differentiation of CD4+ T cells to Th1 cells requires MAP kinase
            JNK2
  JOURNAL   Immunity 9 (4), 575-585 (1998)
   PUBMED   9806643
REFERENCE   10 (bases 1 to 4677)
  AUTHORS   Casanova,E., Garate,C., Ovalle,S., Calvo,P. and Chinchetru,M.A.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX235052.1, AK031959.1, AK031974.1 and BB362351.1.
            
            On Jul 28, 2009 this sequence version replaced NM_207692.1.
            
            Transcript Variant: This variant (alpha2) encodes isoform alpha2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.77581.1,
                                           SRR1660813.116704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               CX235052.1         1-395
            396-1421            AK031959.1         395-1420
            1422-4667           AK031974.1         981-4226
            4668-4677           BB362351.1         288-297
FEATURES             Location/Qualifiers
     source          1..4677
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 29.96 cM"
     gene            1..4677
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /note="mitogen-activated protein kinase 9"
                     /db_xref="GeneID:26420"
                     /db_xref="MGI:MGI:1346862"
     exon            1..225
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /inference="alignment:Splign:2.1.0"
     exon            226..395
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1545
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /EC_number="2.7.11.24"
                     /note="isoform alpha2 is encoded by transcript variant
                     alpha2; MAPK 9; MAP kinase 9; c-Jun N-terminal kinase 2;
                     stress-activated protein kinase JNK2; protein kinase,
                     mitogen-activated 9; Jun kinase; JNK/SAPK alpha"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 9 isoform
                     alpha2"
                     /protein_id="NP_997575.2"
                     /db_xref="CCDS:CCDS24623.1"
                     /db_xref="GeneID:26420"
                     /db_xref="MGI:MGI:1346862"
                     /translation="MSDSKSDGQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAF
                     DTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQ
                     DVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
                     SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEL
                     VKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFP
                     DWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPP
                     PQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVKDQPSDAAVSSKATPSQSSSI
                     NDISSMSTEHTLASDTDSSLDASTGPLEGCR"
     exon            396..525
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /inference="alignment:Splign:2.1.0"
     exon            526..584
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /inference="alignment:Splign:2.1.0"
     exon            585..723
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /inference="alignment:Splign:2.1.0"
     exon            724..889
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /inference="alignment:Splign:2.1.0"
     exon            890..961
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1144
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1269
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1333
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1402
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..4677
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4425..4430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /note="hexamer: ATTACA"
     polyA_site      4443
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
                     /note="major polyA site"
     polyA_site      4677
                     /gene="Mapk9"
                     /gene_synonym="JNK2; p54aSAPK; Prkm9"
ORIGIN      
        1 ctgagcgccg cggcggcggc ggcggcggtg gcagcagcgg agcagaaggg aaccggaccg
       61 gaagggtcgc agcgccccgc gcccctcaca cccactgcga cggcgacggg gcggagcaga
      121 gcggggcggg gcgaccgggt ccaggtcgtg gagctgggtg ccgccagaac gcatcgccgc
      181 cagcgtgccc tccctctgcc tccggcgcgg cggcgcggag ccgaggggtc tgacgaaggc
      241 agcagccctc aggatcctgt atgacactac atcatgagtg acagtaaaag cgatggtcag
      301 ttttacagtg tgcaggtggc ggactcaact ttcactgttc taaaacgtta ccagcaactg
      361 aaaccgatcg gctctggagc ccaaggaatt gtttgtgctg cttttgatac agttcttggg
      421 ataaatgtgg ctgtcaagaa gttaagtcgt ccttttcaga accaaacgca cgcaaagaga
      481 gcctaccgtg aactcgtcct cttaaagtgt gtcaatcata aaaacataat tagcttgtta
      541 aatgtgttca caccacaaaa aacgctagaa gaatttcaag atgtgtactt ggtaatggaa
      601 ctaatggatg ctaacttatg tcaggttatt catatggaac tggaccatga gagaatgtcc
      661 taccttctct accagatgct ctgtggcatc aagcatctgc attcagctgg tatcattcat
      721 agagatttga agcctagcaa cattgtagta aaatcagact gtaccctcaa gatccttgac
      781 tttggcctgg cgcgaacagc ctgtaccaac tttatgatga ctccctatgt ggtaactcga
      841 tactatcggg ctccagaagt catcctgggc atgggctaca aagagaatgt tgatatctgg
      901 tcagtgggtt gcatcatggg agagctggtg aaaggttgtg tgatattcca aggtactgac
      961 catattgatc aatggaataa agttattgaa cagctaggaa caccatccgc agagttcatg
     1021 aagaaacttc agccaactgt aaggaattat gtggaaaaca gaccaaagta ccctggaatc
     1081 aagtttgaag agctctttcc agattggata tttccgtcag aatctgagag agacaaaata
     1141 aaaacaagtc aagccagaga tctgttatca aaaatgctag tgattgatcc agacaagcgg
     1201 atctctgtgg acgaagcctt gcgccacccg tatattactg tttggtatga ccccgctgaa
     1261 gcagaagcgc caccacctca aatttatgat gcccagttgg aagaaagaga gcatgcgatt
     1321 gaagagtgga aagagctaat ttacaaagaa gtgatggact gggaagaaag aagcaagaat
     1381 ggggtaaaag accagccttc agatgcagca gtaagtagca aggctactcc ttctcagtcg
     1441 tcatccatca atgacatctc atccatgtcc actgagcaca ccctggcctc agacacagac
     1501 agcagtctcg atgcctcaac aggacccctg gaaggctgcc ggtgatatgt atgttggaga
     1561 cggcgcactt gtctgtgaag gaactctcac ttccatggcc ccgagcgcgt gggagctgat
     1621 ggaaccaaat cgaaaaactc catgttctgc atgtaagaaa cacgatgcct tgccctgctc
     1681 agttccagta ggattgcctg cttagactat aaaatgaggc agactatgtc tgaagaaaaa
     1741 gtacaaacca cactgttaga aattttgttc aagatcattt caggtgagca attagaatag
     1801 ctgagtttct tttccagttg tgtggtatct gtggtgacag ctcatgtgta actgtgggga
     1861 ctcgtatgca tgtgaccaca aatgcttgct tgaacttgcc catgtagcac tttgggaatc
     1921 agcatttaaa tgccaaataa tcttgcaggt agttctgctt ctagaataat ctcttaatcc
     1981 tctttagtaa tttggtgtct gtccacaaaa aaatagatta tgtgtattaa ttggccaccg
     2041 tcatatatca tatcttaccc actttatggt atgatttatt ctatcttttg tatttcagaa
     2101 ggaatataat taaatttatt taataaataa aaatacagct attcttaaat ttgtgatgtt
     2161 ttaggctgag aattaccact gctctatgta gacactctgt gccctttaaa ctgcccactg
     2221 tgggatactt tatgtacagc tttctgcatg acaaagttcc cagttgtatt ccatgctgct
     2281 taagacatct gtcaccttaa atcctgccca cgaatttcct ttttcttgtt cctttggaca
     2341 tggatctaga atcctccaca gaacttcacc ttctttatca caaagcaccc catctcaata
     2401 gaatgaagcg gcaggctcct gaacccactg cctaatgttg gcatagagct gacagagtgg
     2461 cttccccaga atggtcattg aatggtgcct ccttccctga acccacccat cctttgctcc
     2521 cctctcctta tttaaggtga aaggtgatgg ggtctcacag ccgttccctc tgcagccttc
     2581 cctcctgact tttctttctc actgacagaa gccaccccgt ccagccagag cgcttggtct
     2641 cctaggagac tgagctcact cactgtgcct gttggctgct gtctttttcc attttgtgga
     2701 ggcatttcct ttttctaagg gaattcctca gatgttctag aagcactcag aagaacacag
     2761 aagaaatatt ctagagagta ggggttcatt cttgaatatt ttctgattta aaactgctca
     2821 cctgaaattg atactttcag atcctgatct gtaaattact caagatttga taagaggctg
     2881 agttctctgt gttgctgcag aaatggagtt gggacggtca taccgtggct acctgcgctc
     2941 agagcatttt ctcccttgag cttattttgt taacgattca tatcttgtgt tcagttactt
     3001 tgggagctat ggagtgtgtt ctaggaggaa acttgatagc ttttatgaaa agtaccatct
     3061 aatatgtgat tctgtctgca cccgttgcat cctaatggtt ggtctgatca ttggaacctt
     3121 taatggacaa cattaatctg aaatctgaaa taaggattag ctttgtatca tatatggata
     3181 ctttcaggta cagagtggaa atgctagtgt gggtgggggc tgagacacct gtctatggct
     3241 tcaggttatt gggccctggg agcctgaagt cccacagtgc atcagtcagc atcatgctgt
     3301 gctcttcctg ctgatgcaca ttctttaaat gacttcccgg aaacttaagg aggaaataca
     3361 gaaaggagct gtatcatcta ccctacactg taaggggagt gtgctatgat agaggctcac
     3421 cctggtccca cgggcaggag acagctgtga gtggatccag gtgcccccaa agagcggctt
     3481 tctctctccc cttactctgc atatccattg agtctgttgt ggatggagtc tgtgctggtg
     3541 tgctcagggt cttgtgccaa gaccctcttc catccaggca agtgcaccta tgaccggcct
     3601 cagagcccca aagaaatacc tcaccccagt ttcagggtcc tccctcctga gcctagattt
     3661 gccagggtcc tgggacaatg cgaatggttt tgaactaact tctgtaggca aatgctgatg
     3721 ttggatgaag aactgaaaaa tgtgctcaac tttttcatct tttctatttt atttttgtaa
     3781 tttatattgt acaccctgga agtcactatt ttggacatgt atttttataa accgggtaac
     3841 taatgattat ctggaatttg cactaggtta gtttttgttg ttgttggctt aattttcagc
     3901 caaaagtgga atgactgccc cttccaggtc cgggtttcca tttcaagcgc aggtctggag
     3961 ggcagacatg tccagccagg gtaggagagc ggcctcagaa cacaggctgc tcagtgcctc
     4021 gagcattggg cctgcagaca aaaccaggct gtgctctcaa ctttagaaca caaagaccag
     4081 acccccggtg tgagaaggag aaagccctcc attggccctt gctgacagcc ggggcctgca
     4141 tctaaagcaa aaaacccaac cctggtttca tctgggctga gtggtgtgtg agtctgtctg
     4201 ctgactcctc tgatgtccca tgccgatagt cagtacaggt gtgacctttc agatcgcgta
     4261 tctcaaaagt ggctttgcct aatgttttat aataaaatat gtcatgtgct ttgattggtg
     4321 gaaaataata caaactacat tttaaaagag aaaatgtaca gcatgtccaa ttcctgtgtg
     4381 tttcaaagtg acagttgact gtatctctcc acatcaccat tttgattaca aacctaacac
     4441 gaatagatgt tgaagtgtcg taatttcaga cattcagaag ggttttcaaa cccaaagtag
     4501 gaacgctgct gttagttcta atctctgcat ctgtttccaa aacaatggca gtagatttta
     4561 acttttaaaa attgtacaat gtggttggaa tattggtgac gttgtattct cacgagatgt
     4621 aaccaggaga acctgccaaa ctgtctctat gtatatgtct aaaagccgtt aatggtg
//
