LOCUS       NM_001163449            5510 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus mitogen-activated protein kinase 8 interacting protein
            3 (Mapk8ip3), transcript variant 4, mRNA.
ACCESSION   NM_001163449
VERSION     NM_001163449.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5510)
  AUTHORS   Goodwani,S., Fernandez,C., Acton,P.J., Buggia-Prevot,V.,
            McReynolds,M.L., Ma,J., Hu,C.H., Hamby,M.E., Jiang,Y., Le,K.,
            Soth,M.J., Jones,P. and Ray,W.J.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5510)
  AUTHORS   Guo,H., Lei,H., Zhang,B.G., Xu,Z.C., Dong,C. and Hao,Y.Q.
  TITLE     c-Jun NH2-terminal kinase (JNK)/stress-activated protein
            kinase-associated protein 1 is a critical regulator for arthritis
            progression by meditating inflammation in mice model
  JOURNAL   Int Immunopharmacol 81, 106272 (2020)
   PUBMED   32062074
  REMARK    GeneRIF: c-Jun NH2-terminal kinase (JNK)/stress-activated protein
            kinase-associated protein 1 is a critical regulator for arthritis
            progression by meditating inflammation in mice model.
REFERENCE   3  (bases 1 to 5510)
  AUTHORS   Ma,Q., Liu,Y. and Chen,L.
  TITLE     JIP3 deficiency attenuates cardiac hypertrophy by suppression of
            JNK pathway
  JOURNAL   Biochem Biophys Res Commun 503 (1), 1-7 (2018)
   PUBMED   29604277
  REMARK    GeneRIF: JIP3-KO mice after aortic banding exhibited attenuated
            cardiac function, reduced fibrosis levels and decreased
            hypertrophic marker proteins. Loss of JIP3 also ameliorated
            oxidative stress, inflammatory response, apoptosis and endoplasmic
            reticulum (ER) stress in hearts.
REFERENCE   4  (bases 1 to 5510)
  AUTHORS   Ma,X.J., Xing,H.Z., Ren,G.F., Rao,X.J. and Li,Z.Z.
  TITLE     JIP3 knockout protects mice against high fat diet-induced liver
            injury
  JOURNAL   Biochem Biophys Res Commun 497 (3), 819-826 (2018)
   PUBMED   29454969
  REMARK    GeneRIF: JIP3 absence is associated with decreased lipogenesis,
            oxidative stress and inflammation, supplying a new target for
            nonalcoholic fatty liver disease treatment.
REFERENCE   5  (bases 1 to 5510)
  AUTHORS   Gowrishankar,S., Wu,Y. and Ferguson,S.M.
  TITLE     Impaired JIP3-dependent axonal lysosome transport promotes amyloid
            plaque pathology
  JOURNAL   J Cell Biol 216 (10), 3291-3305 (2017)
   PUBMED   28784610
  REMARK    GeneRIF: These results establish the critical role of
            JIP3-dependent axonal lysosome transport in regulating
            amyloidogenic amyloid precursor protein processing and support a
            model wherein Abeta production is amplified by plaque-induced
            axonal lysosome transport defects.
REFERENCE   6  (bases 1 to 5510)
  AUTHORS   Ito,M., Akechi,M., Hirose,R., Ichimura,M., Takamatsu,N., Xu,P.,
            Nakabeppu,Y., Tadayoshi,S., Yamamoto,K. and Yoshioka,K.
  TITLE     Isoforms of JSAP1 scaffold protein generated through alternative
            splicing
  JOURNAL   Gene 255 (2), 229-234 (2000)
   PUBMED   11024282
REFERENCE   7  (bases 1 to 5510)
  AUTHORS   Kargul,G.J., Nagaraja,R., Shimada,T., Grahovac,M.J., Lim,M.K.,
            Nakashima,H., Waeltz,P., Ma,P., Chen,E., Schlessinger,D. and
            Ko,M.S.
  TITLE     Eleven densely clustered genes, six of them novel, in 176 kb of
            mouse t-complex DNA
  JOURNAL   Genome Res 10 (7), 916-923 (2000)
   PUBMED   10899141
REFERENCE   8  (bases 1 to 5510)
  AUTHORS   Kelkar,N., Gupta,S., Dickens,M. and Davis,R.J.
  TITLE     Interaction of a mitogen-activated protein kinase signaling module
            with the neuronal protein JIP3
  JOURNAL   Mol Cell Biol 20 (3), 1030-1043 (2000)
   PUBMED   10629060
REFERENCE   9  (bases 1 to 5510)
  AUTHORS   Ito,M., Yoshioka,K., Akechi,M., Yamashita,S., Takamatsu,N.,
            Sugiyama,K., Hibi,M., Nakabeppu,Y., Shiba,T. and Yamamoto,K.I.
  TITLE     JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein
            that functions as a Scaffold factor in the JNK signaling pathway
  JOURNAL   Mol Cell Biol 19 (11), 7539-7548 (1999)
   PUBMED   10523642
REFERENCE   10 (bases 1 to 5510)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166102.2 and BC060603.1.
            
            Transcript Variant: This variant (4) contains an alternate in-frame
            exon and uses an alternate in-frame splice site in the 5' coding
            region compared to variant 1. This results in a shorter protein
            (isoform d) compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060603.1, AB043123.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC166102.2         5361-5425
            66-5483             BC060603.1         1-5418
            5484-5510           AC166102.2         44806-44832
FEATURES             Location/Qualifiers
     source          1..5510
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..5510
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /note="mitogen-activated protein kinase 8 interacting
                     protein 3"
                     /db_xref="GeneID:30957"
                     /db_xref="MGI:MGI:1353598"
     exon            1..441
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..4068
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /note="isoform d is encoded by transcript variant 4;
                     C-jun-amino-terminal kinase-interacting protein 3; JNK MAP
                     kinase scaffold protein 3; JNK/SAPK-associated protein 1;
                     sunday driver 2; JUN/SAPK-associated protein 1; c-Jun
                     NH2-terminal kinase (JNK)/stress-activated protein
                     kinase-associated protein 1; JNK-interacting protein 3;
                     JNK/SAPK-associated protein 1c"
                     /codon_start=1
                     /product="C-Jun-amino-terminal kinase-interacting protein
                     3 isoform d"
                     /protein_id="NP_001156921.1"
                     /db_xref="CCDS:CCDS50029.1"
                     /db_xref="GeneID:30957"
                     /db_xref="MGI:MGI:1353598"
                     /translation="MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLI
                     HCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRK
                     QAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKE
                     YNALHQRHTEMIQTYVEHIERSKMQQVGGSGQTESSLPGRSPRQSWRKSRKERPTSLN
                     VFPLADGMCPNDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDY
                     VSVTKNNKQAREKRNSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDVCPE
                     TRLERTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFF
                     GMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLKGELEAAKQAKVKL
                     ENRIKELEEELKRVKSEAVTARREPREEVEDVSSYLCTELDKIPMAQRRRFTRVEMAR
                     VLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPP
                     AKRSYPSVNIHYKSPTAAGFSQRRSHALCQISAGSRPLEFFPDDDCTSSARREQKREQ
                     YRQVREHVRNDDGRLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPS
                     TKLWCAAGVNLSGWKPHEEDSSNGPKPVPGRDPLTCDREGEGEPKSTHPSPEKKKAKE
                     TPEADATSSRVWILTSTLTTSKVVIIDANQPGTIVDQFTVCNAHVLCISSIPAASDSD
                     YPPGEMFLDSDVNPEDSGADGVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGDV
                     ATTANGKVNPSQSTEEATEATEVPDPGPSESEATTVRPGPLTEHVFTDPAPTPSSSTQ
                     PASENGSESNGTIVQPQVEPSGELSTTTSSAAPTMWLGAQNGWLYVHSAVANWKKCLH
                     SIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCM
                     AVVNDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDST
                     LRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITALLIAGNRLWVGTGNGVVIS
                     IPLTETVVLHRGQLLGLRANKTSPTSGEGTRPGGIIHVYGDDSSDKAASSFIPYCSMA
                     QAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPSEGPGPAAPAADAEGQKLKNALV
                     LSGGEGYIDFRIGDGEDDETEECAGDVNQTKPSLSKAERSHIIVWQVSYTPE"
     exon            442..562
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..633
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..725
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..749
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..801
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1048
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1151
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1270
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1282
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1300
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1358
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1511
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1593
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1724
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1781
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1952
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2079
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2175
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2334
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2500
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2683
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2873
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..2993
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3074
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3142
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3291
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3463
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3464..3577
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3616
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3796
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3797..3946
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..5510
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5465..5470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /note="hexamer: AATAAA"
     polyA_site      5483
                     /gene="Mapk8ip3"
                     /gene_synonym="D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a;
                     JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2"
                     /note="major polyA site"
ORIGIN      
        1 aagggagtga cgggcgcggc ctgggcggcg gcacgtccta aggtagcggc tgcctgaggt
       61 gacagcggcc cgtggattcg ggccccggaa cgagccgcgc tggcggcggc ggcggtagcc
      121 gcgatgatgg agatccagat ggacgaggga ggaggagtgg tggtgtacca agacgactac
      181 tgctcgggct cggtcatgtc ggagcgtgtg tcgggcctgg cgggctccat ctaccgcgag
      241 ttcgagcgcc tcattcactg ctatgacgag gaggtggtca aggagctcat gccgctggtg
      301 gtgaacgtgc tggagaacct tgactcggtg ctgagcgaga accaggagca cgaggtggag
      361 ctggagctcc tacgcgagga caacgagcag ctgctcacgc aatacgagcg cgagaaggcg
      421 ctgcgcaaac aggccgagga gaaattcatc gaatttgaag atgccttgga acaagagaag
      481 aaagaactcc agatccaggt agaacattat gagtttcaga cacgccagct ggagctaaag
      541 gccaaaaact atgcagatca gatttcccga ctggaggaac gagaatcgga gatgaagaag
      601 gaatacaatg ccctgcacca gcggcacaca gagatgatcc agacctatgt ggaacacatt
      661 gaaagatcca agatgcagca agttgggggt agcggccaaa cagaaagcag cctgcccggg
      721 cggagtcctc gccagtcgtg gaggaaaagc aggaaggagc gtcccacctc tctgaatgtc
      781 ttccccctgg ctgatggcat gtgtccaaat gatgagatgt ctgagtcagg ccagtcctca
      841 gcagctgcaa cacccagtac cacaggtacc aagtccaaca cacccacgtc ctccgtgccc
      901 tcagcagcag tcacgccact caacgagagc ctacagcccc tgggggacta tgtcagtgtc
      961 acaaagaaca acaagcaggc ccgagagaag cgcaatagcc gtaacatgga ggtccaggtc
     1021 acccaagaga tgcggaacgt cagtatcggc atgggcagca gtgacgagtg gtccgatgtt
     1081 caggacatta tcgactccac cccagagctg gatgtgtgtc ctgaaacccg tctggagcgc
     1141 acaggaagca gcccaaccca gggaattgta aacaaagctt ttggaatcaa cactgactcc
     1201 ttgtatcacg aactctccac ggcgggatct gaggtcatcg gggatgtgga cgagggagct
     1261 gatctcctag gggagttttc agtgcgcgat gatttttttg gaatgggcaa agaagtgggg
     1321 aacctgctgc tggagaactc acagcttcta gagacaaaaa atgctttaaa tgtagtgaag
     1381 aatgacctca ttgctaaggt tgaccaactg tcaggagaac aggaggtcct gaagggtgag
     1441 ctggaagcag ccaagcaagc caaagtcaag ctggagaacc gaatcaaaga gcttgaagaa
     1501 gaactgaaga gagtcaagtc agaggcagta actgcccgcc gtgagcccag agaagaggtg
     1561 gaggatgtaa gcagctatct ctgtacagaa ttggacaaaa tccccatggc ccagcgccga
     1621 cgcttcacac gggtggagat ggcccgagtg ctcatggaac gcaaccagta caaggaacgc
     1681 ctcatggagc tgcaggaggc tgtgaggtgg actgaaatga tcagagcatc aagggaacac
     1741 ccatctgtcc aggagaagaa gaagtccacc atctggcagt tctttagtcg cctcttcagc
     1801 tcctcatcta gcccccctcc ggccaaacga tcctacccat ctgtgaacat tcactacaag
     1861 tcacccactg cagctggctt tagccagcgt cgcagccatg ctttgtgcca gatctcagcc
     1921 ggcagcaggc ccctggagtt cttccctgat gatgactgca cctcttctgc ccggcgggag
     1981 cagaagcggg agcagtaccg ccaggttcgt gaacacgtgc gcaatgatga cgggaggctg
     2041 caggcctgtg ggtggagcct gcctgccaag tacaagcagc tgagccccaa tggaggccag
     2101 gaagacaccc ggatgaaaaa tgtgcctgtc cctgtgtact gccgccctct ggtggagaag
     2161 gacccttcga caaagctgtg gtgtgctgct ggtgtcaacc tgagtgggtg gaagccacat
     2221 gaagaggact ctagcaatgg acccaagcct gtaccaggtc gagaccctct gacctgtgac
     2281 cgggaaggag aaggcgaacc caagagcaca cacccatcac ctgagaagaa gaaggcaaag
     2341 gaaacccctg aggcagatgc tacctccagt cgggtatgga tcctcaccag caccctgaca
     2401 accagcaagg tggtgatcat tgatgccaac cagccaggca caattgtgga tcagttcaca
     2461 gtctgcaatg cccacgtcct gtgtatctcc agcattcctg cggccagtga cagtgactat
     2521 ccccctgggg agatgttcct agacagtgat gtgaaccctg aagattcagg tgctgatggt
     2581 gtgctggctg gcatcaccct ggtggggtgt gctacccgct gcaatgttcc acgtagcaac
     2641 tgttcctcac gaggagacac cccagtactg gacaaggggc agggggatgt ggcgaccact
     2701 gccaatggga aggtcaaccc gtcccaatcc acagaagaag ccacagaagc cacggaggtg
     2761 ccagaccctg gtcccagcga gtcagaagca acgacagtcc ggcccgggcc tctcacagag
     2821 catgtcttta ctgacccagc acccacccca tcctccagca cccagcctgc cagtgagaat
     2881 gggtcagagt ccaatggcac cattgtacag cctcaggtgg agcccagtgg ggaactctca
     2941 acaacaacca gtagcgctgc acccactatg tggctaggag cccagaatgg ctggctctat
     3001 gtgcattcag cggtagccaa ctggaagaag tgtctgcact ccatcaagct aaaagactct
     3061 gtgctgagcc tggtgcatgt caaaggccga gtgctggtag ctcttgcaga tgggaccctg
     3121 gctatcttcc atcgtggaga ggatggccag tgggacctga gcaactacca cctaatggac
     3181 ctgggccacc cacaccactc catccgctgc atggctgttg tgaatgaccg agtttggtgt
     3241 ggctacaaga acaaggtgca tgttatccag cccaagacaa tgcagattga gaaatcattt
     3301 gatgcccacc caaggcggga aagccaggta cgtcagctgg cctggatcgg tgatggagtg
     3361 tgggtctcta ttcgcttgga ttctaccctt cggctctacc atgctcacac ccaccagcac
     3421 ctgcaggatg tggacattga gccctatgtt agcaagatgc taggaaccgg caagctgggc
     3481 ttctccttcg tgcgcatcac agccttactc attgcaggca accgtctgtg ggtgggcact
     3541 ggcaatgggg ttgtcatctc catccccttg actgagactg tggtcctgca tcgaggccag
     3601 ctcctagggc tccgagccaa caagacatcc ccaacatctg gggaggggac ccgcccaggg
     3661 ggcatcatcc atgtgtatgg ggacgacagc agtgacaagg ccgccagtag tttcatcccc
     3721 tactgctcca tggcacaggc tcagctttgc ttccatgggc accgtgatgc tgtcaaattc
     3781 tttgtctctg tgccaggaaa tgtgctggcc actctcaatg gcagtgtgct agacagccca
     3841 tcagagggcc ctgggcctgc tgcacccgct gcagatgctg agggccagaa gttgaagaat
     3901 gcactggtgc tgagtggtgg tgaaggttac attgacttcc gtatcggaga cggagaggat
     3961 gatgaaactg aggaatgtgc cggggacgtg aaccagacaa agccctcgtt gtccaaggct
     4021 gagcgcagcc acatcatcgt gtggcaggtg tcctacaccc ctgagtgaga ccctgtccta
     4081 cctgatgcca actgtacata ggaccctacc tgcctgcctc cccgcctgtt ccctggggca
     4141 gccaggttcg tccatcccct tttaacctct caacttgcag cttttgcctg aggtccagcc
     4201 cctagctgtt agagagggat gaagcagggt ttggggagtg aggcaggaac agatgtcttt
     4261 cccatcaggg aggagagagc ctctgagaca atctctccag cagcccctgg tcttgaccca
     4321 acatgaagtc ccagggggcc ctcagggcaa ggcaggacca aaatgactat gggcagcccc
     4381 tacaggtggc cctggctcca ctccatcctc accagtcctg gcaggagcaa gagcctcata
     4441 ctgccagagt cttccccaag tctacttgct ttgcatgcag ccctgaggaa gggatcctga
     4501 tttccaaccc tttgctctct ctgagggacc caggcctagc caccatcctc tgcccagaag
     4561 caaggttagg gctaccctgg ttcccggggc cccaggcagc cttctctggg cttccccgtc
     4621 tccaaactta cattcccttg gtccctagcc tgggtcttac ctgggaacct ggcatgaaag
     4681 ctcagggcca gcctcccaag ggcagctgct tcaaaagatg acaaataccc gtcaacccaa
     4741 gattgtccag cccctcacag accagttccc ctcggctctt cctggacaca agattcacct
     4801 tggaggagca agtgccctgc ccctcccaga agccccaagg gtagaatttc tcaggctgcc
     4861 agggcaggca caggcctcag gaagaagggt ggccctggtc tccccagagt cagtcctagg
     4921 atgcaggctt agcctcaggt taatggagga tggtgtgctc caagggcctg cctcctgcac
     4981 agggctccaa ggagcccagc tcccagacac gtactaagtg cctagggttg ccggctgtgg
     5041 cctgctccct tggagagcag ctgacaagag gcttccaggc agaggccaga agagctgagg
     5101 accagccagg atgggcacag ttctaagcaa gtgtgtggga gcaggtgctg ccctggctct
     5161 ggccttgctc gtcaggggca ctgagtcagt tggcctctac tgcacgcttc ctaccagaga
     5221 agcacagatc caggggcact gcccctgagc ctgtctggcc acaacaagct gcagcagtgt
     5281 gcagctgcag gcttctcccc accaccctgc cacctctcca ctgtgatgta tgtcccttgt
     5341 ctgttcccac atgagtgtga cgtgaccagg gttagttggg agggtgcaac tggagggaag
     5401 gggccagtgc aactttcctc aggctttggc cttgcaagtg aactcacata tctgctctgt
     5461 atgtaataaa tgtcttaaca ctacttttgt cttgaaactt caccagcgca
//
