LOCUS       NM_021921               3553 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus mitogen-activated protein kinase 8 interacting protein
            2 (Mapk8ip2), mRNA.
ACCESSION   NM_021921
VERSION     NM_021921.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3553)
  AUTHORS   Zhou,Y., Liu,K., Tang,W., Zhang,Y., Sun,Y., Wu,Y., Shi,Y., Yao,Z.,
            Li,Y., Bai,R., Liang,R., Sun,P., Chang,X., Wang,S., Zhu,Y. and
            Han,X.
  TITLE     beta-Cell miRNA-503-5p Induced by Hypomethylation and Inflammation
            Promotes Insulin Resistance and beta-Cell Decompensation
  JOURNAL   Diabetes 73 (1), 57-74 (2024)
   PUBMED   37847900
REFERENCE   2  (bases 1 to 3553)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3553)
  AUTHORS   Eltokhi,A., Santuy,A., Merchan-Perez,A. and Sprengel,R.
  TITLE     Glutamatergic Dysfunction and Synaptic Ultrastructural Alterations
            in Schizophrenia and Autism Spectrum Disorder: Evidence from Human
            and Rodent Studies
  JOURNAL   Int J Mol Sci 22 (1), 59 (2020)
   PUBMED   33374598
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3553)
  AUTHORS   Goodwani,S., Fernandez,C., Acton,P.J., Buggia-Prevot,V.,
            McReynolds,M.L., Ma,J., Hu,C.H., Hamby,M.E., Jiang,Y., Le,K.,
            Soth,M.J., Jones,P. and Ray,W.J.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3553)
  AUTHORS   Soda,T., Mapelli,L., Locatelli,F., Botta,L., Goldfarb,M.,
            Prestori,F. and D'Angelo,E.
  TITLE     Hyperexcitability and Hyperplasticity Disrupt Cerebellar Signal
            Transfer in the IB2 KO Mouse Model of Autism
  JOURNAL   J Neurosci 39 (13), 2383-2397 (2019)
   PUBMED   30696733
  REMARK    Erratum:[J Neurosci. 2019 Aug 28;39(35):7029. doi:
            10.1523/JNEUROSCI.1459-19.2019.. PMID: 31444244]
REFERENCE   6  (bases 1 to 3553)
  AUTHORS   Stockinger,W., Brandes,C., Fasching,D., Hermann,M., Gotthardt,M.,
            Herz,J., Schneider,W.J. and Nimpf,J.
  TITLE     The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and
            -2
  JOURNAL   J Biol Chem 275 (33), 25625-25632 (2000)
   PUBMED   10827199
REFERENCE   7  (bases 1 to 3553)
  AUTHORS   Gotthardt,M., Trommsdorff,M., Nevitt,M.F., Shelton,J.,
            Richardson,J.A., Stockinger,W., Nimpf,J. and Herz,J.
  TITLE     Interactions of the low density lipoprotein receptor gene family
            with cytosolic adaptor and scaffold proteins suggest diverse
            biological functions in cellular communication and signal
            transduction
  JOURNAL   J Biol Chem 275 (33), 25616-25624 (2000)
   PUBMED   10827173
REFERENCE   8  (bases 1 to 3553)
  AUTHORS   Negri,S., Oberson,A., Steinmann,M., Sauser,C., Nicod,P., Waeber,G.,
            Schorderet,D.F. and Bonny,C.
  TITLE     cDNA cloning and mapping of a novel islet-brain/JNK-interacting
            protein
  JOURNAL   Genomics 64 (3), 324-330 (2000)
   PUBMED   10756100
REFERENCE   9  (bases 1 to 3553)
  AUTHORS   Kelkar,N., Gupta,S., Dickens,M. and Davis,R.J.
  TITLE     Interaction of a mitogen-activated protein kinase signaling module
            with the neuronal protein JIP3
  JOURNAL   Mol Cell Biol 20 (3), 1030-1043 (2000)
   PUBMED   10629060
REFERENCE   10 (bases 1 to 3553)
  AUTHORS   Yasuda,J., Whitmarsh,A.J., Cavanagh,J., Sharma,M. and Davis,R.J.
  TITLE     The JIP group of mitogen-activated protein kinase scaffold proteins
  JOURNAL   Mol Cell Biol 19 (10), 7245-7254 (1999)
   PUBMED   10490659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137513.3, CA317486.1, AK158968.1 and BC029704.1.
            
            On Sep 2, 2009 this sequence version replaced NM_021921.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029704.1, AK158968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC137513.3         71972-72007         c
            37-148              CA317486.1         12-123
            149-3538            AK158968.1         3-3392
            3539-3553           BC029704.1         3318-3332
FEATURES             Location/Qualifiers
     source          1..3553
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.92 cM"
     gene            1..3553
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /note="mitogen-activated protein kinase 8 interacting
                     protein 2"
                     /db_xref="GeneID:60597"
                     /db_xref="MGI:MGI:1926555"
     exon            1..375
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..2803
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /note="IB-2; JIP-2; islet-brain-2; JNK-interacting protein
                     2; JNK MAP kinase scaffold protein 2"
                     /codon_start=1
                     /product="C-Jun-amino-terminal kinase-interacting protein
                     2"
                     /protein_id="NP_068740.3"
                     /db_xref="CCDS:CCDS27752.1"
                     /db_xref="GeneID:60597"
                     /db_xref="MGI:MGI:1926555"
                     /translation="MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDC
                     GLGLSYDSDHCEKDSLSLGRSEQPHPICSFQDDFQEFEMIDDNEEEDDEEEEEEEEEE
                     EDGDRQGKAGGGPGSQALAGDSLIPSPSLEESHKLRPTTLHLTTLGAQDSLNNNNGGF
                     TSAPPSSWQETVLRSPAQEPLKELPAPLLPAEEERHEVQSLARPGCDCEGNQPPEPPA
                     SSGGASPSSDPGIEADLRSHSSGGHEGRRSSQELSSPGSDSEDAGGARLGRMISSISE
                     TELELSSDGGSSSGRSSHLTNSIEEASSPASEPEPEPEPLHEPPRRPAFLPVGQDDTN
                     SEYESGSESEPDLSEDADSPWLLSNLVSRMISEGSSPIRCPGQCLSPAPRLPEEAASQ
                     ANSVPQDCQDPEAGPHVELVDMDTLCGPPPPAPAAPRLGPAQPGPCLFLSNPTRDTIT
                     PLWATPGRTARPGRSCSAACSEEEEEDEEEDEEDEEDAEDSVVPPGSRTTGSTAPLDA
                     SLVYDAVKYTLVVDEHTQLELVSLRRCAGLGNDSEEDSSCEASEEEAGATLLGSDQVP
                     EDASPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCVVNGEEREQTHRAVFRFIPR
                     HPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGPAKDLLGSKRS
                     PCWVDRFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLRPPASCDLEISLRGV
                     KLSLSGGGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFACHVFVSQES
                     MRPVARSVGRAFLEYYQEHLAFACPTEDIYLE"
     exon            376..481
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..760
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..857
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..2093
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2169
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2342
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2452
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2560
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2631
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2730
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..3539
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3519..3524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /note="hexamer: AATAAA"
     polyA_site      3539
                     /gene="Mapk8ip2"
                     /gene_synonym="3230402N03Rik; IB2; Jip2"
                     /note="major polyA site"
ORIGIN      
        1 gccagctctc ccgaccagaa tctcaccacc accgctacca ccaccacctc gcatcccgca
       61 tcctttctcg gctcgacccc cattcctccg cccccacctc aggccccgcc ctgcgccact
      121 ccctcccctc acccctgcgg cgcggcttgc tgccgcggtg tcctggcagg gcgctgaggt
      181 gtgtcgccga cgggtgtcgc agggcgtgtc acgaggtgag tggggagaca gaggccgcga
      241 gcctgagcac caagggcgcg cggtgctcct cacccctccc cctcgctgcc ggccggcggt
      301 tccagggaag atggcggatc gcgcggagat gttttctctc tccacctttc actcgctgtc
      361 gcctcccggc tgcaggcctc cccaggacat aagcctggaa gaatttgatg atgaagacct
      421 gtctgagatc acggacgact gtggcctggg ccttagctac gactcggacc actgtgagaa
      481 ggacagtctc tctctgggcc gctcggagca gccacaccct atttgttcct tccaagatga
      541 tttccaggag tttgagatga tcgacgacaa cgaggaggag gacgatgagg aggaggagga
      601 agaggaggaa gaggaggaag atggagatag gcagggcaaa gcagggggag ggcctggttc
      661 acaggcactt gctggagact cccttattcc ctctccttcc ctagaagagt cccacaagct
      721 ccgacccacc actctccatc tgactacact tggagcacag gactctctga ataacaacaa
      781 cggaggcttt acctctgcac ccccatcctc ctggcaggag actgtgctgc gttcgccagc
      841 ccaggagccc cttaaagagc taccagcccc tctcctgcca gcagaagagg agcgccatga
      901 agtacagtcc cttgcacgcc ctggttgtga ctgtgaaggg aaccagcccc cagagccacc
      961 agcatcatca ggtggggcct ccccttcctc ggatcctggt attgaggctg acttgagaag
     1021 ccactctagt ggaggccacg agggtcggcg aagcagtcag gagctctcat caccaggctc
     1081 ggactctgag gatgcaggcg gcgctcgcct agggcgcatg atctcgtcca tttcggagac
     1141 agagctggaa cttagcagcg acggtggcag cagcagtggc cgctcatcac atctcaccaa
     1201 ctccatcgag gaggcttcgt ccccagcctc ggagcctgag ccggagcccg agccactaca
     1261 tgaacctccc cgccgccctg ccttcctgcc tgtgggccag gatgacacca acagcgaata
     1321 cgagtcgggc tctgagtctg agcctgacct gagcgaggat gctgactctc cctggctgct
     1381 cagcaacctg gtgagccgca tgatctctga gggctcctcg cccattcgtt gccctggcca
     1441 gtgcttatct cctgccccac gcctgccaga agaggctgcg tcacaggcca actcggtacc
     1501 ccaggactgc caagaccctg aggcagggcc ccacgtggag ttggtggaca tggacactct
     1561 ttgcgggcca cctccgccgg cgcctgccgc acctcggctt ggtcccgcgc agcctgggcc
     1621 ctgccttttc cttagtaacc caacacggga taccatcacc ccgctttggg ccacaccggg
     1681 acgcactgcc cgccctggcc gctcctgctc tgctgcctgc tcggaggagg aggaggagga
     1741 tgaggaagag gacgaggagg atgaggagga tgcggaggac agcgtggttc cccctggctc
     1801 caggactaca ggctctactg cgccgctgga tgcctcgctg gtgtacgatg cagttaaata
     1861 cacactagtg gtggatgagc acacgcagct agagctggtg agcctgcggc gctgcgcagg
     1921 cctgggcaac gacagtgaag aggacagcag ctgcgaggcc agtgaggaag aggcgggagc
     1981 tacgttacta ggcagtgacc aggtgccaga ggatgcttct cctgacagtc ccgacctcac
     2041 cttctccaag aagttcctca atgtctttgt caacagcacg tctcgatcct ccagcactga
     2101 gtcctttggt cttttttcct gtgtggtgaa tggggaggag agagagcaaa cgcaccgggc
     2161 tgtcttcagg ttcatccctc gacatccgga tgagctagaa ctcgatgtgg atgaccctgt
     2221 gctggtggaa gcagaagagg atgacttttg gtttcgtggc ttcaacatgc gcaccggcga
     2281 gcgtggagtg ttccctgcct tctatgccca tgcggtaccg ggtcctgcca aggacctgct
     2341 ggggagcaag cggagcccgt gctgggtgga tcgcttcgat gtgcagttct tgggctccgt
     2401 ggaggtaccg tgtcaccagg gcaatgggat cctgtgtgca gccatgcaaa agattgccac
     2461 agcccggaaa ctaacggtcc acctgcgccc tcctgcctct tgtgaccttg agatctctct
     2521 gcggggggtc aagctgagtc tcagtggagg aggacctgag ttccagcgct gcagccactt
     2581 cttccagatg aagaacatct cattctgtgg ctgtcatccc cgaaacagct gctattttgg
     2641 cttcatcacc aaacacccgc tgctaagccg ctttgcctgc cacgtctttg tgtcccagga
     2701 gtctatgaga ccagtggcgc ggagtgtggg ccgggccttc ctggagtact accaggagca
     2761 cctggcgttt gcctgcccta cagaggatat ctacctggag tagcagccac ctccctcagc
     2821 tcccatctac acagctctga gtatctcaag gccactgtgg cttgagcaag gactggatcg
     2881 gggacatttg gaaccttacg ttgtgggagt ctctgggctg ggaacttttc tcctttatcc
     2941 ccaggtcatg gcttttggga gctgtttggg gagaggagcc tcagcagcca tatttttctt
     3001 ccgatgcatc tttccctctc ctgtcctcat ttgtcccgtt ccctccgacg gcctttcctc
     3061 tgtctctcgc cccctctctg tgcctgtaga ccttgctctt tgctctctct ttgggaggca
     3121 gaactttgag ggaggggagt aggctcaagg taaccgatga agtcaggttc cctccagtgg
     3181 ttccctcctg cccttctctt gtgatttata aatgaatttt aatttttata gtgaatctca
     3241 agggatcgtc ccacctttga tcacaggaag ggatcctagc ccccaaactc acaaggagct
     3301 cgggaaggag ggggagaggg gtttctaaga gaaccttagg ataactaggt ggttcttgat
     3361 gctcacccaa agcccccaat gctgctagga ggagggcacc cccaaagggt gctccccaca
     3421 ggccatctgc ttttgccgct aacacccctt cagtccagcg agtatctgcc ctgcgtgctg
     3481 ccacctgctg tgtacgtggg ccccgccccc acggcatcaa taaactctgc ttggtgtgaa
     3541 aaaaaaaaaa aaa
//
