LOCUS       NM_011162               2954 bp    mRNA    linear   ROD 20-JUN-2024
DEFINITION  Mus musculus mitogen-activated protein kinase 8 interacting protein
            1 (Mapk8ip1), transcript variant 1, mRNA.
ACCESSION   NM_011162
VERSION     NM_011162.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2954)
  AUTHORS   Fei,Q., Im,D.S., Xu,Y., Huang,T. and Qu,D.
  TITLE     Timing dependent neuronal migration is regulated by Cdk5-mediated
            phosphorylation of JIP1
  JOURNAL   Front Cell Dev Biol 12, 1371568 (2024)
   PUBMED   38606319
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2954)
  AUTHORS   Im,D.S., Joselin,A., Svoboda,D., Takano,T., Rousseaux,M.W.C.,
            Callaghan,S., Slack,R.S., Hisanaga,S.I., Davis,R.J., Park,D.S. and
            Qu,D.
  TITLE     Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth
            through Notch1 inhibition
  JOURNAL   BMC Biol 20 (1), 115 (2022)
   PUBMED   35581583
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2954)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2954)
  AUTHORS   Goodwani,S., Fernandez,C., Acton,P.J., Buggia-Prevot,V.,
            McReynolds,M.L., Ma,J., Hu,C.H., Hamby,M.E., Jiang,Y., Le,K.,
            Soth,M.J., Jones,P. and Ray,W.J.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2954)
  AUTHORS   Dinamarca,M.C., Raveh,A., Schneider,A., Fritzius,T., Fruh,S.,
            Rem,P.D., Stawarski,M., Lalanne,T., Turecek,R., Choo,M.,
            Besseyrias,V., Bildl,W., Bentrop,D., Staufenbiel,M., Gassmann,M.,
            Fakler,B., Schwenk,J. and Bettler,B.
  TITLE     Complex formation of APP with GABAB receptors links axonal
            trafficking to amyloidogenic processing
  JOURNAL   Nat Commun 10 (1), 1331 (2019)
   PUBMED   30902970
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2954)
  AUTHORS   Meyer,D., Liu,A. and Margolis,B.
  TITLE     Interaction of c-Jun amino-terminal kinase interacting protein-1
            with p190 rhoGEF and its localization in differentiated neurons
  JOURNAL   J Biol Chem 274 (49), 35113-35118 (1999)
   PUBMED   10574993
REFERENCE   7  (bases 1 to 2954)
  AUTHORS   Yasuda,J., Whitmarsh,A.J., Cavanagh,J., Sharma,M. and Davis,R.J.
  TITLE     The JIP group of mitogen-activated protein kinase scaffold proteins
  JOURNAL   Mol Cell Biol 19 (10), 7245-7254 (1999)
   PUBMED   10490659
REFERENCE   8  (bases 1 to 2954)
  AUTHORS   Kim,I.J., Lee,K.W., Park,B.Y., Lee,J.K., Park,J., Choi,I.Y.,
            Eom,S.J., Chang,T.S., Kim,M.J., Yeom,Y.I., Chang,S.K., Lee,Y.D.,
            Choi,E.J. and Han,P.L.
  TITLE     Molecular cloning of multiple splicing variants of JIP-1
            preferentially expressed in brain
  JOURNAL   J Neurochem 72 (4), 1335-1343 (1999)
   PUBMED   10098834
REFERENCE   9  (bases 1 to 2954)
  AUTHORS   Whitmarsh,A.J., Cavanagh,J., Tournier,C., Yasuda,J. and Davis,R.J.
  TITLE     A mammalian scaffold complex that selectively mediates MAP kinase
            activation
  JOURNAL   Science 281 (5383), 1671-1674 (1998)
   PUBMED   9733513
REFERENCE   10 (bases 1 to 2954)
  AUTHORS   Dickens,M., Rogers,J.S., Cavanagh,J., Raitano,A., Xia,Z.,
            Halpern,J.R., Greenberg,M.E., Sawyers,C.L. and Davis,R.J.
  TITLE     A cytoplasmic inhibitor of the JNK signal transduction pathway
  JOURNAL   Science 277 (5326), 693-696 (1997)
   PUBMED   9235893
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731709.19 and BC072578.1.
            
            On Jan 29, 2011 this sequence version replaced NM_011162.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF054611.1, AF332075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               AL731709.19        182807-183041       c
            236-341             AL731709.19        172814-172919       c
            342-647             AL731709.19        170753-171058       c
            648-729             AL731709.19        169332-169413       c
            730-1542            AL731709.19        168349-169161       c
            1543-1618           AL731709.19        168141-168216       c
            1619-1791           AL731709.19        167573-167745       c
            1792-1901           AL731709.19        167191-167300       c
            1902-2018           AL731709.19        166925-167041       c
            2019-2089           AL731709.19        166702-166772       c
            2090-2188           AL731709.19        166502-166600       c
            2189-2930           AL731709.19        165458-166199       c
            2931-2954           BC072578.1         3115-3138
FEATURES             Location/Qualifiers
     source          1..2954
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.99 cM"
     gene            1..2954
                     /gene="Mapk8ip1"
                     /gene_synonym="IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip"
                     /note="mitogen-activated protein kinase 8 interacting
                     protein 1"
                     /db_xref="GeneID:19099"
                     /db_xref="MGI:MGI:1309464"
     exon            1..235
                     /gene="Mapk8ip1"
                     /gene_synonym="IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..2261
                     /gene="Mapk8ip1"
                     /gene_synonym="IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip"
                     /note="isoform 1 is encoded by transcript variant 1;
                     C-jun-amino-terminal kinase-interacting protein 1; IB-1;
                     islet-brain-1; JNK-interacting protein 1; JNK MAP kinase
                     scaffold protein 1; protein kinase, mitogen-activated 8
                     interacting protein"
                     /codon_start=1
                     /product="C-Jun-amino-terminal kinase-interacting protein
                     1 isoform 1"
                     /protein_id="NP_035292.2"
                     /db_xref="CCDS:CCDS16446.1"
                     /db_xref="GeneID:19099"
                     /db_xref="MGI:MGI:1309464"
                     /translation="MAERESGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFE
                     DEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGSSGSAGSRLQAEMLQMDLIDAAGD
                     TPGAEDDEEEEDDELAAQRPGVGPPKAESNQDPAPRSQGQGPGTGSGDTYRPKRPTTL
                     NLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQGS
                     PVPTQDRGTSTDSPCRRSAATQMAPPSGPPATAPGGRGHSHRDRIHYQADVRLEATEE
                     IYLTPVQRPPDPAEPTSTFMPPTESRMSVSSDPDPAAYSVTAGRPHPSISEEDEGFDC
                     LSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSL
                     RPCFGDYSDESDSATVYDNCASASSPYESAIGEEYEEAPQPRPPTCLSEDSTPDEPDV
                     HFSKKFLNVFMSGRSRSSSAESFGLFSCVINGEEHEQTHRAIFRFVPRHEDELELEVD
                     DPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWIDQFRVK
                     FLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDAL
                     EAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAES
                     VGRAFQQFYKQFVEYTCPTEDIYLE"
     exon            236..341
                     /gene="Mapk8ip1"
                     /gene_synonym="IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            342..647
                     /gene="Mapk8ip1"
                     /gene_synonym="IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            648..729
                     /gene="Mapk8ip1"
                     /gene_synonym="IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            730..1542
                     /gene="Mapk8ip1"
                     /gene_synonym="IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1618
                     /gene="Mapk8ip1"
                     /gene_synonym="IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1791
                     /gene="Mapk8ip1"
                     /gene_synonym="IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1901
                     /gene="Mapk8ip1"
                     /gene_synonym="IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2018
                     /gene="Mapk8ip1"
                     /gene_synonym="IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2089
                     /gene="Mapk8ip1"
                     /gene_synonym="IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2188
                     /gene="Mapk8ip1"
                     /gene_synonym="IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2934
                     /gene="Mapk8ip1"
                     /gene_synonym="IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccgcgccc gccccagctc agtccgaacc ccgcggcggc ggcggcctcc tccacgcgcc
       61 tccgctgctg ccgccgccgc cgccgccgcc gcctcccgcg ccgctctccg cccggatggc
      121 cagggctgca ccccggaatg gcggagcgag agagcggcct gggcgggggc gccgcgtccc
      181 caccggccgc ttccccattc ctgggactgc acatcgcgtc gcctcccaat ttcaggctca
      241 cccatgacat cagcctggag gagtttgagg atgaagacct ttcggagatc actgacgagt
      301 gtggcatcag cctgcagtgc aaagacaccc tgtctctccg gcccccgcgc gccgggctgc
      361 tgtctgcggg tagcagcggc agcgcgggga gccggctgca ggcggagatg ctgcagatgg
      421 acctgatcga cgcggcaggt gacactccgg gcgccgagga cgacgaggag gaggaggacg
      481 acgagctcgc tgcccaacga ccaggagtgg ggcctcccaa agcggagtcc aaccaggatc
      541 cggcgcctcg cagccagggc cagggcccgg gcacaggcag cggagacacc taccgaccca
      601 agaggcctac cacgctcaac cttttcccgc aggtgccgcg gtctcaggac acgctgaata
      661 ataactcttt aggcaaaaag cacagttggc aggaccgtgt gtctcgatca tcctcccctc
      721 tgaagacagg agaacagacg cctccacatg aacacatctg cctgagtgat gagctgccac
      781 cccagggcag tcctgttccc acccaggacc gcggcacttc caccgacagc ccttgtcgcc
      841 gaagtgcagc cacccagatg gcacctccaa gcggtccccc tgccactgcg cctggtggcc
      901 ggggccactc ccatcgagac cgaatccact accaggcaga tgtgcggctc gaggcgactg
      961 aggagatcta cctgacccca gtgcagaggc ccccagaccc tgcagaaccc acctccacct
     1021 tcatgccacc cacggagagc cggatgtcag ttagctccga tccagaccct gccgcttact
     1081 ctgtaactgc ggggcggcca cacccctcca tcagtgaaga ggatgagggc ttcgactgcc
     1141 tgtcatcccc agagcgagct gagccaccag gtggagggtg gcggggaagc ctcggggagc
     1201 caccaccgcc tccacgggcc tcactgagct cggacaccag cgcactgtcc tacgactcgg
     1261 tcaagtacac actggtggtg gatgaacatg cccagcttga gttggtgagc ctgcggccgt
     1321 gctttggaga ttacagtgac gaaagcgact ctgccactgt ctatgacaac tgtgcctctg
     1381 cctcctcgcc ctacgagtca gccattggtg aggagtatga ggaggcccct cagccccggc
     1441 ctcccacctg cctctcagag gactccaccc cggatgagcc tgatgtccac ttctctaaga
     1501 agtttctgaa tgtcttcatg agtggccgct ctcgttcctc cagtgctgag tcctttgggc
     1561 tgttctcctg cgtcatcaat ggggaggagc atgagcaaac ccatcgggct atattcaggt
     1621 ttgtgcctcg gcatgaagat gaacttgagc tggaagtgga tgaccccctg ctggtggagc
     1681 tgcaggcaga agactattgg tatgaggcct ataacatgcg caccggagcc cgcggggtct
     1741 tccctgccta ctatgccatt gaggtcacca aggagcctga gcacatggca gcccttgcca
     1801 aaaacagcga ctggattgac cagttccggg tgaagttcct ggggtctgtc caggttcctt
     1861 atcacaaggg caatgatgtc ctctgtgctg ctatgcaaaa gatcgccacc acccgccggc
     1921 tcaccgtgca ctttaacccg ccctccagct gtgtccttga gatcagtgtc aggggtgtca
     1981 agataggcgt caaagctgat gatgctctgg aggccaaggg aaataaatgt agccacttct
     2041 tccagctaaa gaacatctct ttctgtggat accatccaaa gaataacaag tactttgggt
     2101 ttatcactaa gcaccctgct gaccaccggt ttgcctgcca tgtctttgtg tctgaagatt
     2161 ccaccaaagc cctggcggag tctgtggggc gtgcatttca gcagttctac aagcagtttg
     2221 tggagtatac ctgtcctaca gaagatatct acttggagta gcagcacccc cactctctgc
     2281 agcccctcag ccccaagcca gtgcaaggac agctggctgc tgacaggatg tggtactgcc
     2341 acaaaagaat gggggaatga gggctgttgg gtcggggggg ccggggtttg gggagaggca
     2401 gatgcagttt attgtaatat atggggttag attaatctat ggaggacagt acaggctctc
     2461 tggggactgg ggaagggtgg ggctgggggg tggggggtca ggcccctggc cacagaggga
     2521 ctccctagga acagaggcac tgtcccatcc tgggcctgtt tcatgctagg ggccctggct
     2581 ttctggctct tggctcctgc cttgacaaag cccatgccac ctggaagtgt ccagcttccc
     2641 ttgtccccac cttgaccgga gccctgagct caggctgagc ccacgcacct ccaaaggact
     2701 ttccagtaag gaaatggcaa cgtgtgaccg tggagaccct gttctcatct gtggggcctc
     2761 tgggcagctc caacctccag cctggctagc acacaggtcc tcgcaaggtt gtgtgtgcaa
     2821 ggagagggcc acagtaagcc ccatctgcca ggaaaaggag gcctcttagc tggccccagc
     2881 cagccggtca ctgtcttgtc acctggctac tattaaagtg ccatttcttg tctgaaaaaa
     2941 aaaaaaaaaa aaaa
//
