LOCUS       NM_001310453            5765 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus mitogen-activated protein kinase 8 (Mapk8), transcript
            variant 4, mRNA.
ACCESSION   NM_001310453 XM_006519031
VERSION     NM_001310453.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5765)
  AUTHORS   Huang H, Kuang X, Zou Y, Zeng J, Du H, Tang H, Long C, Mao Y, Yu X,
            Wen C, Yan J and Shen H.
  TITLE     MAP4K4 is involved in the neuronal development of retinal
            photoreceptors
  JOURNAL   Exp Eye Res 233, 109524 (2023)
   PUBMED   37290629
REFERENCE   2  (bases 1 to 5765)
  AUTHORS   Karatsai O, Lehka L, Wojton D, Grabowska AI, Duda MK, Lenartowski R
            and Redowicz MJ.
  TITLE     Unconventional myosin VI in the heart: Involvement in cardiac
            dysfunction progressing with age
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (6), 166748 (2023)
   PUBMED   37169038
REFERENCE   3  (bases 1 to 5765)
  AUTHORS   Ferreira V, Folgueira C, Garcia-Altares M, Guillen M, Ruiz-Rosario
            M, DiNunzio G, Garcia-Martinez I, Alen R, Bookmeyer C, Jones JG,
            Cigudosa JC, Lopez-Larrubia P, Correig-Blanchar X, Davis RJ, Sabio
            G, Rada P and Valverde AM.
  TITLE     Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a
            metabolic rewiring that prevents hepatic steatosis in male mice
            treated with olanzapine via intraperitoneal: Additional effects of
            PTP1B inhibition
  JOURNAL   Redox Biol 63, 102741 (2023)
   PUBMED   37230004
REFERENCE   4  (bases 1 to 5765)
  AUTHORS   Zhao L, Wang L, Wang H, Xi T, Liu S, Li Y, Ruan J and Huang Y.
  TITLE     Endoplasmic reticulum chaperone GRP78 participates in
            fluoride-induced autophagy in LS8 cells by regulating the
            IRE1-TRAF2-JNK pathway
  JOURNAL   Environ Toxicol 38 (7), 1756-1767 (2023)
   PUBMED   37070943
  REMARK    GeneRIF: Endoplasmic reticulum chaperone GRP78 participates in
            fluoride-induced autophagy in LS8 cells by regulating the
            IRE1-TRAF2-JNK pathway.
REFERENCE   5  (bases 1 to 5765)
  AUTHORS   Sun K, Hou L, Guo Z, Wang G, Guo J, Xu J, Zhang X and Guo F.
  TITLE     JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and
            aggravates osteoarthritis via ferritinophagy
  JOURNAL   Free Radic Biol Med 200, 87-101 (2023)
   PUBMED   36907253
  REMARK    GeneRIF: JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis
            and aggravates osteoarthritis via ferritinophagy.
REFERENCE   6  (bases 1 to 5765)
  AUTHORS   Dong C, Yang DD, Wysk M, Whitmarsh AJ, Davis RJ and Flavell RA.
  TITLE     Defective T cell differentiation in the absence of Jnk1
  JOURNAL   Science 282 (5396), 2092-2095 (1998)
   PUBMED   9851932
REFERENCE   7  (bases 1 to 5765)
  AUTHORS   Meng F and Lowell CA.
  TITLE     A beta 1 integrin signaling pathway involving Src-family kinases,
            Cbl and PI-3 kinase is required for macrophage spreading and
            migration
  JOURNAL   EMBO J 17 (15), 4391-4403 (1998)
   PUBMED   9687507
REFERENCE   8  (bases 1 to 5765)
  AUTHORS   Holland PM, Suzanne M, Campbell JS, Noselli S and Cooper JA.
  TITLE     MKK7 is a stress-activated mitogen-activated protein kinase kinase
            functionally related to hemipterous
  JOURNAL   J Biol Chem 272 (40), 24994-24998 (1997)
   PUBMED   9312105
REFERENCE   9  (bases 1 to 5765)
  AUTHORS   Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T and Davis RJ.
  TITLE     Mitogen-activated protein kinase kinase 7 is an activator of the
            c-Jun NH2-terminal kinase
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7337-7342 (1997)
   PUBMED   9207092
REFERENCE   10 (bases 1 to 5765)
  AUTHORS   Yang D, Tournier C, Wysk M, Lu HT, Xu J, Davis RJ and Flavell RA.
  TITLE     Targeted disruption of the MKK4 gene causes embryonic death,
            inhibition of c-Jun NH2-terminal kinase activation, and defects in
            AP-1 transcriptional activity
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3004-3009 (1997)
   PUBMED   9096336
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030767.1, BC053027.1, AK139498.1, AK047936.1, AK039129.1 and
            AI849689.1.
            
            [WARNING] On Sep 29, 2023 this sequence was replaced by
            NM_001310453.2.
            
            On Jul 14, 2015 this sequence version replaced XM_006519031.2.
            
            Transcript Variant: This variant (4) both contains and lacks an
            alternate in-frame exon in the central coding region, and uses an
            alternate splice donor site in its 3' terminal exon which results
            in a frameshift, compared to variant 1. It encodes isoform 4 has an
            alternate region in the central region of the protein and a longer
            and distinct C-terminus, compared to isoform 1. Isoforms 3 and 4
            are the same length, but differ in a small segment in the central
            region of the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139498.1, SRR10223969.13397.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AK030767.1         3-32
            31-807              BC053027.1         1-777
            808-1681            AK139498.1         796-1669
            1682-2854           BC053027.1         1652-2824
            2855-5029           AK047936.1         1352-3526
            5030-5433           AK039129.1         1972-2375
            5434-5765           AI849689.1         1-332               c
FEATURES             Location/Qualifiers
     source          1..5765
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 20.22 cM"
     gene            1..5765
                     /gene="Mapk8"
                     /gene_synonym="JNK; JNK1; Prkm8; SAPK1"
                     /note="mitogen-activated protein kinase 8"
                     /db_xref="GeneID:26419"
                     /db_xref="MGI:MGI:1346861"
     exon            1..144
                     /gene="Mapk8"
                     /gene_synonym="JNK; JNK1; Prkm8; SAPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            145..313
                     /gene="Mapk8"
                     /gene_synonym="JNK; JNK1; Prkm8; SAPK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1475
                     /gene="Mapk8"
                     /gene_synonym="JNK; JNK1; Prkm8; SAPK1"
                     /EC_number="2.7.11.24"
                     /note="isoform 4 is encoded by transcript variant 4; JNK1
                     beta1 protein kinase; MAPK 8; MAP kinase 8; c-Jun
                     N-terminal kinase 1; stress-activated protein kinase JNK1;
                     protein kinase mitogen-activated 8"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 8 isoform 4"
                     /protein_id="NP_001297382.1"
                     /db_xref="CCDS:CCDS79293.1"
                     /db_xref="GeneID:26419"
                     /db_xref="MGI:MGI:1346861"
                     /translation="MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAY
                     DAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQ
                     DVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
                     SDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM
                     IKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFP
                     DVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPP
                     PKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAMINGSQHPSS
                     SPSVNDMSSMSTDPTLASDTDSSLEASAGPLGCCR"
     exon            314..443
                     /gene="Mapk8"
                     /gene_synonym="JNK; JNK1; Prkm8; SAPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..502
                     /gene="Mapk8"
                     /gene_synonym="JNK; JNK1; Prkm8; SAPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..641
                     /gene="Mapk8"
                     /gene_synonym="JNK; JNK1; Prkm8; SAPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..807
                     /gene="Mapk8"
                     /gene_synonym="JNK; JNK1; Prkm8; SAPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..879
                     /gene="Mapk8"
                     /gene_synonym="JNK; JNK1; Prkm8; SAPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1062
                     /gene="Mapk8"
                     /gene_synonym="JNK; JNK1; Prkm8; SAPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1187
                     /gene="Mapk8"
                     /gene_synonym="JNK; JNK1; Prkm8; SAPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1251
                     /gene="Mapk8"
                     /gene_synonym="JNK; JNK1; Prkm8; SAPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1329
                     /gene="Mapk8"
                     /gene_synonym="JNK; JNK1; Prkm8; SAPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..5751
                     /gene="Mapk8"
                     /gene_synonym="JNK; JNK1; Prkm8; SAPK1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgttagtc agcggagcgg ccgaggccgg acgttgcggc cgaaacgcgg agccgcgaac
       61 aggattgagt agcggccgcg gccaccgcag gacggcgccg ttctccgcta cgggcttcca
      121 ggtcgccgtt ggctgcactg ccggccttgg tgaatatttg gatgaagcca ttagactaat
      181 tgcttgccat catgagcaga agcaaacgtg acaacaattt ttatagtgta gagattggag
      241 attctacatt cacagtccta aaacgatacc agaatttaaa gcctataggc tcaggagctc
      301 aaggaatagt gtgtgcagct tatgatgcca ttcttgaaag aaatgttgca atcaagaagc
      361 tcagccggcc atttcagaat cagacccatg ctaagcgcgc ctaccgagaa ctagttctta
      421 tgaagtgtgt taatcacaaa aatataattg gccttttgaa tgttttcaca ccacagaaat
      481 ccctagaaga atttcaagat gtttacatag tcatggagct catggatgca aatctttgcc
      541 aagtgattca gatggagtta gatcatgaaa gaatgtccta ccttctctat caaatgctgt
      601 gtggaatcaa gcaccttcac tctgctggaa ttattcatcg ggacttaaag cctagtaata
      661 tagtagtcaa atcagactgc actttgaaga ttcttgattt tggactggcg aggactgcag
      721 gaacgagttt tatgatgacg ccttatgtgg tgactcgcta ctacagagca ccagaggtca
      781 ttctcggcat gggctacaag gagaacgttg acatttggtc agttgggtgc atcatgggag
      841 aaatgatcaa aggtggtgtt ttgttcccag gtacagatca tattgatcag tggaataaag
      901 ttattgaaca gctcggaaca ccttgtcctg aattcatgaa gaaactacaa ccaacagtaa
      961 ggacttatgt tgaaaacagg cctaaatacg ctggatatag ctttgagaaa ctgttccccg
     1021 atgtgctttt cccagctgac tcagagcata acaaacttaa agccagtcag gcaagagatt
     1081 tgttatccaa aatgctagta atagatgcat ccaaaaggat ctccgtagat gaagctctcc
     1141 agcacccata catcaacgtc tggtatgatc cttcagaagc agaagcccca ccaccaaaga
     1201 tcccggacaa gcagttagat gagagggagc acacaataga ggagtggaaa gaactgatat
     1261 acaaggaggt aatggatttg gaggaacgaa ctaagaatgg agtcataaga gggcagccgt
     1321 ctcctttagg tgcagcaatg atcaatggct ctcagcatcc atcgtcttcg ccgtctgtca
     1381 atgacatgtc ttcaatgtcc acagatccga ctttggcctc ggatacagac agcagtctag
     1441 aagcatcagc tggacctctg ggctgctgta gatgactact tgggccttgg gtgggtggga
     1501 gggatgggga attggttagt cattgataga actgctttaa aaacaattca gtggtcatat
     1561 ttttgagtga tttttcagaa aatgtagaat tcattttgta gtaaagtagt ttattttttt
     1621 taatttcaag tgttgtaatt taaaacttaa gttgtgtttt taaacagcaa caaaactgta
     1681 ttgtattttt gctgtaatta actgtataat gtaaacctaa ttattttatc atggtttaaa
     1741 ttttgcatat ttgctttatc ttatgctgct gattttttta ctgaatttgt aaaatttttg
     1801 tttatcaaag caactattat gtggtgactt gcatatatca tgaattattt aagatgttta
     1861 taagtttttt attagaattt atttcagatg tttgttcatg atgctatcct tcagggttat
     1921 gtgcttatca atgaaataac cccagaggaa taagggaaaa taacctgtag ccagttatat
     1981 tcaggaataa ctactgtaaa tgatgaacgc atcaagaaac ctccaatatt tgctacttgc
     2041 caatcccaac ttagttaaaa caattggtag gcaaccttac ctaaatttta gcaaacacct
     2101 tatctaatgg cagaataact cagagcatgt ctttaaagat gctgggcaca tccttctcca
     2161 ttttgaatct cctacaccaa cccaagaaaa acttaaacta aggaatgtgg tatattctga
     2221 tcatctgtgg catgcttaaa gcttttgatc acacaaagtt aagaggacac ttcatgaatc
     2281 tacatttccg tggagatcaa cagatgcttc ccctgtcctg gctacgagcc tgcttctgta
     2341 gacactgagt taatctcctc aggctgtagg tcctggcatt ggccacgagc ctggactttc
     2401 cctgttggac agcttctggc ctctggcctt tcccagttcc tgttccttag cgggtcagtc
     2461 tgttgagcac cagtttgtgg tgtttctggc catttgattc tacctgtagc attatcctgt
     2521 ttctactagc tgtcaggagg ttccaaagcc tacttaaact tgtgtaggtg acatttaaat
     2581 gagcaatatg ccgttcatct gaaaatagta gcacacagcc atatgtagga tgtcattttc
     2641 taaggactgt ttcttcacag tgagcagagc aggcatagtg gtggttcttt catctgagtc
     2701 tttggttttt tatatctgat ttccagtatg gacgttgagt agtgtaagaa tggtgctgct
     2761 cctgacaagt gtgtgttaac tgtttacatt ttatatctgc agaatccttt ctctgtaact
     2821 gaattttcct aagtaaaatg tcatcaaggt ctcattattt ctgaaatgat gtctataatg
     2881 cccaggcacc tttggtatta tctggaacaa gagggatttc atgtaatgaa ctgggaaatg
     2941 catacttcat gagctgcaag gttgtaggaa ggagcccgga gccccttgga gctcacaatc
     3001 agcaggagta agagcgggca cagcttggca gatttctgaa aggttgctta gcaggttctt
     3061 ttgttttggt ttttggattt ttcttctttt ggttgctttt taaaaacatt tagtgtacaa
     3121 ttactttcaa gtaagctatt ttaagtcttg ttaatgtgca atacttaaga ttaagatatt
     3181 acctttttaa acatagcaag tttatcaaga tttctagcgt cccatctttt agtgattcct
     3241 tttctatatg tacaacatgg tgcatttatt ttattagaca agtatgaatt tgagactgtt
     3301 acgcctcttg gttctagaaa tacaaggttg aagtcaggat tttagcagaa attggagcat
     3361 gagtgtgttc ttattttata ttagttttgc atctaactgg ttttggtttt gccgtgataa
     3421 aatgtgtcac tattgcactt accagctgat atgctgtagt tagttttctg tgtttgtgtt
     3481 tgattgctga gaagccatct tcttcattca gatttcgggt aagtaaggaa tactagttgt
     3541 ttgattgtct catctgttgt aattgccagc tcccacttgc cagcaatcat gtttcagtta
     3601 aatttaaaaa aaaaaaaaac aacaagctct caatgcttaa tgtaagctga aatacctaac
     3661 agagtatacc taaaagcaag gtctgtttgt taaacatgtg cccaacacat taagatccac
     3721 tgtacacaca cacacacaca cacaaaacac accactgtgt ttaaatcttt taacataaat
     3781 cctactggta cttttagagt cttaaagcat cttaagtatt tttttaagaa attacaaata
     3841 acatttctgt ctatcagtac ttattaagcc accctataat ttgacttttc aattatatat
     3901 acttatgata cccattgtct tactgtctaa aagttgttta gctgagaatt agcattccac
     3961 ttcatggttt aggaaagaga gccttattct tcctacatgt cttcctggtt acaggtctcg
     4021 tacccactaa tacatagtga ccatctgtaa gatgagcatg ttgttgggat tgctttgtta
     4081 tagagcatct cactctttaa tgctatttgc tagtggtttt tactgtgtca tgccatgctg
     4141 ctgattgcca aatctcagaa gagtgcacac cagaagcaaa ggcccagtgt gttcacacct
     4201 ggctagtaag agaagcagta gtccccacca atacagagaa gctggttgtg tacaaagctt
     4261 gcctgtcagc cttatccctc agttctgagc tcatctcact ttgttaccct aagacgtgga
     4321 ggtagaaaag acacttgaca ggataggatg agcagtaggc aagggaagct gtttcctgag
     4381 ttacaaaaag aacttggttt acattattgg ccagtttctg ccgcacacat gaagacatca
     4441 tcagtgttgc ctcagcgcta gcctgcacgg cattttgaga ttgaaaaaaa aaaccaacaa
     4501 catagtatat tttcagaaat actgttgtag tttgtgagtg ttgttcatta gtcactcatt
     4561 agtgtagagt ggatgcatga tgccccatga ccccagtaag tcttaccagt gagtagaata
     4621 cccagcaccg tctctcaccc gtagccctct tcagcattgc ctcgtggctt gttgcattct
     4681 agtgtgcata ttctagtgtg cattgtgttt ctactgatct cttgggtgtt tcctgtgaac
     4741 cacaggaggc acatttgtcc taatcgcacg aaagaaagat gaaagagata agggcattga
     4801 agcagaaatg tgtggtttgg ggtaagatag gaaaattgtg tcctaattaa tttcaaagta
     4861 actgctctta ggcaaattgc ttttaagggg agtctagtaa gcaactttct gggcacttct
     4921 ggtttagatt ctcttcatta ctgaaactcc tgagaaatat tacctgtgga ttagttttgc
     4981 acaatgtcct attctcacaa tgacttaaaa ttaaactagg tttttattga actacctcac
     5041 actgattttc tatgctttcc caagtaagct gtagccctta ctgtttgacc tttactgagt
     5101 gtaaattata aatgtgcgtt gaatactttc tagccactgt tcacaaaata ccagtaagca
     5161 tgtgaagtgc aaaccttgcg tcagtaagag acagtcccgt gtagtcttcc actgtgtctg
     5221 gggaattgtg ctgcatacgc ttattgacat cctcactgtt tttgtaagaa acctgctcga
     5281 gataccagtc catgctttac attttacaga aggagaaaat cttagtaaat tttacgaaga
     5341 aatacattac ttttgtaggc ccaatatttg gtatattttt gagaagctgt taatcttata
     5401 gcggaatgat gaagttacac tgaagtagct gtctgcctgg actgtgatgt ctgttttctc
     5461 attacggttt accctgttaa taaggtttta aacctcaaaa cataggatga taattagatt
     5521 ttttcctctt tccctgtaca tgtcattcct tcatcccgcc ccttccgtgt gctctcctct
     5581 cttctcctct agacaaaaca aatgggcact ttgtagggaa tgctgggatc gttaccgtgg
     5641 gttatcgttc atgccctagt cattcaacat gcaccactgg gtgtaaacag tgttatctag
     5701 tgtgtcaatt ggttataata ttttaaataa aaaagaaaaa gtggtatgaa aaaaaaaaaa
     5761 aaaaa
//
