LOCUS       NM_011841               2999 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus mitogen-activated protein kinase 7 (Mapk7), transcript
            variant 1, mRNA.
ACCESSION   NM_011841
VERSION     NM_011841.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2999)
  AUTHORS   You,H., Song,G., Xu,Z., Chen,S., Shen,W., Liu,H., Deng,B., Li,J.
            and Huang,G.
  TITLE     HuR promotes castration-resistant prostate cancer progression by
            altering ERK5 activation via posttranscriptional regulation of
            BCAT1
  JOURNAL   J Transl Med 22 (1), 178 (2024)
   PUBMED   38369471
  REMARK    GeneRIF: HuR promotes castration-resistant prostate cancer
            progression by altering ERK5 activation via posttranscriptional
            regulation of BCAT1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2999)
  AUTHORS   Guo,Y., Xiang,P., Sun,X., Liu,W., Zhou,J., Yin,B., Hou,L.,
            Qiang,B., Li,H., Shu,P. and Peng,X.
  TITLE     Docking protein 6 (DOK6) selectively docks the neurotrophic
            signaling transduction to restrain peripheral neuropathy
  JOURNAL   Signal Transduct Target Ther 9 (1), 32 (2024)
   PUBMED   38351062
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2999)
  AUTHORS   Savage,H., Pareek,S., Lee,J., Ballaro,R., Conterno Minussi,D.,
            Hayek,K., Sadullozoda,M., Lochmann,B.S., McQuade,J.L., LaVoy,E.C.,
            Marmonti,E., Patel,H., Wang,G., Imanishi,M., Kotla,S., Abe,J.I. and
            Schadler,K.
  TITLE     Aerobic Exercise Alters the Melanoma Microenvironment and Modulates
            ERK5 S496 Phosphorylation
  JOURNAL   Cancer Immunol Res 11 (9), 1168-1183 (2023)
   PUBMED   37307577
  REMARK    GeneRIF: Aerobic Exercise Alters the Melanoma Microenvironment and
            Modulates ERK5 S496 Phosphorylation.
REFERENCE   4  (bases 1 to 2999)
  AUTHORS   Tsitsikov,E.N., Phan,K.P., Liu,Y., Tsytsykova,A.V., Kinter,M.,
            Selland,L., Garman,L., Griffin,C. and Dunn,I.F.
  TITLE     TRAF7 is an essential regulator of blood vessel integrity during
            mouse embryonic and neonatal development
  JOURNAL   iScience 26 (8), 107474 (2023)
   PUBMED   37583551
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2999)
  AUTHORS   Abe,J.I., Imanishi,M., Li,S., Zhang,A., Ko,K.A.,
            Samanthapudi,V.S.K., Lee,L.L., Bojorges,A.P., Gi,Y.J., Hobbs,B.P.,
            Deswal,A., Herrmann,J., Lin,S.H., Chini,E.N., Shen,Y.H.,
            Schadler,K.L., Nguyen,T.H., Gupte,A.A., Reyes-Gibby,C., Yeung,S.J.,
            Abe,R.J., Olmsted-Davis,E.A., Krishnan,S., Dantzer,R.,
            Palaskas,N.L., Cooke,J.P., Pownall,H.J., Yoshimoto,M., Fujiwara,K.,
            Hamilton,D.J., Burks,J.K., Wang,G., Le,N.T. and Kotla,S.
  TITLE     An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and
            Atherosclerosis
  JOURNAL   Circ Res 133 (1), 25-44 (2023)
   PUBMED   37264926
  REMARK    GeneRIF: An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness
            and Atherosclerosis.
REFERENCE   6  (bases 1 to 2999)
  AUTHORS   Regan,C.P., Li,W., Boucher,D.M., Spatz,S., Su,M.S. and Kuida,K.
  TITLE     Erk5 null mice display multiple extraembryonic vascular and
            embryonic cardiovascular defects
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9248-9253 (2002)
   PUBMED   12093914
  REMARK    GeneRIF: Erk5 null mice display multiple extraembryonic vascular
            and embryonic cardiovascular defects.
REFERENCE   7  (bases 1 to 2999)
  AUTHORS   Grewal,P.K., Holzfeind,P.J., Bittner,R.E. and Hewitt,J.E.
  TITLE     Mutant glycosyltransferase and altered glycosylation of
            alpha-dystroglycan in the myodystrophy mouse
  JOURNAL   Nat Genet 28 (2), 151-154 (2001)
   PUBMED   11381262
REFERENCE   8  (bases 1 to 2999)
  AUTHORS   Dalmay,T., Horsefield,R., Braunstein,T.H. and Baulcombe,D.C.
  TITLE     SDE3 encodes an RNA helicase required for post-transcriptional gene
            silencing in Arabidopsis
  JOURNAL   EMBO J 20 (8), 2069-2078 (2001)
   PUBMED   11296239
REFERENCE   9  (bases 1 to 2999)
  AUTHORS   Yan,C., Luo,H., Lee,J.D., Abe,J. and Berk,B.C.
  TITLE     Molecular cloning of mouse ERK5/BMK1 splice variants and
            characterization of ERK5 functional domains
  JOURNAL   J Biol Chem 276 (14), 10870-10878 (2001)
   PUBMED   11139578
REFERENCE   10 (bases 1 to 2999)
  AUTHORS   Kamakura,S., Moriguchi,T. and Nishida,E.
  TITLE     Activation of the protein kinase ERK5/BMK1 by receptor tyrosine
            kinases. Identification and characterization of a signaling pathway
            to the nucleus
  JOURNAL   J Biol Chem 274 (37), 26563-26571 (1999)
   PUBMED   10473620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY207876.1 and AY534740.1.
            
            On Mar 22, 2014 this sequence version replaced NM_011841.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Both variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB019373.1, AK155187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BY207876.1         31-96
            67-1740             AY534740.1         1-1674
            1741-2999           AY534740.1         1778-3036
FEATURES             Location/Qualifiers
     source          1..2999
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     gene            1..2999
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /note="mitogen-activated protein kinase 7"
                     /db_xref="GeneID:23939"
                     /db_xref="MGI:MGI:1346347"
     exon            1..187
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            188..495
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            496..661
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            662..1740
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..2396
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2530
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2989
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2966..2971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /note="hexamer: AATACA"
     polyA_site      2984
                     /gene="Mapk7"
                     /gene_synonym="b2b2346Clo; BMK-1; BMK1; ERK-5; ERK5;
                     Erk5-T; PRKM7"
                     /note="major polyA site"
ORIGIN      
        1 tgggagctgg aggagcgtgg tcccggggcg gccggtgggg tggtctgctt cggcgcacgc
       61 gaggctttgg tggtggccgc ggttcttgtt aagtgagcga gcccggggga acactcatca
      121 ctgggttggc aagactcagg aatcccaaat tcccgaggag gcgtggcggc ggggtgccgg
      181 ccggtcggtc ctgcctccaa acccacagag gcggaactga gaggccctca ggacgatctt
      241 ctcatcagcg cttcgtacag accatggccg aaccgctgaa ggaggaggac ggcgaagatg
      301 gctctgggga gccccctggg agggtgaagg cagaacccgt tcacaccgct gcctctgtgg
      361 tggccaagaa cctggccctg ctcaaagccc gctccttcga cgtgaccttt gacgtggggg
      421 acgagtacga gatcatcgag accataggca atggggccta cggggtggtg tcttcggcgc
      481 gccgccgcct cacgggccag caggtggcca tcaagaagat acctaatgct tttgatgtgg
      541 tgaccaatgc caaacggacc ctcagggagc tgaagatcct caaacacttc aaacacgaca
      601 atatcatcgc catcaaggac atcctgaagc ctactgtgcc ctatggagaa ttcagatctg
      661 tctatgtggt actggacctc atggagagcg acctacacca gatcattcac tcttcacagc
      721 cgctcaccct ggaacatgtg agatacttcc tgtaccagct gcttcggggc ctcaaataca
      781 tgcactctgc tcaggtcatc caccgtgatc ttaaaccctc taaccttctg gtcaatgaga
      841 actgtgagct caagatcggt gactttggaa tggcccgtgg cctctgtact tcccctgccg
      901 agcaccagta cttcatgact gagtatgtgg ctactcgctg gtaccgtgcc ccggagctca
      961 tgctttccct gcacgagtat acgcaggcaa tcgacctctg gtctgtgggc tgcatctttg
     1021 gtgagatgct ggctcggcgc cagctcttcc caggcaaaaa ctacgtgcac cagttacagc
     1081 tgatcatgat ggtgttggga actccgtcac cagctgtgat tcaggctgtg ggggctgaaa
     1141 gggtgcgagc ctatatccag agcctgccac caaggcaacc tgtgccttgg gagacagtat
     1201 acccaggtgc tgaccgccag gccctctccc tgctgggacg catgttgcga tttgaaccca
     1261 gtgcccgaat ctcagctgct gctgcccttc gccacccctt cctggctaag taccatgacc
     1321 ctgatgatga gcctgattgc gccccacctt ttgactttgc ttttgaccgt gaagccctta
     1381 ccagggagcg cattaaggag gccattgtgg ctgagattga ggacttccat gcacgacggg
     1441 agggcatccg ccaacaaatc cgcttccagc cttctctgca gcctgtggct agtgagcctg
     1501 tgtgtccaga tgttgagatg cccagtccct gggctccaag tggagactgt gccatggagt
     1561 cgcctcctcc agcactgcca ccatgctctg atcctgcacc tgacaccgtt gatctgactc
     1621 tgcagcctgc cccgccggcc agtgagcttg ctccaccaaa aagagagggt gccatctccg
     1681 acaataccaa agcagccctc aaagctgccc tgctcaagtc cctaaggagc aggctcagag
     1741 atgggcccag tgcacccttg gaggcgcctg agcctcgaaa gcccgtgaca gctcaggaac
     1801 gccagcgaga acgagaagag aagcgcagga ggcgacaaga gagagccaag gagcgggaga
     1861 agcgacgaca agagagagaa cgcaaggaga ggggggctgg taccttgggg ggcccctcta
     1921 ctgaccctct ggctggactg gtgctcagtg acaatgaccg aagcctgcta gagcggtgga
     1981 ctcgcatggc taggcctcct gcccctgccc ctgccccagc gccagcacca gcgccagcac
     2041 cgtcctctgc ccagcccact agtactccta ctggccccgt atctcagtct actggtcctc
     2101 tacagcctgc aggctctatt ccgggtcctg cctcccagcc tgtttgccca ccccctggcc
     2161 ctgttcccca gcctgctggc cctatccctg ctccgctcca gactgcccct tccactagcc
     2221 ttttggcctc ccagtcactt gtgccaccta gtgggttgcc tggttctggt gccccagaag
     2281 ttctgcctta cttcccatct ggcccaccac ctccagatcc tgggctcacc cctcagcctt
     2341 ctacatcaga gtcacctgat gtcaacctgg tgactcagca gctgtccaag tctcaggtgg
     2401 aggaccccct gcctcctgtg ttctctggca ctccaaaggg cagtggggct ggctacggag
     2461 ttggctttga tctggaggaa ttcttaaatc aatcttttga tatgggtgtg gctgatgggc
     2521 cacaggatgg ccaggcagac tcagcctcac tctcagcctc tctccttgct gactggcttg
     2581 agggccatgg catgaaccct gctgacattg agtctctgca gcgtgagatc cagatggact
     2641 ccccaatgct gctgtctgac ctgcctgacc tccaagagcc ctgaaaccca cagcttgtgc
     2701 cttgctgcca ggatagaccc agcatcaagg tccaggggtg cgatccaaag ggctgcaccc
     2761 tgggcctggc aggtgaggct tggcttgagt tactctgcag gttcatctca gacccacctt
     2821 tcagccttaa gcagccacct gagccaccac cgagccataa caggaccagg agactctact
     2881 cctccctgag cagtcttctc cagtattgta ttttttatta ttgttgtaat atgcatttgt
     2941 tttgccatca aaatgaggcc tgtgaaatac aaggttttct ttaacctgaa aaaaaaaaa
//
